Sabbin Magungunan Anti-tsufa: Nicotinamide Mononucleotide (NMN)

Shin kun mutu ne a kan tsufa? Da kyau, wata magungunan rigakafin tsufa ba shakka ba ne mafi kyawun zaɓin zaɓi na sake juyowar agogon rayuwarka. Yi la'akari da muhimman abubuwan da ke tattare da Nicotinamide Mononucleotide (NMN), da rawar da yake ciki, da kuma yadda za a samu magani.

Gabatarwa

Tsarin girma yana da makawa. Duk da haka, akwai yiwuwar sake juya tsarin tsufa ta amfani Nicotinamide Mononucleotide. Riƙe dawakanku domin zan ba ku cikakkun bayanai game da yadda ma'anar kayan aiki a cikin jikin mutum.

Gyada gashi daidai ne da hikima!

Wannan gaskiyar ita ce mafi kyawun abin da za ku yi magana mai girma. Duk da haka, murmushi ɗinka zai ragu lokacin da ka fara fara kallon wrinkles a jikin fata. Abinda ya fi haka, tsufa yana shafar ayyukan aiki na jiki da na zuciya.

Bari mu fuskanta. Da Anti-tsufa mayukan fuska da tiyatar kwalliya sun kasance a cikin abu a wannan karnin na zamani. Abin da ya kamata ku sani shi ne cewa waɗannan hanyoyin na ɗan gajeren lokaci ne kuma suna iya haifar da mummunan sakamako.

A zahiri, ya kamata ku yi yaƙi da tsufa ta hanyar fara fahimtar salon salula da tsarin ilimin halittar jiki waɗanda ke taka rawa a cikin yanayin da suka shafi shekaru. Bayan haka, yana da sauƙi a cire hanyoyin da ake yin yaƙi da nasu. Nicotinamide Mononucleotide na rigakafin tsufa yana aiki don dawo da ƙuruciya.

Dukanmu muna so mu yi girma da kyau, gaskiya? Da kyau, wannan hakikanin abu na iya zama mai banƙyama yayin da jikinka ya ci gaba da raunana, kuma ka ƙare zama magnet ga dukan cututtukan zuciya, Alzheimer's, ƙwaƙwalwar ajiya, da sauransu.

Ystungiyar Nicotinamide mai ban mamaki Mononucleotide (NMN)

Don haka, menene duk abin da ke faruwa game da Nicotinamide Mononucleotide? Bari in bayyana.

NMN yana cikin siffofin alpha (α) da beta (β). Duk da haka, β-NMN shine nau'i mafi nau'i. Wannan nucleotide bioactive wani matsakaici ne a cikin biosynthesis na nicotinamide adenine dinucleotide ko NAD +.

Wannan fili ya wanzu a cikin avocadoes, tumatir, kokwamba, cabbages, broccoli, da kuma naman gwari. A cikin dakin gwaje-gwaje, ana samuwa a matsayin ƙwayar foda mai girma na nicotinamide mononucleotide.

A cikin takunkumin sa, yana nuna daidai da lambar CAS, 1094-61-7. Filin ya fito ne daga abin da ya faru tsakanin nucleoside, kamar nicotinamide riboside da kuma rukunin phosphate.

A cikin binciken bincike na yau da kullun, aikin Nicotinamide Mononucleotide akan mice ya tabbatar da kasancewa mai amfani a cikin ayyukan sinadarai na salula, sarrafa cutar Alzheimer, ciwon sukari da ke da alaƙa da shekaru, rikice-rikice waɗanda ke tasowa daga kiba, da kariya ta zuciya. Duk da waɗannan ayyukan harhada magunguna da ke da alaƙa da Nicotinamide Mononucleotide, mafi mahimmancin ganowa shine shigar da ayyukan rigakafin tsufa.

A cikin jikin mutum, NMN shine babban tushen makamashi a cikin sel. Yayin da kake tsufa, makamashin salula ya ragu saboda ƙananan matakan nicotinamide mononucleotide da rage yawan NAD +. NMN jagorancin za ta kawar da tsari kuma ta biya gazawar.

(1) Ta yaya NMN mai ban mamaki?

Wadannan kwayoyi masu kare tsufa suna tafiya kamar walƙiya daga hanji zuwa yanayin jini. A cikin 'yan mintina kaɗan, za a ɗauke su zuwa cikin jini. A saboda wannan dalili, ya bayyana sarai cewa akwai yuwuwar babu wani tasirin kwayar halitta wanda ke faruwa a cikin hanyar ƙwayoyin.

Saurin rikitarwa ya sanya masu bincike su kammala yiwuwar mai jigilar kaya, wanda ke taimakawa isar da mai cikin kwayar halitta. Misali, Imai da abokan aikinsa sun dukufa neman amsuwa ta hanyar binciken da ya yi kwanan nan wanda aka buga a ranar 7 ga Janairu, 2019.

Tare da tsufa, jiki yana amfani da NAD + fiye da yadda yake iya ƙera shi. Duk yadda kayi amfani da nicotinamide mononucleotide, aikin har yanzu zai zama ɓata lokaci matuƙar babu wata kwayar halitta da zata taimaka jigilar ta. Ci gaba da gungurawa don buɗe fasinjan jigilar da zai warware 90% na matsalolin tsufa.

(2) Formats na gina jiki na Nicotinamide Mononucleotide

(3) Nicotinamide Mononucleotide Specifications

Product name	Raw Nicotinamide Mononucleotide (NMN) foda
CAS ba.	1094-61-7
Tsarin tsarin	C11H15N2O8P
kwayoyin nauyi	334.221 g / mol
Appearance	White crystalline foda
tsarki	> 98%
solubility	Ruwa mai narkewa
Storage zazzabi	-20 ° C
sauran sunayen	Nicotinamide-1-ium-1-β-D-ribofuranoside 5'-phosphate · Β-nicotinamide mononucleotide · Beta-NMN · Nicotinamide ribonucleotide · 3- (Aminocarbonyl) -1- (5-O-phosphonato-beta-D- ribofuranosyl) pyridinium · Nicotinamide ribonucleoside 5'-phosphate

Nicotinamide Mononucleotide da NAD +

Dukansu Nicotinamide Mononucleotide da NAD + su ne masu mahimman bayanai a cikin salula na man fetur.

NMN wani matsakaici ne a cikin biosynthesis na adonine dinucleotide Nicotinamide (NAD +). Abun yana aiki ne a matsayin madogara don ƙananan enzymes kamar nicotinamide mononucleotide adenylyltransferase, wanda ya tuba zuwa NAD + a jikin mutum. Bayan rashin raguwa, wannan fili ya canza zuwa nicotinamide. Daga bisani, yana karɓar wani motsi wanda ya hada da nicotinamide phosphoribosyltransferase (NAMPT) da ke samar da NMN.

Wadannan kwayoyi guda biyu an hade su kamar yadda babu wani daga cikinsu zai shafar wani. Ɗauka, alal misali, lokacin da matakan NMN suka fāɗi ƙasa ƙasa, watakila saboda senescence, yawancin NAD + zai koma baya.

Yayin da kake da shekaru, wasu ayyukan enzymatic suna cin NAD + fiye da jikin da zai iya samar da man fetur. Masu sirtu, NADase, da poly-ADP-ribose polymerase (PARP) suna daga cikin enzymes, wanda ke ƙone NAD + da ke haifar da rikici.

Duk da haka, ragewar man fetur na cellular ba ƙari ba ne. Ɗauka, alal misali, aikin da ake ciki a cikin enzymatic wanda ya shafi PARP yana taimaka wajen gyaran DNA ta lalata. Har ila yau, 'yan jarida suna taka muhimmiyar rawa a inganta tsarin cinikayyar salula.

Kodayake akwai alaƙar magunguna tsakanin waɗannan alamomin halittu guda biyu, ba za ku taɓa iya sarrafa NAD + kai tsaye a cikin tsarin ba. A cikin yadda hanyar zai yiwu, da illa zai zama insufferable. Misali, babban kashi yana nuna gajiya, damuwa, da rashin barci. Abin da ya fi haka, abin da ke tattare da shi ba shi da ƙarancin lalacewa ta hanyar ƙwayar plasma.

(1) Kayan Kyau

The anti-tsufa Nicotinamide Mononucleotideyana samuwa a matsayin magani mai magunguna. Hanyoyinta ta hanyar bangon guttura da kuma cikin tsarin siginal na farawa cikin kimanin minti uku. Ta hanyar 15^th min, duk za'a ɗauke shi. Cikakken binciken Imai da abokan bincikensa sun tabbatar da cewa akwai furotin da ke hanzarta saurin saurin sha.

Bayan zubar da ciki a cikin kyallen takarda, NMN za ta tuba zuwa NAD + don dacewa da ajiya. Tsarin aikin metabolism zai iya ɗaukar har zuwa sa'a daya. Tsarancin NAD + yana cike da ƙwayoyin ƙwanƙun ƙwayoyin cuta, fararen fata, hanta, da kuma ƙwayoyin cuta. Duk da haka, gudanar da dogon lokaci na Nicotinamide Mononucleotide ya kai matakin NAD + a wasu kwayoyin kamar launin launin ruwan kasa.

(2) NMN Biosynthetic Pathways

A cikin Kwayoyin Halitta, akwai matakan hanyoyi uku da suka dace da rashin raunin NAD.

①Hanyar De Novo

De Novo kalma ne na Lain, ma'anar "tun daga farkon." A nan, nucleotides na samo daga tryptophan ko acidic nicotinic, wanda ya samo asali ne daga abinci mai arzikin NMN.

A cikin wannan hanya, jerin jerin ayyukan biochemical na haifar da samuwar ƙwayar ƙwayoyin ƙwayoyin ƙwayoyin ƙwayoyin ƙwayoyin ƙwayoyin ƙwayoyin ƙwayoyin ƙwayoyin ƙwayoyin ƙwayoyin ƙwayoyin maganin nicotinic acid, diccleotide adinine acicine acid, da kuma karshe da aka yi tsammani NAD +. De Novo ya samar game da 15% na yawan man fetur din.

②Hanyar Salvage

A nan, hanya ta dawo da nucleosides a lokuta da DNA ta rushe. Yana da asusun fiye da 80% na jimlar NAD +, wanda jikin mutum yake buƙatar na aikin salula. Hanyar da aka yi amfani da su da nicotinic acid da nicotinamide don haɗa sabon NAD +.

Nicotinate phosphoribosyltransferase accelerates da samuwar nicotinic acid mononucleotide daga nicotinic acid. Daga bisani, 1 adenylyltransferase na nicotinamide adenylyltransferase ya haɓaka adenylation na samfurin samarwa zuwa adnine mononucleotide na Nicotinic, kuma daga karshe zuwa NAD +.

NMN aiki akan ɗan adam ya dogara da wannan hanyar.

③NR Conversion

Rijiyarside Nicotinamide wani mafarin NAD+ ne. Bayan phosphorylation a gaban nicotinamide riboside kinase, biomarker yana haifar da NMN kafin yin wani juzu'in enzymatic zuwa NAD +.

Tarihin NAD + da NMN a Bincike

A cikin shekaru, binciken da maganin warkewa na amfani da adinine dinucleotide na nicotinamide da kuma wadanda suka riga sun ƙaddara sunyi fushi. Duk da haka, ya kamata ka lura cewa waɗannan anti-tsufa kari an gudanar da su cikin bincike tun daga tsakiyar 1900s.

A cikin 1906, malaman farko sun nuna cewa NAD + ya kara yawan yisti na yisti. Daga bisani, wasu masu binciken halitta sun bi gurbin ta hanyar rarraba shi a matsayin nucleotide.

Ta hanyar bincikensa a 1937, Conrad Elvehjem ya gano cewa nicotinamide da nicotinic su ne bitamin da kuma wadanda suka riga sun zama NAD +. Daga bisani, ya gano cewa wadannan biyu zasu iya sauke pellagra a cikin karnuka. Dalilin shi ne cewa matakan nicotinic acid da nicotinamide sun kasance mafi kyau duka a kan wadanda ke fama da cutar.

A cikin 1963, ƙungiyar masana kimiyya sun tabbatar da cewa aikin Nicotinamide Mononucleotide akan ƙuda zai ƙarfafa enzymes masu dogaro da DNA, waɗanda ke da mahimmanci wajen haɓaka ayyukan salula. Shekaru biyu bayan haka, wasu masu bincike sun kawo hanyoyin NAD + masu amfani da sinadarai wanda ya shafi tryptophan da acid nicotinic.

Tun daga wannan lokacin, biochemists sun ci gaba da nuna sha'awar binciken NMN da NAD. A wannan zamanin, muhimmancin mayar da hankali ga muhimmancin waɗannan anti-tsufa da kwayoyi a tsawon lokaci da kuma hana rikice-rikice na shekaru.

Binciken da aka saba yi game da Ayyuka na Monotonamide a kan Mice

Akwai ƙididdiga masu yawa game da tsarin murine wanda ke haifar da amfanin lafiyar Nicotinamide Mononucleotide (1094-61-7).

Bari mu mayar da hankali kan wasu, wanda ya yi tasirin juyin juya hali a cikin biochemistry.

(1) A cewar Sinclair, NAD + wani tafkin matasan ne

Dokta Sinclair da abokan aiki sun wallafa wasu darussa na bincike game da yiwuwar nicotinamide mononucleotide da NAD + a cikin juyawa da tsufa. Bisa ga binciken 2013, Sinclair da tawagar sun gano cewa mahaifiyar 22 a watanni shida da ke ɗauke da NMN na tsawon kwanaki shida ya nuna ingantawa a kan karfin muscle, ƙarfin zuciya, da jimiri.

Daga bisani a cikin takardar bincike na 2016, kungiyar ta tabbatar da cewa NMN yana da irin wannan amfãni yayin yin amfani da shi. Maimakon gudu a kan takaddama yau da kullum, har yanzu za a iya samun irin wannan sakamako yayin da kake amfani da Nicotinamide Mononucleotide a maimakon.

A cewar wannan Harvard Geneticist, da NMN aiki a kan mutum ya yi yunkurin bunkasa jini a kan tsofaffin 'yan wasa da' yan wasa.

(2) Mills Yayi da'awar cewa NNN ta Sauke Kwayoyin Halittar Kwayoyin Halittar Kwayoyin Tsarin Kwayoyi

Dangane da binciken 2016, Mills et al. gano cewa NMN magani zai magance raguwa a cikin aikin ilimin lissafi da na rigakafi a cikin tsofaffin beraye. A ƙarshen wannan ƙarin bincike na NMN, rodents sun yi rajistar karuwa a cikin maganganun ƙwayoyin rigakafi, yaduwar lymphocytic, da raguwa a cikin neutrophils.

A baya, a cikin 2011, Mills, Yoshino, da Imai sunyi amfani da ƙirar ƙira don tabbatar da rawar NAD + a cikin maganin rage cin abinci da ciwon sukari da ke da shekaru. A wani binciken kuma na 2016, ya haɗu tare da wasu masu binciken waɗanda suka tabbatar da cewa ƙarin NMN zai magance ƙarancin ƙwayoyin cuta da lalata jijiyoyin jiki a cikin tsofaffin yara.

(3) NMN yana fama da cututtukan Alzheimer (AD) a cikin ƙirar Murmin

A cikin 2015, Long et al. bincika tasirin NMN akan ƙananan raunin numfashi na kwakwalwa akan ƙananan yara tare da cutar Alzheimer. Notedungiyar ta lura cewa maganin NMN na iya magance ilimin ilimin AD, gami da ƙananan OCR (ƙimar amfani da iskar oxygen), NAD + falloff, da rashin daidaito na mitochondria.

A cikin 2016, Wang da abokansa sun buga bincikensu, suna kammala cewa waɗannan Anti-tsufa magunguna suna fama da larurar hankali da jijiyoyin jiki, wanda ke haifar da oligomer am-amyloid (A o). Wannan furotin na Aβ neurotoxic ne kuma shine ke da alhakin samar da abin rubutu a cikin kwakwalwar marasa lafiyar AD. Wang et al. Ya ƙare da cewa gudanarwar NMN a cikin ƙananan yara ya haifar da raguwa a cikin masu oligomers na Aβ, don haka haɓaka ayyukan haɓaka.

Bayan nazarin 2017, Hou da abokan aikinsa sun gano cewa NAD + kari ya rage samar da β-amyloid oligomers. Shekara guda bayan haka, Yao da tawagarsa sun tabbatar da cewa Nicotinamide Mononucleotide yana rage tarin Aβ da asarar synaptic a cikin tsarin AD-Tg murine.

(4) NMN da Cardio-kariya

Dangane da littafin da Yamamoto da abokan aikinsa suka wallafa a 2014, NMN kare zuciya daga rauni na ischemic da sake bayyanawa. Kafin wannan binciken, Yamamoto na daga cikin ƙungiyar 2012, wanda ya gano cewa NAD + yana ƙididdige kiba mai haifar da kiba a cikin beraye.

A cikin 2016, De Picciotto et al. da takwarorinsa masana kimiyyar nazarin halittu sunyi nazarin tasirin karin NMN akan aikin jijiyoyin beraye masu tsufa. Daga abin da aka fahimta, nicotinamide mononucleotide ya tabbatar da cewa yana da tasiri wajen juya lalacewar jijiyoyin jiki, sanya karfin abu a jiki, da raguwar elastin.

(5) Bincike akan Sabuwar Wayar Wayar Ciki ta Shin-Ichiro Imai

A cikin bincike na baya-bayan nan, wata ƙungiyar masana kimiyya da Imai ta jagoranci ta gano kuma ta ba da izinin daukar nauyin NMN a cikin sel.

Wannan bincike na NMN na farko ya kasance a cikin Janairu 2019 a cikin Yanayin Metabolism. Imai ya tabbatar da cewa wani furotin na musamman, Slc12a8, yana da alhakin saurin fasalin NMN zuwa NAD + da kuma kai shi cikin tantanin halitta. Wannan enzyme yana da mahimmanci a cikin tsofaffi tsofaffi maimakon na matasa ko masu lafiya.

A cikin dukkan binciken farko, masana kimiyya zasu narkar da sanannun matakan nicotinamide mononucleotide foda da yawa a ruwa kafin a basu maganin berayen.

Amfanin daga Nicotinamide Mononucleotide (NMN)

NMN yana da ayyuka masu yawa na warkewa da tasirin magunguna akan jikin ɗan adam. A cikin ƙasa da shekaru goma, masana kimiyya sun sadaukar da lokacinsu don nazarin duk fa'idodin Nicotinamide Mononucleotide gami da hanyoyin da ke bayyana tsufa da cututtukan da suka shafi shekaru.

Bari mu shiga cikin fa'idodin mahaɗin a cikin tsarin ɗan adam.

(1) Ana cigaba da ƙwaƙwalwar salon salula

Har zuwa farkon 21^st karni, malaman suna da dalilai masu yawa don bayyana tsufa a matsayin tsari marar iyaka. Duk da haka, wannan ra'ayi ya ɓata ba tare da godiya ba ga binciken da aka samu anti-tsufa kari kamar Nicotinamide Mononucleotide.

NMN na faruwa ne a cikin kwayoyin halitta kuma yana da alhakin biosynthesis na NAD + da samar da makamashi. Yayin da kake tsufa, wadannan mahaɗannan abubuwa guda biyu suna haifar da rikici na kwayoyin kwayoyin. Ka tuna, waɗannan raka'a aikin suna buƙatar isaccen man fetur don yin amfani da su akai-akai, sabili da haka, fadiwa zai rage gajeren salula.

Sarrafa magungunan maganin tsufa kamar NMN zai sake aiwatar da tsari kuma jinkirta ma'anar tsufa.

(2) Tsayawa matakan makamashi na matasa

Tushen asali na cututtuka da ke haɗaka da tsufa yana ƙuntata zuwa matakin salula. Raguwar samar da makamashi a cikin kwayoyin halitta shine babbar hanyar bayar da gudunmawar tsofaffi bayyanar cututtuka.

Kasancewa na NAD +, NMN yana da rawar da za ta taka a riƙe da mafi kyawun matakin makamashi na mitochondria. Ƙungiyar zai haifar da raguwa a cikin maida hankali na NAD +. A sakamakon haka, tsarin tsufa na dan lokaci ne ya jagoranci ci gaba da cututtuka.

Wani digo a cikin kwayoyin makamashi a cikin kwayoyi masu muhimmanci irin su tsokoki, tasoshin jini, kodan baya, hanta, ko pancreas ko da yaushe yana tsangwama ga lafiyar jiki da na zuciya. Saboda haka ne cututtuka irin su ischemia, yanayin zuciya, rashin cin nasara koda, cututtukan neurodegenerative, da sauransu harbe harbe.

Cikakken bayani shine ta hanyar kara kayan jiki Nicotinamide mononucleotide da NAD + tare da maganin NMN na waje. Wadannan magungunan rigakafin tsufa suna ba da sabon salon rayuwa ga sel masu tsufa, wanda zai sanya kyan gani na matasa.

(3) Inganta Yanayin Jiki

Ɗaya daga cikin canje-canje da ke faruwa a lokacin tsofaffi shine karuwar ingancin jini a cikin jikin mahaifa. Saboda haka, tsarin tsawaita jiki yana fama da damuwa a yayin ɗaukar kayan abinci, oxygen, zafi, ko cire sharar gida daga gabobin. Tun da halin da ake ciki yana ci gaba, yana damuwa a tsawon lokacin da ke haifar da cututtuka na tsawon lokaci.

Nicotinamide Mononucleotide yana da alhakin samar da jini. Bada izinin bayyana. Cibiyar ta hada NAD +, wanda ke kunna ladaran ciwon dajin da ke cikin sirri (SIRT1).

Sabanin haka, SIRT1 rassan lysine na dacetylates da ke taimakawa wajen samar da oxygen free radicals. Wannan tsari yana yaki da yiwuwar mawuyacin yanayin oxydative, reperfusion, ko ischemic raunin da ya faru. A cikin al'amuran al'amuran, jiki da kansa zai yi musgunawa da ischemia da kuma alaƙa da ta dace ta hanyar ƙaddamarwa ta musamman (IPC). IPC za ta yi aiki don tada samar da SIRT1.

Kuna iya ba da umarni na NMN kafin wani abu mai sauƙi ya faru ko lokacin bayyanarsa. Kafin abin da ya faru, gidan yana samar da kariya ta katin ƙarfafa ta hanyar inganta ATP ta hanyar glycolysis.

Dangane da Ischemia, har yanzu zaka iya amfani da Nicotinamide Mononucleotide saboda zai haifar da acidosis kuma zai haifar da mitochondrial impermeability; sabili da haka, tabbatar da kariyar tsarin zuciya.

(4) Muscle Endurance

Me kuke tsammani lokacin da jini ya ragu? Da kyau, jihar zata haifar da asarar tsoka. Babu shakka za ku lura da tsoffin mutanen da ke da ƙarancin aiki, rashin jimiri, mara motsi, kuma suna gajiya sosai koyaushe.

Ofaya daga cikin abubuwan binciken ƙasa na Dakta Sinclair ya ta'allaka ne akan ingancin NMN wajen haɓaka ƙarfin tsoka. Dangane da 2013 da karatun 2018 na kwanan nan, tsoffin beraye da aka nuna wa magani na NMN na kwana bakwai sun zama masu ƙoshin lafiya da aiki kamar ƙarancin takwarorinsu.

Ƙarfin tsoka da juriya na tsofaffin beraye (watanni 30) sun kasance daidai da na ƙaramin ɗan wata biyar. Waɗannan shekarun sun yi kama da kusan shekaru 70 da 20 a cikin mutane. Daga binciken, zaku iya tunanin cewa NMN yana aiki akan ɗan adam tabbas mutuwa.

(5) Cin da Cutar Neurodegenerative

Kwaƙwalwarka ta fi kama da tashar na'urarka. Wannan batu shine dalilin da yasa likitoci zasu dogara da aikin kwakwalwa yayin furtawa lokacin mutuwar.

Ragewa a cikin matakan NAD + a cikin kwakwalwa yana shawo kan lafiyar marasa lafiya tsakanin tsofaffi. Gudanar da NMN ta hanzarta samar da NAD +, don haka, kare kullun ayyukan.

Yawancin karatu sun tabbatar da cewa Nicotinamide Mononucleotide fa'idodin fa'ida, bugun jini, da hana asarar ƙwaƙwalwar ajiya, wanda ke yaduwa tare da tsufa. A taƙaice, wannan Anti-tsufa kari yana da alhakin kiyaye jijiyoyin jiki.

NMN yafi ƙaddamar da ilimin ilimin kowane yanayin yanayin jijiya. Misali, Alzheimer's cuta na faruwa ne saboda raguwar NAD +, ƙananan ƙarancin amfani da iskar oxygen a cikin kwakwalwa, da rashin daidaito na mitochondrial. Asingara adadin NMN a cikin ƙididdigar jiki duk waɗannan tasirin.

Dangane da binciken da aka buga a 2012, Nicotinamide Mononucleotide zai iya sarrafa lalacewar intracerebral yadda ya kamata, wanda yakan haifar da bugun jini. Tsoffin beraye waɗanda ke ƙarƙashin sashin NMN sun yi rijistar ingantaccen ci gaba a cikin aikin samar da NAD +. Wadannan samfuran binciken suna da kariya mafi girma daga cutar bugun jini, mutuwar jijiyoyi, da kumburin jijiyoyin jiki.

(6) Inganta Metabolism a Tsohon Alkawari

Yawancin masu bincike sunyi nazari kuma sun tabbatar da cewa NMN yana taimakawa wajen haɓaka glucose yayin kara inganta karfin sukari a kan balagagge tsufa da abinci mara kyau. Wannan binciken kuma yana amfani da mutanen da ke ci gaba da ciwon sukari ko sakamakon sakamakon babban sukari ko abinci mara kyau. Bugu da ƙari, cin abinci mai cin abinci mai yalwa yana haifar da gwajin insulin.

Nicotinamide Mononucleotide yana da mahimmanci samar da NAD +, wanda hakan ya rage yawan ƙonewa a lokacin da yake inganta cigaba da insulin a cikin sassan jiki.

(7) Jiyya na Ciwon sukari

Mutanen da ke da ciwon sukari na II koyaushe suna nuna juriya ga insulin. Wannan halayyar ta faru ne saboda lalacewa a cikin NAD +. A sakamakon haka, ƙwayoyin suna shan wahala da kumburi mai kumburi. Idan har yanzu kai saurayi ne, jiki zai sake sabonta kansa ta hanyar wasu ayyukan motsa jiki. Koyaya, tare da tsufa, matakan NAD + sun ragu a cikin gabobin da ke tallafawa rai kamar ƙwayoyin ƙashi, hanta, kwakwalwa, da ƙoshin ciki.

Wani abin da ke ba da gudummawa ga ciwon sukari mai alaka da shekaru shine abinci mai-mai. Abubuwa masu yawa na kitsen mai suna hana haɓakar halittar NAD +. A kokarin su na tabbatar da ingancin Nicotinamide Mononucleotide wajen kula da shekaru da ciwon siga da ke haifar da abinci, Yoshino da abokan aikin sa sunyi amfani da samfurin ɓeraye biyu.

Bayan sun ba da kashi na NMN na yau da kullun kusan kwanaki 10, malamai sun tabbatar da cewa ɓerayen, waɗanda aka ci abinci mai ƙoshin mai, sun yi ingantaccen rashin haƙuri na insulin. A gefe guda kuma, berayen masu ciwon sukari sun nuna babban ci gaba a cikin hyperlipidemia.

(8) Kashewa da tsufa

Gwagwarmayar lafiyar lokaci na yau da kullum suna bin tsarin tsufa. Kamar yadda jiki yana da sauye-sauye na physiological, wasu daga cikin salon salula sun fadi. Alal misali, matakan nicotinamide adinine dinucleotide yana raguwa a jikin kwayoyin halitta, wanda zai haifar da raguwar samar da makamashi ta mitochondrion cell.

Tsufa ya kafa motsi daban-daban kamar lalata DNA saboda kwayoyin da ba a ba da izini ba, gajiya mai kwakwalwa da sauransu, da sauran cututtuka. Ka san abin da ya faru? To, akwai tsarin gina jiki na DNA (PARP1) a cikin tsarin mutum. A cikin yanayin lalacewar DNA, NAD + zai kunna wannan gina jiki don gyara cell da ya shafi.

Yawancin karatu sun fito da fa'idodin nicotinamide mononucleotide a cikin tsufa. Misali, Mills da abokan aikinsa sun yi amfani da ƙirar beraye don bincika sakamakon raguwar shekarun NMN.

A cikin binciken, masu bincike sun lura cewa gudanar da magani na tsawon lokaci ya haifar da daidaitaccen kwayoyin halitta a cikin hanta, ƙwaƙwalwar ƙuƙumma, da ƙwayar jikin mutum. Abinda ya fi haka, binciken ya tabbatar da cigaban cigaban kwayoyin halitta, karuwa a cikin lymphocytes, da kuma kunnawa na leukocytes.

Wani hali na tsofaffi shine kasancewar launin launi mai haske a cikin ido. Wannan yanayin tare da ƙarancin kashi mai yawa da rashin iyawa don samar da hawaye sunyi nazarin sosai a kan rodents. Masana kimiyya sun lura cewa ƙwayar mice, wanda aka sanya a kan NNN na watanni 12, yana da duk yanayin da aka sama.

Lokaci shine kawai dalilin da yasa mutane saya Nicotinamide Mononucleotide.

(9) Jiyya na Kiba

Ga tsofaffi, NMN na iya ragewa zuwa 10% na nauyin jiki na farko ba tare da gano tsakiya tsakanin cin abinci da ci gaba ba. Hanyar daji na kiba da ciwon sukari suna haɓaka. Ƙananan NAD + matakan suna haifar dysfunction mitochondrial; saboda haka, ragewa a samar da ATP.

Kiba cikin nauyi na mitochondria a samar da makamashin ATP don sel. Da zarar ka umurci Nicotinamide Mononucleotide, miyagun ƙwayoyi za su inganta glucose rashin haƙuri da sauran ayyuka na al'ada da suka danganci kiba.

Idan ya zo ga inganta yanayin jini, NMN don maganin kiba yana yin kama da motsa jiki. Kwayar kwaya daya zata yi kyau kamar amfani da na'urar motsa jiki a kullum. Koyaya, bambanci ya zo a cikin matakan NAD + a cikin gabobin jiki. Ganin cewa Nicotinamide Mononucleotide yana haɓaka NAD + a cikin hanta da ƙwayoyin tsoka, motsa jiki kawai yana gina mahaɗin cikin tsokoki.

Shin Nicotinamide Mononucleotide (NMN) Yake Aiki A Dan Adam?

Da kyau, wannan na iya zama tambayar da ake yi a yanzu a cikin kwakwalwar ku. A cikin kowane hali, duk bincike da Nazarin farko wanda ya shafi Nicotinamide mononucleotide da NAD + suna niyya ne akan ƙirar murine.

Idan kana da damuwa game da yadda NMN ke aiki a kan mutum, ga duk abin da kake bukata ka sani. Dokta David Sinclair, babban jami'in binciken, kuma mai ilimin halitta a Jami'ar Harvard, daya daga cikin masu karɓar NMN.

Sinclair ya furta cewa ya ɗauki ƙarin. Ya zuwa yanzu, masanin bai rubuta wani kabari nicotinamide mononucleotide ba illa. Akasin haka, ya furta cewa yana jin matashi da kaifin hankali. Hangovers da jet lak yanzu sun wuce masa. Ya ci gaba da cewa mahaifinsa wanda ya cika shekara saba’in shi ma yana karbar kari.

Bugu da ƙari, Dokta Sinclair ya yi amfani da magani a matsayin gwajin farko a Brigham da Hospital Hospital. Yana da shirye-shiryen ƙarin gwada gwaji akan tsofaffi tsofaffi. Kodayake bincikensa na farko yana cikakke, har yanzu ba a yi takarda ba. Sinclair ya fara na biyu na wannan asibitin Ƙarin NMN bincike a 2018.

gwajinsu

A cikin binciken asibiti wanda yakamata akan 1^st Yuni 2020, masu bincike suna kallo don kafa canji a hankali da kuma ayyukan beta-cell tare da ƙarin NMN a cikin mutane. Masanan sun fito ne daga Cibiyar Makarantar Ma'aikatar Ilimin Jami'ar Washington ta Jami'ar Koyon Jami'ar Keio a Tokyo.

A cikin gwajin dan Adam da aka kaddamar a 2016 a Jami'ar Keio, malaman suna kallo don tantance lafiyar NMN cikin masu lafiya. A cikin halin da ake ciki na biyu, irin wannan cibiyar, wadda Shin-Ichiro ta jagoranci, na binciko tsarin NMN na dogon lokaci. Mene ne ƙari, ƙungiyar ta nema ta kimanta abubuwan da ke tattare da cutar ta hanyar ciwo, da NMN kinetics, da kuma maganin miyagun ƙwayoyi a kan gwanon glucose metabolism.

A cikin binciken nazarin asibitin 2017 da Jami'ar Washington, mahalarta sun hada da matan 50 a cikin shekaru 55 zuwa 75 shekaru. An saka rukuni a cikin nauyin 250mg na yau da kullum na mako guda takwas na NMN. Ko da yake sun kasance masu lafiya, waɗannan mata suna da ƙananan glucose jini, triglyceride, da BMI. Binciken bai riga ya kammala ba.

Kamar yadda yake a yanzu, babu wallafe-wallafen da ke tabbatar da aikin NMN akan ɗan adam. Koyaya, yakamata ku rataya saboda wani abu yana girki kuma gwajin gwaji na iya zama mai bege.

Yadda za a Yi Amfani da Nicotinamide Mononucleotide (NMN) Don Tsufa?

Idan kuna neman siyan nicotinamide mononucleotide, akwai kaɗan abubuwan da kuke buƙatar sani.

Kuna iya ɗaukar magani kawai azaman abincin abinci ne tun lokacin da bai riga ya sami amincewar FDA ta ƙarshe don zama magani mai magani ba.

Matsakaicin adadin ya bambanta tsakanin 25mg da 300mg dangane da amfanin kiwon lafiya kuna son cimmawa. Duk da haka, wasu mutane sun furta shan har zuwa 1000mg kowace rana. Dauki, alal misali, Dr. Sinclair yana ɗaukar 750mg / rana. Bugu da ƙari, yana haɓaka wannan tsarin tare da resveratrol da metformin.

A cikin jarrabawar NMN, yawancin masu bincike zasu sanya batutuwa a kan nauyin 100mg zuwa 250mg.

Oral vs. Sublingual

Idan kana so ka kara ingantaccen batu na wannan ƙarin, ya kamata ka sayi Allunan Allunan Nicotinamide Mononucleotide don kulawa na kasa. Yin amfani da miyagun ƙwayoyi yana da sauƙin rage adadin da ake ciki a cikin kyallen takarda. Dalilin shi ne cewa yana fama da ciwon zuciya da rashin raguwa yayin da yake wucewa ta hanyar ɓarna da hanta.

NMN ta ƙaddamarwa ta shiga kai tsaye ba tare da wani filtrations ba. Hanya na shayarwa ta wannan hanyar aikawa ita ce kusan sau biyar fiye da na baka. A wannan yanayin, dole ne ka ƙara sashi don daidaitawa na farko na wucewar metabolism a cikin hanta. Idan kana tsammani kake yin bincike, zaka iya buƙatar foda mai girma don ka kammala karatun.

Hanyoyin Kyau na Kwayoyin Halittar Kwayoyin Kasa da Ya kamata Ya Kamata Ku sani

Na al'ada suna daidai da waɗanda aka nuna ta niacinamide da sauran bitamin B3 compoundnicotinamide mononucleotide side effects s. Koyaya, yawancin mutane basu ma dandana su kwata-kwata. Misali, babban masanin kimiyyar bincike na Jami'ar Harvard ya yarda da shan NMN, amma bai lura da wani tasiri ba.

Ya zuwa yanzu, a cikin duk aikin Nicotinamide Mononucleotide akan mice, babu wani bayani da ya nuna wanzuwar kowane. illa a cikin samfurori na murine. Babu wani mai bincike da ya rubuta wata alama mara kyau duka a cikin gajeriyar gudanarwar NMN na dogon lokaci.

Wasu mutane na iya lura da wadannan tarzoma masu kyau;

• Tashin zuciya
• Vomiting
• Dizziness
• Dama tada
• zawo
• Maganin rashin tausayawa irin su lalacewa, amya, ko rashes

A wasu lokuta masu rikitarwa, sakamakon ƙwayar maganin nicotinamide na mononucleotide zai iya zama mai tsanani har sai da za ku nemi duba lafiyar gaggawa. Don ambaci wasu, matsaloli na numfashi, ƙwaƙwalwar ƙwaƙwalwar ajiya, ci gaba da zubar da jini, launin launin fata, da asarar ci abinci yana cikin manyan alamu.

contraindications

Har zuwa wannan batu, gwajin asibiti ya dogara ne kawai akan manya masu lafiya a cikin shekaru 45 zuwa 75. Don haka yakamata kungiyoyi masu zuwa suyi taka tsantsan kafin gudanar da NMN anti-tsufa kari.

• Masu ciki da kuma uwa masu juna biyu
• Kowane mutum yana da tarihin rashin sanarwa ga NMN
• Magunguna suna shan magunguna don cututtuka na kullum

A ina zan iya samun maganin ƙwayoyin cuta-Nicotinamide Mononucleotide (NMN)?

(1) NMN Abincin Abincin

Kila za ku yi la'akari da dalilin da ya sa za ku saya Nicotinamide Mononucleotide lokacin da za ku iya samun shi cikin wasu abinci. Bari in bayyana a taƙaice dalilin da ya sa wannan kari ya zama dole.

Kamar yadda NAD + ya raguwa cikin jiki saboda tsufa, sel ba zasu iya magance sakamakon ba. A wannan lokaci, zaɓinka kawai zai iya amfani da kariyar NMN. Magunguna zasu karfafa maka ka dauki abinci mai arzikin NMN kamar broccoli, namomin kaza, edamame, ko shrimp. Duk da haka, waɗannan abincin zasu ba da kadan fiye da 5% na abin da jikinka yake bukata.

FDA ta bada shawarar cewa kowane mutum yana bukatar kimanin 560mg na NMN kowace rana. Idan kuna tsammani za ku sami ƙarin daga broccoli, dole ku cinye 1500 fam din guda ɗaya.

(2) Karin NMN

The Nicotinamide mononucleotide foda mai girma yana samuwa don sayarwa a mafi yawan masana'antu da magunguna ko dakunan gwaje-gwaje. Idan kana son wasu don bincikenka, zaka iya yin adadi mai yawa, wanda ya zo tare da farashin kuɗi da hawaye akan zargin cajin.

Yin sayayya na kan layi na NMN ba kawai yana adana lokacinku ba amma yana ba da kyakkyawan dandamali don kwatanta farashi daban-daban. Idan ba mai bincike ba ne, har yanzu kuna iya siyan ƙarin kayan aikin Nicotinamide Mononucleotide don amfanin kanku. Kafin yin oda, tabbatar da ingancin samfurin abinci ne.

Summary

Yana da tsaran ganewa cewa NMN ta ƙara tsawon rayuwar mutane. Duk da haka, wannan furtawa yana riƙe da. Sakamakon mutuwa tsakanin tsofaffi ne saboda cututtukan da suka kamu da shekaru, wanda ya faru ne saboda sakamakon aikin salula mara kyau.

Nicotinamide Mononucleotide na tsufa kawai matakai don inganta isar da mai da kuma haɓaka aikin sel. Yana aiki ta hanyar haɓaka NAD +, wanda ke yin raguwa yayin da muke tsufa.

Yin amfani da tsinkayen fuska mai tsofaffi, moisturizers, sunscreens, ko yin amfani da kayan yau da kullum akan cin abinci mai lafiya zai canza fuskarka kawai. Duk da haka, kana buƙatar fahimtar tushen dalilin matsalolin tsufa don magance su akayi daban-daban. Nicotinamide mononucleotide ya juyawa tsarin tsufa ta hanyar gyara DNA ta lalata, kare kwakwalwa, tsarin zuciya, inganta ayyukan muscle, da ƙarfafawa.

Idan kana so foda mai girma nicotinamide, duba tare da mu kuma ku ji dadin farashi.

References

1. Mills, KF, Yoshino, J., Yoshida, S., et al. (2016). Gudanarwa na tsawon lokaci na Nicotinamide Mononucleotide Mitigates Age-Associated Physiological Rage a Mice. Cell Metabolism.
2. Yoshino, J., Mills, KF, Imai, SI, da Yoon, MJ (2011). Nicotinamide Mononucleotide, mai mahimmanci NAD + Intermediate, Yana Kula da Dabbar Daban Abincin Abinci- da kuma Ciwon sukari na Yammacin Miki. Cell Metabolism.
3. Yamamoto, T., Byun, J., Zhai P., Ikeda, Y., Oka, S., da Sadoshima, J. (2014). Nicotinamide Mononucleotide, Tsakanin NAD + kira, Kare Tsaro daga Ischemia da Reperfusion.
4. Sinclair, DA, Uddin, GM, Youngson, NA, da Morris, MJ (2016). Haɗa zuwa kwatankwacin Kasa na Nasarar Kwararru tare da NAD + precursor Nicotinamide Mononucleotide (NMN) da makonni shida na Harkokin Kasuwanci a Obese Female Mice.
5. Imai, S., Yoshino, J., Mills, KF, Grozio, A., et al. (2019) Slc12a8 ne mai amfani da Nitotinamide Mononucleotide. Yanayin Metabolism.
6. De Picciotto, NE, Mills, KF, Imai, S., Gano, LB, et al. (2016). Nicotinamide Mononucleotide Ya Kashe Kwayoyin Dasfunction da Ƙananan Matsala tare da Mice.
7. Yao, Z., Gao, Z., Yang, W., da Jia, P. (2017). Nicotinamide Mononucleotide Inhibits JNK Kunnawa don Kashe Alzheimer cuta.
8. Hou, Y., Wang, Y., Zhang, Y., Lautrup, S., et al. (2018). NAD + Ƙarin Ƙaƙaitaccen Yanayin Alzheimer na Mahimmanci da Damage na DNA Responses a Sabuwar Dokar Mouse na AD tare da Ƙaddamarwar Rarraba ta DNA.
9. raw GASKIYAR GASKIYA (NMN) WUTA (1094-61-7).