Labarin Lactoferrin

Lactoferrin (LF) furotin na halitta ne wanda yake a cikin madara mai shayarwa kuma yana nuna kaddarorin ƙwayoyin cuta. Tun lokacin da aka kafa shi a cikin 60s, an yi karatu da yawa don tabbatar da darajar warkewar glycoprotein da rawar da ke takawa cikin rigakafi.

Kodayake ƙananan yara na iya samun ƙari daga shayar da uwayensu, ana sanya lactoferrin foda don kasuwanci ta kowane zamani.

1. Menene Lactoferrin?

Lactoferrin (146897-68-9) glycoprotein mai ƙarfe ne wanda yake na dangi ne. Wannan furotin yana da wadataccen kayan rigakafi kuma yana nan a cikin madarar mutum da na saniya. Bayan haka, shine yaduwar yawancin kwayoyin halittun rayuwa kamar su hawaye, yau, ruwa mai hanci, ruwan lemonciko, da bile. Jiki zai zazzage glycoprotein a cikin martani ga mai kara kuzari.

Kafin ka iya yin a lactoferrin saya, ɗauki ganye daga wannan sharhin don ganin idan ƙarin ɗin ya cancanci hakan.

Yawancin lactoferrin suna nan a cikin colostrum, wanda shine ruwa na farko da aka fara bayarwa bayan haihuwa. Ana ɓoye shi cikin madara a cikin kwanakin farko biyu na uku na bayan haihuwa. Kodayake ɓoye ƙwayar cuta ta ƙare, ƙimar lactoferrin zai kasance har yanzu za'a sami canji a cikin madara da madara.

Don haka, ta yaya kuke fitar da lactoferrin daga ƙwayar cuta ta bovine?

Bada ni in dauke ku ta wata hanya madaidaiciya na warewar lactoferrin.

Mataki na farko ya ƙunshi raba whey daga madara. Whey shine ruwan da yake gudana bayan ya narke ko cokulating madara tare da acidic. Tsarin keɓewa ya sa ana amfani da ma'amala tsakanin hydrophobic da chromatography da ion-musanya chromatography daga baya nasarar hade tare da mafita mai gishiri.

Bovine colostrum ya fito ne daga shanu. Yana da arziki a cikin sunadarai, kwayoyin kariya, ma'adanai, bitamin, carbohydrates, da kitsen. Wadannan sigogi sun tabbatar da darajar warkewar cutar kwalliya, saboda haka, jawo sha'awa tsakanin masana kimiyya a fannin likitanci.

Ganin cewa abun lactoferrin yana raguwa yayin da bayan aikin ya karu, ana bada shawarar madadin ga jariri. ,Auki, alal misali, ƙwayar LF ta kai tsaye bayan haihuwa ta kusan 7-14mg / ml. duk da haka, maida hankali na iya sauke zuwa kusan 1mg / ml tare da madara mai girma.

Idan kana son yin reno a cikin lactoferrin immunological, ya kamata ka banki akan haɓakar ƙwayar ƙwayar cuta ta bovine.

Lactoferrin bulk foda na kasuwanci shine samfuran ƙwayar cuta ta bovine. Koyaya, samfurin ya kasance damuwa ga wasu mutanen da suke ganin sun damu da kamuwa da cutar saniya. Da kyau, bari na tabbatar muku cewa wannan yanayin yana da wuya. Bayan haka, wasu daga cikin abubuwan abinci na lactoferrin sune kayan abinci na shinkafa, wanda ya dace da mutanen da basu da damar shan maganin lactose.

Menene Amfanin Lactoferrin Amfanin Ga manya da Baban jarirai

2. Me yasa amfani da foda na Lactoferrin a matsayin kari, amfanin Lactoferrin?

Gudanar da Acne

Cutibacterium da propionibacterium suna da alhakin yawancin kuraje. Ayyukan Lactoferrin suna hana waɗannan ƙwayoyin baƙin ƙarfe kuma yana rage tasirin su.

A cikin wasu yanayi, tsararrun iska da nau'in oxygen mai ba da amsa suna ba da gudummawa ga raunin sel da lalacewar DNA. Sakamakon damuwa na oxidative, kumburi na iya faruwa da tasiri kan ci gaban ƙuraje. A cewar masana kimiyyar bincike, lactoferrin abune mai tsayayyen kuzarin shaye shaye, saboda haka, yuwuwar yakar masu tsattsauran ra'ayi.

Shan lactoferrin kusa da bitamin E da zinc zai rage cututtukan cututtukan fata da kuma comedones a cikin watanni kadan.

Bayan haka, kumburi kai tsaye na haifar da haifar da cututtukan fata da cysts ta hanyar toshe pores. Abubuwan rigakafin kumburi na lactoferrin suna bada garantin warkar da raunuka.

Masana ilimin hakora suna jaddadawa kan cewa lafiyar ƙoshin ku kwatankwacin fata ne. Misali, idan jijiyoyinku najasa ne ko kuma mara lafiya, amfani da dukkan nau'ikan shafe-shafe na fatar fuska ko kayan gwauro na duniya ba zai magance kumburin fata ba, wasanni, ko eczema. Laaukar lactoferrin zai zubar da ƙananan ƙwayoyin cuta a cikin narkewar abinci yayin inganta ayyukan masu amfani da ƙwayoyin Bifidus flora.

Baya ga kula da cututtukan fata, lactoferrin ya sauƙaƙe alamun cutar ta psoriasis kuma yana hanzarta murmurewa daga cututtukan ƙafafun ƙafa na neuropathic, wanda ya zama ruwan dare tsakanin masu fama da cutar sankara.

Wakilin Anti-Microbial

Karatattun bincike sun tabbatar da cewa Lactoferrin (LN) yana hana ƙwayoyin cuta, ƙwayoyin cuta, cututtukan fata, da cututtukan fungal daga kai hari ga jikin mutum. kwayar tana aiki ta hanyar ɗaure wa waɗannan ƙwayoyin cuta, lalata tsarin tantanin halitta, da kuma toshe masu karɓa.

A wani bincike na musamman, masana kimiyyar sun lura da hakan lactotransferrin (LTF) ya fi dacewa da hana kwayar cutar herpes fiye da sigar mutum. Nazarin in vitro ya kuma nuna cewa wannan ƙarin aikin yana magance tasirin kwayar cutar ta HIV.

A dan kadan mafi girma allurai, lactoferrin ayyuka don sarrafa virulence na Hepatitis C. A cewar Binciken Hepatology, wannan jiyya yana ƙara magana da interleukin-18, furotin wanda ke da alhakin dawo da kwayar Hepatitis C. Don iyakar ƙarfin aiki, marasa lafiya yakamata su ɗauki kimanin 1.8 zuwa 3.6 na ƙarin ƙarin kowace rana. Dalilin shi ne cewa low allurai na lactoferrin ba zasu iya bambance komai ba.

Akwai jita-jita, waɗanda ke ɗaukar LF azaman magani don cututtukan helicobacter pylori. A yayin da kuka sanya kayan haɗi tare da maganin kumburin kumburin kumburin kumburin ku da cutar ku, damarar ita ce magungunan zasu fi tasiri. Wannan ikirarin ya kasance hujja tsakanin kashi a tsakanin masu bincike yayin da yawancin suka amince cewa amfani da lactoferrin foda zai zama mara amfani yayin rashin magunguna.

Dokar ƙarfe ƙarfe na baƙin ƙarfe

Lactoferrin ba wai kawai zai daidaita yawan iron din bane kawai a cikin jiki harma zai kara yawan sha.

Akwai wani binciken da ke gudana wanda ya nemi kwatanta inganci na LF da keɓaɓɓen sinadarin sulfate a cikin ƙarancin iskar baƙin ƙarfe yayin daukar ciki. To, daga fitinar, lactoferrin ya tabbatar da cewa yana da karfin gwiwa wajen karfafa samuwar haemoglobin da kwayoyin halittar jini.

Mata masu cin glycoprotein suna da matakan ƙarfin ƙarfe tare da sakamako masu illa. Ayyukan Lactoferrin don rage yiwuwar ɓarna, haihuwar haihuwa, da ƙananan nauyin haihuwa.

Don haka, a bayyane yake kyakkyawan gamsuwa ne ga masu juna biyu da kuma mata masu haihuwa, waɗanda suka rasa baƙin ƙarfe lokacin da suke cikin lamurransu. Masu cin ganyayyaki da masu bayar da jini na yau da kullun na iya amfana daga abincin lactoferrin.

Cutar Gastrointestinal Tract

Lactoferrin ƙarin jariri yana cire kwanciyar hankali kuma yana tabbatar da lafiyar sa. Yana kawar da ƙwayoyin cuta masu cutarwa, waɗanda suke da alhakin kumburi. Misali, wadannan kananan kwayoyin suna dauke da yawan cututtukan gastroenteritis da enterocolitis, wadanda suke lalata ganuwar hanji da ke haifar da mutuwa. Idan saboda wasu dalilai, jaririnku baya shayarwa, yana da matukar bada shawara cewa ku matsa zuwa lactotransferrin (LTF).

Menene Amfanin Lactoferrin Amfanin Ga manya da Baban jarirai

3. Lactoferrin fa'idodi akan Jariri

Toarin jarirai Lactoferrin yana haifar da haɓaka ƙwayoyin ƙwayoyin cuta a cikin goron jarirai. Wadannan microbes sun hada da Escherichia coli, Bacillus stearothermophilus, Staphylococcus Albus, Candida albicans, da Pseudomonas aeruginosa. Yawancin karatu sun adana gaskiyar cewa yawan cin abinci na lactoferrin da yawa yana rage damar cutar gastroenteritis a cikin jarirai.

Har yanzu a cikin gut, LF yana haɓaka yaduwar ƙwayoyin endothelial yayin da suke nuna haɓakar ƙwayoyin tsofaffin ƙwayoyin cuta. Saboda haka, ya zama tabbaci cewa ƙarin lactoferrin na iya zama takardar sayan magani ga ƙurajewar hanji mai lalacewa.

Shayarwa nono shine asalin tushen ƙarfe don neonates. Koyaya, likitocin dabbobi suna bada shawarar cewa ƙarin kari na baƙin ƙarfe ya zama dole tunda madarar nono ta ƙunshi adadi kaɗan na wannan ma'adinin.

Bada ni in faɗi abin da yasa LF ya zama kyakkyawan ƙari ga jarirai masu haihuwa da jarirai masu ƙananan nauyin haihuwa. Yawancin lokaci, wannan rukunin yana da matukar rauni ga raunin baƙin ƙarfe. Gudanar da ƙarin lactoferrin jariri zai haɓaka haemoglobin da ƙwayoyin jini a cikin tsarin haɓaka. Haka kuma, bincike ya nuna cewa karin ƙarfe yana haɓaka ci gaban jijiyoyin jarirai.

A wasu lokuta, ƙwayoyin cuta masu cutarwa kamar E.coli suna ciyar da baƙin ƙarfe da ke kan ƙwayar hanji na ciki. Laaukar lactoferrin zai kwantar da ƙwayoyin ƙarfe na baƙin ƙarfe ya lalata su yayin tabbatar da cewa rundunar ta karɓi dukkanin ma'adinan da ke ƙasa.

LF tana taka rawa sosai wajen haɓakar tsarin rigakafin jariri. Wasu daga cikin waɗannan amfani da lactoferrin foda sun haɗa da haɓakar ayyukan macrophages, immunoglobulins, sel na NK, da kuma T lymphocytes, waɗanda ke da alhakin rigakafin cututtukan ƙananan yara. Abinda yafi, gudanar da LF yana rage yiwuwar halayen rashin lafiyan.

4. Ta yaya Lactoferrin ke inganta tsarin rigakafi?

Matsakaici tsakanin Ayyukan Adapt da Innate Immune Function

Don m amsawar rigakafin, lactoferrin abubuwa a hanyoyi da yawa. Misali, yana haɓaka ayyukan ƙwayoyin sel masu kisan kai (NK) da kuma keɓaɓɓu. Sunadarin na haɓaka phagocytosis kuma yana haifar da haɓakar macrophages.

Don amsawar da za a iya daidaitawa, LF yana taimaka wa a cikin tasirin sel-T da sel. Dangane da batun siginar kumburi, duka biyun da aikin rigakafin daidaita yanayin za su haɗu don magance abin da ya faru.

Lactoferrin shine ke tsara haɓakar cytokines na pro-mai kumburi da interleukin 12, wanda ke nuna kaddarorin kariya a cikin cututtukan ƙwayoyin cuta.

Masu shiga tsakani a cikin Ciwon Maganin Ciwon Ciwon Sihiri (SIRS)

Matsayin da lactoferrin foda ta kashe nau'in oxygen mai saurin canzawa (ROS) ya kasance mai mahimmanci a cikin nazarin dangantakarta dangane da kumburi da ci gaban kansa. Increasearin ROS yana fassara zuwa mafi girman haɗarin yanayin kumburi saboda apoptosis ko rauni na salula.

Nasihu Ga Abubuwan Ta'addaci

Abubuwan rigakafin ƙwayoyin cuta na lactoferrin sun yanke ƙetaren ƙwayoyin cuta, hoto ko bidiyo mai zagaya yanar gizo da sauri, da cututtukan fungal.

Beswayoyi suna haɓakawa kuma sun dogara da ƙarfe don haɓaka da rayuwa. Lokacin da suka mamaye rundunar, LF suna hana karfin amfani da ƙarfe.

A lokacin farkon kamuwa da cuta, lactoferrin (LF) matakai don magance karɓar baƙi daga ƙasashen waje. Sunadarin zai iya toshe masu karban wayar ko kuma ya daure wa kwayar cutar, don haka, ya hana shigowar sa. Sauran ayyukan anti-microbial na lactoferrin sun hada da lalata hanyar tantanin halitta ko toshe abubuwan hakar su.

Yawancin karatu sun tabbatar da amfani da foda lactoferrin foda a cikin gudanarwar kwayar cutar ta Herpes, kwayar cutar HIV, hepatitis C da B, mura, da hantavirus. Bayan wannan, ƙarin ya hana yaduwar alphavirus, rotavirus, papillomavirus ɗan adam, da sauransu da dama.

A wasu halayen, Lactoferrin bazai iya fitar da dukkan cututtukan ba amma kuna iya tabbata cewa hakan zai rage zafin cutarwar da take gudana. A cikin karatun da suka gabata, LF tayi tasiri wajen magance cutar ta SARS. Tunda SARS-CoV-2 ya fadi a aji guda kamar SARS-CoV, akwai yuwuwar cewa lactoferrin na iya rage virulence na COVID-19.

Kodayake masana kimiyya suna ɗauka cewa haɓaka ayyukan rigakafin ku ba ya kiyaye mutum daga coronavirus, ƙarin lactoferrin zai taimaka a cikin yaƙin. Bayan duk wannan, masu ilimin guda ɗaya sun lura cewa tsofaffi da mutanen da ke da ƙarancin rigakafi suna cikin haɗarin haɗari na yin kwangilar COVID-19.

5. Lactoferrin foda yana amfani da aikace-aikace

Lactoferrin girma foda yana samuwa ga masana kimiyya da masana da suke so su kafa ƙimar magani a jikin ɗan adam. Yana da tsammanin aikace-aikace mai yawa a cikin rigakafin cutar, abinci mai gina jiki, abinci da magungunan maganin rigakafi, da kayan kwaskwarima.

Don nazarinku da gwaje-gwajen gwaji, tabbatar da samun tushen daga masu samar da foda mai inganci.

Lactoferrin foda yi amfani da in madara madara foda

Tsarin ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar jarirai yana haɓaka ci gaba zuwa nuna kwayar halitta na ainihin madara nono daga uwa. Lactoferrin shine kashi biyu mafi yawan furotin a cikin madarar uwa. Ya shahara wajen kawo kowane nau'in fa'idodi ga jariri gami da haɗa baƙin ƙarfe don rigakafi, rigakafin cutar daji, da inganta ƙasusuwa masu lafiya tsakanin sauran.

Lactoferrin abu ne mai yawa wanda aka san shi a cikin madarar saniya wanda aka sanshi da launi. Kwancen ƙwayar cuta tana da kusan mil biyu na mililiter kamar yadda ake shayar da nono. Wannan yana nuna cewa ƙaramin ƙananan yara suna buƙatar mafi yawan lactoferrin mafi girma don haɓaka haɓaka.

Haɓaka tsarin rigakafi na jarirai yana da tallafi ta ɓangaren Lactoferrin a cikin tsarin jarirai. Sunadarin yana aiki mai mahimmanci a cikin tsarin rigakafin jarirai kuma yana wakiltar tsarin rigakafi na rigakafi da rigakafin ƙwayoyin cuta na farko. Babban mahimmancin rigakafin ƙwayar cuta shine mafi yawanci ana haifar da chelation baƙin ƙarfe-ion, waɗanda suke da mahimmanci ga haɓakar ƙwayoyin cuta. Bayan haka, lactoferrin an kuma yi imanin cewa yana maganin antioxidant wanda zai iya ƙarfafa martanin rigakafi ta hanyar ba da bambanci, yaduwa, da kunna ƙwayoyin rigakafi.

Menene Amfanin Lactoferrin Amfanin Ga manya da Baban jarirai

6. Tasirin Lactoferrin

Amincin LF pivots akan wasu fewan dalilai.

Toarancin yawa na Lactoferrin na iya zama chancy. Misali, lokacinda abun yake shine madarar saniya, zaku iya shan karfin shi har tsawon shekara guda. Koyaya, lokacin da samfurin ya samo asali daga shinkafa, damar shine cin nasara fiye da kima na makonni biyu zai haifar da wasu matsalolin marasa kyau.

Hanyoyin cutar lactotransferrin (LTF) na yau da kullun sun haɗa da;

  • zawo
  • Rashin ci
  • Skin rashes
  • maƙarƙashiya
  • Hannu

Ba kamar yawancin magunguna ba, lactoferrin ba shi da haɗari ga masu shayarwa da masu shayarwa.

Don kewaye sakamako masu illa na lactoferrin, ana bada shawarar sashi tsakanin 200mg da 400mg. Ya kamata ka karba shi tsawon watanni biyu zuwa uku. A lokuta da dama, lokacin na iya zuwa watanni shida.

7. Wanene zai iya amfana daga Lactoferrin?

Mahaifi

Lactoferrin yana amfani ga uwa da jariri.

A lokacin lokacin haila, gudanar da wannan ƙarin zai kasance da tasiri a kan girman tayin da nauyin haihuwarta. Idan uwa ta ci gaba da maganin lactoferrin yayin lokacin lactation, nono da nono zai inganta sosai. Bayan haka, jariri zai yi alfahari kai tsaye a cikin damben don kiyaye nauyin jikinsa mai lafiya.

Antsaantsan jarirai da Childrenan Matasa waɗanda ba su shayarwa ba

Ctoarin lactoferrin yana tabbatar da cewa jariri ya haɓaka tsarin rigakafi mai ƙarfi yayin yana kiyaye ƙaƙƙarfan ƙwayar jijiyoyi daga cututtukan ƙwayoyin cuta. Bayan wannan, ƙarin yana aiki azaman maganin laxative, yana taimaka wa motsi na farko na jariri. Tsarin ƙananan yara masu wadataccen launuka masu yawa ana samun su daga masu siyarwar layin ƙasa na kan layi da kan layi.

Rashin Tsarin Maganin baƙin ƙarfe

Toarin Lactoferrin yana haɓaka matakan hawan jini, ƙwayoyin jini, da ferritin. Dukda cewa mafi yawan mutane suna amfani da sinadarin sulfate wajen magance karancin iron, binciken bincike da yawa yana tabbatar da cewa lactoferrin yafi karfin ta.

Idan kai mai cin ganyayyaki ne ko mai ba da gudummawar jini sau da yawa, zaku buƙaci abinci mai ƙwararruwan baƙin ƙarfe don yin ƙarancin matakan haemoglobin da ferritin. In ba haka ba, zaku iya yin kyakkyawan lactoferrin sayayya daga masu siyar da kan layi.

Mutane masu ƙarancin rigakafi

Lactoferrin yana kare jiki daga cututtukan cututtukan cututtukan cututtukan ƙwayoyin cuta ta hanyar hana ƙananan ƙwayoyin cuta da kuma hana yaduwar ƙwayoyin cuta da ƙwayoyin cuta. Cibiyar tana da hannu sosai a cikin yanayin nuna alama ta hanyoyi masu alhakin kula da martanin martanin da mai garkuwa ke bayarwa.

Lactoferrin yana aiki azaman matsakanci ne, yana haɗawa da daidaita ma'amala tsakanin ayyukan daidaitawa da aikin rigakafi. Misali, yana haɓaka ayyukan phagocytic ta hanyar haɓaka abubuwan tsalle-tsalle da macrophages. Don tsarin rigakafin motsa jiki, wannan fili yana haɓaka haɓakar T-sel da B-sel, waɗanda ke nuna tsaruwa tsakanin sel da rigakafin ƙwayoyin cuta, bi da bi.

8. Lactoferrin tare da IgG

Kamar dai lactoferrin, IgG ko immunoglobulin G shine furotin mai kariya na microbial wanda yake cikin madara mai shayarwa.

Akwai karatu da yawa don bayyana ma'anar tsakanin lactoferrin da IgG.

Hankalin lactoferrin a cikin yawan ƙwayar cuta ya fi girma fiye da na IgG. A cewar masana kimiyyar bincike, abubuwa da yawa suna shafar adadin wadannan furotin a cikin madara.

Misali, duka lactoferrin da IgG suna da hankali ga zafin rana da sanya kwayar cuta. Immunoglobulin G na iya jurewa zafin zafi na har zuwa 100 ° C amma a takaice dai na wasu 'yan dakiku. Sabanin haka, lactoferrin a hankali yana raguwa tare da karuwa a zazzabi har sai ya lalata gaba ɗaya a 100 ° C.

Yin kwanciyar hankali a kan waɗannan abubuwan, dole ne kun lura cewa lokaci da dumama zafin rana sune fifikon farashi lokacin aiki da madara. Tunda rubar nono ya kasance mai rikicewa, yawancin mutane suna yanke shawara don daskarewa-daskarewa.

Mayar da hankali na Lactoferrin (146897-68-9) yana kan ganiyarsa bayan haihuwa. Yayin da lokacin haihuwa ya ke ƙaruwa, wannan furotin yana raguwa a hankali, wataƙila saboda raguwar ƙwayar cuta. A gefe guda, faduwar cikin matakan immunoglobulin G kusan sakaci ne a duk lokacin lactation.

Kodayake yawancin lactoferrin sun ragu a cikin madara mai shayarwa, maida hankali zai kasance har yanzu ya fi na IgG girma. Wannan gaskiyar har yanzu tana tsaye ko a cikin launi, canzawa, ko cikin madara mai girma.

References

  • Yamauchi, K., et al. (2006). Bovine Lactoferrin: Amfanin da keɓaɓɓen Hanyar Aiwatar da Cututtukan. Halittar Kiba da Kiba.
  • Jeffrey, KA, et al. (2009). Lactoferrin a matsayin Modulator na Halicci Na Zamani. Tsarin Magunguna na Zamani.
  • Lepanto, MS, et al. (2018). Inganci na Lactoferrin Gudanar da Oral a cikin Jiyya na Cutar Cutar Kwayar ciki da Cutar Fitsari a cikin Mata Masu Ciki da Marayu Mata: Nazarin Shiga ciki. Faransanci a Immunology.
  • Goldsmith, SJ, et al. (1982). IgA, IgG, IgM da Lactoferrin Abubuwan Miliyan Mil a yayin Lactation farkon da Tasirin Gudanarwa da Adanawa. Jaridar Kariyar Abinci
  • Smith, KL, Conrad, HR, da Porter, RM (1971). Lactoferrin da IgG Immunoglobulins daga Gulayon Bovine Mammary Gland ne. Jaridar Kimiyyar Kimiyya na madara.
  • Sanchez, L., Calvo, M., da Brock, JH (1992). Aikin Halittu na Lactoferrin. Rarraban Cutar A cikin Yara.
  • Niaz, B., et al. (2019). Lactoferrin (LF): Maganin Halittar Anti-Microbial. Jaridar kasa da kasa ta Kayan Abinci.