1. Menene Pterostilbene?

Pterostilbene wata sinadarai ce mai mahimmanci da aka kirkira a rayuwar rayuwar wasu tsirrai a matsayin hanyar yakar cututtuka. Wannan fili yana kama da wani fili wanda aka sani da resveratrol kuma ana samunsa cikin ƙarin tsari. Pterostilbene kari suna da yawa. Wannan yana nufin ana iya amfani dasu a jiki cikin sauki da sauri kuma ba a rage su a cikin narkewar abinci ba. Pterostilbene foda yana da inganci, duk da haka rabin rayuwarsa yana ɗan gajere tunda yana ƙasa da minti 100.

Maɓallin abinci na Pterostilbene

Pterostilbene kayan abinci sun hada da shudi, almon, giya, mulmula, gyada, giya, innabi, ganyen innabi, giyan itacen kyan India, Jan sandalwood, da koko. Abun furanni, duk da haka, shine mafi girman tushen abinci na Pterostilbene, amma adadin ruwan 'ya'yan itace a cikin blue har ila yau yana da ƙananan idan aka kwatanta da kayan abinci na Pterostilbene. Pterostilbene blueberries abun ciki an yi imanin cewa zai kusa da nanogram 99 zuwa 52, a cikin kowane gram na blueberries.

pterostilbene-foda

 

2.Pterostilbene tsarin aikin

Tsarin aikin Pterostilbene ya bambanta da na resveratrol. Pterostilbene fili shine mafi ƙarfin Stilbene. Abubuwan daban-daban na Pterostilbene foda sun dace da wani tsarin aikin daban kuma. Ayyukan pharmacological na trans-pterostilbene sun hada da antineoplastic, antioxidant, da anti-mai kumburi.

Pterostilbene yana nuna ingantattun ayyukan antifungal waɗanda suka fi sau goma ƙarfi fiye da resveratrol. Hakanan fili na Pterostilbene yana nuna tasirin rigakafi. Kariyar tsire-tsire daga wasu ƙwayoyin cuta da alama alama ce mai mahimmanci na stilbenes, ciki har da Pterostilbene, kuma waɗannan ayyukan suna kan dabbobi da mutane.

Pterostilbene kuma yana nuna tasirin cututtukan anticancer ta hanyoyin kwayoyi da yawa. Bincike ya nuna ayyukan Pterostilbene sun hada da kwayoyin halittar tumor, tare da sauya hanyoyin juyawar siginar, oncogenes, kwayoyin halittar bambanci, da kuma tsarin sake zagayowar kwayoyin halitta.

Abubuwan da ke cikin antioxidative na Pterostilbene sun bambanta sosai da na resveratrol. A cikin resveratrol, rukunin hydroxyl ukun sun rage ROS (nau'in oxygen mai tayar da hankali) a cikin tsararrun ƙwayoyin cuta da jini gaba daya yayin da Pterostilbene, wanda ke da rukunin hydroxyl 1 da 2 methoxy suna rage ROS mai ɓarna. Ididdigar asalin kaddarorin antioxidation yana ba da damar amfani da Pterostilbene foda don yin niyya ga ƙwayoyin oxygen wanda ke jujjuya ƙwayoyin cuta, wanda ke haifar da lalacewar nama yayin kumburi na kullum.

Da ke ƙasa akwai ƙarin hanyoyin pterostilbene na aikin da aka tattauna dalla dalla;

 

Pterostilbene tsarin aiwatarwa; Sirtuin Kunnawa

Pterostilbene yana motsa hanyar siginar SIRT1 a cikin ƙwayoyin da ke ba da kariya daga lalacewar salula, don haka kunna shi. Wannan hanyar ta inganta maganganun p53. P53 furotin ne wanda ke kare DNA daga lalacewa kuma yana kare kwayoyin daga maye gurbi wanda zai haifar da cutar kansa.

SIRT1 na iya hana ku lalacewa da lalata sel, wanda ke ci gaba yayin da kuka girma.

 

Magungunan Anti-Inflammatory Effects

Yawancin karatu sun nuna cewa pterostilbene fili sunadarai yana rage kumburi wanda aka tsara ta hanyar TNF-alpha (tumor necrosis factor-alpha). Damuwa na Oxidative yana kawo kumburi; Pterostilbene yana toshe interleukin-1b da TNF-alpha ta rage nau'in oxygen mai ratsa jiki.

Wannan mahaɗin kuma yana kariya daga damuwa cikin ɓangaren kayan aikin sel da aka sani da ER (endoplasmic reticulum). A cikin bincike, lokacin da aka fallasa sassan jikin jijiyoyin jini zuwa Pterostilbene foda, layinsu bai amsa siginar kumburi ba, kuma ba su bayyana kumburi ba.

 

Pterostilbene tsarin aiwatarwa; Magungunan Anti-Cancer

Abin mamaki, duk da rage damuwa na ER (endoplasmic reticulum) a cikin murfin jijiyoyin jini, Pterostilbene yana haɓaka damuwa a cikin ƙarshen reticulum na ƙarshen ƙwayoyin ƙwayoyin cuta. Saboda haka, yana lalata ƙwayoyin cutar kansa kuma yana kariya daga andarfin ƙwayoyin cuta a cikin ƙwayoyin lafiya.

A cikin kashin baya ko kwayoyin kwakwalwa (glioma) kwayoyin cutar kansa, Pterostilbene ya rage Bcl-2 kuma ya daukaka Bax; wadannan canje-canjen suna bunkasa siginar “kashe kansa” alamun da ke haifar da kashin baya ko kwayoyin kwakwalwa su mutu.

Kwayoyin ciwon daji suna amfani da wata hanyar da aka sani da Notch-1, don hana kansu aiwatar da magungunan kera, gami da oxaliplatin da fluorouracil. Pterostilbene yana toshe kwayar cuta mai mahimmanci-1 yana sanya ciwace-ciwacen daji ya zama mai da hankali ga jiyya ta hanyar ƙwaƙwalwar ƙwaƙwalwa.

Pterostilbene ya rage samar da wasu kwayoyi masu yada cutar kansar huhu, wadanda suka hada da MUC1, b-catenin, Sox2, NF-κB, da CD133. Waɗannan tasirin suna haɗuwa da rage kumburi kuma ya sa ya kusan yiwuwa yiwuwa ga ci gaban ƙwayoyin kansa.

 

neuroprotection

Pterostilbene ya sami damar kai wa yankin hippocampus zabi a cikin kwakwalwa. Anan, yana haɓaka CREB (furotin mai ɗaukar nauyin cAMP), BDNF (abubuwan da ke haifar da ƙwaƙwalwar ƙwaƙwalwar ƙwaƙwalwar ƙwaƙwalwar ƙwayar kwakwalwa), da MAPK (sunadarai masu motsi na mitogen),

Sunadaran ukun suna taimakawa neurons wajen ninka, girma, da kuma mayar da martani da kyau ga mahallinsu. Abubuwan kwantar da hankali na SNRI suma suna yin amfani da waɗannan hanyoyin.

Pterostilbene kuma yana haɓaka furotin da aka sani da Nrf2 a cikin hippocampus, wanda a cikin hakan yana haɓaka faɗakarwar sunadaran antioxidant.

Pterostilbene yana hana jiki daga cutar Alzheimer ta hanyar bayar da kariya ga kwakwalwa daga beta-amyloid (Aβ). Yana yin hakan ta hanyar haɗa Akt da PI3K, sunadarai guda biyu waɗanda ke tallafawa ci gaban neuron, ƙwaƙwalwar ajiya, da ilmantarwa.

 

3. Pterostilbene foda yana da amfani

Tattaunawa da ke ƙasa sune uku mafi mahimmanci pterostilbene foda fa'idodi;

pterostilbene-foda-2

i. Pterostilbene kamar yadda nootropics

Yayinda muke tsufa, sabbin hanyoyin tunani suna zama mafi wahalar shiga, kuma tuni membobinci suna da wahalar samun damar shiga. Rashin iya aiwatar da aikin na yau da kullun yana raguwa sosai. Pterostilbene kari zai iya taimakawa a cikin ƙirƙirar wani yanki mai sabunta yanayin rayuwa a kowane zamani.

Pterostilbene ne mai ƙarfi nootropic, wanda ke taimakawa cikin nutsuwa da haɓaka cognition. Hakanan ana ɗaukar shi akai-akai yayin aikin kafin saboda iyawarsa don taimakawa cikin vasodilation na hanyoyin jini. Yana, saboda haka, yana ba da sakamako masu kama da na sauran sinadaran nitric oxide.

An yi amannar fa'idodin nootropic na Pterostilbene sun kasance sakamakon iyawarta don haɓaka matakan dopamine. A cikin rodents, Pterostilbene ya saukar da damuwa da haɓaka yanayi. A cikin binciken da ya shafi tsofaffin beraye, abubuwan pterostilbene sun haɓaka matakan dopamine da haɓaka haɓaka. Hakanan, lokacin da aka samar da Pterostilbene a cikin berayen kwakwalwar bera hippocampus, ƙwaƙwalwar aikin su ta haɓaka.

A wani binciken da ya shafi beraye, Pterostilbene ya inganta haɓakar sabbin ƙwayoyin halitta a cikin hippocampus. Hakanan, ƙwayoyin sel da aka ciro daga kwakwalwar ƙananan yara sun girma da sauri lokacin da suka kamu da cutar Pterostilbene.

Dangane da nazarin kwayar halitta, pterostilbene foda yana toshe MAO-B (monoamine oxidase B) kuma yana haɓaka dopamine a cikin kwakwalwarmu. Wannan aikin yayi kama da magungunan da ke magance cutar Parkinson, kamar su rasagiline, safinamide, da selegiline. A cikin bincike, Pterostilbene kuma yana kare jijiyoyin daga lahani da ke tattare da AD (cutar Alzheimer).

Hakanan ana iya yarda da ikon sarrafa tashin hankali na Pterostilbene ya kasance sakamakon ikonta na toshe monoamine oxidase B. A cikin wani nazari na musamman, Pterostilbene ya nuna aikin damuwa a cikin allurai biyu da ɗaya na mg / kg. Wannan aikin ɓacin ran gidan ya kasance kama da na diazepam a ɗaya da biyu mg / kg a cikin EPM.

 

ii. Pterostilbene kuma kiba

Binciken da aka bincika ikon Pterostilbene don sarrafa kiba ya nuna cewa akwai babban yarjejeniya tsakanin ƙarin pterostilbene da kuma nauyin kulawa. Masana kimiyya sun yi imanin cewa Pterostilbene foda yana da ikon shafar matakan ƙoshin mai saboda ƙarfinsa na rage lipogenesis. Lipogenesis shine aiwatar da ƙirƙirar ƙwayoyin mai mai wuce haddi. Pterostilbene kuma yana haɓaka kitse mai mai ko kitse a cikin hanta.

A cikin binciken da ya shafi mutane masu matsakaicin shekaru tare da babban cholesterol, ƙungiyar mahalarta waɗanda ba sa shan ƙwayoyin cholesterol sun rasa wani nauyi yayin shan abubuwan pterostilbene. Wadannan sakamakon sun zo wa masu bincike da ba zata saboda wannan binciken ba ana nufin auna kariyar pterostilbene ba ne a matsayin taimakon rage nauyi.

Karatun dabbobi da kwayar halitta sun kuma nuna cewa kwayar pterostilbene na iya taimakawa wajen inganta yanayin insulin. Abin da Pterostilbene ke yi shine ta hana aiwatar da canza sukari ya zama mai. Hakanan yana hana sel mai girma girma da haɓaka.

Pterostilbene kuma yana canza tsarin gut flora a cikin hanji da kuma taimakawa wajen narke abinci.

Abubuwan ruwan da aka ciyar dasu tare da Pterostilbene suna da ingantaccen ƙwayar gut da kuma babban haɓaka a cikin Akkermansia muciniphila. A. muciniphila wani nau'in kwayoyin cuta ne wanda ya bayyana don hana kumburi-mara nauyi, kiba, da ciwon suga. Wannan kwayar cuta ta zama babban abin daukar hankali game da binciken dan adam a kwanannan.

 

iii. Pterostilbene yana haɓaka Longevity

Pterostilbene anti amfanin tsufa suna haɗuwa da sinadarin bioactive da aka sani da Trans-pterostilbene. An tabbatar da wannan sinadarin don rage kumburi, koma baya ga fahimta, da kuma daidaita sukarin jini. A cikin rayuwa da cikin inti na karatu suna tallafawa Pterostilbene don yin rigakafi da warkewa. Wannan sinadarin kuma yana aiki azaman maganin hana amfani da caloric, wanda ke motsa jiki don sakin biochemicals, gami da adiponectin wanda ke tafiyar da aikin tsufa yayin da yake inganta waraka.

Wannan ƙarin maganin tsufa an san shi ne don kare shi daga cututtukan da ke da alaƙa da shekaru, ta hakan ne yake tsawaita rayuwa. A cikin rodents, ƙananan allurai na waɗannan magungunan sunadarai masu saukar da alamu da ke tattare da tsufa. Binciken ya ba da shawarar cewa cin abinci mai yawa na abubuwan abinci na pterostilbene kamar su blueberries na iya jinkirta kalubalen kiwon lafiya da suka danganci tsufa, ciki har da dementia da cancer.

pterostilbene-foda-3

4. Pterostilbene da resveratrol

Babu tantama cewa Pterostilbene da resveratrol suna da alaƙa ta kusa. Resveratrol sananne ne sosai a matsayin sinadarin bioactive a cikin ruwan inabi ja da inabi.

Amfanin lafiya na resveratrol yayi kama da na Pterostilbene kuma sun hada da kariya daga cutar Alzheimer, cututtukan cututtukan daji, haɓaka ƙarfin jimrewar makamashi, cututtukan cututtukan kumburi, yiwuwar cutar ciwon sukari, da fa'idodin zuciya.

Pterostilbene a zahiri sunadarai ne mai kama da resveratrol, amma bincike ya rigaya ya ruwaito cewa Pterostilbene na iya zama mai ƙarfi fiye da resveratrol a cikin sarrafa wasu yanayin kiwon lafiya. Pterostilbene ya nuna ƙarin damar inganta haɓaka aiki, lafiyar zuciya, da matakan glucose.

Hakanan rabin rabin Pterostilbene yana da guntu fiye da rabin rayuwar resveratrol. Pterostilbene a zahiri yana da sauri sau hudu don ɗauka daga tsarin narkewa a cikin jiki fiye da resveratrol. Tun da farko, wannan na iya sa Pterostilbene ya fi tasiri sau da yawa fiye da resveratrol. Koyaya, ana buƙatar ƙarin bincike don tabbatar da wannan.

Pterostilbene da resveratrol suma wasu lokuta ana haɗa su don samar da ƙarin haɗin kai a cikin nau'i na kapanin. Ana ganin ƙarin abin haɗewa yana da ƙarfi yayin da yake inganta amfanin abubuwan mahaɗin biyu.

 

5. Tearin aikin Pterostilbene

Babu wata shakka cewa don cimma fa'idodin fa'idodi na Pterostilbene, ana ba da shawarar ku ɗauka azaman ƙarin foda. Pterostilbene kari Ana kasuwa a cikin shagunan abinci na ɗimbin yawa da cikin shagunan kan layi waɗanda suka ƙware a cikin abincin abinci. Hakanan zaka iya samun masana'antun pterostilbene akan layi.

Yawancin Pterostilbene ana samun su sosai a cikin nau'in capsules, tare da sigogi iri-iri. Lallai ya kamata ku karanta lakabin ko alamar kuma ku lura da yawan Pterostilbene a cikin kowane kwabo kafin ku saya. Wannan yana da mahimmanci saboda allurai daban-daban na iya nuna sakamako daban-daban.

Hakanan, wasu pterostilbene ƙarin allurai na iya zama sama da abin da aka yi bincike a cikin mutane. Yawancin allurai na yau da kullun suna tsakanin 50 mg da 1,000 MG a cikin kowane kwalliya.

Kamar yadda aka ambata a baya, ana samun ƙarin kayan haɗin abinci, tare da mafi kyawun haɗuwa kasancewa Pterostilbene da resveratrol. Hakanan an haɗa Pterostilbene tare da curcumin, koren shayi, astragalus, da sauran mahadi na halitta.

Hakanan zaka iya nemo mayukan rana wanda yake dauke da Pterostilbene dukda cewa wannan ba kasafai ake ganinsa ba. Ba a bincika adadin Pterostilbene don kare ka da kyau daga cutar kansa ba, amma yana iya ba da ƙarin kariya.

 

6. A ina zan sami mafi ingancin Peterostilbene foda?

Idan kuna neman ingantaccen foda pterostilbene don siyarwa, to kuna kan wurin da ya dace. Muna ɗaya daga cikin mashahuri, masani, kuma gogaggen masana'antun pterostilbene a China. Muna samar da kaya masu tsafta kuma waɗanda aka kwaɗaɗa waɗanda koyaushe ke gwada su ta hanyar dakin gwaje-gwaje na ɓangare na uku don tabbatar da tsabta da aminci. Kullum muna isar da umarni a duk faɗin Amurka, Turai, Asiya, da sauran sassan duniya. Don haka idan kuna so ku sayi foda pterostilbene na mafi ingancin inganci, kawai ku tuntube mu yanzu.

 

References

  1. Rimando AM, Kalt W, Magee JB, Dewey J, Ballington JR (2004). "Resveratrol, pterostilbene, da piceatannol a cikin vaccinium berries". J Agric Abincin Chem. 52 (15): 4713–9.
  2. Kapetanovic IM, Muzzio M., Huang Z., Thompson TN, McCormick DL Pharmacokinetics, bioavailability na baka, da kuma bayanin rayuwa na resveratrol da na dimethylether analog, pterostilbene, a cikin berayen. Uwar uwa. Pharmacol. 2011; 68: 593-601.
  3. Tsaro na trans-resveratrol na roba a matsayin sabon abincin abinci bisa ƙa'idar (EC) No 258/97 ″. EFSA Jarida. Hukumar Tsaron Abincin Turai, Kwamitin EFSA kan Kayayyakin Abincin Abinci, Gina Jiki da Allergies. 14 (1): 4368
  4. Becker L, Carré V, Poutaraud A, Merdinoglu D, Chaimbault P (2014). "MALDI hotunan kyan gani don wuri guda na resveratrol, pterostilbene da viniferins akan ganyen inabi". Kwayoyin halitta 2013 (7): 10587-600.

 

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