1. Menene Pterostilbene?

Pterostilbene wata sinadarai ce mai mahimmanci da aka kirkira a rayuwar rayuwar wasu tsirrai a matsayin hanyar yakar cututtuka. Wannan fili yana kama da wani fili wanda aka sani da resveratrol kuma ana samunsa cikin ƙarin tsari. Pterostilbene kari suna da yawa. Wannan yana nufin ana iya amfani dasu a jiki cikin sauki da sauri kuma ba a rage su a cikin narkewar abinci ba. Pterostilbene foda yana da inganci, duk da haka rabin rayuwarsa yana ɗan gajere tunda yana ƙasa da minti 100.

Maɓallin abinci na Pterostilbene

Pterostilbene kayan abinci sun hada da shudi, almon, giya, mulmula, gyada, giya, innabi, ganyen innabi, giyan itacen kyan India, Jan sandalwood, da koko. Abun furanni, duk da haka, shine mafi girman tushen abinci na Pterostilbene, amma adadin ruwan 'ya'yan itace a cikin blue har ila yau yana da ƙananan idan aka kwatanta da kayan abinci na Pterostilbene. Pterostilbene blueberries abun ciki an yi imanin cewa zai kusa da nanogram 99 zuwa 52, a cikin kowane gram na blueberries.

pterostilbene-foda

2.Pterostilbene tsarin aikin

Tsarin aikin Pterostilbene ya bambanta da na resveratrol. Pterostilbene fili shine mafi ƙarfin Stilbene. Abubuwan daban-daban na Pterostilbene foda sun dace da wani tsarin aikin daban kuma. Ayyukan pharmacological na trans-pterostilbene sun hada da antineoplastic, antioxidant, da anti-mai kumburi.

Pterostilbene yana nuna ingantattun ayyukan antifungal waɗanda suka fi sau goma ƙarfi fiye da resveratrol. Hakanan fili na Pterostilbene yana nuna tasirin rigakafi. Kariyar tsire-tsire daga wasu ƙwayoyin cuta da alama alama ce mai mahimmanci na stilbenes, ciki har da Pterostilbene, kuma waɗannan ayyukan suna kan dabbobi da mutane.

Pterostilbene kuma yana nuna tasirin cututtukan anticancer ta hanyoyin kwayoyi da yawa. Bincike ya nuna ayyukan Pterostilbene sun hada da kwayoyin halittar tumor, tare da sauya hanyoyin juyawar siginar, oncogenes, kwayoyin halittar bambanci, da kuma tsarin sake zagayowar kwayoyin halitta.

Abubuwan da ke cikin antioxidative na Pterostilbene sun bambanta sosai da na resveratrol. A cikin resveratrol, rukunin hydroxyl ukun sun rage ROS (nau'in oxygen mai tayar da hankali) a cikin tsararrun ƙwayoyin cuta da jini gaba daya yayin da Pterostilbene, wanda ke da rukunin hydroxyl 1 da 2 methoxy suna rage ROS mai ɓarna. Ididdigar asalin kaddarorin antioxidation yana ba da damar amfani da Pterostilbene foda don yin niyya ga ƙwayoyin oxygen wanda ke jujjuya ƙwayoyin cuta, wanda ke haifar da lalacewar nama yayin kumburi na kullum.

Da ke ƙasa akwai ƙarin hanyoyin pterostilbene na aikin da aka tattauna dalla dalla;

Pterostilbene tsarin aiwatarwa; Sirtuin Kunnawa

Pterostilbene yana haɓaka hanyar siginar SIRT1 a cikin sel waɗanda ke ba da kariya daga lalacewar salula, don haka kunna shi. Wannan hanyar tana haɓaka faɗakarwar p53. P53 furotin ne wanda ke kare DNA daga lalacewa kuma yana kare sel daga maye gurbi wanda zai iya haifar da cutar kansa.

SIRT1 na iya hana ku lalacewa da lalata sel, wanda ke ci gaba yayin da kuka girma.

Magungunan Anti-Inflammatory Effects

Yawancin karatu sun nuna cewa pterostilbene fili sunadarai yana rage kumburi wanda aka tsara ta hanyar TNF-alpha (tumor necrosis factor-alpha). Damuwa na Oxidative yana kawo kumburi; Pterostilbene yana toshe interleukin-1b da TNF-alpha ta rage nau'in oxygen mai ratsa jiki.

Wannan kwaleji yana kare kariya daga damuwa a wani bangare na inji wanda aka sani da ER (endoplasmic reticulum). A cikin bincike, lokacin da aka fallasa ruhin jijiyoyin sel zuwa Pterostilbene foda, ruwansu bai amsa siginar ƙwayar kumburi ba, kuma ba su bayyana ba.

Pterostilbene tsarin aiwatarwa; Magungunan Anti-Cancer

Abin ban mamaki shine, duk da rage damuwa ER (endoplasmic reticulum) damuwa a cikin rufin jijiyoyin jini, Pterostilbene yana haɓaka damuwa a cikin ƙwayar endoplasmic reticulum of cancer cancer. Yana, sabili da haka, yana lalata lalata ƙwayoyin kansa kuma yana kare damuwa daga damuwa da damuwa a cikin ƙwayoyin lafiya.

A cikin ƙwayoyin kashin baya ko kwakwalwa (glioma) ƙwayoyin kansa, Pterostilbene ya lotsa Bcl-2 kuma ya tayar da Bax; Waɗannan canje-canje suna haɓaka alamun siginar "kashe kansa" wanda ke haifar da kashin baya ko ƙwayoyin kwakwalwa su mutu.

Kwayoyin ciwon daji suna amfani da wata hanyar da aka sani da Notch-1, don hana kansu aiwatar da magungunan kera, gami da oxaliplatin da fluorouracil. Pterostilbene yana toshe kwayar cuta mai mahimmanci-1 yana sanya ciwace-ciwacen daji ya zama mai da hankali ga jiyya ta hanyar ƙwaƙwalwar ƙwaƙwalwa.

Pterostilbene ya rage samar da wasu kwayoyi masu yada cutar kansar huhu, wadanda suka hada da MUC1, b-catenin, Sox2, NF-κB, da CD133. Waɗannan tasirin suna haɗuwa da rage kumburi kuma ya sa ya kusan yiwuwa yiwuwa ga ci gaban ƙwayoyin kansa.

neuroprotection

Pterostilbene ya sami damar kai wa yankin hippocampus zabi a cikin kwakwalwa. Anan, yana haɓaka CREB (furotin mai ɗaukar nauyin cAMP), BDNF (abubuwan da ke haifar da ƙwaƙwalwar ƙwaƙwalwar ƙwaƙwalwar ƙwaƙwalwar ƙwayar kwakwalwa), da MAPK (sunadarai masu motsi na mitogen),

Sunadaran ukun suna taimakawa neurons wajen ninka, girma, da kuma mayar da martani da kyau ga mahallinsu. Abubuwan kwantar da hankali na SNRI suma suna yin amfani da waɗannan hanyoyin.

Pterostilbene kuma yana haɓaka furotin da aka sani da Nrf2 a cikin hippocampus, wanda a cikin hakan yana haɓaka faɗakarwar sunadaran antioxidant.

Pterostilbene yana hana jiki daga cutar Alzheimer ta hanyar ba da kariya ga kwakwalwa game da beta-amyloid (Aβ). Yana yin wannan ta hanyar haɗawa da Akt da PI3K, sunadarai biyu waɗanda ke tallafawa ci gaban neuron, ƙwaƙwalwa, da kuma koyo.

3. Pterostilbene foda yana da amfani

Tattaunawa da ke ƙasa sune uku mafi mahimmanci pterostilbene foda fa'idodi;

pterostilbene-foda-2

i. Pterostilbene as nootropics

Yayinda muke tsufa, sabbin hanyoyin tunani suna zama mafi wahalar shiga, kuma tuni membobinci suna da wahalar samun damar shiga. Rashin iya aiwatar da aikin na yau da kullun yana raguwa sosai. Pterostilbene kari zai iya taimakawa a cikin ƙirƙirar wani yanki mai sabunta yanayin rayuwa a kowane zamani.

Pterostilbene ne mai ƙarfi nootropic, wanda ke taimakawa cikin nutsuwa da haɓaka cognition. Hakanan ana ɗaukar shi akai-akai yayin aikin kafin saboda iyawarsa don taimakawa cikin vasodilation na hanyoyin jini. Yana, saboda haka, yana ba da sakamako masu kama da na sauran sinadaran nitric oxide.

Ana amfani da fa'idodin noteropic na Pterostilbene saboda iyawarta don haɓaka matakan dopamine. A cikin rodents, Pterostilbene ya saukar da damuwa da haɓaka yanayi. A cikin binciken da ya shafi tsoffin ƙwayoyin tsofaffin ƙwayoyin cuta, kayan abinci na pterostilbene sun haɓaka matakan dopamine da haɓaka haɓaka. Hakanan, lokacin da aka samar da Pterostilbene a cikin kwakwalwar berayen hippocampus, ƙwaƙwalwar ajiyar aiki ta inganta.

A cikin wani binciken da ya shafi berayen, Pterostilbene shima ya haɓaka sabon haɓakar ƙwayoyin sel a cikin hippocampus. Hakanan, kwayoyin da aka samo daga kwakwalwar kananan jijiyoyi sun girma da sauri lokacin da aka fallasa su ga Pterostilbene.

Dangane da nazarin kwayar halitta, pterostilbene foda mai suna MAO-B (monoamine oxidase B) kuma yana haɓaka wadatar dopamine a cikin kwakwalwarmu. Wannan matakin ya yi kama da magungunan da ke maganin cutar ta Parkinson, kamar rasagiline, safinamide, da selegiline. A cikin bincike, Pterostilbene kuma yana kare neurons daga lalacewa da ke tattare da cutar AD (cutar Alzheimer).

Hakanan an yi imani da ikon sarrafa karfin damuwa na Pterostilbene saboda ikonta na toshe monoamine oxidase B. A cikin wani bincike na musamman, Pterostilbene ya nuna aikin anxiolytic a kashi biyu da daya / mg. Wannan aikin anxiolytic na fili ya kasance daidai da na diazepam a daya da biyu / mg a cikin EPM.

ii. Pterostilbene kuma kiba

Binciken da aka bincika ikon Pterostilbene don sarrafa kiba ya nuna cewa akwai babban yarjejeniya tsakanin ƙarin pterostilbene da kuma nauyin kulawa. Masana kimiyya sun yi imanin cewa Pterostilbene foda yana da ikon shafar matakan ƙoshin mai saboda ƙarfinsa na rage lipogenesis. Lipogenesis shine aiwatar da ƙirƙirar ƙwayoyin mai mai wuce haddi. Pterostilbene kuma yana haɓaka kitse mai mai ko kitse a cikin hanta.

A cikin binciken da ya shafi mutanen da ke tsakiyar shekaru masu dauke da kwayar cholesterol, rukuni na mahalarta wadanda ba sa shan magungunan cholesterol sun rasa nauyi yayin shan magungunan pterostilbene. Wadannan sakamakon sun zama abin mamaki ga masu binciken saboda wannan binciken ba a nufin auna pterostilbene a matsayin taimakon asarar nauyi ba.

Karatun dabbobi da kwayar halitta sun kuma nuna cewa kwayar pterostilbene na iya taimakawa wajen inganta yanayin insulin. Abin da Pterostilbene ke yi shine ta hana aiwatar da canza sukari ya zama mai. Hakanan yana hana sel mai girma girma da haɓaka.

Pterostilbene kuma yana canza tsarin gut flora a cikin hanji da kuma taimakawa wajen narke abinci.

Abubuwan ruwan da aka ciyar dasu tare da Pterostilbene suna da ingantaccen ƙwayar gut da kuma babban haɓaka a cikin Akkermansia muciniphila. A. muciniphila wani nau'in kwayoyin cuta ne wanda ya bayyana don hana kumburi-mara nauyi, kiba, da ciwon suga. Wannan kwayar cuta ta zama babban abin daukar hankali game da binciken dan adam a kwanannan.

iii. Pterostilbene yana haɓaka Longevity

Amfanin Pterostilbene na tsufa yana da alaƙa da sinadarai masu aiki da aka sani da Trans-pterostilbene. An tabbatar da wannan sinadaran don rage kumburi, koma baya da fahimta, da kuma tsayar da sukari na jini. A cikin vivo da a cikin binciken vitro suna tallafawa ayyukan Pterostilbene na hanawa da warkewar cutar. Wannan sinadarai shima yana aiki azaman ƙarancin sinadarai na caloric, wanda yake motsa jiki don sakin ƙarancin ƙwayoyi, gami da adiponectin dake rage jinkirin aiwatar da tsufa yayin inganta warkarwa.

Wannan ƙarin maganin tsufa an san shi ne don kare shi daga cututtukan da ke da alaƙa da shekaru, ta hakan ne yake tsawaita rayuwa. A cikin rodents, ƙananan allurai na waɗannan magungunan sunadarai masu saukar da alamu da ke tattare da tsufa. Binciken ya ba da shawarar cewa cin abinci mai yawa na abubuwan abinci na pterostilbene kamar su blueberries na iya jinkirta kalubalen kiwon lafiya da suka danganci tsufa, ciki har da dementia da cancer.

pterostilbene-foda-3

4. Pterostilbene da resveratrol

Babu wata shakka cewa Pterostilbene da resveratrol suna da alaƙa da juna. Resveratrol sanannu ne da ake kira bioactive sunadarai a cikin giya mai ruwan inabi da inab.

Amfanin kiwon lafiya na resveratrol yayi daidai da na Pterostilbene kuma sun haɗa da kariya daga cutar Alzheimer, tasirin azanci, haɓaka haɓaka ƙarfin kumburi, tasirin rigakafi, yuwuwar kamuwa da cutar kansa, da fa'idar jijiyoyin zuciya.

Pterostilbene a zahiri sunadarai ne mai kama da resveratrol, amma bincike ya rigaya ya ruwaito cewa Pterostilbene na iya zama mai ƙarfi fiye da resveratrol a cikin sarrafa wasu yanayin kiwon lafiya. Pterostilbene ya nuna ƙarin damar inganta haɓaka aiki, lafiyar zuciya, da matakan glucose.

Hakanan rabin rabin Pterostilbene yana da guntu fiye da rabin rayuwar resveratrol. Pterostilbene a zahiri yana da sauri sau hudu don ɗauka daga tsarin narkewa a cikin jiki fiye da resveratrol. Tun da farko, wannan na iya sa Pterostilbene ya fi tasiri sau da yawa fiye da resveratrol. Koyaya, ana buƙatar ƙarin bincike don tabbatar da wannan.

Pterostilbene da resveratrol suma wasu lokuta ana haɗa su don samar da ƙarin haɗin kai a cikin nau'i na kapanin. Ana ganin ƙarin abin haɗewa yana da ƙarfi yayin da yake inganta amfanin abubuwan mahaɗin biyu.

5. Tearin aikin Pterostilbene

Babu wata shakka cewa don cimma fa'idar fa'idodin Pterostilbene, ana ba da shawarar ku karɓe shi azaman kari foda. Pterostilbene kari Ana kasuwa a cikin shagunan abinci na ɗimbin yawa da cikin shagunan kan layi waɗanda suka ƙware a cikin abincin abinci. Hakanan zaka iya samun masana'antun pterostilbene akan layi.

Yawancin Pterostilbene ana samun su sosai a cikin nau'in capsules, tare da sigogi iri-iri. Lallai ya kamata ku karanta lakabin ko alamar kuma ku lura da yawan Pterostilbene a cikin kowane kwabo kafin ku saya. Wannan yana da mahimmanci saboda allurai daban-daban na iya nuna sakamako daban-daban.

Hakanan, wasu pterostilbene ƙarin allurai na iya zama sama da abin da aka yi bincike a cikin mutane. Yawancin allurai na yau da kullun suna tsakanin 50 mg da 1,000 MG a cikin kowane kwalliya.

Kamar yadda aka ambata a baya, ana samun ƙarin kayan haɗin abinci, tare da mafi kyawun haɗuwa kasancewa Pterostilbene da resveratrol. Hakanan an haɗa Pterostilbene tare da curcumin, koren shayi, astragalus, da sauran mahadi na halitta.

Hakanan zaka iya nemo mayukan rana wanda yake dauke da Pterostilbene dukda cewa wannan ba kasafai ake ganinsa ba. Ba a bincika adadin Pterostilbene don kare ka da kyau daga cutar kansa ba, amma yana iya ba da ƙarin kariya.

6. A ina zan sami mafi ingancin Peterostilbene foda?

Idan kuna neman ingantaccen pterostilbene foda don siyarwa, to kuna a daidai inda ya dace. Muna daya daga cikin shahararrun masanan, masu ilimi, da gogaggen masana'antun pterostilbene a kasar Sin. Muna samar da samfuran tsarkakakke waɗanda aka shirya waɗanda kullun ƙwararren dakin gwaje-gwaje na duniya ya gwada don tabbatar da tsabta da aminci. Muna bayar da umarni koyaushe a cikin Amurka, Turai, Asiya, da sauran sassan duniya. Don haka idan kuna son siyan pterostilbene foda na mafi girman ingancin yiwu, kawai tuntube mu yanzu.

References

  1. Rimando AM, Kalt W, Magee JB, Dewey J, Ballington JR (2004). "Resveratrol, pterostilbene, da piceatannol a cikin berriescini". J Aikin Abinci na Chem. 52 (15): 4713–9.
  2. Kapetanovic IM, Muzzio M., Huang Z., Thompson TN, McCormick DL Pharmacokinetics, oa bioavailability, da bayanin martaba na resveratrol da analog dinta, pterostilbene, a cikin bera. Inna. Pharmacol. 2011; 68: 593-601.
  3. Tsaro na trans rat resveratrol azaman sabon labari abinci bisa ga toa'idar (EC) Babu 258/97 ″. Jaridar EFSA. Hukumar Kula da Abinci ta Turai, Kwamitin EFSA akan Kayan Abinci, Abinci da Cutar Abinci. 14 (1): 4368
  4. Becker L, Carré V, Poutaraud A, Merdinoglu D, Chaimbault P (2014). "MALDI taro spectrometry hoto don lokaci daya na resveratrol, pterostilbene da viniferins a kan ganyen innabi". Molecules. 2013 (7): 10587-600.

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