Cycloastragenol Bayani

Cycloastragenol (CAG) wanda aka fi sani da T-65 shine tetracyclic triterpenoid na halitta wanda aka samo daga Astragalus membranaceus shuka. An fara ganowa ne lokacin da Astragalus membranaceus ana kimanta tsantsa don abubuwanda take aiki dasu tare da kayan tsufa.

Hakanan za'a iya samo Cycloastragenol daga Astragaloside IV ta hanyar aikin hydrolysis. Astragaloside IV shine babban sashi mai aiki a cikin Astragalus membranaceus ganye. Kodayake Cycloastragenol da Astragaloside IV suna kama da tsarin sunadarai, cycloastragenol ya fi wuta nauyi nauyi fiye da Astragaloside IV. Sakamakon haka, Cycloastragenol ya fi inganci saboda haɓakar haɓakar rayuwa kuma saboda haka haɓakar haɓakar cycloastragenol. Babban maganin metabolism na cycloastragenol an lura dashi a cikin epithelial na hanji ta hanyar yadawa mai saurin gaske.

Anyi amfani da ganyen astragalus a matsayin maganin gargajiya na kasar Sin tsawon karnoni kuma ana amfani da shi a yau. Anyi amfani da tsire-tsire Astragalus saboda fa'idodi masu amfani ciki har da anti-bacterial, anti-inflammatory da kuma ikon haɓaka rigakafi.

CAG an nuna shi azaman mahaɗan tsufa wanda ke haɓaka aikin enzyme telomerase da warkar da rauni. A halin yanzu shine babban haɗin da aka sani don haifar da telomerase a cikin mutane, saboda haka babban haɓaka mai yiwuwa don ƙarin ci gaba.

An gano Cycloastragenol a matsayin mai kunnawa na telomerase, wanda ke taka rawa don ƙara tsawon telomeres. Telomeres sune iyakokin kariya wadanda aka hada da maimaita nucleotide a karshen chromosome. Wadannan telomeres sun zama sun fi guntu bayan kowane rarrabuwa wanda ke haifar da lalatawar kwayar halitta da lalacewa. Bugu da ari, ana iya taƙaita telomeres ta gajiya mai raɗaɗi.

Wannan matsanancin gajartar telomeres yana da alaƙa da tsufa, mutuwa da wasu rikice-rikice masu alaƙa da ag. Abin farin ciki, enzyme na telomerase zai iya ƙara tsawon waɗannan telomeres.

Kodayake babu wani karatu mai zurfi don tabbatar da ikon cycloastragenol don tsawanta rayuwa, yana da kyakkyawan yanayin hana tsufa. An tabbatar da kawar da alamun tsufa ciki har da layuka masu kyau da wrinkles. CAG na iya rage barazanar haifar da cututtukan lalacewa kamar na Parkinson, Alzheimer's, da ciwon ido. 

Duk da yawa cycloastragenol fa'idodin kiwon lafiya, akwai damuwa cewa zai iya haifar da ciwon daji ko hanzarta ciwon daji. Koyaya, wasu nazarin da aka gudanar tare da batutuwa na dabba suna ba da rahoton fa'idodi na cycloastragenol ba tare da wani ciwon daji ba.

Cycloastragenol foda don siyarwa ana samun su ta yanar gizo kuma za'a iya siye su daga sanannun masu siyar da kayan cycloastragenol.

Kodayake, yawancin fa'idodin kiwon lafiyar cycloastragenol da aka nuna, har yanzu sabon memba ne a ƙarƙashin karatu. Bugu da ƙari, sakamakon tasirin cycloastragenol ba a bayyane yake ba, don haka ya kamata a yi amfani da taka tsantsan.

 

Menene Cycloastragenol?

Lankanars

Cycloastragenol shine tarin saponin mai saurin triterpenoid wanda aka samo shi daga asalin ganyen Astragalus. Astragalus membranaceus An yi amfani da tsire-tsire a cikin Magungunan gargajiyar gargajiyar gargajiyar gargajiyar ƙasar (TCM) tun sama da shekaru 2000 kuma har yanzu ana amfani da shi a cikin shirye-shiryen ganye.

Ganyen astragalus an san shi da ikon inganta rigakafi, kare rayayyu, aiki azaman diuretic da mallaka sauran kiwon lafiya kayan aiki irin su anti-hypersensitivity, antibacterial, Anti-tsufa da kuma amfanin danniya.

Cycloastragenol wanda aka fi sani da TA-65 amma kuma an kira shi Cyclogalagenin, Cyclogalegenin, Cyclogalegigenin, da Astramembrangenin. Cycloastragenol kari shine mafi yawan sananne a matsayin wakili mai tsufa, amma, sauran fa'idodin lafiyar cycloastragenol sun haɗa da haɓaka tsarin rigakafi, anti-inflammatory da anti-oxidative Properties.

Lankanars

Cycloastragenol da Astragaloside IV

Dukansu cycloastragenol da Astragaloside IV suna faruwa ne kwatsam a cikin cirewar tsiren astragalus. Astragaloside IV shine farkon aiki a cikin astragalus membranaceus, duk da haka, yana faruwa a cikin adadi kaɗan a cikin asalin. Tsarin cire wadannan saponins, cycloastragenol da astragaloside IV, yawanci yana da wahala saboda matakin tsarkakewa da ake bukata.

Duk da yake duka biyu cycloastragenol da astragaloside IV ana samunsu ne daga ciyawar astragalus, ana iya samun cycloastragenol daga astragaloside IV ta hanyar aikin hydrolysis. 

Wadannan mahadi guda biyu suna da irin wannan tsarin sunadarai, duk da haka, cycloastragenol ya fi wuta nauyi ainun fiye da astragaloside IV kuma shima yafi samuwa.

 

Hanyar Aikin Cycloastragenol

i. Amfani da Telomerase

Telomeres sune maimaita nucleotide a ƙarshen chromosomes na layi kuma suna ɗaure da wasu saitin sunadarai. Telomeres ya gajarta tare da kowane ɓangaren sel. Telomerase, hadadden ribonucleoprotein wanda ya kunshi enzymes masu saurin jujjuya bayanan baya (TERT) da bangaren RNA na telomerase (TERC) ya tsawaita telomeres. Tunda mahimmin aikin telomeres shine kare chromosomes daga haɗuwa da lalacewa, ƙwayoyin halitta galibi suna gane gajeren telomeres azaman DNA.

Sakamakon sakamako na kunnawa na telomerase na Cycloastragenol don haɓaka telomeres wanda hakan ke nuna sakamako mai fa'ida.

 

ii. Ara inganta haɓakar lipid

Lipids a dabi'ance suna aiki ne a matsayin ma'aji don kuzari a jikinmu. Koyaya, yawan wadannan mayukan na iya cutar da lafiyarmu.

Cycloastragenol yana inganta ingantaccen maganin kiba ta hanyar masu sarrafa kwayoyin halittar jiki.

Na farko, a ƙananan allurai, CAG yana rage ƙwayoyin liptoplasmic a cikin 3T3-L1 adipocytes. Abu na biyu, lokacin da aka yi amfani da shi a manyan allurai, CAG yana hana bambancin 3T3-L1 preadipocytes. A ƙarshe, CAG na iya haifar da kwararar alli a cikin preadipocytes 3T3-L1.

Tunda alli mai cikin cikin jiki na iya danne bambance-bambancen adipocytes, CAG yana kawo daidaito a cikin sinadarin lipid ta hanyar kara kuzarin shigar da alli.

 

iii. Ayyukan antioxidant

Danniya mai kumburi shine asalin musabbabin cututtuka da kuma tsufa. Stresswajin damuwa yana faruwa lokacin da akwai ƙarin ƙwayoyin cuta a jiki.

Cycloastragenol yana nuna alamun anti-oxidative ta haɓaka ƙarfin antioxidant. Wannan aikin antioxidant yana da alaƙa da rukunin hydroxyl da aka samo a cikin CAG.

Bugu da ƙari, danniya mai kumburi shine babban dalilin rage telomere, saboda haka kariyar telomere ta samo asali ne daga ayyukan antioxidant da kunna telomerase.

 

iv. Ayyukan anti-inflammatory

Duk da yake kumburi wata hanya ce ta jiki wacce jiki ke yaƙi da kamuwa da cuta ko rauni, kumburi na yau da kullun yana da illa. Konewa na yau da kullun yana haɗuwa da cuta da yawa kamar su ciwon huhu, ciwon suga, cututtukan zuciya da amosanin gabbai.

Cycloastragenol foda yana nuna alamun anti-inflammatory. Amfanin anti-inflammatory na cycloastragenol sune ta hanyoyi daban-daban gami da hana yaduwar kwayar lymphocytes da inganta haɓakar protein kinase (AMPK) da ke samar da phosphorylation. 

 

Fa'idodin Cycloastragenol

i.Cycloastragenol da tsarin rigakafi

Cycloastragenol na iya taimakawa inganta rigakafin ta hanyar haɓaka yaduwar kwayar T lymphocyte. Abilityarfin haɓakar cycloastragenol don kunna telomerase yana ba shi damar haɓaka gyaran DNA yayin jagorancin ci gaba da haɓaka telomere.

 

ii.Cycloastragenol da Anti-tsufa

Cycloastragenol mai tsufa kadarori sune babban sha'awar yawancin bincike a yau. CAG an nuna shi don jinkirta tsufa a cikin mutane tare da rage alamun tsufa kamar wrinkles da layuka masu kyau. Cycloastragenol aikin tsufa yana samuwa ta hanyoyi daban-daban guda huɗu. Hanyoyin maganin tsufa na cycloastragenol sun hada da;

Lankanars

 

  • Yin gwagwarmaya da damuwa

Stressaƙƙarwar Oxidative na faruwa ne ta halitta idan akwai rashin daidaituwa tsakanin ƙwayoyin cuta da antioxidant a cikin jiki. Idan ba a sarrafa shi ba, damuwa mai sanya kuzari na iya hanzarta tsarin tsufa kazalika haifar da mummunan yanayi kamar ciwon daji, cututtukan zuciya da ciwon sukari.

Cycloastragenol astragalus cirewa shine kyakkyawan hadadden antioxidant sannan kuma yana inganta karfin antioxidant na yanzu. Wannan yana taimakawa jinkirta tsufa kuma yana hana faruwar rikice-rikicen shekaru.

 

  • Cycloastragenol yayi aiki azaman telomerase activator

Kamar yadda aka tattauna a cikin sashin da ke sama game da yadda ake aiwatar da aiki, cycloastragenol yana taimakawa tsawan telomeres. Wannan yana taka muhimmiyar rawa wajen tabbatar da ci gaban sel don haka jinkirta tsufa. Wannan kuma yana taimakawa wajen kiyaye gabobin jiki suyi aiki yadda yakamata.

 

  • Cycloastragenol yana ba da kariya daga hasken UV

Idan mutum ya fallasa zuwa hasken rana na tsawon lokaci kwayoyin jikin mutum na iya lalacewa kuma sakamakon haka ya kasa yin aiki da kyau. Wannan yana haifar da wani nau'i na tsufa wanda bai kai ba wanda ake kira da tsufa a hoto.

Cycloastragenol foda ya zo wurin ceto kamar yadda aka nuna don kare fata daga cutarwa daga hasken UV.

 

  • Cycloastragenol ya hana glycation mai gina jiki

Glycation tsari ne wanda suga kamar su glucose ko fructose ke mannewa zuwa lipid ko furotin. Glycation shine ɗayan masu nazarin halittu don ciwon sukari kuma yana da alaƙa da tsufa da sauran cututtuka.

Cycloastragenol kari yana taimakawa hana tsufa saboda glycation ta hanyar hana samuwar kayan glycation.

 

iii.Sauran Fa'idodin Kiwan Lafiya na Cycloastragenol:
  • Cycloastragenol maganin kansa

Ana nuna yiwuwar warkar da cutar sankara ta cycloastragenol ta ikonsa na lalata kwayoyin cutar kansa, inganta rigakafi tare da kare mutum daga halayen cutarwa na chemotherapy.

A wani binciken da aka yi na mutanen da ke da cutar sankarar mama, cycloastragenol ciwon daji magani ya nuna ta ikon rage mace-mace da kimanin kashi 40%. 

 

  • Zai iya kare zuciya daga lalacewa

Cycloastragenol na iya ba da kariya game da lalacewar zuciya.

A cikin nazarin beraye tare da lalacewar zuciya, an gano ƙarin cycloastragenol don inganta haɓakar zuciya ta hanyar inganta autophagy a cikin ƙwayoyin myocardial tare da murƙushe maganganun matrix metalloproteinase-2 (MMP-2) da MMP-9.

 

Bisa ga sake dubawa na cycloastragenol, zai iya inganta ingancin bacci. Koyaya, ana buƙatar karatun asibiti don samar da cikakkiyar hujja akan ikon haɓaka bacci.

Lankanars

  • Zai iya taimakawa wajen yaƙar baƙin ciki

An sami gajeren telomere a cikin mutanen da ke fama da rikicewar damuwa kamar su lamuran yanayi da cututtuka kamar Alzheimer.

A cikin nazarin beraye a cikin gwajin ninkaya da aka tilasta, an gano ƙarin kayan aikin cycloastragenol da aka gudanar na kwanaki 7 don rage rashin motsi. An nuna shi don kunna telomerase a cikin ƙananan ƙwayoyin cuta da kuma a cikin ƙwayoyin PC1, wanda ke bayanin tasirin sa na rashin damuwa.

 

  • Iya hanzarta warkar da rauni

Warkar da rauni babban al'amari ne ga masu fama da ciwon sukari Wannan tsari na warkar da rauni yana faruwa ta hanyar jerin ayyuka. Wadannan ayyukan sune; aikin kumburi, daskarewa, dawo da epithelium, sake gini da kuma tsari na karshe na kwayar halitta. Waɗannan ƙwayoyin halittar jini suna da mahimmanci wajen warkar da ciwon sukari.

An nuna cewa lalacewar telomere yana shafar warkar da rauni. Wannan inda cycloastragenol foda ya shigo don gyara gajeren telomere tare da haɓaka haɓaka da motsi na ƙwayoyin sel. Wannan kuma yana taimakawa cikin saurin rauni.

 

  • Inganta lafiyar gashi

Binciken Cycloastragenol ta masu amfani na sirri sun nuna cewa cycloastragenol na iya taimakawa hana asarar gashi, haɓaka haɓakar gashi da haɓaka launin gashi.

Karin amfanin cycloastragenol astragalus cire abubuwa shine;

  1. Yana ba da aikin rigakafin ƙwayoyin cuta akan ƙwayoyin CD4 + na ɗan adam.
  2. Energyara ƙarfi.
  3. Inganta lafiyar fata.
  4. Zai iya inganta hangen nesa

 

Matsakaicin Tsarin Cycloastragenol

Daidaitacce cycloastragenol sashi yana kusan 10 mg kowace rana. Koyaya, tunda wannan sabon sabo ne kari sashi zai dogara ne akan amfani, shekaru da mahimmancin yanayin kiwon lafiya.

Wannan daidaitaccen maganin na cycloastragenol ya kamata a haɓaka cikin tsofaffi waɗanda suka wuce shekaru 60 don cimma daidaito na telomere tare da rage saurin tsufa.

 

Shin Cycloastragenol yana da lafiya?

Cycloastragenol foda gabaɗaya ana ɗaukarsa mai aminci a wasu tsaran jigilar abubuwa. Koyaya, tunda sabon salo ne kari ba a san tasirin tasirin cycloastragenol ba tukuna.

Reviewsan binciken da ake yi na cycloastragenol a kan fa'idodin faɗin cycloastragenol ba cikakke ba ne da zai ba da damar amfani da shi.

Bugu da kari, akwai damuwar cewa kari na cycloastragenol zai iya hanzarta kamuwa da cutar kansa ta hanyar bunkasa ciwan ciwace-ciwacen. Wannan jita-jita ce bisa ka'ida dangane da cewa babban salon aikin cycloastragenol shine ta hanyar telomere elongation. Don haka ake tunanin cewa zai inganta ci gaban kwayar cutar kansa.

Don haka yana da kyau a guji bawa cycloastragenol ga masu cutar kansa har sai an sami ingantattun bayanai dangane da wannan hasashe kuma don kauce wa duk wani cutar da ba a san ta ba. 

 

A Ina Zamu Samu Mafi Kyawun Cycloastragenol?

Well, cycloastragenol foda don sayarwa ana samun saukinsa akan layi da kuma shagunan abinci masu yawa. Koyaya, koyaushe bincika cycloastragenol foda don siyarwa daga waɗanda aka yarda da su da kuma masu sanadin ingancin cycloastragenol don tabbatar da cewa kun sami tsarkakewar cycloastragenol sosai.

 

Researarin bincike

Cycloastragenol foda an nuna shi don mallakar sakamako mai amfani da yawa kuma ƙari don kayan tsufa na tsufa. Cycloastragenol kunnawa telomerase shine babban yanayin aiki wanda hakan yana ƙaruwa telomere. Wadannan an nuna su a cikin nau'ikan dabbobin da yawa da kuma fewan kaɗan bawan nazarin.

Gwajin gwaji na cycloastragenol astragalus cire sakamako akan tsawan telomere ba su da yawa kuma saboda haka ana buƙatar ƙarin karatu don bayar da cikakkiyar shaida.

Tasirin tasirin TA-65 a cikin haɓaka haɓakar zuciya ba shi da zurfi sosai saboda ƙarancin karatu yana wanzu don tallafawa wannan aikin TA-65.

Yin nazarin tasirin metabolism na cycloastragenol a cikin cikakkun bayanai zai inganta kan bayanan da ke akwai tare da tona asirin duk wani guba na cycloastragenol da ke iya faruwa saboda yawan haɗuwa.

Arin karatu don kimanta ingancin cycloastragenol kari a cikin fa'idodin da aka tanada. Har yanzu ba a san tasirin tasirin cycloastragenol ba. Sabili da haka, yakamata ayi bincike don tantance yiwuwar cycloastragenol sakamako masu illa kazalika da hulɗa tare da wasu magunguna.

A fahimtar fa'idodin lafiyar cycloastragenol, zai taimaka gano hanyoyin da ke haifar da waɗannan ayyukan CAG.

Bugu da ƙari, ƙaddarar cycloastragenol mai dacewa yana buƙatar ƙarin karatu don kimanta sashin shawarar da aka ba da shawara ga rukunin shekaru daban-daban. Daban-daban masu samar da cycloastragenol sun ba da magunguna daban-daban wadanda ya kamata a daidaita su ta hanyar bincike.

 

References
  1. Yuan Yao da Maria Luz Fernandez (2017). "Fa'idodi masu Amfani na Tasirin Telomerase (TA-65) Game da Cutar Cutar Tushe" EC Gina Jiki 6.5: 176-183.
  2. Wang, J., Wu, M.-L., Cao, S.-P., Cai, H., Zhao, Z.-M., & Waƙa, Y. -H. (2018). Cycloastragenol yana inganta lalacewar zuciya a cikin berayen ta hanyar inganta kwayar cutar ta hanyar hana siginar AKT1-RPS6KB1. Biomedicine & Pharmacotherapy, 107, 1074-1081. Doi: 10.1016 / j.biopha.2018.08.016
  3. Rana, C., Jiang, M., Zhang, L., Yang, J., Zhang, G., Du, B.,… Yao, J. (2017). Cycloastragenol ya gabatar da kunnawa da kuma yaduwar yaduwa a cikin kwayar sinadarin lymphocyte mai kunnawa mai motsi. Immunopharmacology da Immunotoxicology, 39 (3), 131-139. Doi: 10.1080 / 08923973.2017.1300170.
  4. Ip F, C, F, Ng Y, P, An H, J, Dai Y, Pang H, H, Hu Y, Q, Chin A, C, Harley C, B, Wong Y, H, Ip N, Y: Cycloastragenol Mai Tasirin Telomerase ne a cikin ƙwayoyin Neuronal: Abubuwan da ke tattare da Gudanar da Bacin rai. Neurosignals 2014; 22: 52-63. Doi: 10.1159 / 000365290.
  5. Yu, Yongjie & Zhou, Limin & Yang, Yajun & Liu, Yuyu. (2018). Cycloastragenol: Wani ɗan takara mai ban sha'awa don cututtukan da ke tattare da shekaru (Dubawa). Gwajin gwaji da Magunguna. 16. 10.3892 / etm.2018.6501.
  6. MULKIN CYCLOASTRAGENOL (78574-94-4)

 

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