Galantamine Hydrobromide overview

Galantamine hydrobromide magani ne da aka yi amfani da shi don magance cutar mantuwa ta cutar mantuwa. Galantamine an fara samo shi ne daga dusar dusar ƙanƙara Galantus spp. Galaarin galantamine duk da haka babban alkaloid ne wanda aka hada shi da sinadarai.

Kodayake ba a fahimci abin da ke haifar da cutar Alzheimer ba, amma an san cewa mutanen da ke fama da cutar ta Alzheimer suna da ƙananan ƙwayoyin sinadarin acetylcholine a cikin kwakwalwar su. Acetylcholine yana da alaƙa da aikin haɓaka ciki har da ƙwaƙwalwar ajiya, ilmantarwa da sadarwa da sauransu. Rage wannan sinadarin (acetylcholine) an alakanta shi da rashin hankali na Alzheimer ta cutar.

Galantamine yana amfanar marasa lafiya na cutar Alzheimer saboda tsarin aikinta guda biyu. Yana aiki ta ƙara matakan acetylcholine a cikin hanyoyi biyu. Isaya shine ta hana ɓarkewar acetylcholine kuma ɗayan shine ta hanyar gyaran allosteric na nicotinic acetylcholine receptors. Wannan matakai guda biyu suna taimakawa wajen kara adadin enzyme, acetylcholine.

Duk da yake yana iya rage alamun cutar Alzheimer, galantamine hydrobromide ba cikakkiyar magani ba ce ta cutar Alzheimer tunda ba ta shafar ainihin dalilin cutar.

Baya ga amfanin galantamine na magance alamomin cutar Alzheimer, galantamine tana da alaƙa da mafarki mai ma'ana. Galantamine da mafarkin lucid ƙungiya ce wacce aka samu rahotonta daga daidaikun masu amfani. Don cimma wannan galantamine ana ɗaukar ɗan lokaci tsakanin tsakanin bacci misali bayan minti 30 na bacci. Wasu masu ba da sabis na kiwon lafiya za su ƙarfafa galantamine da fa'idodi masu fa'ida ta hanyar tsarin kulawa don kauce wa tasirin da ba dole ba.

Ntarin galantamine na faruwa ne a cikin nau'ikan kwamfutar hannu, maganin baka da kuma ɗan kwantaccen sako. Yawanci ana ɗauka tare da abinci da shan ruwa da yawa don kauce wa illolin da ba'a so.

Abubuwan illa na galantamine na yau da kullun sun haɗa da tashin zuciya, amai, ciwon kai, rashin jin daɗin ciki ko ciwo, raunin tsoka, jiri, jiri, da gudawa. Wadannan tasirin tasirin galantamine hydrobromide yawanci sauki ne kuma suna faruwa ne lokacin da ka fara shan wannan magani. Suna iya ɓacewa tare da lokaci, duk da haka idan basu tafi ba tuntuɓi likitanka. Hakanan akwai wasu cututtukan da ba a sani ba amma masu tsanani waɗanda na iya faruwa kamar matsalar numfashi, ciwon kirji, ciwon ciki mai tsanani, matsalar fitsari, kamuwa, suma cikin wasu.

Galantamine Hydrobromide

 

Galantamine Hydrobromide

(1) Menene Galantamine Hydrobromide?

Galantamine hydrobromide magani ne na likitanci da ake amfani dashi don magance matsakaici ko matsakaici dementia hade da cutar Alzheimer. Cutar Alzheimer cuta ce ta ƙwaƙwalwa wanda yawanci yakan lalata ƙwaƙwalwar ajiya da ƙarfin tunani, ilmantarwa, sadarwa da ikon aiwatar da ayyukan yau da kullun.

Magungunan galantamine hydrobromide na iya magance cutar Alzheimer da ke ci gaba amma ana iya amfani da ita tare da sauran magungunan Alzheimer.

Yana faruwa a cikin manyan nau'i uku tare da ƙarfi daban-daban. A galantamine siffofin ne na baka bayani, Allunan da wani Extended-saki capsules.

 

(2) Me yasa ake amfani da shi? wa ya kamata ya sha wannan magani?

Galantamine hydrobromide ana amfani dashi don magance alamomin matsakaici zuwa matsakaitan alamun cutar Alzheimer. Ba a nuna sinadarin Galantamine hydrobromide don maganin cutar Alzheimer saboda ba ya tasiri tasirin aiwatarwar cutar.

Galantamine hydrobromide ana nuna shi don amfani da mutane masu sauƙi zuwa matsakaitan alamun cutar Alzheimer.

 

(3) Yaya yake aiki?

Galantamine yana cikin aji na kwayoyi da ake kira masu hana acetylcholinesterase.

Galantamine yana aiki don kara adadin enzyme, acetylcholine a hanyoyi biyu. Da farko yana aiki ne azaman mai juyawa da gasa mai hana maye gurbin acetylcholinesterase don haka hana karyewar acetylcholine a cikin kwakwalwa. Abu na biyu, shi ma yana motsa masu karɓar nicotinic a cikin kwakwalwa don sakin ƙarin acetylcholine. 

Wannan yana haifar da adadin acetylcholine a cikin kwakwalwa, wanda na iya taimakawa rage alamun da ke tattare da cutar rashin hankali.

Galantamine na iya taimakawa haɓaka ikon tunani da tsari memory kazalika da rage jinkirin fahimtar aiki a cikin marasa lafiyar cutar Alzheimer.

 

Galantamine Hydrobromide fa'idodi akan Alzheimer's cuta

Cutar Alzheimer tana sa ƙwayoyin kwakwalwa lalacewa kuma daga ƙarshe su mutu. Ainihin abin da ba a san shi sosai ba amma wannan cutar ci gaba tana haifar da rage aiki da hankali kamar memory, ilmantarwa, tunani da ikon aiwatar da ayyukan yau da kullun. Abinda aka sani game da marasa lafiya na cutar Alzheimer shine ƙananan matakin sunadarai acetylcholine.

Galantamine yayi amfani da shi wajen kula da alamun rashin lafiyar da ke tattare da cutar Alzheimer da ke faruwa saboda yanayin yanayin aikin sa biyu. yana ƙara matakin acetylcholine, maɓallin enzyme a cikin haɓaka haɓaka. Galantamine yana aiki azaman mai juyawa da gasa acetylcholinesterase mai hanawa saboda haka ya hana raunin acetylcholine. Hakanan yana motsa masu karɓar nicotinic don sakin ƙarin acetylcholine.

Galantamine Hydrobromide

Sauran Fa'idodin Dama

(1) Sunan mahaifa

An san damuwa mai sanyaya cikin jiki shine ya haifar da rikice-rikice masu yawa kamar cutar Parkinson, cutar Alzheimer, ciwon suga, da sauransu. Yana faruwa ta halitta tare da shekaru amma idan akwai rashin daidaituwa tsakanin masu kyauta da antioxidants, lalacewar nama na iya faruwa.

Galantamine an san shi ne don rarraba nau'in oxygen mai amsawa kuma yana ba da kariya ga ƙananan jijiyoyi ta hanyar hana lalacewar ƙwayoyin cuta ta hanyar damun ƙwayoyin cuta. Galantamine na iya rage haɓakar haɓakar haɓakar oxygen mai haɓakawa ta ƙara matakin acetylcholine. 

 

(2) Maganin hana ƙwayoyin cuta

Galantamine yana nuna aikin antibacterial.

 

Yadda ake shan wannan magani?

i Kafin shan Galantamine hydrobromide

Kamar yadda yake tare da sauran magunguna yana da kyau a ɗauki matakan kiyayewa kafin ɗaukar galantamine hydrobromide.

Sanar da likitan ku ko kuna rashin lafiyan galantamine ko wani kayan aikin sa.

Bayyana duk magungunan da kuke sha a halin yanzu ciki har da magungunan da aka rubuta, magungunan kan-kan-kanshi, magunguna na ganye ko duk wani kayan kiwon lafiya.

Yana da kyau ka sanar da likitanka wasu yanayin da kake fama da su sun hada da;

  • cututtukan zuciya
  • Ciwon hanta,
  • Asma,
  • Matsalolin koda,
  • Cutar ciki,
  • M zafi na ciki,
  • Kamu,
  • Prostara girman prostate,
  • Aiki na kwanan nan musamman kan ciki ko mafitsara.

Yakamata a sanar da mai kula da lafiyarku ko kuna da ciki ko kuna shirin yin ciki kuma kuna shayarwa. Idan kun sami ciki yayin shan ƙarin galantamine, ya kamata ku yi magana da likitanku da wuri.

Yana da muhimmanci ka fadawa likitanka cewa kana shan galantamine kafin ayi wani aikin ciki harda tiyatar hakori.

Galantamine hydrobromide sakamakon hada bacci. Don haka ya kamata ka guji tuƙi da injunan aiki. 

Shan galantamine da barasa na iya kara tasirin bacci na galantamine hydrobromide.

 

ii. An ba da shawarar sashi

(1) Rashin hankali wanda cutar Alzheimer ta haifar's cuta

Galantamine hydrobromide don magance cutar Alzheimer na faruwa ne ta hanyar tsari kamar yadda sunayen galantamine suke kamar Razadyne wanda a da ake kira Reminyl.

Galantamine hydrobromide yana faruwa a cikin nau'i uku tare da ƙarfi daban-daban. Ana samun kwamfutar hannu ta baka a cikin 4 MG, 8 MG da kuma 12 mg na alluna. Ana sayar da maganin baka a cikin nauyin 4mg / ml kuma a mafi yawan lokuta a cikin kwalbar 100 ml. Ana samun iska mai ɗauke da baki a ciki 8 MG, 16 MG da 24 MG allunan.

Yayinda ake daukar allunan baka da na maganin na baki sau biyu a rana ana daukar karin kaifin kwaya sau daya a rana.

Farawa samfurin galantamine don siffofin al'ada (kwamfutar hannu da maganin baka) shine 4 MG sau biyu a rana. Ya kamata a sha kashi tare da abincinku na safe da maraice.

Don ƙara-fitaccen kwantaccen magani na farko shine 8 MG yau da kullun tare da abincin safe. Ya kamata a ɗauki keɓaɓɓiyar kawun ɗin gaba ɗaya don ba da damar sakin jinkirin shan magani a cikin yini. Sabili da haka, kada a murkushe ko yanke kwanten.

Don sashi na kiyayewa ya danganta da haƙurinka zuwa galantamine a cikin tsari na al'ada ya kamata a ɗauka a 4 MG ko 6 MG sau biyu a rana da kuma ƙaruwa na 4 MG kowane 12 hours akalla awanni 4 na tazara.

Ya kamata a kiyaye kawunin da aka shimfiɗa a 16-24 MG kowace rana da haɓaka 8 MG a cikin tazarar makonni 4.

Galantamine Hydrobromide

Wasu mahimmin la'akari yayin shan galantamine

Koyaushe ku sha galantamine tare da abincinku da yawan ruwa. Wannan zai taimaka kauce wa sakamakon da ake so galantamine.

Yana da kyau ka dauki samfurin galantamine a kusan lokaci daya kowace rana. Idan ka rasa kashi, dauki shi da zaran ka tuna idan kashi na gaba bai kusa ba. In ba haka ba tsallake kashi kuma ci gaba da tsarinku na yau da kullun. Koyaya, idan kun rasa adadin ku na 3 a jere kwana, kira likitan ku wanda zai iya ba ku shawara ku fara kan adadin ku.

Dangane da manufar da aka nufa, likitanku na iya daidaita allurarku daidai gwargwadon ƙara ta a mafi ƙarancin tazarar makonni 4. Kada ku daidaita sashin galantamine don kanku.

Idan aka baku makunnin da aka faɗaɗa, ku tabbata ku haɗiye shi duka ba tare da taunawa ko murƙushe shi ba. Wannan saboda an canza kwamfutar hannu don sakin maganin a hankali cikin yini.

Don takardar maganin maganin baka, koyaushe ku bi shawarar da aka bayar kuma kawai ƙara ƙwayoyi zuwa abin sha mara sa maye wanda ya kamata a sha nan da nan. 

 

(2) Sashin Adult (shekaru 18 zuwa sama)

Caparawar-ƙaramin kwafin yana da samfurin farko na 8 MG da ake sha sau ɗaya kowace rana da safe. Mai ba da sabis na kiwon lafiya na iya daidaita sashin ku ta hanyar haɓaka shi da 8 MG kowace rana bayan mafi ƙarancin makonni 4. Don kulawa ya kamata ka dauki 16-24 MG kowace rana kamar yadda likitanka ya ba ka shawara.

Don saurin sakin saurin, farkon farawa shine 4 MG da aka sha sau biyu a rana tare da abinci saboda haka 8 MG kowace rana. Likitan likitancin zai iya kara yawan maganin ta hanyar 4 MG kowace rana bayan mafi karancin tazarar makonni 4.

 

(3) Sashin Yara (shekaru 0-17)

Ba a yin nazarin tasirin Galantamine hydrobromide a cikin yara (shekaru 0-17), ya kamata a yi amfani da shi kawai tare da ƙwararrun likitocin likita.

 

iii. Menene za a yi idan an sha ƙari?

Idan ku ko marasa lafiyar da kuke sa ido suna daukar yawancin galantamine, ya kamata ku kira likitanku ko cibiyar kula da guba nan da nan. Hakanan kuna iya zuwa ɓangaren gaggawa mafi kusa da wuri.

Alamomin gama gari da ake dangantawa da galantamine yawan wuce gona da iri sune tashin zuciya mai tsanani, gumi, tsananin raunin ciki mai wahala, numfashi, jijiyoyin jiki ko rauni, kamuwa da jiki, suma, bugun zuciya da ba matsala.

Likita na iya ba ka wasu kwayoyi kamar atropine don sauya tasirin tasirin galantamine da ke haɗuwa da ɓarna.

 

Menene illoli masu alaƙa da amfani da Galantamine hydrobromide?

Duk da yake galantamine hydrobromide na ba da fa'idodi ga lafiyar mutanen da ke fama da cutar Alzheimer, ana iya samun wasu tasirin galantamine da ba a so. Akwai galantamine sakamako masu illa hakan na iya faruwa amma ba kowa ne zai iya fuskantar su ba

Mafi mahimmancin tasirin da zaku iya fuskanta tare da amfani da galantamine sune; 

  • tashin zuciya
  • vomiting
  • nutsuwa
  • zawo
  • dizziness
  • ciwon kai
  • asarar ci
  • ƙwannafi
  • nauyi asara
  • ciwon ciki
  • rashin barci
  • runny hanci

Wadannan cututtukan sune na kowa lokacin da ka fara shan galantamine amma yawanci suna da sauki kuma suna iya bacewa tare da ci gaba da amfani da maganin. Koyaya, idan sun dage ko sun kasance masu tsanani tabbas tabbatar da kiran likitan ku don neman ƙwararren masaniya.

 

Babban sakamako mai tsanani

Wasu mutane na iya fuskantar mummunar illa. Wadannan cututtukan ba su da kyau kuma ya kamata ka kira likitanka da zarar ka lura da su.

Babban illa mai haɗari sun haɗa da:

  • Tsananin rashin lafiyan irin wannan kumburin fata, kaikayi da wani lokacin kumburin fuska, maƙogwaro ko harshe.
  • bayyanar cututtuka na atrioventricular toshe ciki har da saurin zuciya, kasala, jiri da suma
  • gyambon ciki da zubar jini
  • Vomits wanda yake da jini ko bayyana kamar filayen kofi
  • Ci gaban matsalolin huhu a cikin mutanen da ke fama da asma ko wasu cututtukan huhu
  • kama
  • matsalar yin fitsari
  • tsananin ciwon ciki / ciki
  • jini a cikin fitsari
  • jin zafi ko zafi yayin fitsari

wasu post marketing galantamine side-effects wanda aka ruwaito sun hada da;

  • kamawa / girgizawa ko dacewa
  • hallucinations
  • motsin rai,
  • tinnitus (ringing a kunnuwa)
  • atrioventricular toshe ko cikar zuciya
  • hepatitis
  • hauhawar jini
  • haɓakawa a cikin enzyme hanta
  • fata rash
  • kumburi ja ko shunayya (erythema multiforme).

Wannan jerin mutane da yawa basu dauke da dukkan illolin galantamine. Saboda haka yana da kyau a kira likitan ku idan kun fuskanci wani tasiri na ban mamaki yayin shan wannan magani.

Galantamine Hydrobromide

Wani irin kwayoyi ke hulɗa da galantamine hydrobromide?

Maganganun ƙwayoyi yana nufin hanyar da wasu ƙwayoyi ke tasiri wasu. Waɗannan mu'amala suna shafar yadda wasu kwayoyi ke aiki kuma yana iya yin rashin tasiri ko ma hanzarta faruwar abubuwan illa.

Akwai sanannu galantamine hydrobromide hulɗa tare da wasu kwayoyi. Likitanku na iya rigaya ya san wasu mu'amala da ƙwayoyi. Mai ba ku kiwon lafiya zai iya canza wasu allurai don rage damar hulɗa da ƙwayoyi ko kuma zai iya canza magungunan gaba ɗaya. Yana iya zama da amfani a gare ka ka samo magani kuma musamman takardar sayan magani daga tushe guda kamar su kantin magani don haɗuwa mai kyau

Har ila yau, adana jerin magungunan da kuke sha kuma ku bayyana wannan bayanin ga mai ba ku kiwon lafiya kafin kowane takardar sayan magani.

Wasu daga cikin mu'amala da galantamine hydrobromide sune;

 

  • Yin hulɗa tare da anti-depressants

Ana amfani da waɗannan magungunan don magance ɓacin rai kuma suna iya yin tasiri yadda galantamine ke aiki wanda ke ba shi tasiri. Wadannan kwayoyi sun hada da amitriptyline, desipramine, nortriptyline da doxepin.

 

  • Yin hulɗa tare da kwayoyi da ake amfani dasu don magance rashin lafiyan

Wadannan kwayoyi na rashin lafiyan na iya shafar hanyar da galantamine ke aiki.

Wadannan kwayoyi sun hada da chlorpheniramine, hydroxyzine da diphenhydramine.

 

  • Yin hulɗa tare da magungunan cutar motsi

Wadannan kwayoyi suna tasiri aikin galantamine hydrobromide.

Wadannan magunguna sun hada da dimenhydrinate da meclizine.

 

  • Magungunan cutar Alzheimer

Magunguna suna aiki kamar galantamine hydrobromide. Lokacin da aka yi amfani da waɗannan magungunan tare zasu iya haɓaka haɗarinku na fuskantar tasirin illa na galantamine. Waɗannan magunguna sun haɗa da ƙararraki da rivastigmine.

Koyaya, ana iya cimma wasu tasirin haɗin gwiwa tare da wasu haɗuwa.

 

  • Memantine

Ana amfani da Galantamine da memantine don magance cutar Alzheimer. Duk da yake Galantamine ne acetylcholinesterase inhibitor memantine mai karɓa ne na mai karɓar NMDA.

Lokacin da kuke ɗaukar galantamine da memantine tare, kuna da ingantaccen haɓakawa fiye da lokacin da kuke amfani da galantamine shi kaɗai.

Koyaya, wasu karatun da suka gabata basu sami ci gaba mai mahimmanci ba a cikin aikin fahimi lokacin da aka yi amfani da galantamine da memantine tare.

 

  • Yin hulɗa tare da ƙwayoyi don yawan mafitsara

Wadannan magunguna suna tasiri yadda galantamine ke aiki. Idan kun kasance kuna amfani tare baza ku girbe daga galantamine ba. Wadannan kwayoyi sun hada da darifenacin, tolterodine, oxybutynin da trospium.

 

  • Magungunan ciki

Wadannan kwayoyi sun hada da dicyclomine, loperamide da hyoscyamine. Suna iya shafar yadda galantamine ke aiki.

 

  • Galantamine da magungunan autism

Lokacin da ake amfani da galantamine da magungunan autism kamar risperidone tare. An bayar da rahoton inganta wasu alamun bayyanar cututtukan ƙwayoyin cuta kamar rashin jin daɗi, rashin ƙarfi, da kuma janyewar zamantakewar jama'a

 

A ina za mu sami wannan samfurin?

Galantamine hydrobromide za'a iya samo shi daga likitan ku na gida ko daga shagunan kan layi. Abokan ciniki na galantamine saya daga likitan magani wanda aka yarda dashi wanda zai iya bada umarnin shan magani. Idan kayi la'akari da galantamine zaka siye shi daga ƙungiyoyi masu daraja kuma kayi amfani dashi kawai kamar yadda mai ba da sabis na kiwon lafiya ya tsara.

 

Kammalawa

Galantamine magani ne mai kyau don maganin cututtukan rashin hankali da ke tattare da Alzheimer's cuta. Duk da haka ba magani ba ne ga cutar tunda ba ta kawar da tushen cutar Alzheimer.

Ya kamata a yi amfani dashi azaman ɓangare a cikin maganin cutar Alzheimer tare da sauran dabaru. Kyakkyawan kari ne saboda tsarin sa na ƙara acetylcholine a cikin kwakwalwa. Yana ba da ƙarin fa'idodi a cikin kariya ta jijiyoyin jiki ta hana ƙin damuwa.

 

References
  1. Wilcock GK. Lilienfeld S. Gaens E. Inganci da amincin galantamine a cikin marasa lafiya da cutar Alzheimer mai sauƙi. 2000; 321: 1445-1449.
  2. Lilienfeld, S., & Parys, W. (2000). Galantamine: ƙarin fa'idodi ga marasa lafiya da cutar Alzheimer. Dementia da cututtukan ƙwaƙwalwa11 Suppl 1, 19–27. https://doi.org/10.1159/000051228.
  3. Tsvetkova, D., Obreshkova, D., Zheleva-Dimitrova, D., & Saso, L. (2013). Ayyukan antioxidant na galantamine da wasu daga dangoginsu. Chemistry na magani na yanzu20(36), 4595–4608. https://doi.org/10.2174/09298673113209990148.
  4. Loy, C., & Schneider, L. (2006). Galantamine don cutar Alzheimer da raunin fahimta. Cochrane database na sake dubawa na yau da kullun, (1), CD001747. https://doi.org/10.1002/14651858.CD001747.pub3.

 

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