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Abin da kuke Bukatar Ku sani game da Lalacewar Cutar Lantarki
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Abin da kuke Bukatar Ku sani game da Lalacewar Cutar Lantarki

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1. Mene ne Linaclotide (Linzess)?
2. Me ake amfani da Linaclotide?
3. Mene ne tsarin aikin Linaclotide?
4. Ta yaya ya kamata a yi amfani da Linaclotide?
5. Menene sashi don Linaclotide (Linzess)?
6. Wadanne abubuwa ne Linaclotide zai iya haifar?
7. Wadanne magunguna ne ko kuma magunguna masu haɗi zasuyi hulɗa da Linaclotide?
8. Menene bambance-bambance tsakanin Linaclotide da lubiprostone?
9. Wani bayani game da Linaclotide ya kamata in sani?


1. Mene ne Linaclotide (Linzess)?Phcoker

Linaclotide (Linzess) magani ne na FDA wanda aka yarda da shi wanda magani ne wanda yawanci ke amfani dashi ga marasa lafiya da ke fuskantar maƙarƙashiya na maƙarƙashiya ko maƙarƙashiya saboda ciwo na hanji. Linaclotide 851199-59-2 ya zo a saman jerin sabon rukuni na miyagun ƙwayoyi da ake magana da su a matsayin agonists na guanylate cyclase-C.

Sunan Linaclotide shine Linzess kuma yana da mahimmanci a tuna cewa a wannan lokacin babu wani nau'in samfurin Linaclotide. Don haka, idan kuna neman Linaclotide na siyarwa ko amfanin kai na mutum, sai a nemi masu sayar da magunguna ta yanar gizo masu zamba wadanda suke sayarwa ba bisa ka'ida ba Labarin linaclotide magani.

Linzess shine agonist na guanylate cyclase-C da peptide na 14-amino acid. sunan sunadarai shine L-cysteinyl-L-cysteinyl-L-glutamyl-L-tyrosyl-L-cysteinyl-L-cysteinyl-L-asparaginyl-L-prolyl-L-alanyl-L-cysteinyl-L-threonyl-glycyl- L-cysteinyl-L-tyrosine, cyclic (1-6), (2-10), (5-13) -tris (disulfide).

Tsarin kwayoyin sa shine C59H79N15O21S6 yayin da nauyin kwayoyin yake 1526.

Linaclotide foda fari ne ga fari-fari kuma yana narkewa kadan cikin ruwa. Hakanan zai iya narke dan kadan a cikin sinadarin sodium chloride (0.9%).

A karshe Linzess yana cikin nau'in wuya capsules mai wuya gelatin wanda ya ƙunshi beads mai lullube da Linaclotide. Calcium chloride dihydrate, L-leucine, titanium dioxide, microcrystalline cellulose, gelatin, tare da hypromellose suna daga cikin abubuwan da ke aiki a cikin Linzess

2. Me ake amfani da Linaclotide?Phcoker

Idan ya zo ga amfani da Linaclotide, mutane kan yi amfani da shi azaman jiyya ga wasu batutuwa na hanji kamar su hanji na hanji wanda ke sanyin maƙarƙashiya da maƙarƙashiyar rashin haihuwa a ciki.

Abin da kuke Bukatar Ku sani game da Lalacewar Cutar Lantarki

Linaclotide don rashin jijiyar ciwo bayyanar cututtuka

Ƙwararrun ciwo na jijiyoyin (IBS) cuta ce ta tsawan rai wanda ke hana hanjin cikin jiki aiki. Wannan manunin Linaclotide ana kuma kiransa da ciwon farji (spastic colon) kuma wani lokacin cutar hanji na aiki. Babban alamun cutar shine maƙarƙashiya, zawo da ciwon ciki tare da maƙarƙashiya ko madadin gudawa da zawo.

A cikin binciken asibiti don tabbatar da ingancin Linaclotide don sauƙin bayyanar cututtuka na rashin damuwa na hanji, an yi amfani da marasa lafiyar manya a cikin gwaji guda biyu, gwaji mai yawa. Gwajin farko ya ƙunshi marasa lafiya na 800 waɗanda aka sa su a kan 290 mcg kullun magani na linzess yayin da aka sanya 804 zuwa na biyu wanda ke kan placebo.

Dukkanin marasa lafiyar da aka yi amfani da su a cikin kungiyoyin biyu sun hadu da ka'idodin IBS Rome II kuma ana tsammanin su cimma ma'anar zafin jin zafi na 3 aƙalla kan sikelin sifili zuwa goma kuma aƙalla cikakke motsin hanji guda ɗaya a kowane mako a cikin hanyar jiyya zamani.

A ƙarshen lokacin magani, marasa lafiyar da ke kan hanyar linzess sun sami ƙarin ingantattun alamun BIS idan aka kwatanta da takwarorinsu na larura ta sharri:

  • Lokaci mai motsawa na hanji
  • Stool daidaito
  • Adadin lokaci da ƙoƙari na zahiri da mutum yake amfani da shi don wucewa stool.
  • Baƙin ciwon ciki

Wannan ya tabbatar da gaskiyar Linaclotide a matsayin magani mai inganci don BIS.

Linaclotide don Cututtukan Idiopathic Maƙarƙashiya (CIC) alamu

A cikin binciken don tantance tasiri na Linzess don CIC alamun bayyanar kulawa, marasa lafiyar manya tare da mawuyacin hali na idiopathic an sanya su a cikin bazuwar, gwaji na asibiti da yawa, makamancin binciken da aka bayyana a sama na BIS.

Kowane daga cikin marassa lafiya sun sadu da ingantattun ka'idodin maƙarƙashiya na Rome II kuma sun karɓi 72mg, 145 mcg Linzess, 290 mcg Linzess ko magani na placebo yau da kullun a cikin makon magani na 12-mako.

Bayan ƙarshen lokacin jiyya, masu binciken sun lura da ƙarin alamun CIC na ci gaba tsakanin marasa lafiya waɗanda ke kan aikin Linzess kamar yadda aka kwatanta da waɗanda ke kan placebo. Musamman, sun ɗanɗana haɓaka matakin haɓaka gwargwadon ƙarfin matsi, daidaitaccen daidaituwa da ƙarancin motsi na hanji.

Daga cikin dukkan allurai guda uku na Linzess, suna da karancin sakamako bayan banda bayar da alamun bayyanar CIC. Wannan yana tabbatar da alamar Linaclotide na iyawar sa don kula da CIC.

Abin da kuke Bukatar Ku sani game da Lalacewar Cutar Lantarki

3. Mene ne tsarin aikin Linaclotide?Phcoker

Ba kamar wasu magunguna waɗanda ake amfani da su don magance abubuwan kiwon lafiya da aka ambata na baya ba, ƙirar Linaclotide ta bambanta- ba a cikin jikin ku ba. Injin linaclotide yana faruwa ne a cikin hanjin ku ta hanyar ƙara yawan ruwa, saboda haka inganta hanjin hanji da kuma sauƙaƙa zafin da zai iya haifar da matsalar hanji.

Linaclotide (Linzess) yana sa hanji ya samar da karin ruwa ta hanyar haɓaka aikin monophosphate na cyclic.

Lokacin da Linaclotide yayi amfani da ƙarfinsa don haɓaka ruwa a cikin hanjin ku, abinci yana motsawa ta hanzarta hancin saurin kuma ingantaccen salon yana inganta. Wannan yana inganta alamomin cututtukan dake motsa jijiyoyin zuciya kamar faduwar ciki, ciwon ciki / rashin jin daɗin ciki da kuma cikakkiyar jijiyar motsin rai.

4. Ta yaya ya kamata a yi amfani da Linaclotide?Phcoker

Lokacin da kayi Linaclotide saya, hakika tare da takardar izinin likita, yana da mahimmanci a tabbatar cewa kun karanta jagorar magunguna wanda likitan likitan ku zai basu kafin shan maganin. Jagorar zata gaya muku madaidaicin kashi na Linaclotide a gare ku, daidai lokacin jinkiri da kuma shawarar lokacin kulawa.

Idan kuna buƙatar kowane bayani kan Kashi na linaclotide, kada ku yi shakka a tuntuɓi likitan ku ko mai harhaɗa magunguna don guje wa tasirin sakamako na Linaclotide ko hulɗa da Linaclotide.

Kasancewa da magani na baka, ya kamata a sha Linaclotide ta bakin. Ya kamata ku karɓe shi yayin da ciki bai zama komai ba, zai fi dacewa minti na 30 kafin ɗaukar abincinku na farko a rana. Magungunan Linaclotide na ƙarshe suna cikin nau'in capsule kuma ya kamata a hadiye shi gaba ɗaya. Bai kamata ka karya ko tauna Linaclotide capsules ba.

Koyaya, idan kun yi ƙoƙarin haɗiye kwanson ƙwaƙwalwa amma a banza, kuna iya buɗe su kuma haɗa abubuwan da ke ciki a cikin cokalin applesauce. Ki hadiye cakuda nan da nan kuma kamar yadda ake yi-kar a ɗan tauna shi. Haɗa kawai adadin da ya kamata ku ɗauka a wannan lokacin saboda adana cakuda zai sa miyagun ƙwayoyi su daina tasiri.

Idan baku da applesauce, zaku iya amfani da ruwa azaman madadin. Auna guda oce ko 30mm na ruwa, bude maganin maganin maganin maganin maganin maganin maganin cajin din Linaclotide kuma sanya komai a cikin ruwa. Gudun ruwa - Linaclotide abun ciki na kimanin seconds na 20 sannan a sha shi nan da nan. Kawai kamar yadda ke cakuda applesauce, kar ku tauna abinda ke ciki - ku hadiye shi gaba daya.

Idan akwai niyyar samarda maganin ta hanyar nasogastric ko bututun ciki, nemi jagora kan gudanarwar daga likitan ku ko likitan ku. Koyaya, Anan ga tsarin kulawa na bututu.

  • Auna 30 mil na tsabta da ruwan zafin-daki kuma saka shi cikin akwati mai tsabta.
  • Bude kabarin Linaclotide kuma ka kwantar da abin da yake ciki (beads) cikin ruwa
  • Tsakanin ruwa da beads na Linaclotide ta jujjuya cakuda a hankali don ba kasa da Xan daƙihun 20.
  • Zana sama ruwan cakuda Linaclotide zuwa cikin sirinji na dama tare da tip mai kama da na catheter da girman da ya dace. Sannan a watsa cakuda zuwa cikin nasogastric ko bututu na ciki wanda mai haƙuri yayi amfani da shi ta hanyar amfani da tsayayyen matsakaici amma saurin matsawa kusan 10 mL / 10 seconds akan sirinji.
  • Idan akwai wasu beads Linaclotide da suka rage a cikin akwati, ƙara 30ml na ruwa mai tsabta a ciki, jujjuya cakuda, kuma sarrafa shi kamar yadda aka bayyana a baya.
  • Da zarar an gama yin ku tare da gudanar da cakuda gwal na Linaclotide da ruwa, yi amfani da aƙalla mlil 10 na ruwa don haskaka bututun gudanarwa.

5. Menene sashi na Linaclotide (Linzess)?Phcoker

Matsakaicin da ya dace da Linaclotide ya bambanta daga mutum zuwa wani, gwargwadon yanayin da aka yi niyya don bi dashi da kuma yadda mutum zai amsa maganin. Hakanan, yana da mahimmanci a lura cewa bai kamata amfani da miyagun ƙwayoyi ta hanyar mutanen da basu kai shekarun 18 ba.

Kidsaramin ƙananan yara suna cikin haɗarin fuskantar haɗari Linaclotide sakamako masu illa Shin yakamata suyi amfani da maganin?

(1) Adult na Al'ada na al'ada don Ciwon Ciwon Ciwon ciki

Ga wani dattijo wanda ke fama da Ciwon Ciwon ciki wanda yake tare da maƙarƙashiya, yakamata ya ɗauki kashi na Linaclotide na 290 mcg kowace rana. Kamar yadda aka ambata a baya, ya kamata a sha miyagun ƙwayoyi a kan komai a ciki. Don tabbatar da hakan, ɗauka kafin abincinku na farko a rana.

(2) Adult na Al'ada na Al'ada don Tsuruke

Dangane da Hukumar Abinci da Magunguna ta Amurka, shawarar Linaclotide da aka ba da shawara ga tsofaffi wanda ke fama da maƙarƙashiya na rashin lafiya (CIC) shine 72 mcg.

Koyaya, za'a iya ba da shawarar kashi 145 mcg ga ɗan haƙuri tare da CIC, gwargwadon gabatarwarsa da haƙuri. Kuna iya wurin biya linzess 72 mcg sake dubawa domin samun fahimtar yadda maganin yake aiki da kuma masu amfani da suka amfana dashi.

Dangane da ra'ayoyi daban-daban na linzess 72 mcg, tsakanin sauran ra'ayoyin game da maganin, mai haƙuri tare da batutuwan kiwon lafiya da aka ambata da kuma fatan samun fa'ida daga yuwuwar sa ya kamata ya yi amfani da shi akai-akai don cimma sakamakon da ake so. Bayan haka, yakamata a ɗauka a lokaci guda a kowace rana a cikin lokacin da aka tsara lokacin kulawa.

Yana da mahimmanci a san cewa mai yiwuwa Linzess tana iya haifar da hulɗa da Linaclotide tare da kwayoyi daban-daban. Don haka, kuna buƙatar bayyana wa likitanka game da kowane irin magani da kuka kasance a halin yanzu kafin fara amfani da shi (Linaclotide).

Hakanan, mata masu juna biyu ya kamata suyi taka tsantsan yayin la'akari da shan Linaclotide saboda miyagun ƙwayoyi na iya haifar da babban haɗari ga tayin. Yakamata su nemi kulawar likita don tabbatar da amincin su da kuma na jariran da basu haife su ba idan sun sha magani. Haka batun yake ga uwaye masu shayarwa da waɗanda kuke niyyar yin juna biyu yayin amfani da maganin.

Koyaya, ko da suna da CIC ko Irritable Bowel Syndrome, marasa lafiyar da ke ƙasa da shekaru 6 bai kamata su ɗauka ba Linzess foda (851199-59-2). Gwaje-gwaje na asibiti sun lura cewa miyagun ƙwayoyi sun haifar da mutuwar mutane a cikin jijiyoyin yara tare da tsararraki waɗanda ke daidai da shekarun 6 a cikin mutane.

Don haka, an ba da magungunan ga marasa lafiyar da basu kai shekaru ba saboda yana sanya su a cikin hatsarin kamuwa da gudawa da mummunar illarta.

Bayan haka, akwai bayanan asibiti wanda ke nuna aminci da ingancin linzess tsakanin marasa lafiya waɗanda shekarunsu suka zarce 6 zuwa shekaru 17. Kamar wannan, a cikin yanayin yaro ko saurayi wanda ke ƙasa da shekarun 18 wanda ke buƙatar taimako na ICI ko BIS, ya kamata a nemi shawarar likita da farko.

Kuna iya ɗaukar har zuwa makonni biyu kafin ku ɗanɗana alamar taimako sakamakon maganin. Don haka, yi haƙuri kaɗan tare da shi. Ci gaba da amfani da shi kamar yadda aka umurce ka.

Koyaya, idan cutarku ba ta inganta ko yin muni ko da bayan amfani da linzess, kar ku ɗauki kashi wanda ya wuce adadin da aka wajabta. Bai kamata yin hakan ta kowace hanya ba. Madadin haka, sanar da likitanka don kafa abin da zai haifar da maganin rashin amfani da magani da shawara kan hanya ta gaba.

Yana da kyau a guji amfani da Linaclotide koda kuna jin ƙyamar sa ko kuma hanjin ku yana da matsala.

Idan kayi asarar maganin Linaclotide, kar kayi ƙoƙarin yin sakiyar da aka rasa. Manta game da shi kuma ci gaba da ɗaukar allurai na gaba da kyau a lokacin da aka tsara.

Idan kai ko ƙaunataccenka yana shan ƙwayar Linaclotide da yawa (yawan shan ruwa fiye da kima), ya kamata a kawo abin da ya faru a likitan nan da nan. A madadin haka, zaku iya tuntuɓar sabis na Poison Taimaka ta buga kira 1-800-222-1222.

Abin da kuke Bukatar Ku sani game da Lalacewar Cutar Lantarki

6. Wadanne abubuwa ne Linaclotide zai iya haifar?Phcoker

A cewar daban-daban Linaclotide sake dubawa da nazarin kimiyya, masu zuwa sune abubuwanda suka haifar na Linaclotide:

  • Zazzabin ciwan guda biyu
  • M zafi ciki ko rashin jin daɗi
  • bloating
  • ƙwannafi
  • vomiting,
  • ciwon kai
  • Cold bayyanar cututtuka kamar m / hanci hanci, makogwaro mai zafi sinus ko hura ciki
  • bala'i
  • kungiyar kunne
  • zazzabi
  • asarar murya
  • iskar gas
  • hanci ko runtsi
  • hanci na jini
  • convulsions
  • idanu masu kauri
  • kirji mai kama

Kodayake da wuya, zaku iya samun ɗayan waɗannan sakamako masu illa na Linaclotide:

  • Mai tsananin ciwo ko ci gaba da zazzabi
  • Zawo guda ɗaya wanda ke tattare da amai da gudawa ko jin daɗi wanda zai sa ka ji kamar kana iya wucewa
  • Ƙafafun kafa
  • Yanayin motsi
  • Rashin tausayi
  • Rashin rikitarwa
  • Ƙananan kalmomin zuciya
  • Andara da dagewa da ƙishirwa
  • Chest yana motsawa
  • Iyakancewa ji
  • Ƙarfin tsoka
  • Mai tsananin zafin ciki
  • baki, na jini, ko fery feces
  • amya
  • wahalar numfashi
  • fuska, lebe, harshe, ko makogwaro

Kuna buƙatar neman taimakon gaggawa idan kun sami kumburi akan sassan da aka ambata, matsalar numfashi ko amya.

Idan kuma akwai wasu cututtukan da ake amfani da su na Linaclotide, to ya kamata ku daina amfani da miyagun ƙwayoyi kuma ku tuntuɓi likitanku nan da nan don ƙarin jagora.

7. Wadanne magunguna ne ko kuma magunguna masu haɗi zasuyi hulɗa da Linaclotide?Phcoker

Mu'amala da Linaclotide na iya faruwa idan ana amfani da Linaclotide tare da wasu kwayoyi gami da abubuwan maye, kayan bitamin, kayan ganyayyaki da magunguna. Wasu daga cikin magungunan da aka bayar da rahoton cewa zasu iya haifar da cudanya da Linaclotide sun hada da:

  • Abilify
  • Amitiza
  • Aspir 81
  • Strearancin Asfirin
  • Ativan
  • Murfin ciki
  • Dulcolax (ƙaramar hulɗa)
  • Kira
  • Cymbalta
  • Damuwa
  • Flexeril
  • Metamucil (karamin hulɗa)
  • Levothyroxine (hulɗar matsakaici)
  • lubiprostone
  • Metoprolol Succinate ER
  • Norco
  • Paracetamol
  • Raguwa
  • Symbicort
  • Vitamin B12
  • Vitamin C
  • Vitamin D3
  • xanax
  • Zyrtec

8. Mene ne bambancis tsakanin Linaclotide da lubiprostone?Phcoker

Dukansu Linaclotide da lubiprostone sune magungunan da aka yarda da DFA don maganin maƙarƙashiya na rashin haihuwa da rashin lafiyar hanji a cikin manya. Idan kuna son karuwar motsawar hanji, zaku iya zaban kowane ɗayan.

Koyaya, suna da bambance-bambance da dama dangane da:

(1)Ajinsu daban daban

Lubiprostone yana cikin rukuni na miyagun ƙwayoyi da aka sani da masu gwagwarmayar tashoshin chloride A gefe guda, Linaclotide (Linzess) memba ne na aji na magani wanda ake magana da shi a matsayin agonists na guanylate cyclase-C.

(2)Kwancen yau da kullun

Yayinda yakamata a dauki kashi na Linaclotide wanda aka bada shawarar shan shi sau daya a rana, musamman kafin karin kumallo, ana yawan shan Lubiprostone sau biyu a rana. Sabili da haka, idan kuna fuskantar matsalar tuna magunguna a kowace rana, Linaclotide zai zama zaɓi mafi dacewa a gare ku.

Wani abu kuma da ya banbance su biyu dangane da kashi shine adadin da mutum yakamata ya dauka sau daya. Misali, ga CIC, shawarar da aka bayar da shawarar Linaclotide shine 72 mcg yayin da na Lubiprostone shine 8 mcg.

(3)Hulɗa da ƙwayoyi

Wani bambanci Linaclotide foda (851199-59-2) da lubiprostone yana cikin ma'amala da magunguna. Tare da kusan game da maganin cututtukan 58 da aka sani don yin hulɗa tare da Linaclotide, hulɗa da Linaclotide ya fi kyau sosai idan aka kwatanta da lubiprostone wanda ke da alaƙa da ma'amala ɗaya na magani kawai.

(4)Ranar amincewa

An yarda da Linzess akan 30th August 2012 yayin da yardawar lubiprostone ya faru a Janairu 31, 2006

(5)Ma'amala tsakanin abinci

Lokacin da kuke da abinci a cikinku kuma kun ɗauki Linaclotide, alamominku na ciki kamar gudawa, zafin ciki da gas yana iya zama mafi muni, godiya ga hulɗa da abinci na Linaclotide. Idan kun kamu da zazzabin cizon sauro guda biyu kuma kuna shan magani na gaba, shaƙar ɗayan na iya cutar da shi cikin matsala.

Don rage rashin haƙuri na ciki sakamakon ma'amala da abinci, yakamata a ɗauki Linaclotide a kan komai a ciki.

A gefe guda, akwai tabbatar da ilimin kimiyya game da hulɗar abinci ta Lubiprostone. Koyaya, wannan ba shine yanke hukunci game da cudanya mai yiwuwa ba. Kamar wannan, yana da mahimmanci don neman ƙarin bayani akan mafi kyawun lokacin don amfani da magani daga mai kula da lafiyar ku

(6)Hadarin na mahaifa a cikin uwaye masu juna biyu

Har zuwa yanzu, wani sashi na binciken da ya dace da sake nazarin Linaclotide ya nuna cewa mai yiwuwa Lubiprostone na iya haifar da lahani ga tayin idan mahaifiyar da take da ciki ta sha maganin. A gefe guda, babu wani binciken guda daya wanda ya nuna cewa Linzess na iya haifar da lahani ga tayi idan mace mai tsammani ta ɗauke ta.

Masana kimiyya sun danganta wannan amincin da aminci ga ƙarancin shan magunguna. Koyaya, haɗarin ba zai iya kasancewa da cikakken bayani ba yayin da ake ci gaba da bincike don tabbatar da amincin ko haɗarin miyagun ƙwayoyi ga jaririn da ba a haife shi ba.

Don haka, ko da niyyar ɗaukar Lubiprostone ko Linaclotide, mahaifiyar da take da juna biyu ya kamata ta nemi likita game da cancantar yanke hukunci.

(7)Saiti

Abin da kuke Bukatar Ku sani game da Lalacewar Cutar Lantarki

Bayan CIC, lubiprostone na iya b

e amfani da shi azaman jiyya ga Opioid-induced constipation (OIC) kazalika da cutar sankara na Irritable bowel tare da maƙarƙashiya a cikin matan da suke ƙaran shekaru 18.

Idan ya zo game da Linaclotide, ban da CIC, yana kuma magance cututtukan hanji mai ɓacin rai wanda ke haɗuwa da maƙarƙashiya (IBS-C) a cikin mata da maza. Ba'a amfani dashi azaman magani don OIC.

(8)Kudin Linaclotide

Idan ya zo ga Kudin Linaclotide, yayi dan kadan sama da na lubiprostone. A lokacin, farashin Linaclotide kusan $ 450 ne don maganin kafatanin 30 yayin da 60 capsules na lubiprostone na iya cin kimanin $ 396. Koyaya, farashin ya bambanta daga mai siyarwa zuwa wani kuma daga lokaci zuwa lokaci.

(9)manufacturer

Wanda ya kirkiro da Linaclotide wani kamfani ne da aka sani da Allergan yayin da lubiprostone shine samfurin kamfanin Sucampo.

Duk da bambance-bambancen da ke sama, yana da mahimmanci a lura cewa ana sayar da lubiprostone da Linaclotide ga masu siye da nau'in maganin kawancin magana kuma basu da ilimin halittar jini. Hakanan, duka magunguna suna buƙatar takardar sayan likita don guda ɗaya don samun su daga kowane mai siyarwa.

9. Abin da wasu bayanai game da Linaclotide yakamata in sani?Phcoker

Kamar kowane magani, Liatlotide foda (851199-59-2) ko kwayayen kwalliya yakamata a adana su har zuwa ajiyar yara don kiyaye su daga yin amfani da ita. Hakanan, kasancewar sayan magani, wasu mutane na iya jarabtar su raba magunguna tare da wasu don gujewa wahalar zuwa likita don sayan magani.

Koyaya, raba Linaclotide yana da haɗari saboda likita dole ne ya sanya abubuwa da yawa a cikin la'akari kafin rubuta magunguna da ƙetare matakan zai iya haifar da mummunar illa.

Idan kuna son siyar da Linaclotide, kuna buƙatar sanin cewa a yawancin ƙasashe, gami da Amurka, kuna buƙatar takaddar likita don samun maganin. Wannan ba tare da la'akari da ko kuna son siye shi ta yanar gizo ko kan-kan-kanta ba.

Idan ya zo wurin ajiya, da shawarar zafin jiki da aka ba da shawarar don Linaclotide 851199-59-2 shine 25 ° C (77 ° F). Ko kuna ma'amala da maganin Linaclotide foda ko capsules, ya kamata a adana magungunan a wuri mai rashin ruwa kuma, bai kamata a rarraba ko sake rarraba shi ba. Madadin haka, ajiye duk maganin a cikin akwatinta na asali.

Hakanan, tabbatar cewa akwati tana rufe sosai tare da kayanta a ciki don barin danshi.

Ko kuna son siyan Linaclotide 851199-59-2 don amfanin masana'antu, Linaclotide don siyarwa ko wasu abubuwan amfani da Linaclotide, tabbatar cewa kun samo shi daga asalin martaba da amintaccen. Yin bita akan layi na Linaclotide na iya jagorantar ku zuwa ga mai siye mai kyau.

In ba haka ba, ba tare da yin himma ba, cewa mai siyarwar layi / kan layi wanda ke da'awar cewa yana da gaske Linaclotide na siyarwa na iya zama sayar da kayayyakin kwastomomi ko sata kuɗin da kuka samu da yawa.

References

  1. Andresen, V., Camilleri, M., Busciglio, IA, Grudell, A., Burton, D., McKinzie, S.,… & Currie, MG (2007). Tasiri na kwanakin 5 linaclotide akan aikin jigilar ciki da aikin hanji a cikin mata tare da maƙarƙashiya-mawuyacin cuta mai rikicewar hanji. Gastroenterology, 133(3), 761-768.
  2. Chey, WD, Lembo, AJ, Lavins, BJ, Shiff, SJ, Kurtz, CB, Currie, MG,… & Baird, MJ (2012). Linaclotide don cututtukan hanji mai ɓacin rai tare da maƙarƙashiya: wani-mako-mako na 26, bazuwar, makanta biyu, jarabawar sarrafawa don sarrafa inganci da aminci. Littafin mujallar nan ta Amurka game da cututtukan gastroenterology, 107(11), 1702.
  3. Kofin Cup, J., Blikslager, AT, Chakrabarti, J., Nighot, PK, & Malinowska, DH (2012). Abubuwan da ke bambanta sakamakon linaclotide da lubiprostone akan sake dawo da kayyakin shinge da keɓaɓɓun ƙwayoyin cuta da homeostasis na cellular bayan bayyanar wahalar ƙwayoyin. BMC pharmacology, 12(1), 3.
  4. Harris, A. (2013). LINACLOTIDE. Consultant.
  5. Johnston, JM, Kurtz, CB, Drossman, DA, Lembo, AJ, Jeglinski, BI, MacDougall, JE,… & Currie, MG (2009). Nazarin matukin jirgi kan tasirin linaclotide a cikin marasa lafiya da maƙarƙashiya. Littafin mujallar nan ta Amurka game da cututtukan gastroenterology, 104(1), 125.
  6. Lembo, AJ, Kurtz, CB, MacDougall, JE, Lavins, BJ, Currie, MG, Fitch, DA,… & Johnston, JM (2010). Inganci na linaclotide ga marasa lafiya da maƙarƙashiya na maƙarƙashiya. Gastroenterology, 138(3), 886-895.
  7. Lembo, AJ, Schneier, HA, Shiff, SJ, Kurtz, CB, MacDougall, JE, Jia, XD,… & Jeglinski, BI (2011). Biyu gwaje-gwaje iri-iri na linaclotide don maƙarƙashiya na lokaci. New England Journal of Medicine, 365(6), 527-536.