Nicotinamide riboside (NR) da kuma nicotinamide riboside (Chloride)

Nicotinamide riboside (NR) chloride wani nau'in chlorinated ne na nicotinamide riboside (NR).

 

1.Menene Nicotinamide Riboside (NR)?

NR wani nau'i ne na bitamin B3 ko niacin. An gano mahaɗin a cikin 1940s azaman haɓakar haɓaka don H. mura. A farkon 21st karni, yawan karatun zai tabbatar da cewa NR shine farkon NAD +. A jikin mutum, wannan sinadarin na rage yawan matakan cholesterol, yana saukaka barazanar cututtukan zuciya, da bunkasa ayyukan kwakwalwa, da kuma rage radadin cututtukan zuciya.

Nicotinamide riboside (NR) pyridine-nucleoside ce, tana aiki azaman share fage ga NAD + (Nicotinamide adenine dinucleotide). NAD + yana haɓaka yawancin ayyukan nazarin halittu gami da gyaran DNA, samar da kuzarin salula, saita sautin motsa jiki, da ƙari. Abun takaici, wadannan kwayoyi suna raguwa bisa dabi'a. 

 

2.Menene Nicotinamide Riboside (NR) Chloride?

Nicotinamide Riboside (NR) chloride (NIAGEN) ya samo asali ne daga NR da chlorine. Haɗin yana haɓaka matakan NAD + kuma yana kunna SIRT1 da SIRT3. Yana canza tsufa ta hanyar haɓaka haɓakar ƙwayar cuta da kuma magance abubuwan da ke tattare da abinci mai haɗari.

A Amurka, nicotinamide riboside chloride an yarda dashi gaba ɗaya amintacce. Sabili da haka, shine ingantaccen kayan abinci don amfani dashi a cikin rawanin furotin, ruwan bitamin, gumis, da sauran su kari.

 

3.Kammalawa

'Yan Adam suna taƙasa tsufa ta hanyar niyya ga fata. A wani lokaci, tabbas ka riski wasu Anti-tsufa creams don share zurfin wrinkles na fata, sagging fata, da kuma blotchiness. Koyaya, waɗannan jiyya marasa aiki ne da gajere. Tabbatacciyar hanyar tsufa da kyau ita ce ta hanyar tabbatar da sauye-sauyen halittu a bayan tsufa da kuma magance tushen abin.

Masu bincike sun riga sun kafa hanyar haɗi tsakanin ƙananan matakan NAD + da cututtukan da suka shafi shekaru. Wannan binciken da aka gano ya zama ruwan dare game da yanayin kiwon lafiya ta hanyar kara yiwuwar sauya tsarin tsufa. Saboda wannan, nicotinamide riboside chloride foda ya yawaita layukan farfajiyar bincike na asibiti saboda ingancinsa wajen kifar da agogon nazarin halittu.

 

Chemicalayyadaddun Chemical na Nicotinamide Riboside (Chloride) Foda

Product Name Nikotinamide riboside chloride (NR-CL) (23111-00-4)
Chemical Name NRC; 3-Carbamoyl-1-beta-D-ribofuranosylpyridinium chloride; Nicotinamide ribose chloride; 3-Carbamoyl-1- (β-D-ribofuranosyl) pyridinium chloride; 3-carbamoyl-1 - ((2R, 3R, 4S, 5R) -3,4-dihydroxy-5- (hydroxymethyl) tetrahydrofuran-2-yl) pyridin-1-ium chloride; Nicotinamide BD Riboside Chloride (WX900111); NR-CL;
CAS Number 23111-00-4
InChIKey YABIFCKURFRPPO-IVOJBTPCSA-N
Smile C1 = CC (= C [N +] (= C1) C2C (C (C (O2) CO) O) O) C (= O) N. [Cl-]
kwayoyin Formula C11H15ClN2O5
kwayoyin Weight 290.7002
Monoisotopic Mass 290.066949 g / mol
Ƙaddamarwa Point N / A
Launi farin
Girgizar ajiya -20 ° C Daskare
Aikace-aikace abincin abinci, filin magani

Nicotinamide riboside chloride

Sanin Fa'idodin Nicotinamide riboside (NR), menene Fa'idodin Nicotinamide Riboside Chloride?

Fa'idodin sunadaran ribaside na nicotinamide tare da nicotinamide riboside suna kama da juna tunda dukkansu suna aiki don kunna sunadaran NAD da sirtuin 1.

 

Lafiyayyen Lafiyar Lafiya don Gudanar da Kiba

Yawancin bincike sun tabbatar da ingancin nicotinamide riboside chloride a rage nauyi. Masu amfani zasu iya rasa kashi 10% na kitsen jikinsu ba tare da ƙarancin ci ko horo na jiki ba.

Shan shan magani yana taimaka wajan rage LDL cholesterol yayin da yake kara matakan mai kyau. Wannan yana faruwa yayin da yake riƙe da aikin enzymes masu alhakin kira na triglycerides. Sakamakon haka, samar da kwayoyi masu nauyin low-low yana raguwa.

Nicotinamide riboside chloride yana amfanar marasa lafiya masu kiba da ciwon sukari. Supplementarin yana haɓaka metabolism ta haɓaka haɓakar glucose

 

neuroprotection

Lokacin da matakan NAD suka faɗi ƙasa da mafi kyau, tsarin jijiyoyinku da lafiyar hankalinku na iya kasancewa cikin haɗari. ,Auka, alal misali, marasa lafiya da cutar Alzheimer suna nuna ƙarancin NAD + da rashin aiki na mitochondria.

Daga cikin magungunan da ke amfani da sinadarin riboside na chloride na nicotinamide, gudanar da harkoki a cikin tsufa a saman jerin. Miyagun ƙwayoyi suna aiki akan ɓarna a cikin intracerebral, cutar bugun jini, kumburin jijiyoyin jiki, da mutuwar neuronal. 

 

Anti-tsufa kari

Ofayan maɓallin Nicotinamide riboside chloride da ake amfani dashi ya haɗa da haɓakawa lafiya tsufa. Haɗin yana haifar da haɓaka cikin samarwar NAD, wanda ke taka muhimmiyar rawa a cikin kwayar halitta. Misali, yana daga karfin matakan salula a cikin tsokoki, hanta, da koda. Bayan wannan, Nicotinamide riboside chloride yana hana tsufa ta hanyar ƙara yaduwar jini a cikin waɗannan gabobin masu mahimmanci.

 

Gyara DNA

Nicotinamide riboside chloride yana amfani da kayan halittar gado ta hanyar gyara tsohuwar DNA da lalacewa. Idan naddin NAD ya fadi, deoxyribonucleic acid da ya ji rauni na iya haifar da nau'in oxygen mai aiki, wanda ke haifar da gajiya mai narkewa, da saukin kamuwa da cutar kansa.

Nicotinamide riboside chloride

Ta yaya Nicotinamide Riboside Chloride zai iya tsufa?

Yayin tsufa, jiki yana fuskantar wasu canje-canje na ilimin lissafi yayin da ayyukan salula ke komawa baya. Misali, jiki ya gama sunadarin NAD + da SIRT1 fiye da yadda zai iya hadawa. Levelsananan matakan waɗannan coenzymes suna hanzarta tsufa yayin da suke haifar da cututtukan da suka shafi shekaru ciki har da ciwon sukari, cututtukan zuciya, da kiba.

Gudanar da nicotinamide riboside chloride yana amfani da garkuwar jiki ta hanyar inganta jijiyoyin jini, kamar su lymphocytes da leucocytes. Haɗin yana haɓaka aikin NAD +, saboda haka, yana haɓaka matakan sunadaran SIRT1. Sakamakon haka, SIRT1 yana jinkirta saurin tsufa ta hanyar ƙara yawan jini zuwa ƙwayoyin jijiyoyin jiki, tsarin zuciya da jijiyoyin jiki.

Bayan haka, karin nicotinamide riboside chloride juyawa tsufa ta samar da ƙarin NAD + don taimakawa cikin gyaran DNA a cikin tsarin salon salula. Wannan tasirin yana hana gajiyawar gajiya

Binciken da aka samo ya kuma tabbatar da cewa nicotinamide riboside chloride yana ƙididdige ƙimar ƙashi, raguwar samar da hawaye, da kuma samar da kuɗi. Duk waɗannan halaye suna yaduwa tsakanin tsofaffi.

 

NAD⁺ Precursors: Nicotinamide Riboside Chloride vs Nicotinamide Mononucleotide

Akwai abubuwan da suka gabata na NAD + sama da biyar amma a yanzu, zamu iya canza hankalinmu zuwa nicotinamide riboside chloride vs nicotinamide mononucleotide (NMN).

Wadannan mahadi guda biyu suna kara matakan NAD + a cikin jiki don inganta ayyukan salula da rage saurin tsufa.

Abin da ke gaya wa waɗannan biyun baya shine cewa NMN ba nau'in bitamin B3 bane. Sinadarin ba zai ratsa cikin kwayar ba har sai ya koma zuwa nicotinamide riboside. Dalilin kuwa shine cewa girman kwayar halittarsa ​​ta fi girma girma fiye da ta nicotinamide riboside chloride foda. Saboda wannan kadarorin, kasancewar NMN da kuma damar da yake da shi na kunna matakan NAD + ya kasance wata matsala a fagen bincike.

A cewar Dokta Sinclair, masanin kwayar halitta a Jami'ar Harvard, ingancin NMN bai dace ba. Ya furta yin amfani da wannan kari, wanda ke sanya shi jin kuruciya da sabunta shi. Sinclair yayi daidai da ingancin NMN don gudana a cikin na'urar motsa jiki. Masanin kimiyya ya lura cewa yana inganta yaduwar jini, yana inganta ƙarfin tsoka, da ingantaccen metabolism.

Akasin haka, kwayar Nicotinamide riboside chloride ta dauke kai tsaye ta hanyar kwayar halitta. Kwayar ita ce madadin bitamin B3. Zai haɓaka matakan NAD + sama da 60% a cikin jikin mutum. Ba kamar yawancin ba NAD masu gaba, waɗanda suke cikin jerin kallon FDA, nicotinamide riboside (NR) chloride yana cikin jerin sunayen kayan abinci na GRAS (Gabaɗaya An Gane su da Lafiyayyu).

 

Me zai hana a ɗauki NAD foda kai tsaye? Nicotinamide Riboside Chloride vs Nicotinamide Adenine Dinucleotide (NAD)

Tunda hankalinmu game da ɗaukaka NAD a cikin jiki ne, mai yiwuwa kuna tambayar dalilin da ya sa hargitsi kan nicotinamide riboside chloride. Shin bai kamata ku gudanar ba nad kai tsaye cikin tsarinka maimakon shiga cikin matsala ta amfani da tsaka-tsakin kamar NIAGEN, NR, ko NMN? Da kyau, bani dama in muku bayani game da nicotinamide riboside chloride vs nicotinamide adenine dinucleotide.

Babban dalilin da yasa baza ku taɓa ɗaukar NAD kai tsaye ba shine cewa mai ƙirar halitta ba shi da tabbas ga tantanin halitta.

Plusarin amfani da nicotinamide riboside chloride vs nicotinamide adenine dinucleotide shi ne cewa tsohon yana da matukar tasiri ga membrane plasmic. Yawan shan sa yana da matukar girma ta hanyar tsarin narkewa, zuwa cikin jini, kuma daga karshe zuwa kwakwalwa. 

Nicotinamide riboside chloride

Nicotinamide riboside (NR) Sashi na Chloride: Yaya ake Amfani?

A cikin 2016, nicotinamide riboside chloride kari ya sami matsayin GRAS. Shekarar da ta gabata, FDA ta amince da shi azaman tushen niacin da kuma kayan abinci mai cin abinci a kowace rana na 180mg.

A halin yanzu, matsakaicin lasisin nicotinamide riboside chloride matakan sashi zuwa 300mg kowace rana. Koyaya, a cikin wasu gwajin ɗan adam, batutuwa zasu sha har zuwa 2000mg na magani. Ya kamata ku lura da cewa wucewa da yawa na 500mg zai iya haifar da sakamakon rashin tasirin nicotinamide na riboside.

Maganin niacin kawai ya shafi lafiya manya, hada da mata masu ciki da uwaye masu shayarwa.

 

Nicotinamide Riboside Chloride Side Effects: Shin yana da Amfani da Nicotinamide Riboside Chloride kari?

Nicotinamide riboside chloride foda yana da aminci kuma yana riƙe da matsayin kwadayin matsayi na abubuwan GRAS. Wannan gaskiyar ba ta nufin cewa gidan ba shi da alamun bayyanar cututtuka. Bayan haka, ruwa shine rayuwa amma kuma yana jawo wasu maganganu marasa kyau lokacin da kuka zage shi. Don magance tasirin, tabbatar cewa maganin ku na Nicotinamide riboside chloride yayi kasa-kasa. 

Wasu daga cikin munanan halayen sun hada da;

  • Dama tada
  • Tashin zuciya
  • Vomiting
  • zawo
  • Hanyoyin fata kamar rash da ƙara ƙwanƙwasawa

Bayan abubuwan da ke tattare da sinadarin riboside chloride na nicotinamide a sama, ku ma kuna iya fuskantarwa nauyi asara. Koyaya, wannan sakamakon shine alkhairi a ɓoye musamman idan kuna da nauyi, kiba, ko kuna ƙoƙarin kiyaye nauyin ku a cikin dubawa.

 

Inda zaka Sayi (NR) Nicotinamide Riboside Chloride a Bulk?

Kuna iya siyan nicotinamide riboside chloride saya a shagon kan layi. Ko kuna son furotin a cikin ƙananan ƙwayoyi ko ƙarin ƙimar abinci, tabbatar da neman mai sayarwa na gaske. Plusarin sayayya na kama-da-wane shine cewa zaku iya kwatanta farashi kuma bincika ainihin lokacin abokin ciniki. Koyaya, ku ma kuna iya faɗuwa don jabun kuɗi.

Mu alama ce mai amintacce kuma duk samfuranmu suna bin matakan kula da inganci. Muna ma'amala da sinadarai daban daban kuma abin da ake ci kari. Tuntube mu don odarku da ambaton abokantaka.

 

References
    1. Conze, D., Brenner, C., & Kruger, CL (2019). Tsaro da Tsarin Tsarin Tsarin Mulki na NIAGEN (Nicotinamide Riboside Chloride) a cikin Randomized, Double-Blind, Gwajin Clinical mai kula da Ciwon Kiba na Lafiya. Rahoton kimiyya.
    2. Bogan, KL & Brenner, C. (2008). Nicotinic Acid, Nicotinamide, da Nicotinamide Riboside: Moididdigar ƙwayoyin cuta na NAD + pre-pre-vitamin a cikin Gina Jiki na Mutum. Binciken shekara-shekara na Gina Jiki.
    3. Mehmel, M., Jovanovic, N., & Spitz, U. (2020). Nicotinamide Riboside - Yanayi na Bincike da Amfani da Lafiya.
    4. Turck, D., Castenimiller, J., et al. (2019). Tsaron Nicotinamide Riboside Chloride a matsayin Abincin Abincin Abinci wanda ke Bin Dokar (EU) 2015/2283 da Bioavailability na Nicotinamide daga wannan Tushen, a cikin Yanayin Dokar 2002/46 / EC. EFSA Jarida.
    5. Elhassan, YS et al. (2019). Nicotinamide Riboside yana mentsaukaka Sarjin Humanan Adam da Ya tsufa NAD + Metabolome kuma Ya Transaddamar da Rubutun Rubutun da Sa hannu na Anti-inflammatory Rahoton Kwayoyin.
    6. Aman, Y., Qiu, Y., Tao, J., & Fang, EF (2018). Hanyar Magungunan Kiwan Lafiya na Boosting NAD + a cikin Tsufa da Cututtuka masu Alaka. Maganin fassara na tsufa.
    7. RAW NICOTINAMIDE MONONUCLEOTIDE (NMN) MARA (1094-61-7)
    8. RAW LORCASERIN HCL MARA (846589-98-8)

 

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