α-ketoglutaric

Phcoker yana da damar samar da taro da kuma samar da Calcium 2-oxoglutarate da Alpha-Ketoglutaric Acid a ƙarƙashin yanayin cGMP.

Waɗanne sunaye ne sanannun acide na Alpha-ketgoglutaric?

Acide, A-Ketoglutaric Acid, Acide 2-Oxoglutarique, Acide a-cétoglutarique, Acide Alpha-Cétoglutarique, Alfa-Cetoglutarato, Alpha-Cétoglutarate, Alpha-Cétoglutarate d'Arginine, Alpha-Cétogagene , Alpha-Cétoglutarate de Glutamine, Alpha-Cétoglutarate de L-Arginine, Alpha-Cétoglutarate de L-Leucine, Alpha-Cétoglutarate de Taurine, Alpha Keto Glutaric Acid, Alpha Ketoglutarate, Alpha Ketoglutaric Acid, Alfa KG, AAKG, AGG -Ketoglutarate, Calcium Alpha-Ketoglutarate, Halitta Alpha-Ketoglutarate, Glutamine Alpha-Ketoglutarate, L-Arginine AKG, L-Arginine Alpha Keto Glutarate, L-Leucine Alpha-Ketoglutarate, Taurine Alpha-Ketoglutarate, 2-Oxoglicic Acid Acid.

Menene Alpha-Ketoglutaric acid?

Alpha-ketoglutaric (AKG) acid ne mai mahimmanci wanda yake da mahimmanci don ingantaccen ƙarancin dukkanin amino acid mai mahimmanci da kuma canja wurin ƙarfin salula a cikin zagayen ruwan citric acid. Yana da gaba ga acid na glutamic, amino acid mara mahimmanci wanda ke cikin haɗin furotin da kuma daidaita matakan glucose na jini. A hade tare da L-glutamate, AKG na iya rage yawan sinadarin ammonia da aka kirkira a kwakwalwa, tsokoki da koda, hakanan zai taimaka wajen daidaita sinadarin nitrogen na jiki da kuma hana yaduwar sinadarin nitrogen a cikin kayan jiki da ruwa. Mutanen da ke da yawan amfani da furotin, cututtukan ƙwayoyin cuta, ko dysbiosis na ciki na iya cin gajiyar ƙarin AKG don taimakawa daidaita matakan ammoniya da kare kyallen takarda.

Wasu mutane suna ɗaukar alpha-ketoglutarate don haɓaka ƙwarewar wasan motsa jiki. Masu samar da abinci mai gina jiki na motsa jiki suna da'awar alpha-ketoglutaric acid na iya zama muhimmiyar ƙari ga ingantaccen abinci da horo ga ɗan wasan da ke son ci gaba sosai. Sun kafa wannan iƙirarin akan karatun da ke nuna ƙarin ammoniya a jiki na iya haɗuwa da alpha-ketoglutarate don rage matsalolin da ke tattare da yawan ammoniya (yawan cutar ammoniya). Amma, ya zuwa yanzu, karatun kawai da ke nuna alpha-ketoglutarate na iya rage yawan cutar ammonia an yi shi a cikin marasa lafiyar hemodialysis.

Masu ba da lafiya a wasu lokuta suna ba da alpha-ketoglutarate cikin intraven (ta IV) don hana rauni ga zuciya sakamakon matsalolin gudummawar jini yayin tiyatar zuciya da kuma hana raunin tsoka bayan tiyata ko rauni.

Hanyoyin aiwatar da aikin Alpha-Ketoglutaric acid

Ba a bayyana ainihin hanyoyin aikin for-Ketoglutarate ba. Wasu daga cikin ayyukan α-Ketoglutarate sun haɗa da yin aiki a cikin zagayen Krebs a matsayin matsakaiciya, halayen ɓarna yayin yaduwar amino acid, samar da acid na glutamic ta haɗuwa da ammoniya, da rage nitrogen ta haɗuwa da shi shima. Game da ayyukan α-Ketoglutarate tare da ammonia, an ba da shawarar cewa α-Ketoglutarate na iya taimaka wa marasa lafiya da ke da ilimin ilimin ilimin ilimin ilimin ilimin ilimin ilimin ilimin ilimin ilimin ilimin ilimin ilimin ilimin ilimin ilimin ilimin ilimin ilimin ilimin ilimin ilimin ilimin ilimin ilimin ilimin ilimin ilimin likita wanda ke da matakan ammonia da ƙananan matakan ammonia da glutamate a cikin jini. Saboda an samar da glutamate / glutamine daga α-Ketoglutarate, marasa lafiya na propionic acidemia sun lalata samar da α-Ketoglutarate da ƙarin α-Ketoglutarate ya kamata inganta yanayin waɗannan marasa lafiya. Sauran binciken gwaji da yawa sun nuna cewa gudanar da α-Ketoglutarate a cikin abinci mai gina jiki na iyaye wanda aka ba marasa lafiya bayan sun gudanar da aiki ya taimaka rage haɓakar haɗin furotin na tsoka wanda ake gani sau da yawa bayan tiyata. Wannan haɓakar ƙwayar tsoka ana yin hasashe saboda ƙananan matakan α-Ketoglutarate.

Karin Alpha ketoglutaric acid (AKG) - Menene fa'idodin Alpha ketoglutaric acid?

Alpha-Ketoglutarate (AKG) azaman Suparin Aiwatar da Wasanni
Alpha ketoglutaric acid, ko Alpha-ketoglutarate samfurin mitochondria ne kuma yana taka muhimmiyar rawa wajen canza abinci zuwa makamashi. Har ila yau, tushen abinci ne na glutamine da glutamate. A cikin tsokoki, glutamine da glutamate suna hana raunin furotin da haɓaka kira mai gina jiki.

Alpha-ketoglutarate yana inganta ƙirar ƙashi. Yana daidaita kira na collagen mai yiwuwa ta hanyar kara yawan kwayoyin da ake samu don kira. Collagen wani muhimmin abu ne na kayan ƙashi.

Alpha-ketoglutarate yana motsa samar da insulin-like girma factor-1 da girma hormone. Waɗannan duka hormones ne waɗanda ke tsara sake amfani da ƙashi da samuwar sabon ƙashi.

alpha ketoglutaric acid amfanin kan tsufa
Nazarin ya nuna cewa AKG na iya yiwuwar magance yanayi da yawa idan aka ɗauka kamar yadda aka umurta.

Koyaya, akwai wasu alamomi da ke nuna cewa Alpha-Ketoglutarate (AKG) na iya taimakawa da abubuwan tsufa.

Wani babban binciken da aka gudanar a Buck Institute for Research on tsufa tare da Ponce de Leon Health sun sami ingantaccen kiwon lafiya kamar yadda kashi 60% a cikin bincikensu na dabbobi masu shayarwa.

α-ketoglutaric
AKG ya tsawaita shekarun C. elegans. (A) AKG ya tsawaita rayuwar tsofaffin tsutsotsi. (B) Hanyar amsa-doguwar amsa AKG akan tsawon rai.
Bugu da kari, Ponce De Lon Health (PDL) ta fitar da wani rahoton gwaji, rahoton ya nuna cewa bayan rabin shekara, shekarun ilimin lissafi na batutuwa sun ragu a matsakaicin shekaru 8.5 bayan shan alpha-ketoglutarate (AKG) da ke cikin kamfanin.

Sauran mahaukatan, kamar maganin rapamycin mai yaduwa da kuma maganin ciwon sukari na metformin, sun nuna irin wannan tasirin a cikin gwajin bera. Amma AKG halitta ce ta beraye da jikunanmu, kuma tuni masu amintattu suke cin sa.

Abubuwan da yakamata mu kula dasu shine tsarkakakken alpha ketoglutaric acid yana da ƙanshi sosai kuma bashi da sauƙin ci. Ana kara kayan motsa jiki a kasuwa tare da arginine-α-ketoglutarate (AAKG), babban abin da ke cikin su shine arginine, yayin da wanda Ponce De Lon Health yayi amfani dashi shine calcium-ketoglutarate calcium.

Alpha-ketoglutarate shima yana da kayan haɓaka kumburi
AKG ana kiranta mahimmin abinci mai gina jiki kuma yana taka muhimmiyar rawa a cikin ƙwayar ƙwayar ƙwayar ƙwayar cuta. Tuni dai an riga an san cewa AKG muhimmiyar hanya ce ta wadataccen abinci da ƙoshin lafiya, ana bayyana shi azaman haɓakar glutamine da ƙari. A cikin jiki, an rikide shi zuwa glutamine. Glutamine na iya kara yawan kwayoyin halittar farin jini (macrophages da neutrophils) .AKG kamar yadda ake kira homoamine na amfani da sinadarai masu dauke da sinadarai masu inganta garkuwar jiki, zai iya kiyaye shingen hanji, ya kara kwayoyin halittar garkuwar jiki da ayyukan neutrophils da phagocytosis, rage yaduwar kwayoyin cuta a cikin rayuwa.

reference:

  1. Aussel C, Coudray-Lucas C, Lasnier E, et al. Alpha-Ketoglutarate ɗaukar cikin fibroblasts ɗan adam. Kwayar Biol Int 1996; 20: 359-63.
  2. Wernerman J, Hammarqvist F, Vinnars E. Alpha-ketoglutarate da kuma bayan motsa jiki catabolism. Lancet 1990; 335: 701-3.
  3. Blomqvist BI, Hammarqvist F, von der Decken A, Wernerman J. Glutamine da alpha-ketoglutarate suna hana raguwar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayarfancin ƙwayar cuta da ƙwallon ƙwallon ƙwallon ƙwallon ƙwallon ƙwallon ƙwallon ƙwallon ƙwallon ƙwallon ƙwallon ƙwallon ƙwallon ƙwallon kansa Tsarin Halitta 1995; 44: 1215-22.
  4. Hammarqvist F, Wernerman J, von der Decken A, Vinnars E. Alpha-ketoglutarate yana kiyaye haɗin furotin da kyauta mai ƙoshin lafiya a cikin ƙwayar jijiyoyin jiki bayan tiyata. Yin aikin tiyata. 1991; 109: 28-36.
  5. Zhang W, Qu J, Liu GH, da sauransu. Tsarin halittar tsufa da sabunta shi [J]. Binciken Halitta Tsarin Halittar Kwayoyin Halitta, 2020, 21 (3).
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  7. Alpha-Ketoglutarate, an Endogenous Metabolite, Extends Lifespan and Compresses Morbidity in Aging Mice. Asadi Shahmirzadi A, Edgar D, Liao CY, Hsu YM, Lucanic M, Asadi Shahmirzadi A, Wiley CD, Gan G, Kim DE, Kasler HG, Kuehnemann C, Kaplowitz B, Bhaumik D, Riley RR, Kennedy BK, Lithgow GJ.