Maniyyi

Maniyyi da polyamines

Don haka menene polyamines? Kuma me yasa suke da mahimmanci a matsayin tsufa? Polyamines suna samuwa a ko'ina a cikin sel masu rai da kyallen takarda. An san su da amines biogenic waɗanda ke tattare da ƙungiyoyin amino sama da biyu. Polyamines suna faruwa ta halitta a jikinmu kuma abin takaici, yayin da muke tsufa waɗannan matakan suna raguwa.

Polyamines suna taka rawa a cikin:

• Rarraba cell da bambanci
• Yaduwar kwayar halitta
• DNA da furotin kira
• Homeostasis (ikon jiki don daidaitawa da kiyaye yanayin kwanciyar hankali)
• Da kuma bayanin kwayoyin halitta (lambar kwayar halittar da ake amfani da ita don jagorantar haɗin furotin)

Duban duk ayyukan polyamines, zamu iya ganin dalilin da ya sa ya kamata mu damu idan tsufa ya sa matakan mu ya ragu. Wadannan mahadi masu mahimmanci suna da alama suna da hannu sosai a cikin matakai na haɓakar tantanin halitta da kiyaye kwanciyar hankali na kwayoyin halitta. Don haka, suna taimakawa rage tsarin tsufa da inganta rayuwarmu da tsawon lafiyar mu (ingantacciyar rayuwarmu). Sakamakon raguwar matakan polyamines ɗinmu yana hana mu wasu fa'idodin warkewa.

Babban polyamines da ake samu a cikin ƙwayoyin mammalian har ma da tsire-tsire su ne spermidine, spermine, da putrescine. Mutane da tsire-tsire suna da abubuwa da yawa a hade, daya daga cikin abubuwan shine mu duka biyun muna yin duk abin da za mu iya don tabbatar da cewa muna rayuwa tsawon lokaci. Ɗaya daga cikin hanyoyin da za mu iya cimma hakan ita ce ta hanyar shan polyamines da polyamine synthesis. Wannan tsari yana inganta autophagy, wanda shine tsarin jikinmu na maye gurbin kwayoyin da suka lalace da sababbin kwayoyin halitta. Kamar yadda zaku iya tunanin, wannan tsari zai iya taimaka mana mu rayu tsawon rai, farin ciki, rayuwa mai koshin lafiya. Maniyyi misali ne na polyamine wanda zai iya taimakawa wajen inganta autophagy.

Menene Maniyyi?

Maniyyi polyamine ne da ke faruwa a zahiri wanda ke faruwa a duk eukaryotes, amma yana da wuya a cikin prokaryotes. Yana da mahimmanci don haɓakar tantanin halitta a cikin nama na al'ada da neoplastic. Maniyyi yana samuwa ta hanyar ƙara ƙungiyar aminopropyl zuwa spermidine ta hanyar maniyyi synthase. Maniyyi yana da tushe mai ƙarfi a cikin hali, kuma a cikin maganin ruwa a pH na jiki, duk rukunin amino ɗinsa za'a same shi azaman polycation.

Ana iya amfani da maniyyi a cikin aikace-aikace iri-iri na ilimin halitta azaman kari ko wakili na tsari. Ana amfani dashi azaman matrix tare da DHB don MALDI-MS na sialylated glycans a cikin yanayin ion mara kyau.

Menene maniyyi tetrahydrochloride foda?

Spermine tetrahydrochloride shine polyamine wanda ke haifar da nau'ikan tasirin daidaitawa akan tashar mai karɓar NMDA, yana aiki ta takamaiman rukunin yanar gizo akan hadaddun wanda zai iya haifar da tasirin agonist da antagonist. Spermine tetrahydrochloride foda shine nau'in tetrahydrochloride na Spermine. Maniyyi tetrahydrochloride foda ne fari foda siffan yayin da Spermine free tushe ne a cikin ruwa tsari. Spermine tetrahydrochloride foda amfanin iri ɗaya ne tare da fa'idodin Spermine.

Tsarin aikin maniyyi: yaya yake aiki?

Maniyyi yana samuwa daga spermidine ta hanyar maniyyi synthase. Maniyyi polyamine ne, ƙananan ƙwayoyin halitta waɗanda ake buƙata gaba ɗaya don haɓakar ƙwayoyin eukaryotic. Maniyyi, yawanci ana samuwa a cikin adadin millimolar a cikin tsakiya. Maniyyi yana aiki kai tsaye azaman mai ɓarna mai ɓacin rai, kuma yana samar da nau'ikan addu'o'in da ke hana lalata oxidative ga DNA. Lalacewar Oxidative ga DNA ta nau'in iskar oxygen mai amsawa matsala ce ta ci gaba da dole ne sel su kiyaye don tsira. Don haka, maniyyi babban fili ne na halitta na ciki wanda ke da ikon kare DNA daga harin da ya dace. Har ila yau, maniyyi yana da tasiri a cikin tsarin maganganun kwayoyin halitta, da daidaitawar chromatin, da kuma rigakafin rarrabuwar DNA mai tsaka-tsakin endonuclease.

Amfanin maniyyi - Menene ake amfani da maniyyi?

Maniyyi polyamine ne na endogenous mai ɗauke da rukunonin amino da yawa. An samo shi yana taka muhimmiyar rawa a cikin metabolism na salula a cikin dukkanin kwayoyin eukaryotic. Maniyyi, polyamine da ke faruwa a zahiri, kwanan nan ya fito kamar yadda yake nuna abubuwan hana tsufa. Abubuwan da ake amfani da su na maniyyi wanda Spermine tetrahydrochloride foda ya yi yana kara yawan rayuwa da juriya ga danniya, kuma yana rage yawan abin da ya faru na ilimin cututtuka na shekaru da asarar ikon locomotor.

Maniyyi inganta ƙwaƙwalwar ajiya asarar.
Bayan jiyya na Maniyyi, ikon riƙe ƙwaƙwalwar ajiya ya inganta sosai a cikin mice SAMP8. Maniyyi tetrahydrochloride foda ya inganta sosai tsawon lokacin binciken abin labari.

Maniyyi yana rage yawan damuwa a cikin kwakwalwar beraye.
Mun kimanta tasirin polyamine da rapamycin akan damuwa na oxidative. Maniyyi ya rage matakan MDA a cikin kwakwalwar berayen SAMP8. Ayyukan SOD ya karu musamman a cikin rukuni na maniyyi. Wadannan sakamakon sun nuna cewa Spermine tetrahydrochloride foda yana inganta danniya na oxidative a cikin SAMP8.

Maniyyi yana haɓaka filastik synaptic da abubuwan neurotrophic
An gano maganganun abubuwan neurotrophic da sunadarai na synaptic a cikin rukunin maniyyi. Mahimmin haɓakar jijiya (NGF), ƙwayar neurotrophic da aka samu ta kwakwalwa (BDNF), ƙarancin postsynaptic da ƙarancin postsynaptic a fili an inganta su a cikin rukunin maniyyi.

Maniyyin gyaran mitochondrial dysfunction
Sakamakon da aka nuna, maganganun sunadaran da ke da alaƙa da mitochondion sun inganta sosai a cikin rukunin maniyyi. Maniyyi a fili ya haifar da phosphorylation na DRP 1. Matsakaicin ATP ya kasance ƙasa a cikin ƙungiyar berayen SAMP8 fiye da ƙungiyar maniyyi.

Maniyyi yana haifar da autophagy
Bayan maganin Spermine tetrahydrochloride foda, an haɓaka matakin phosphorylation na AMPK. Matsayin sunadaran da ke da alaƙa da autophagy ciki har da sun karu sosai a cikin rukunin maniyyi.

Maniyyi inganta apoptosis

Maniyyi attenuate kumburi
Sakamakon da aka nuna, Bayan maganin maniyyi, maganganun sunadaran masu kumburi sun ragu sosai. Abubuwan kari na maniyyi da Spermine tetrahydrochloride foda ke yi zai iya rage kumburi a cikin kwakwalwa.

Maniyyi da kuma Spermidine

Abubuwan da ke cikin spermidine da maniyyi a cikin ƙwayoyin mammalian suna da muhimmiyar rawa a cikin furotin da kuma tsarin tsarin nucleic acid, kariya daga lalacewar oxidative, ayyukan tashoshi ion, yaduwar kwayar halitta, bambance-bambance, da apoptosis.

Maniyyi wani nau'in polyamine ne. Dukansu mahadi suna da alaƙa da juna. Maniyyi an samo shi daga Spermidine kuma yana da mahimmanci ga metabolism na sel a cikin mutane da tsire-tsire. Shan abubuwan kari na spermidine yana tabbatar da cewa kuna samun amfanin maniyyi kuma.

Maniyyi tetrahydrochloride foda aikace-aikace

An yi amfani da foda na maniyyi tetrahydrochloride don ƙaddamar da DNA don bincike na cytometric daga sabon daskararren ƙwayar nono, nama na glandan salivary, renal da thyroid tumors2 da kuma jajayen kwayoyin kaji. Yanzu Spermine tetrahydrochloride foda an yi amfani da shi a cikin abubuwan da ake amfani da su na rigakafin tsufa. Sayi maniyyi tetrahydrochloride foda akan layi.

Inda za a saya girma na Maniyyi?

A cikin duniyar zamani, zaku iya siyan kayan abinci na Maniyyi da Spermine tetrahydrochloride foda ke yi a cikin kwanciyar hankali na gidan ku akan layi. Koyaya, dole ne ku bincika ko'ina don masu samar da samfuran foda mai inganci na Spermine tetrahydrochloride. Binciken abokin ciniki hanya ɗaya ce don tabbatar da fa'idodin foda na Spermine tetrahydrochloride da kuma tattara bayanai akan yiwuwar illar maniyyi.

Akwai foda da yawa na maniyyi tetrahydrochloride don siyarwa a kasuwa. Phcoker a matsayin masana'antar masana'anta yana ba da babban adadin maniyyi tetrahydrochloride foda. Mafi kyawun ƙarin foda na maniyyi yana tare da tsabta mai tsabta da bioavailability. Maniyyi tetrahydrochloride foda sayan sayan zai sami farashi mai kyau.

FAQ

Shin Spermine Anti tsufa?
Wata takarda da aka buga a cikin 1992 ta yi hasashen cewa maniyyi da maniyyi suna kare DNA daga lalacewar oxidative free-radical. Matakan mu na maniyyi suna raguwa yayin da muke tsufa, wanda ba albishir ba ne a gare mu saboda muna iya rasa waɗancan fa'idodin rigakafin tsufa da lafiya. A cikin gwaji guda, berayen da ba su iya samar da maniyyi da maniyyi ba sun rasa gashin kansu, sun sami fata mai laushi, kuma sun mutu a ƙanana fiye da mice na al'ada, amma babu abin da ya bayyana rashin lafiya a cikin kowane gabobin.

Shin maniyyi antioxidant ne?
A cewar wasu bincike, gudanar da maniyyi na iya kara yawan karfin antioxidant a cikin hanta da kuma hanta kuma zai iya inganta matsayin antioxidant a cikin saifa da hanta a ƙarƙashin damuwa na oxidative. An gano maniyyi a matsayin mai karfi antioxidant da anti-mai kumburi wakili. Ginin yana nan a cikin dukkan kwayoyin halitta da dukkan gabobin.

Menene maniyyi yake yi a cikin maniyyi?
Tun da daidai lokacin da ake iya samun ƙarfin aiki da kuma halayen acrosome suna da mahimmanci don samun nasarar hadi, ana ba da shawarar cewa aikin maniyyi na seminal shine don hana ƙarfin da ba a kai ba da kuma halayen acrosome.

A ina ake samun maniyyi?
Maniyyi polyamine ne, ƙananan ƙwayoyin halitta waɗanda ake buƙata gaba ɗaya don haɓakar ƙwayoyin eukaryotic. Maniyyi, yawanci ana samuwa a cikin adadin millimolar a cikin tsakiya. Maniyyi yana aiki kai tsaye azaman mai ɓarna mai ɓacin rai, kuma yana samar da nau'ikan addu'o'in da ke hana lalata oxidative ga DNA.

Shin maniyyi furotin ne?
Ko da yake spermidine yana da muhimmiyar mahimmanci kuma na musamman a matsayin mai mahimmanci na hypusine wani gyare-gyare na bayan-fassara na elongation factor eIF5A, wanda ya zama dole don wannan furotin ya yi aiki a cikin haɗin furotin, babu wani matsayi na musamman ga maniyyi da aka gano ba tare da wata shakka ba.

Yaya ake adana maganin maniyyi?
Adana a zazzabi na 2-8 ° C. Maganganun tushen tushen maniyyi suna da iskar oxygen da sauri. Magani sun fi karɓuwa idan an shirya su a cikin ruwan da aka zubar kuma a adana su a cikin daskararrun aliquots, ƙarƙashin argon ko iskar nitrogen. maniyyi tetrahydrochloride foda ne mafi barga nau'i na maniyyi free tushe.

Ina maniyyi ya fito?
Maniyyi yana samuwa a yawancin kwayoyin halitta ciki har da dabbobi, tsire-tsire, wasu fungi, wasu archaea, da wasu kwayoyin cuta. An haɗa shi ta hanyar maniyyi synthase, wani takamaiman aminopropyltransferase. Maniyyi yana samuwa daga spermidine ta hanyar maniyyi synthase.

Menene pH na maniyyi?
Don tabbatar da cewa maniyyi yana aiki da ilimin halitta a pH 7.4 mun gwada tasirin sa akan masu karɓar glutamate (GluR3).

Shin maniyyi yana da amfani ga fata?
A haƙiƙa, babu wata hujjar kimiyya da za ta goyi bayan ra'ayin sanya maniyyi a fata. Baya ga yin kadan don taimakawa launin fata, yana iya haifar da rashin lafiyan halayen da cututtukan da ake ɗauka ta hanyar jima'i (STIs).

1.Daya daga cikin da'awar amfanin maniyyi ga fatar fuska shine maganin kuraje. Amfanin maniyyi ga kyau an yi imanin ya fito ne daga sinadarin maniyyi. Maniyyi wani abin da aka samu daga sinadarin spermidine a cikin maniyyi namiji, wanda aka yi imanin yana aiki a matsayin wakili na antioxidant da anti-inflammatory. Baya ga maniyyin namiji, ana kuma iya samun maniyyi a cikin kwayoyin jikin mutum. An yi imanin cewa maniyyi yana magance kuraje da kuma yaki da tabo.

Abin takaici, babu wani sakamakon binciken kimiyya da zai iya tabbatar da fa'idar maniyyi ga fata mai saurin kuraje.

2.Claims Amfanin maniyyi wajen kyau shine hana bayyanar da alamun tsufa da wuri,kamar wrinkles ko layukan lallau,kuma ana da'awar amfanin maniyyi ga fuskar mace domin maniyyi yana dauke da maniyi. An yi imani da cewa maniyyi shine maganin antioxidant wanda zai iya canza alamun tsufa, irin su wrinkles da layi mai kyau, yana sa fata ta zama ƙarami. Wani bincike da aka buga a mujallar Nature Cell Biology ya ce maniyyi na iya rage saurin tsufa idan aka yi amfani da shi ta hanyar allura kai tsaye cikin kwayoyin fatar jikin mutum.

Duk da haka, amfanin maniyyi ga fuska, wanda ake amfani da shi ta hanyar shafa shi kai tsaye a saman fata, ba a tabbatar da shi ba. Wato amfanin maniyyi ga fuskar mata wajen hana tsufa da wuri, tatsuniya ce kawai.

reference:

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