Urolithin foda

Phcoker yana da damar samar da taro da kuma samar da urolithin a, urolithin b da Urolithin A 8-Methyl Ether a ƙarƙashin yanayin cGMP.

Menene Urolithin A?

Urolithin A shine mahaɗan ƙwayar cuta wanda ya haifar da canjin ellagitannins ta ƙwayoyin cuta. Ya kasance cikin rukunin mahaɗan ƙwayoyin da ake kira benzo-coumarins ko dibenzo-α-pyrones. Urolithin A an nuna shi don haɓaka mitophagy da haɓaka lafiyar tsoka a cikin tsofaffin dabbobi kuma a cikin ƙirar ƙirar tsufa. A halin yanzu, shi ma an nuna shi ya ƙetare shingen ƙwaƙwalwar jini, kuma yana iya samun sakamako na neuroprotective akan cutar Alzheimer.

Urolithin Wani foda shine samfurin halitta tare da aikin antiproliferative da antioxidant. Urolithin A an kafa shi ne ta hanyar metabolism daga polyphenols da ake samu a wasu kwayoyi da 'ya'yan itatuwa, musamman rumman. Magabatansa - ellagic acid da ellagitannins - suna cikin yanayi a ko'ina, gami da tsire-tsire masu ci, kamar su rumman, strawberries, raspberries, walnuts, shayi da inabi na muscat, da kuma 'ya'yan itatuwa masu yawa na wurare masu zafi.

Tun daga 2000s, urolithin A ya kasance batun karatun farko game da tasirin ilimin halitta.

Ta yaya Urolithin A ke aiki?

Urolithin A shine urolithin, wani kwayar halittar dan adam da ake samu a jikin dan adam wanda yake samarda abinci mai kamala (kamar su ellagic acid). A cikin kwayar cutar da ke cikin kwayoyin, ellagitannin da ellagic acid suna haifar da samuwar urolithins A, B, C da D. Daga cikinsu, urolithin A (UA) shi ne mafi tasirin aiki da tasiri na hanji, wanda za a iya amfani dashi azaman anti mai tasiri -m mai kumburi da antioxidant.

A cikin binciken dakin gwaje-gwaje, an nuna cewa urolithin A yana haifar da mitochondria, wanda shine zaɓin dawo da mitochondria ta hanyar autophagy. Autophagy tsari ne na cire mitochondria mai rauni bayan rauni ko damuwa, kuma yana aiki yayin tsufa. ƙasa da ƙasa. An lura da wannan tasirin a cikin jinsunan dabbobi daban-daban (ƙwayoyin dabbobi masu shayarwa, rodents da Caenorhabditis elegans).

Koyaya, saboda tushen ellagitannin ya banbanta, abun da ke cikin kowane rukunin kwayan zai zama daban, saboda haka ingancin jujjuya zuwa urolithin A ya banbanta sosai a cikin mutane, kuma wasu mutane basu da wata hira.

Urolithin Amfanin

Urolithin A (UA) abinci ne na ɗabi'a, mai narkewar abinci wanda aka samo daga al'umar microbial. Yana da fa'idodi daban-daban na kiwon lafiya, gami da rage sigina mai kumburi, tasirin cutar kansar da hana tarin lipid.

A matsayin mafi inganci da tasiri mai narkewar hanji, urolithin A (UA) na iya aiki azaman mai tasiri mai saurin kumburi da antioxidant. Hakanan zai iya motsa tasirin phagocytosis na mitochondrial a cikin tsofaffin dabbobi da samfuran zamani na tsufa da inganta lafiyar tsoka.

Shin za a iya amfani da Urolithin A a matsayin kari?

A cikin 2018, Hukumar Abinci da Magunguna ta Amurka ta rarraba urolithin A a matsayin amintaccen sashi a abinci ko samfuran ƙarin kayan abinci, tare da adadin da ya fara daga milligram 250 zuwa gram 1 a kowane aiki.

Shin akwai wasu sakamako masu illa na Urolithin A?

Nazarin lafiya a cikin tsofaffi ya nuna cewa urolithin A yana da haƙuri sosai. A cikin nazarin rayuwa ba a tantance ko akwai wani abu mai guba ko takamaiman illolin cin abincin urolitin A mai ci ba.

Hakanan, ba a san aminci na dogon lokaci don ƙarin Urolithin A da ruman, kodayake magani na ɗan gajeren lokaci tare da cirewar pomegranate yana da lafiya.

Menene Urolithin B? Urolithin B foda?

Urolithin B foda (CAS NO: 1139-83-9) shine urolithin, wani nau'in mahaɗan phenolic da aka samar a cikin hanjin ɗan adam bayan shayar da abinci na ellagitannins kamar pomegranate, strawberries, red raspberries, walnuts ko oak-shekarun jan giya . Ana samun Urolithin B a cikin fitsari ta hanyar urolithin B glucuronide.

Urolithin B yana rage lalacewar furotin kuma yana haifar da hawan jini. Urolithin B ya hana aikin aromatase, enzyme wanda ke canza yanayin estrogen da testosterone.

Urolithin B shine samfurin halitta tare da aikin antiproliferative da antioxidant. Urolithin B an nuna shi ya haye shinge na kwakwalwar jini, kuma yana iya samun tasirin kwayar cutar cutar Alzheimer.

Urolithin B shine ƙwayar ƙwayar ƙwayar ƙwayar cuta na hanji na ellagitannis kuma yana nuna ƙarfin anti-oxidant da ayyukan pro-oxidant dangane da tsarin assay da yanayin. Urolithin B zai iya nuna aikin estrogenic da / ko anti-estrogenic aiki.

Menene Urolithin B ke amfani dashi? Fa'idodin Urolithin B (UB)

Fa'idodin Urolithin B:

Imarfafa Syungiyar Maganin Muswayar Muscle

Rage Rushewar sunadarin Muscle

Haveila Na Iya samun Tasirin kariya na Muscle

Iya Iya Samun Anti-Aromatase Properties

Urolithin B don yawan tsoka

Urolithin B na iya rage lalacewar tsoka da aka samu yayin motsa jiki mai ƙarfi da kuma kare tsoka daga abubuwan damuwa da ke haifar da abinci mai-mai-yawa. Binciken asibiti a kan Urolithin B a cikin mice sun gano cewa yana haɓaka haɓakar myotubes da bambanta ta hanyar haɓakar furotin. Ya nuna ikon da zai iya hana hanyar samun abinci mai gina jiki (UPP), babbar hanyar samarda furotin. Hakanan ya jawo hauhawar tsoka da rage kiba a jiki.

Idan aka kwatanta da testosterone, Urolithin B lokacin da aka karɓa a 15 uM ya karu da aikin mai karɓar androgen ta hanyar 90% yayin da testosterone ya sami damar kammala karuwar aikin mai karɓar 50% a 100uM. Wannan yana nufin yana ɗaukar Urolithin B da yawa don haɓaka aikin androgen sosai yadda yakamata sannan adadin mafi yawan testosteronewhich yana ƙaruwa aikin androgen ƙasa da inganci.

Haka kuma, mafi inganci na 15uM na Urolithin B mafi girma sashin furotin na tsoka ta hanyar kashi 96% yayin da aka kwatanta da 100uM na insulin, wanda ya fi girma ƙwayar furotin tsoka ta hanyar mafi inganci 61%. Amincewa shine cewa yana ɗaukar Urolithin B mai nisa sosai don tsawaita aikin furotin na muscle tare da babban matakin ingantaccen tasiri.

Wannan nazarin ya nuna cewa Urolithin B na iya hana catabolism furotin yayin da lokaci guda ke kara hadarin sunadarai, wani sinadari ne na halitta wanda ke taimakawa wajen gina tsoka yayin da yake hana kasala tsoka.

Urolithin B shine ɗayan ƙwayoyin maganin ƙwayoyin cuta na ellagitannins, kuma suna da cututtukan kumburi da antioxidant. Urolithin B yana hana ayyukan NF-κB ta hanyar rage yawan phosphorylation da lalata na IκBα, kuma yana danne phosphorylation na JNK, ERK, da Akt, kuma yana inganta phosphorylation na AMPK. Urolithin B shima mai daidaitawa ne akan ƙwayar tsoka.

Menene Urolithin A 8-Methyl Ether?

Urolithins sune metabolites na sakandare na ellagic acid waɗanda aka samo daga ellagitannins. A cikin mutane ellagitannins ana canza su ta hanyar gut microflora zuwa ellagic acid wanda aka kara canzawa zuwa urolithins A, urolithin B, urolithin C da urolithin D a cikin manyan hanji.

Urolithin A 8-Methyl Ether shine tsaka-tsakin samfurin yayin aikin Urolithin A. Yana da mahimmancin metabolite na ellagitannin kuma ya mallaki antioxidant da anti-mai kumburi abubuwa.

Ta yaya Urolithin A 8-Methyl Ether ke aiki?

(1) Kayan Antioxidant

Urolithin A 8-Methyl Ether yana da tasirin antioxidant ta hanyar rage radicals free, musamman rage matakin nau'in oxygen mai amsawa (ROS) a cikin sel, da kuma hana lipid peroxidation a wasu nau'in kwayoyi.

(2) Abubuwan kariya ga kumburi

Urolithin A 8-Methyl Ether yana da abubuwan kare kumburi ta hanyar hana samar da sinadarin nitric. Musamman sun hana bayyanar da furotin inricible oxide synthase (iNOS) da mRNA wanda ke haifar da kumburi.

Urolithin A amfanin 8-Methyl Ether

Urolithin A 8-Methyl Ether shine matsakaiciyar samfur a cikin aikin hada Urolithin A, kuma wani muhimmin abu ne na biyu na ellagitannin, tare da sinadarin antioxidant da anti-inflammatory. A matsayin mai amfani da Urolithin A, yana iya samun wasu fa'idodin Urolithin A:

(1) Iya kara tsawon rai;
(2) Taimakawa wajen hana kamuwa da cutar kansar mafitsara;
(3) Inganta fahimi;
(4) Mai yuwuwar rage kiba

Amfani da Urolithin A 8-Methyl Ether kari?

Urolithin Ana samun kari a kasuwa azaman ellagitannin mai wadataccen tushen abinci. A matsayin samfurin rayuwa na Urolithin A, Urolithin A 8-Methyl Ether Hakanan za'a iya amfani dashi a cikin kari.

Koyaya, babu datas da yawa game da ƙarin bayani, kuma ana buƙatar ƙarin bincike.

reference:

  1. Garcia-Muñoz, Cristina; Vaillant, Fabrice (2014-12-02). "Tsarin rayuwa na Ellagitannins: Abubuwan da suka shafi Kiwon Lafiya, da Ra'ayoyin Bincike don Ingantaccen Abincin Aiki". Mahimman bayanai game da Kimiyyar Abinci da Gina Jiki. 54 (12): 1584–1598. Doi: 10.1080 / 10408398.2011.644643. ISSN 1040-8398. PMID 24580560. S2CID 5387712.
  2. Ryu, D. et al. Urolithin A yana haifar da mitophagy kuma yana tsawanta rayuwa a cikin C. elegans kuma yana haɓaka aiki na tsoka a cikin beraye. Nat. Likita 22, 879–888 (2016).
  3. "FDA GRAS sanarwa GRN No. 791: urolithin A". Hukumar Abinci da Magunguna ta Amurka. 20 Disamba 2018. An dawo da 25 Agusta 2020.
  4. Singh, A.; Andreux, P.; Blanco-Bose, W.; Ryu, D.; Aebischer, P.; Auwerx, J.; Rinsch, C. (2017-07-01). "Urolithin A na magana da baki yana amintacce kuma yana gyara tsoka da mitochondrial biomarkers a cikin tsofaffi". Bidi'a a cikin tsufa. 1 (suppl_1): 1223-1224.
  5. Heilman, Jacqueline; Andreux, Pénélope; Tran, Nga; Rinsch, Chris; Blanco-Bose, William (2017). "Binciken lafiya na urolithin A, wani abu mai narkewa wanda hanjin dan adam yake samarwa akan abincin da ake samu na ellagitannins da ellagic acid". Abinci da Sinadarin Toxicology. 108 (Pt A): 289-297. Doi: 10.1016 / j.fct.2017.07.050. PMID 28757461.