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Peptide Degarelix foda Cikakken Magani ne wanda aka yi amfani da shi don cutar kansa
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Peptide Degarelix foda: Magungunan Gaskiya ne da ake Amfani da shi don Ciwon Mara

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1. Mene ne Degarelix?
2. Menene Amfani da Degarelix foda ake amfani da shi?
3. Degarelix foda Hanyar aiki
4. Hadin gwiwar Degarelix
5. Shin akwai wata haɗari idan na ɓace daga kashi na Degarelix ko yawan shan ruwa?
6. Wani Sakamakon Gano da Gargadi zasu iya haifar da Fa'idar Degarelix?
7. Kammalawa
8. Karin Bayani

Lambar rubutu

Tunanin zamani, cutar sankarar fata ta zama ɗayan cututtukan da ke barazanar lafiyar jiki da tunanin mutum. Yin rigakafin farko da magani ya zama dole don magance wannan cutar. Degarelix foda magani ne mai inganci don maganin cutar kansa, kuma yakamata mu dauki matakin fahimtar wasu mahimman bayanai game da shi domin mu iya amfani da shi yadda yakamata da lafiya.

1. Mene ne Degarelix?Phcoker

Degarelix (214766-78-6) magani ne na maganin hormone wanda ke rage adadin kwayoyin homon a jiki, gami da testosterone. An rarrabe shi a ƙarƙashin wani aji na magunguna da aka sani da gonadotropin-sakin hormone (GnRH) antagonists. Wannan magungunan roba na peptide na asali ana san shi da sunan shi "Firmagon". Bayani mai zuwa ne:

  • Class Class of Drug: Cancancin GnRH; Mai adawa da GnRH; Antigonadotropin
  • Tsarin Kemikal: C82H103ClN18O16
  • Mass Molar: 1630.75 g / mol g · mol − 1
  • Bioavailability: 30-40%
  • Hanyoyi na Gudanarwa: Allurar allura
  • Excretion: Feces (70-80%), Urine (20-30%)
  • Cire rabin Rabin-Rayuwa: kwanakin 23-61

2. Menene Amfani da Degarelix foda ake amfani da shi?Phcoker

Ana amfani da foda na Degarelix don magance cutar kansa ta hanji. FDA ta yarda da maganin don maganin cututtukan cututtukan mahaifa a cikin marasa lafiyar Amurka a kan 24th Disamba, 2008. A kan 17th Fabrairu, 2009, Hukumar Turai ta bi kara kuma ta amince da magani na Degarelix don amfani a cikin mazan maza da suka kamu da cutar kansa ta kansa.

Lura cewa Degarelix allurar yakamata a gudanar da shi daga likita ko ma'aikacin kula da shi a cikin asibiti. Hakanan za'a iya amfani da Degarelix don wasu dalilai. A Sweden, alal misali, ana nazarin magungunan don amfani dashi azaman wakilin wasan yara wanda za'a yiwa allurar jima'i. Hakanan ana ɗaukar magani na nono Degarelix azaman madadin magani don maganin nono a cikin maza.

Likitanka na iya ba da shawarar wannan maganin don sauran yanayi. Idan baku tabbatar da dalilin da yasa kuke shan wannan magani ba, yana da mahimmanci kuyi magana da likitan ku. Kamar yadda yake tare da sauran magunguna, bai kamata ku ba Degarelix ga kowa ba, koda kuwa suna da alamu guda ɗaya kamar ku. Wannan saboda magani zai iya zama cutarwa idan an sha shi ba tare da faɗakarwar likitan ba.

(1) Ya kamata ku san wani abu beforeari kafin ɗaukar Degarelix

Abubuwa masu zuwa wasu muhimman abubuwa ne da yakamata ku sani kafin shan wannan magani:

  • Degarelix na iya haifar da rasa haihuwa na maza. Idan kuna sa ran zama uba a nan gaba, yana da mahimmanci ku tattauna da likitan ku. Kuna iya la'akari da adana maniyyi kafin fara magani.
  • Ba a yarda da wannan maganin don amfani da mata ba. Mata masu juna biyu kada amfani da wannan magani. Wannan saboda miyagun ƙwayoyi na iya cutar da tayin. Mata masu shayarwa, ko kuma waɗanda ke da niyyar haihuwa, suma su guji amfani da wannan maganin. A zahiri, mata gaba ɗaya bai kamata su yi amfani da Degarelix ba.
  • Ba shi da haɗari ku ɗauki Degarelix idan kuna da yanayin rashin lafiyar. Tabbatar sanar da likitanka idan kana da cutar QT mai tsawo, wanda shine matsalar matsalar zuciya wacce zata haifar da rauni, bugun bugun zuciya, ko mutuwa kwatsam. Hakanan yakamata ku sanar da likitan ku idan kuna da zuciya, koda, ko cutar hanta. Hakanan ka gaya wa likitanka idan kana da ko sodium, magnesium, potassium, ko alli a cikin jininka.
  • Hakanan yana da mahimmanci a gaya wa mai shayarwar ku ko likitan ku idan kun kasance kuna rashin lafiyar wasu magunguna ko kayan abinci. Wannan zai ba su damar sanin idan kun kasance rashin lafiyan allurar Degarelix.

(2) Maganin allurar Degarelix

Degarelix ya zo ta fuskoki biyu:

  • 120 mg vial: Kowane vial-amfani guda ɗaya ya ƙunshi 120 mg na Degarelix foda a matsayin Degarelix acetate.
  • 80 mg vial: Kowane vial amfani da shi yana dauke da 80 mg na Degarelix foda kamar yadda acetate Degarelix.

Degarelix ya zo da nau'in foda, wanda yakamata a haɗe shi da ruwa da allura a ƙarƙashin fata a cikin yankin ciki, wani wuri tsakanin haƙarƙarin da kugu. Farkon lokacin da kuka karɓi wannan magani, za'a baku allurar Degarelix guda biyu. Bayan farkon allurar Degarelix, zaku sami allura guda daya ne kawai yayin ziyarar bayan-wata.

Initialarancin farko shine yawanci Degarelix 240 mg ana gudanar dashi azaman 2 subcutaneous injections na Degarelix 120 mg kowane a cikin taro na 40 mg / mL. Bayan kashi na farko, zaku sami allurar subcutaneous guda ɗaya na 80 mg a taro na 20 mg / mL kowane kwanakin 28.

Lokacin da za ku karɓi allurar Degarelix, ya kamata ku guji sanya sutura mai tauri, wando ko bel a ciki yayin da za'a yi allura. Bayan kun sami allurar Degarelix, tabbatar cewa takalminku ko bel ɗinku baya sa matsi a kan allurar. Hakanan ya kamata ku guji shafa ko goge yankin da aka allurar da maganin.

Kulawa da alamun cututtukan daji na prostate wanda ke dogara da testosterone don haɓaka yana buƙatar matakan tsufa na hormone akai-akai. Don cimma wannan, yana da matuƙar mahimmanci a gudanar da Degarelix acetate daidai kamar yadda likitan likitan ya bada shawara.

Don tabbatar da cewa ƙwaƙwalwar Degarelix tana taimaka wa yanayinku, kuna iya buƙatar yin gwaje gwajen jini akai-akai. Tabbatar kiyaye duk alƙawarin sake biyowa tare da likitanka.

Hakanan ya kamata ku lura cewa allurar Degarelix na iya shafar sakamakon wasu gwaje gwajen likita. Da zarar kun kasance karkashin wannan magani, tabbatar da gaya wa likitanka cewa kun karɓi wannan magani lokacin yin gwaje-gwaje na likita.

Peptide Degarelix Wani Magungunan Gaskiya ne Wanda Aka Amfani da shi Don Cutar Kwaro

3. Degarelix foda Hanyar aikiPhcoker

An ce kwayoyin testosterone na maza suna kara haɓakar ƙwayoyin cutar kansa a cikin hanji. Magungunan da ke hana gwaje-gwajen samar da kwayoyin testosterone an san su ragewa ko dakatar da haɓakar ƙwayoyin cutar kansa a cikin prostate. Hakanan akwai magunguna waɗanda ke dakatar da aikin testosterone ta hanyar yanke bayar da hormone na namiji ga ƙwayoyin kansa.

Degarelix foda (214766-78-6) yana aiki ne ta hanyar rage adadin sinadarin testosterone da jiki yake samarwa. Yana yin hakan ta hanyar toshe masu karɓar GnRH a cikin ƙwayar pituitary a cikin kwakwalwa. Wannan yana hana samar da hormone na luiteinising, don haka ya hana gwaje-gwajen samar da kwayoyin testosterone.

4. Hadin gwiwar DegarelixPhcoker

Kamar dai sauran magungunan ciwon daji, Degarelix na iya hulɗa tare da wasu magunguna da kayan ganyayyaki. Wadannan suna daga wasu nau'ikan magungunan da zasu haifar da ma'amala yayin amfani dasu tare da Degarelix:

  • Anti-psychologists
  • Magungunan rigakafi
  • Akwai wasu inhibitors na furotin
  • Maganganun maganganun Tricyclic
  • Antifunglas
  • Magungunan rigakafin Macrolide
  • Zabi Serotonin Reuptake Inhibitors
  • Alfuzosin
  • Amiodarone
  • Buprenorphine
  • Chedral hydrate
  • Chloroquine da
  • Yin rashin biyayya, da sauransu.

Lokacin amfani dashi tare da Degarelix, wasu magunguna na iya ƙara haɗarin irin nau'in bugun zuciya wanda ba a sani ba da tsawaita QT. Lallai kuna cikin haɗarin haɗarin wannan mummunan yanayin da rikice-rikice idan kun:

  • Shin dattijo ne (Shekaru 65 da haihuwa)
  • Yi tarihin dangi game da cututtukan zuciya marasa ƙaranci ko cututtukan zuciya
  • Yi tarihin mutuwar zuciya kwatsam
  • Yi jinkirin bugun jini ko bugun zuciya
  • Yi tsawaita shekarun haihuwa na QT
  • Suna masu ciwon sukari
  • Sun sami bugun jini
  • Ka sami karancin kalsiyam, magnesium, ko potassium

Idan kuna da kowane ɗayan yanayin da ke sama, ko kuna shan wasu magunguna don sarrafa kowane yanayin kiwon lafiya, yana da mahimmanci ku gaya wa likitanku kafin amfani da magani na Degarelix. Tabbatar sanar da kantin magunguna ko likita game da takardar sayan magani, magunguna game da magunguna, abubuwan abinci masu gina jiki, kayan ganyayyaki da bitamin da kake sha ko shirin dauka. Wannan zai taimaka muku daga magungunan da zasu iya haifar da ma'amala tsakanin Degarelix.

Yana da mahimmanci a tattauna tare da likitan ku game da yanayin lafiyar ku da magungunan da zaku iya ɗauka saboda dalilai da yawa. Da fari dai, zai ba likita damar tattaunawa tare da ku yadda amfani da wannan magani tare da wasu magunguna na iya shafar yanayin lafiyar ku. Hakanan likitanku zai sanar da ku yadda yanayin lafiyar ku zai iya shafar allurar, har ma da tasiri na Degarelix. Likitanku kuma zai sanar da ku ko za a buƙaci wani kulawa ta musamman.

5. Shin akwai wata haɗari idan na ɓace daga kashi na Degarelix ko yawan shan ruwa?Phcoker

Babu ƙwarewar asibiti tare da haɗarin da ke tattare da ɓacewa ko wucewa akan Degarelix. Koyaya, bai kamata ku daina shan wannan magani ba tare da tuntuɓar likitan ku ba. Idan kun rasa alƙawari don allurar Degarelix, kira likita don umarnin.

tun Degarelix acetate ya kamata a gudanar da shi ta hanyar likita, yana da matukar wuya cewa yawan abin sha zai iya faruwa. Idan ana cikin matsalar yawan ƙwayar cutar ta Degarelix, koyaya, yana da mahimmanci ku kira cibiyar kulawa da guba ko kuma neman magani nan da nan. Ka kasance a shirye don nuna ko ka faɗi abin da ka ɗauka, ɗayan nawa kuka ɗauka, da kuma lokacin da kuka ɗauka.

Peptide Degarelix foda Cikakken Magani ne wanda aka yi amfani da shi don cutar kansa

6. Wani Sakamakon Gano da Gargadi zasu iya haifar da Fa'idar Degarelix?Phcoker

Kamar yadda yake da sauran magunguna da yawa, Degarelix na iya haifar da sakamako masu illa iri-iri. Tasirin sakamako na Degarelix na iya zama mai laushi ko mai rauni, kuma zasu iya zama na ɗan lokaci ko na dindindin. Wadannan sune gama gari Degarelix sakamako masu illa, wanda mutane da yawa ba sa shan wannan magani:

  • Binciken baya
  • Hannu
  • maƙarƙashiya
  • Rage libido
  • Erectile dysfunction
  • Rage girman adadin kwayoyin
  • zawo
  • Dizziness
  • Needara buƙatar urinate akai-akai
  • ciwon kai
  • Hoton haske
  • Tashin zuciya
  • Urination akai-akai
  • Gyaran fata a wurin allura, kamar jin zafi, jan launi, tauri, kumburi
  • sweating
  • Haƙuri
  • rashin barci
  • rauni
  • Amfanin nauyi

Kodayake yawancin sakamakon cutarwar Degerelix da ke sama ba mai tsanani bane, zasu iya haifar da matsaloli masu mahimmanci idan suka dage tsawon lokaci. Yana da mahimmanci ka nemi taimakon likita idan ka lura da waɗannan abubuwan da ba a san su ba, amma mummunan sakamako masu illa:

  • Yawan kumburi
  • Cikewar rauni ko jin zafi
  • Rashin lafiyar nono da kumburi
  • Kwayar cutar dake kama da amai, kamar tari, zazzabi, hutu, da ciwon makogwaro
  • Ikearu cikin cholesterol jini
  • Karu cikin karfin jini

Tunda Degarelix yana rage samarwa na testosterone, yana iya haifar da ƙananan matakan sel jini, yanayin da aka sani da anaemia. Bayyanar cututtukan anemia sun hada da amai, fatar fata, gajiya mara nauyi da / ko gajeruwar numfashi, yana da muhimmanci ka kira likitan ka kai tsaye. Likitanka zaiyi gwajin jini daga lokaci zuwa lokaci domin lura da yawan adadin sel da ke cikin jini.

Degarelix kuma an ce yana kara hadarin ciwon sukari. Idan kana da ciwon sukari, yana da muhimmanci ka riƙa yin gwaje gwaje na yau da kullun don lura da matakan sukarinka na jini.

An kuma ce Degarelix yana kara hadarin osteoporosis. Yana iya sa kashin ya zama mai laushi kuma ya karye sauƙin. Idan kun sami osteoporosis, yana da mahimmanci ku sanar da likitanka domin a iya tantance yadda yanayin lafiyar ku zai iya yin tasiri ga allurar Degarelix.

Wasu marasa lafiya na iya fuskantar tasirin sakamako na Degarelix ban da waɗanda aka lissafa a sama. Shin yakamata ku sami duk wata alama wacce zata baku damuwa ko kuma ta damu da ku, zai fi kyau a ga likita ba tare da bata lokaci ba.

Likitanka na iya ba ku shawara ku daina shan allurar Degarelix in har kun sami alamun cutar bugun zuciya. Waɗannan bayyanar cututtuka na iya haɗawa da jin kirji kwatsam, jin zafi yana faɗuwa a bayanku, jin motsin matsin lamba ko tsawan kirji, tashin zuciya, amai, amai, da / ko damuwa.

Likitanku kuma na iya ba ku shawara da ku daina amfani da Degarelix in har kun sami alamun cutar rashin lafiyan. Waɗannan bayyanar cututtuka na iya haɗawa da angioedema, wanda yanayin halin kwatankwacinsa, bakin numfashi, da busa fuska, baki, hannaye da / ko ƙafa.

Akwai daban Gargadin Degarelix a kiyaye. Ofayansu shine cewa wannan magani na iya wucewa ta ruwa (amai, fitsari, gumi, feces). Sabili da haka, ya kamata ku guji ƙyale ruwan jikinku ya shiga tafin hannuwanku ko fatar wani da fatar mutum na aƙalla sa'o'i 48 bayan an sami allurar Degarelix.

An shawarci masu kulawa dasu sanya safofin hannu na roba mai kariya yayin tsaftace ruwan jikin mai haƙuri da kuma lokacin kula da wanki ko mayafin da aka gurbata. Hakanan ya kamata a wanke suturar da baƙin ciki ya bambanta da sauran wankin.

Duk da yake akwai wasu sakamako masu illa na Degarelix don damuwa da su, akwai kuma wasu fa'idodin Degarelix don sa ido yayin amfani da wannan magani. A cikin nazarin asibiti, an nuna cewa allurar Degarelix tana ba da raguwa da sauri a cikin matakan testosterone fiye da sauran hanyoyin magance cututtukan jijiyoyin horarwa. Wannan magungunan ba koyaushe yana haifar da farawa na testosterone na farko wanda zai iya haifar da yanayin jinkirin bayyanar cututtuka.

Wani fa'idodin Degarelix shine cewa an yarda da miyagun ƙwayoyi gabaɗaya, banda Bincike ya nuna cewa maganganun allura sun faru a cikin 40 bisa dari na ayoyin rukuni na Degarelix <1 bisa dari na rukunin leuprolide. Waɗannan halayen sun kasance masu sauƙi ko matsakaici, kuma sun faru da yawa bayan allurar farko.

Bayanan farko daga binciken da yawa na asibiti sun nuna cewa idan aka kwatanta da aghorat na LHRH, an danganta Degarelix da rayuwa mafi girma a cikin 1st shekarar jiyya. Gaskiyar cewa damar da ake samu cikin nasara game da cutar sankarar mahaifa ta fi girma yayin amfani da wannan magani yana daga cikin fa'idodin Degarelix waɗanda ke sa wannan maganin ya zama dole-gwada.

Degarelix da barasa

Shan shan giya da ƙarancin abu ba alama ce da za ta iya amfana da lafiyar rashin lafiyar mazaɓe. Koyaya, koyaushe ya kamata ka guji shan giya mai yawa yayin shan wannan magani.

7. KammalawaPhcoker

Idan kai ko ƙaunataccen yana da cutar sankara a cikin mahaifa, to, babu tantama cewa Degarelix chemotherapy shine mafi kyawun zaɓuɓɓukan magani da zaku iya zaba. Dalilin da yasa tunanin ku yakamata ku zabi tiyata akan maganin cututtukan hormonal kamar Degarelix zai zama farashi. Koyaya, kowane bambanci farashi zai kasance yana mamaye fa'idodin Degarelix.

8. Bugu da ari, InformationPhcoker

Wataƙila kuna mamakin game da tsadar Degarelix. Matsakaicin farashin shekara-shekara na magani tare da Degarelix kusan $ 4,400. Wannan yana dacewa da farashin sauran hanyoyin da ake samu na maganin cututtukan daji don cutar kansa ta kansa. Farashin allurar Degarelix don allurar MG na 80 yana da kusan $ 519 don wadatar da foda ɗaya don allura. Hakanan farashin zai dogara da kantin magani da kuka ziyarta.

Hakanan zaka iya samun “Degarelix saya akan layi"Talla. Za ku so duk da haka ku yi taka tsantsan lokacin da sayen maganin a kan layi. Tabbatar cewa kayi cikakken bincike na asalin da kuma ƙarfin aiki kafin ka umarci miyagun ƙwayoyi daga mai siyar da kan layi. Tabbatar cewa mai siyarwa ko kantin magani na kan layi halatta kuma cewa abin da suke siyarwa shine halal da tsabta na miyagun ƙwayoyi.

Ya kamata a adana Degarelix a zazzabi a daki. Tabbatar kare wannan magani daga haske da danshi. Kamar yadda yake tare da sauran magunguna, kiyaye Degarelix waje yara.

Karku zubar da foda na Degarelix a cikin datti na gida ko cikin ruwan sharar gida, misali a cikin ɗakin bayan gida ko kwanon shara. Tambayi likitanka ko mai harhaɗa magunguna yadda zaka zubar da magunguna waɗanda suka lalace ko kuma ba a amfani da su.

References

  1. Van Poppel H, Tombal B, et al (Oktoba 2008). Degarelix: tsohuwar gonadotropin-sakewa hormone (GnRH) mai karba-karba - sakamakon ne daga shekara daya, multicentre, bazuwar, binciken kashi biyu na magani a maganin cutar kansa. Eur. Urol. 54: 805-13.
  2. Cibiyar Nazarin Cibiyar Nazarin Magunguna ta Amurka ta Cibiyoyin Lafiya na Kasa, Binciko mai amfani da tsada game da yankirelix a cikin jiyya game da cutar kansa na ciwan kansa da ke kan jijiyoyin ciki a cikin United Kingdom, Lee D1, Porter J, Brereton N, Nielsen SK, 2014 Apr; 17 (4) ): 233-47.
  3. Gittelman M, Pommerville PJ, Persson BE, et al (2008). Shekaru na 1, alamar buɗewa, rabe-raben sashi na II binciken binciken wurarenrelix don maganin cututtukan mahaifa a Arewacin Amurka. J. Urol. 180: 1986-92.