Quinone na Pyrroloquinoline (PQQ) (72909-34-3)

Maris 11, 2019

Pyrroloquinoline quinone (PQQ), wanda kuma ake kira methoxatin, shine mai haɗin gwiwar redox. Ana samun shi a cikin ƙasa da abinci irin su kiwifruit, kamar …… ..

 


Status: A Mass Production
Naúra: 25kg / Drum

 

Pyrroloquinoline quinone (PQQ) (72909-34-3) bidiyo

Bayani na Pyrroloquinoline quinone (PQQ) (72909-34-3) Bayani

Product Name Farashin quinone (PQQ)
Chemical Name Coenzyme PQQ; Methoxatine; Quinone Pyrrolo-quinoline;

Pyrroloquinolinequinone,4,5-Dihydro-4,5-dioxo-1H-pyrrolo[2,3-f]quinoline-2,7,9-tricarboxylic acid, Methoxatin, PQQ;4,5-Dioxo-4,5-dihydro-1H-pyrrolo[2,3-f]quinoline-2,7,9-tricarboxylic acid

CAS Number 72909-34-3
InChIKey MMXZSJMASHPLLR-UHFFFAOYSA-N
Smile C1=C(C2=C(C(=O)C(=O)C3=C2NC(=C3)C(=O)O)N=C1C(=O)O)C(=O)O
kwayoyin Formula C14H6N2O8
kwayoyin Weight 330.21
Monoisotopic Mass 330.012415 g / mol
Alamar Boliing 1018.6 ± 65.0 ° C (Tsinkaya)
Matsayi mai walƙiya 569.8 ° C (1,057.6 ° F; 842.9 K)
yawa 1.963 ± 0.06 g / cm3 (Tsinkaya)
Launi Orange-Red M
Girgizar ajiya 2-8 ° C
solubility Soluble cikin ruwa
Aikace-aikace An ruwaito PQQ yana aiki azaman bitamin mai narkewa / ruwa wanda yake narkewa kuma azaman maganin antioxidant. Hakanan an yi nufin amfani dashi a cikin kayan abinci, irin su makamashi, sauya kayan abinci, da sanduna masu karko da sauransu.

 

Mene ne Quinone na Pyrroloquinoline(PQQ)?

Pyrroloquinoline quinone (PQQ), wanda kuma ake kira methoxatin, shine redox cofactor. Ana samo shi a cikin ƙasa da abinci irin su kiwifruit, kazalika da madarar nono na mutum. Pyrroloquinoline quinone shine pyrroloquinoline wanda ke da oxo rukuni a cikin matsayi na 4- da 5 da ƙungiyoyi na carbonxy a wurare 2-, 7- da 9. Yana da rawa kamar bitamin-mai narkewa cikin ruwa da kuma mai samar da abinci. Kuma, alama ce mai nuna alama don garkuwar dangi da ke tattare da bambancin sel kwayoyin halittun mammali. Babban redox na sake sarrafawa na PQQ na iya ba shi rawar kantin magani wajen kare shi daga cutar kansa da kuma cutar kansa. (A matsayin wakili na redox, Pyrroloquinoline quinone yana da cikakken kwanciyar hankali kuma yana iya shiga cikin daruruwan ƙarin halayen fiye da sauran maganin antioxidants, kamar ascorbic acid, quercetin, da epicatechin.

Quinone na Pyrroloquinoline wani sabon abu ne wanda aka samar dashi, kuma anada shi azaman enzyme cofactor a cikin kwayoyin cuta. Bincike ya nuna cewa Pyrroloquinoline quinone na iya kasancewa kasancewar a duk lokacin da aka fara nazarin halittu da juyin halitta. A matsayinsa na haɓakar shuka mai ƙarfi, ya wanzu cikin haɓakar dabbobi da mutane. An ruwaito Pyrroloquinoline quinone don shiga cikin jerin ayyukan nazarin halittu tare da fa'idodin tsira na rayuwa (alal misali, ingantaccen haɓaka ƙarancin haihuwa da aikin haihuwa) a cikin dabbobi.

Haka kuma, Pyrroloquinoline quinone yana da antioxidant da ayyukan bitamin-B, tare da fa'idodi da yawa don kwakwalwa da jiki. Yana inganta lafiyar hankali da ƙwaƙwalwa ta hanyar magance lalatawar mitochondrial da kuma kare jijiyoyi daga lalacewar iskar gas. Nazarin asibiti a cikin mutane ya nuna cewa Pyrroloquinoline quinone yana haɓaka ƙwaƙwalwar ajali da kulawa, inganta haɓaka ƙarfin makamashi da tsufa lafiya, da rage alamun alamomi, da inganta halayyar jin daɗi gaba ɗaya.

 

Ta yaya Pyrroloquinoline kwalin(PQQ) aiki?

Nazarin bera ya nuna inganci mai ban sha'awa ga Pyrroloquinoline quinone a cikin motsa jiki mai tasirin mitochondrial biogenesis. Berayen hepatocytes da aka sanya su tare da PQQ a 10-30 forM na 24-48 h sun nuna "ƙara yawan haɗarin haɗi da aikin cytochrome c oxidase, ƙazantar Mitotracker, ƙunshin mitochondrial DNA, da numfashi na oxygen. Shigar da wannan tsari ya faru ne ta hanyar kunna protein mai hade da sinadarin CAMP (CREB) da kuma karba mai saurin yaduwa da aiki-ac coactivator-1α (PGC-1α), hanyar da aka sani don tsara halittar mitochondrial biogenesis. ” A cikin nazarin rayuwa a cikin berayen kuma suna nuna fa'idodi masu amfani daga ƙarin abinci tare da PQQ (2mg PQQ / kg na abinci). Waɗannan sun haɗa da raginin ƙwayar plasma triglycerides, ƙara yawan kuzarin kuzari (wanda yake da alaƙa da abin da ke cikin mitochondrial na hanta), da haɓaka haƙuri ga ischemia / reperfusion na zuciya. Gwajin gwaji na bugun jini da raunin jijiyoyin baya sun nuna cewa Pyrroloquinoline quinone yana haɓaka mutuwar kwayar neuronal, a wani ɓangare ta hanyar Pyrroloquinoline quinone mai kare masu karɓar N-methyl-d-aspartic acid (NMDA). Rat model na cutar Parkinson ya nuna cewa Pyrroloquinoline quinone supplementation yana rage asarar neuronal, yana ƙaruwa da ƙarfin haɓakar iskar oxygen, da kuma ba da kariya ta hanyar ƙarin hanyoyin.

 

Amfanin Quinone na Pyrroloquinoline(PQQ) fa'idodi

A cikin kwakwalwa da jiki, PQQ yana da fa'idodi da yawa.

- PQQ yana tallafawa aikin mitochondrial ingantacce

Mitochondria sune masu samar da makamashi a cikin sel kuma suna taka muhimmiyar rawa a lafiyarmu gaba ɗaya. PQQ ta hanyar kare mitochondria na yanzu kuma yana haɓaka ƙarni na mitochondrial, don haka samar da ATP (Energy). Marin aikin mitochondria na aiki, ƙarin kuzari.

- PQQ yana tallafawa abubuwan ci gaban jijiya

PQQ yana haɓaka samar da ƙwaƙwalwar ƙwaƙwalwar ƙwaƙwalwar Nerve (NGF.), Yana karewa da kuma dawo da lalacewar kwakwalwa da ƙwayoyin jijiya, don haka yana hana raguwar hankali (asarar ƙwaƙwalwa, wahalar koyo, da sauransu) saboda tsufa, bugun jini ko rikicewar neurodegenerative, kuma yana inganta rigakafi da maganin antioxidant ayyuka, da kariya daga cututtukan zuciya da kuma abubuwan da suka faru na cututtukan zuciya.

- PQQ yana hana damuwa

PQQ yana ba da kariya mai kariya ta antioxidant, yana kare sel a cikin jiki daga lalacewar iskar shaka da lalata abubuwa masu illa. Yana tallafawa metabolism na makamashi da tsufa lafiya, kuma sunyi la'akari da sabon cofactor tare da antioxidant da bitamin-kamar ayyukan.

Bayan haka, PQQ yana iya kasancewa yana da hana kulawa da lalata hanta da aikin maganin cututtukan mahaifa.

Aikace-aikacen / amfanin Quinone na Pyrroloquinoline(PQQ)

A cikin wani bincike na 2009 da aka buga a cikin mujallar likita game da Kayan Abinci, an nuna Pyrroloquinoline Quinone yana da ikon taimakawa kare. Ana amfani dashi don kula da raguwar hankali (asarar ƙwaƙwalwa, wahalar ilmantarwa, da sauransu) saboda tsufa, bugun jini ko rikicewar neurodegenerative, da kariya daga cututtukan zuciya da abubuwan da suka faru na zuciya. An bayar da rahoton irin wannan sakamakon a cikin binciken bin diddigin 2011 wanda aka ba da Pyrroloquinoline Quinone kai tsaye a matsayin karin abinci, irin su abubuwan sha na maye gurbin madara.

 

Yadda ake isa Quinone na Pyrroloquinoline(PQQ)?

A rayuwa, zaka iya samun PQQ daga wasu masu jin dadin abinci, a dabi'ance yana cikin abinci da abin sha iri daban-daban, gami da barkono kore, faski, shayi ko kiwifruit da sauransu. Amma, idan aka kirga yawan abincin da mutum yake ci a kowace rana, yawancin daga cikinmu ba za mu iya samun isasshen PQQ daga abincinmu na yau da kullun ba. Sabili da haka, idan kuna son ƙarin fa'idodi mafi girma, kuna iya samun ƙarin PQQ ta wasu hanyoyin, kamar ƙarin abincin abincin PQQ.

 

reference:

  • Lambatu, Kelsey (12 Fabrairu 2017). "Antioxidant na Halitta na iya hana Ciwon Hanta". msn.com. An dawo da 14 Fabrairu 2017.
  • Ameyama M, Matsushita K, Shinagawa E, Hayashi M, Adachi O (1988). "Quinone na Pyrroloquinoline: hurawar ta methylotrophs da kuma haɓakar haɓakar ƙwayoyin cuta". Halittu 1 (1): 51-3. PMID 2855583.
  • Felton LM, Anthony C (2005). "Biochemistry: rawar PQQ a matsayin mai samar da enzyme mai shayarwa?". Yanayi. 433 (7025): E10, tattaunawa E11–2. Doi: 10.1038 / yanayi03322. PMID 15689995.
  • Westerling J, Frank J, Duine JA (1979). "Theungiyar karuwancin methanol dehydrogenase daga Hyphomicrobium X: shaidar karba-karba ta lantarki don tsarin ƙirar". Kamfanin Biochem Biophys Res Comm. 87 (3): 719-24. Doi: 10.1016 / 0006-291X (79) 92018-7. PMID 222269.
  • Matsutani M, Yakushi T. Pyrroloquinoline quinone-dogara dehydrogenases na kwayoyin acid.Pl Microbiol Biotechnol. 2018 Nuwamba; 102 (22): 9531-9540. doi: 10.1007 / s00253-018-9360-3. Epub 2018 Sep 15. PMID: 30218379.