J-147 foda (1146963-51-0) bidiyo
J-147 foda (1146963-51-0) Ƙididdiga
| Product Name | J-147 foda |
| nufin abu ɗaya ne | J147; j 147; N- (2,4-Dimethylphenyl) -2,2,2-trifluoro-N'-[(E)-(3-methoxyphenyl) methylene] acetohydrazide |
| CAS Number | 1146963-51-0 |
| Drug Class | Babu bayanai akwai |
| InChI key | HYMZAYGFKNNHDN-SSDVNMTOSA-N |
| Smile | CC1=CC(=C(C=C1)N(C(=O)C(F)(F)F)N=CC2=CC(=CC=C2)OC)C |
| kwayoyin Formula | C18H17F3N2O2 |
| kwayoyin Weight | 350.341 g / mol |
| Monoisotopic Mass | 350.124 g / mol |
| Ƙaddamarwa Point | Babu bayanai akwai |
| tafasar Point | Babu bayanai akwai |
| Eiyakance rabin-rai | Babu bayanai akwai |
| Launi | White zuwa kashe-farin foda |
| solubility | DMSO (> 30 mg / ml) ko EtOH (> 30 mg / ml) |
| Syawan zafin rana | firiji |
| Aikace-aikace | gwaji magani tare da rahotannin sakamako akan cutar Alzheimer da tsufa a cikin ƙirar linzamin kwamfuta na saurin tsufa |
J-147 Bayani
J-147 foda ya kasance a cikin 2011 a Cibiyar Nazarin Neurobiology na Cellular na Cibiyar Salk. Tun lokacin da aka fara shi, an yi nazari da yawa waɗanda suka tabbatar da ingancinsa wajen magance cutar Alzheimer da kuma juyar da tsarin tsufa.
Dokta Dave Schubert tare da abokan aikinsa masu bincike a Cibiyar Salk sun ya taka muhimmiyar rawa a cikin nazarin J-147 curcumin. A cikin 2018, likitocin neurobiologists sun buɗe J-147 tsarin aikin na nootropic da rawar da yake takawa wajen kula da cututtuka na neurodegenerative.
Nazarin da bincike na wannan magani sun ta'allaka ne akan mahimmancinsa a cikin kula da yanayin cutar Alzheimer. Koyaya, masu amfani da lafiya sun kasance suna sha'awar fa'idodin J-147 kamar haɓaka ƙwaƙwalwar ajiya, haɓaka ƙarfin koyo, da haɓakar ƙwayoyin cuta.
A cikin 2019, masana harhada magunguna sun yunkuro don yin gwaji tare da maganin J-147 na Alzheimer a kan mutane.
Menene Nootropic J-147 Foda?
J-147 foda ya samo daga curcumin da Cyclohexyl-Bisphenol A. The magungunan ƙwayoyi yana da duka abubuwan neuroprotective da abubuwan neurogenic. Ba kamar yawancin nootropics ba, J-147 kariyar tsufa yana haɓaka haɓaka ba tare da shafar acetylcholine ko enzymes na phosphodiesterase ba.
Curcumin yana aiki ne da ƙwayar turmeric kuma yana da amfani wajen kula da cututtukan neurodegenerative. Koyaya, wannan polyphenol baya tsallake shingen ƙwaƙwalwar jini da inganci. Sakamakon haka, J-147 nootropic ya zama babban yanki yayin da yake ketare shingen kwakwalwar jini da sauki.
Ta yaya J-147 ke aiki?
Har zuwa 2018, tasirin J-147 akan kwayar halitta ya kasance abin ban mamaki har sai Salk Institute Neurobiologists sun yanke hukuncin wuyar warwarewa. Magungunan yana aiki ta hanyar haɗuwa da ATP synthase. Wannan furotin na mitochondrial yana daidaita samar da kuzarin salula, saboda haka, yana sarrafa tsarin tsufa.
Kasancewa da ƙarin J-147 a cikin tsarin ɗan adam yana hana ƙwayoyin cuta masu alaƙa da shekaru waɗanda ke haifar da rashin aiki mitochondria da haɓakar ƙari na ATP.
Tsarin aiki na J-147 kuma zai haɓaka matakan ƙwayoyin jijiya daban-daban ciki har da NGF da BDNF. Bayan haka, yana aiki akan matakan beta-amyloid, waɗanda koyaushe suna da girma a tsakanin marasa lafiya da Alzheimers da dementia.
Sakamakon J-147 ya haɗa da rage jinkirin ci gaban Alzheimer, hana ƙarancin ƙwaƙwalwar ajiya, da haɓaka samar da ƙwayoyin neuronal.
Fa'idodin Fa'idar J-147
Yana Inganta Haɓakawa
J-147 kari yana haɓaka sararin samaniya da ƙwaƙwalwar ajiyar dogon lokaci. Magungunan miyagun ƙwayoyi suna canza lahani na hankali tsakanin tsofaffi waɗanda ke fama da rashin lahani. J-147 don siyarwa ana samun sa azaman kanshin kanti ne kuma samari suna ɗaukar shi don haɓaka ƙarfin koyo.
Saukewa: J-147 magungunan rigakafin tsufa Hakanan zai haɓaka ƙwaƙwalwar ajiya, hangen nesa, da tsabtar tunani.
Gudanar da Cutar Alzheimer
J-147 yana amfanar da marasa lafiya da cutar Alzheimer ta hanyar rage ci gaban yanayin. Misali, shan kari yana rage matakan beta-amyloid (Aβ) mai narkewa, wanda ke haifar da rashin aiki. Bayan haka, J-147 curcumin yana canza siginar neurotrophin don tabbatar da rayuwar neuronal, sabili da haka, ƙirƙirar ƙwaƙwalwar ajiya da cognition.
Marasa lafiya tare da AD suna da ƙananan abubuwan neurotrophic. Koyaya, shan ƙarin J-147 na Alzheimer yana haɓaka duka NGF da BDNF. Waɗannan ƙananan ƙwayoyin cuta suna taimaka wa ƙwaƙwalwar ajiya, koyo, da ayyukan fahimi.
neuroprotection
J-147 nootropic yana hana mutuwar neuronal wanda ke faruwa saboda damuwa na oxidative.
Hakanan wannan ƙarin yana toshe ƙimar karɓar masu karɓar NMDA (N-Methyl-D-aspartate), wanda ke da alhakin neurodegeneration.
Shan magani J-147 zai kara abubuwan da ke haifar da kwakwalwa (BDNF) da abubuwan ci gaban jijiyoyi (NGF). Waɗannan ƙananan ƙwayoyin jijiyoyin suna kori ƙananan cututtukan neurodegenerative kamar Alzheimer da lalata. Menene ƙari, BDNF yana da mahimmanci a cikin neurogenesis.
Inganta aikin Mitochondrial
Shan magungunan J-147 zai inganta matakan ATP kai tsaye ta hanyar haɓaka ayyukan mitochondrial.
Tsufa yana da alhakin raguwar mitochondria saboda rashin aiki da karuwa a cikin nau'in iskar oxygen mai amsawa. Duk da haka, ƙarin J-147 yana fama da wannan tsarin ta hanyar hana ATP5A synthase. Nazari marasa adadi sun ƙidaya maganin don tsawaita rayuwar ɗan adam.
J-147 da Anti-tsufa
A cewar Salk Researchers, J-147 kariyar tsufa yana sa ƙwayoyin tsufa su bayyana matasa.
Dysfunctional mitochondria yana hanzarta tsarin tsufa. Gidajen tafiye-tafiye na salon salula zai rage, saboda haka, raguwa a cikin aikin ilimin lissafi. Bayan haka, lalacewar kwayar halitta da lalacewar mitochondrial za su biyo baya saboda samar da ROS (nau'in oxygen mai amsa sigina). Shan foda J-147 zai magance wannan tasirin, sabili da haka, rage jinkirin tsufa.
Hakanan ana danganta tsufa da raguwar fahimi da cututtukan neurodegenerative. Duk da haka, da yawa abubuwan da suka shafi J-147 sun tabbatar da ingancin miyagun ƙwayoyi a cikin mayar da asarar ƙwaƙwalwar ajiya, inganta haɓaka iyawar fahimta, da kuma magance cutar dementia, Alzheimer's, da sauran cututtuka masu alaka da shekaru.
Matsakaicin Tsarin J-147
(1) Yawan shan kashi
Matsakaicin J-147 na yau da kullun yana tsakanin 5mg da 30mg. Kuna iya raba adadin J-147 zuwa biyu. Zai fi dacewa, adadin ku yakamata ya kasance akan ƙananan kewayon kuma haɓaka shi gwargwadon juriyar jikin ku.
Wannan ƙarin yana aiki da baki. Ya kamata ka guji shan shi daga baya da yamma ko da daddare saboda wasu ra'ayoyin J-147 sun bayyana cewa zai iya rikitar da yanayin barcin ka.
(2) Yawan haƙuri
Masu bincike sun yi amfani da 10mg/kg na J-147 sashi don magance cutar Alzheimer cuta a cikin ƙirar linzamin kwamfuta
Koyaya, yawan ku yakamata ya dogara da yanayinku. Auka, misali, idan kai ne bayan haɓaka haɓakar ka, ya kamata ka tabbatar ka ɗauki 5mg zuwa 15mg. Ba tare da bata lokaci ba, don kariya ta jijiyoyin jiki da kuma kula da cututtukan da suka shafi jijiyoyin jiki, zaka iya fadada maganin zuwa kusan 20mg da 30mg.
A cikin gwaje-gwajen asibiti na J-147, batutuwa za su ɗauki kashi nan da nan bayan azumin sa'o'i 8 na dare.
Bambanci tsakanin J-147 da T-006
T-006 ya samo asali ne na J-147 nootropic. An tsara mahaɗin ta maye gurbin rukunin methoxyphenyl na J-147 foda foda tare da tetramethylpyrazine.
Ƙarawa tare da T-006 na kusan watanni uku zai rage hazo na kwakwalwa da haɓaka ƙarfin gaba ɗaya. Menene ƙari, foda yana ƙara jin daɗin magana kuma yana sa mai amfani ya nutsu. Sabanin haka, abubuwan J-147 sun haɗa da ingantaccen ƙwaƙwalwar ajiya, gani, da wari.
Duk da waɗannan ƙananan bambance-bambance, abubuwan haɗin guda biyu suna da sakamako iri ɗaya.
Shin J-147 lafiyayye yayin amfani?
J-147 magani lafiyayye ne. Ya sami nasarar wuce gwajin toxicology a cikin gwajin dabba kamar yadda Hukumar Abinci da Magunguna ta buƙata (FDA). Bayan wannan, gwajin gwajin asibiti na J-147 an fara shi na wani lokaci.
Babu wani bayanan da ke nuna illar J-147 a cikin gwaji na yau da kullun da na ɗan adam.
J-147 gwaji na asibiti
Sashin farko na gwajin gwaji na J-147 ya fara a farkon 2019 kamar yadda Abrexa Pharmaceuticals, Inc. ke tallafawa.Shirin binciken shine ya auna aminci da juriya na ɗaukar nootropic, da kayan aikin sa na magani a cikin batutuwa masu lafiya.
Nazarin na asibiti ya shafi yara da tsofaffi. Researchungiyar bincike ta kasance bazuwar, makafi biyu, da kuma sarrafa wuribo tare da allurai masu zuwa guda ɗaya.
A ƙarshen gwajin ɗan adam, masana kimiyya za su kafa sakamakon da ya dogara da sakamako mara kyau, bugun zuciya da bugun jini, sauye-sauyen jiki, da fa'idodin J-147 akan tsarin jijiyoyin jini.
Binciken mai amfani / abubuwan gogewa bayan amfani da J-147
Ga wasu daga cikin bayanan J-147;
Capybara din yana cewa;
“...Akwai kuma iya jin yawan kuzari a farkon. Ba maganin kafeyin ko nau'in makamashi na amphetamine ba, amma ƙarin makamashi na halitta. Na ji daɗin wannan lokaci tun da na sami damar yin tunani game da yin wani abu kamar hawan keke, sannan na yi ba tare da wata shakka ba ko kuma in shawo kan kaina don farawa. Ƙarfafa kaina ya kasance ba ko da yaushe. Wannan ya ɓace bayan ƴan makonni, kuma yayin da nake jin daɗin wannan jin, wasu na iya ƙi, don haka ina lissafta wannan azaman yuwuwar. gefen tasiri."
F5fireworks yana cewa;
“Ya zama kamar mai ban sha'awa da kuma bege nootropic. A bayyane yake akwai binciken asibiti a Amurka a bara. ”
Wani mai amfani yana cewa;
“Yayi, na samu jiya kuma na sha 10mg na allurai 3 tuni. Na dauke shi da sauki kuma ya narke sosai. Bata dandana dadi ba. Nan da nan sakamako ya fara da sauri a gare ni. Gani da tunanina sun zama kamar sun kara haske ko ta yaya, amma zai iya zama wuribo ne kawai. Da alama ba shi da wani mummunan tasiri kwata-kwata, amma lokaci ya yi da za a faɗi… Na ji komai lafiya kuma na sami ƙarfi a yini duka tare da wani 10 MG da safe da misalin karfe 6 na safe. ”
Fafner55 yana cewa;
"Na ci gaba da ɗaukar J147 ba tare da wata fa'ida ba in ban da rage kumburi da kumburi da aka ambata a baya."
J-147 foda manufacturer - A ina za mu iya saya J-147 foda?
Halaccin wannan nootropic har yanzu ƙashi ne na jayayya amma ba zai hana ku samun halaltattun samfuran ba. Bayan haka, J-147 na gwajin asibiti na Alzheimer yana gudana. Kuna iya siyan foda a cikin shagunan kan layi yayin da kuke samun dama don kwatanta farashin J-147 a tsakanin masu siyarwa daban-daban. Koyaya, yakamata ku tabbatar kun siyayya daga ingantattun masu kaya tare da gwajin dakin gwaje-gwaje masu zaman kansu.
Idan kuna son wasu J-147 don siyarwa, shiga tare da kamfaninmu. Muna ba da nootropics da yawa a ƙarƙashin kulawar inganci. Kuna iya siya da yawa ko yin sayayya guda ɗaya dangane da burin ku na tunani. Da fatan za a tuna cewa farashin J-147 yana da abokantaka ne kawai lokacin da kuka siya a cikin siyarwa.
References
- Lapchak, AP, Bombien, R., da Rajput, SP (2013). J-147 a Novel Hydrazide Lead Compound don Magance Neurodegeneration: CeetoxTM Tsaro da Nazarin Halittu. Jaridar Neurology da Neurophysiology.
- Kafin, M., et al. (2013). Tungiyar Neurotrophic J147 Ta Sauya Rashin Lafiya a Mice Alzheimer na Cutar Mice. Alzheimer ta Bincike & Far.
- Magungunan Alzheimer ya juya baya agogo a cikin ƙarfin ƙwayar ƙwayoyin halitta. Cibiyar Salk.Janairu 8, 2018.
- Qi, Chen., Da sauransu. (2011). Littafin Neurotrophic na Novel don Ingantaccen haɓakawa da Cutar Alzheimer. Makarantar Kimiyya ta Jama'a.
- Daugherty, DJ, et al. (2017). Wani Littafin Cucumin wanda aka kirkira don Maganin Ciwon Neuropathy.
- Lejing, Lian., et al. (2018). Tasirin Anti-Depressant-kamar na Novel Curcumin Deivative J147: Shigar 5-HT1A Neuropharmacology.
