N-Acetyl-L-cysteine ​​ethyl ester (NACET) (59587-09-6)

Maris 11, 2020

NACET (N-Acetylcysteine ​​ethyl ester) wani sabon littafi ne mai kwayar lipophilic-permeable cysteine ​​tare da wani abu mai ban sha'awa na pharmacokinetic da remarkable ..

 


Status: A Mass Production
Naúra: 25kg / Drum

 

N-Acetyl-L-cysteine ​​ethyl ester (NACET) (59587-09-6) bidiyo

NACET (59587-09-6) Bayani

Product Name NACET (59587-09-6)
Chemical Name R) -ethyl 2-acetamido-3-mercaptopropanoate;
L-Cysteine, N-acetyl-, etyl ester;
N-ACETYL-L-CYSTEINE ETHYL ESTER;
ethyl (2R) -2-acetamido-3-sulfanylpropanoate;
L-Cysteine, N-acetyl-, etyl ester;
N-Acetylcysteine ​​ethylester;
CAS Number 59587-09-6
InChIKey MSMRAGNKRYVTCX-LURJTMIESA-N
Smile CCOC (= O) C (CS) NC (= O) C
kwayoyin Formula C7H13NO3S
kwayoyin Weight 191.25
Monoisotopic Mass 191.061614 g / mol
Ƙaddamarwa Point 44.1-44.5 ° C
tafasar Point  337.6 ± 32.0 ° C (Tsinkaya)
yawa 1.138 ± 0.06 g / cm3 (Tsinkaya)
Launi Kusa da fari
Aikace-aikace Nootropics da ƙwaƙwalwar ƙwaƙwalwa, ana iya amfani dasu don haɓaka ƙwaƙwalwa, mayar da hankali, kerawa, hankali da motsawa. Hakanan za'a iya amfani dashi azaman karin abinci.

 

Mene ne NACET(N-Acetylcysteine ​​ethyl ester)?

NACET (N-Acetylcysteine ​​ethyl ester) wani sabon abu ne na kwayar lipophilic wanda zai iya cysteine ​​tare da wani abu mai ban sha'awa na pharmacokinetic da kuma karfin antioxidant mai ban mamaki. NACET tana da kwayar halittar jiki ta baka. Yana da ƙarfin antioxidant da wadataccen tsarin GSH, wanda ke da alaƙa da acid ɗin sa na kyauta N-acetyl -L ya bambanta da -cysteine ​​(NAC). NACET farin foda ne a dakin da zafin jiki kuma ana iya narkewa cikin ruwa da abubuwan kara kuzari.

NAC asali ne na cysteine. Tun daga shekarun 1970, ana amfani da shi don kula da marasa lafiya tare da maganin hana ƙwayoyin cuta na acetaminophen da raunin jijiyoyin jiki, kuma ana tallata shi azaman magani da ƙari na abinci. Idan aka kwatanta da NAC, NACET yana da mafi yawan lipophilicity da ingantattun kayan magunguna. Yana da damar maye gurbin NAC na pharmacological, a matsayin wakili na mucolytic, antioxidant, mai ba da kyautar GSH, paracetamol antidote, kuma aƙalla Donor na mai ba da jijiyoyin H 2 S da wakilin kariya na UV.

Bugu da kari, karfi mai karfin halitta da rage karfin NACET shima an tabbatar dashi a cikin jinin jinin dan adam. An samo shi don tarawa cikin ƙwayoyin jinin ɗan adam, ta yadda zai iya yin tsayayya da lalacewar sanadarin da hydroperoxides ke haifarwa. Sabili da haka, damar NACET a matsayin antioxidant da ke haifar da anti-nitrite ta fi ta NAC methemoglobinemia da sauran ƙarfi oxidants ƙarfi. Karatuttukan beraye sun gano cewa NACET ya fi saurin nutsuwa fiye da NAC lokacin da ake yin NACET da baki. Yana iya shiga cikin ƙwayoyin halitta da samar da NAC da cysteine, wanda ke haɓaka hydrogen sulfide (H (2) S) a cikin zagayawa. Kyakkyawan ɗan takara ne don amfani da baka a matsayin mai samar da H (2) S,

 

Fa'idodin NACET (N-Acetylcysteine ​​ethyl ester)

A matsayin mai amfani da maganin antioxidant, NACET yana da fa'idodi masu yawa akan lafiyar ɗan adam.

- Inganta yanayin kiwon lafiya da yawa da kuma taimakawa alamomin rashin tabin hankali;

- Maganin yawan kwayar cutar acetaminophen, kariya ta koda da hanta;

- Inganta aikin huhu ta hanyar rage kumburi da fasa majina, ta hakan yana saukaka cututtukan da suka shafi numfashi.

- Inganta lafiyar kwakwalwa ta hanyar sanya kwayar alkama da kuma kara yawan abinci, ana iya amfani dasu don magance cututtuka kamar su cutar Alzheimer da ta Parkinson;

- Inganta haihuwa ga maza da mata

- Na iya inganta aikin rigakafi a cikin cututtuka da yawa, hana lalacewar iska ga zuciya, da rage haɗarin kamuwa da cututtukan zuciya.

- Zai Iya Tabbatar da Sugar Jini Ta Hanyar Rage Kumburi a Cikin Kwayoyin Fat

 

Kayan aikin NAECT (N-Acetylcysteine ​​ethyl ester)

Saboda NACET ya nuna babban sakamako akan cutar tabin hankali, cututtukan numfashi na yau da kullun da rashin tabin hankali, galibi ana amfani dashi azaman magani da ƙarin abinci don kare ƙwaƙwalwa, haɓaka aikin tunani da na jiki, don haɓaka ƙwaƙwalwa, sani da wasan motsa jiki.

 

reference:

  • Giustarini D, Milzani A, Dalle-Donne I, Tsikas D, Rossi R. N-Acetylcysteine ​​ethyl ester (NACET): wani abu mai ma'ana na cysteine ​​cell-permeable cysteine ​​wanda aka saba dashi tare da sifofin magunguna na yau da kullun wanda ba a san shi ba da kuma damar da ta shahara. Pharmacol na Biochem. 2012 Dec 1; 84 (11): 1522-33. doi: 10.1016 / j.bcp.2012.09.010. Epub 2012 Sep 20. PMID: 23000913.
  • S-Nitroso-N-acetyl-L-cysteine ​​ethyl ester (SNACET) da kuma N-acetyl-L-cysteine ​​ethyl ester (NACET) -Cisanin magungunan masu amfani da magunguna tare da bayanan bayanan magunguna na musamman don amfani da baki kamar KO, H2S da masu siyarwar GSH da azaman antioxidants: Sakamako da dubawa. 2018 Feb; 8 (1): 1-9. doi: 10.1016 / j.jpha.2017.12.003. Epub 2017 Dec 13. Bita. PMID: 29568662
  • N-acetylcysteine ​​ethyl ester a matsayin GSH mai haɓakawa a cikin ƙwayoyin endothelial na ɗan adam: Nazarin kwatancen tare da wasu kwayoyi. 2018 Oct; 126: 202-209. doi: 10.1016 / j.freeradbiomed.2018.08.013. Epub 2018 Aug 14. PMID: 30114478.
  • DimitriosTsikasa, Kathrin S.Schwedhelma, Andrzej Surdackib, Daniela Giustarinic, Ranieri Rossid, Lea Kukoc-Modune, George Kediaf, Stefan Ückertf. S-Nitroso-N-acetyl-L-cysteine ​​ethyl ester (SNACET) da kuma N-acetyl-L-cysteine ​​ethyl ester (NACET) –Wannan yan takarar magungunan likitanci tare da bayanan bayanan magunguna na musamman don amfani da baki kamar KO, H2S da GSH masu sayarwa da azaman antioxidants: Sakamako da dubawa. Jaridar Nazarin Magunguna. Juz'i na 8, fitowa ta 1, Fabrairu 2018, Shafuka 1-9.