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NADP gishirin gishiri (24292-60-2)

Nicotinamide adenine dinucleotide phosphate (NADP +) wani cofactor ne wanda aka yi amfani dashi a cikin halayen anabolic. -Nicotinamide adenine ……


Status: A Mass Production
Naúra: 25kg / Drum

description

Nic-Nicotinamide adenine dinocleotide phosphate disodium salt (NADP gishirin gishiri) Sfasali

Product Name Nic-Nicotinamide adenine dinucleotide phosphate gishiri disodium (NADP gishirin gishiri)
Chemical Name NADP Disodium; Nadide phosphate disodium; NADP; β-NADP; Triphosphopyridine nucleotide disodium gishiri;
CAS Number 24292-60-2
InChIKey UNRRSQIQTVFDLS-WUEGHLCSSA-L
Smile C1=CC(=C[N+](=C1)C2C(C(C(O2)COP(=O)([O-])OP(=O)(O)OCC3C(C(C(O3)N4C=NC5=C(N=CN=C54)N)OP(=O)([O-])[O-])O)O)O)C(=O)N.[Na+].[Na+]
kwayoyin Formula C21H26N7Na2O17P3
kwayoyin Weight 787.37
Monoisotopic Mass 787.039342 g / mol
Ƙaddamarwa Point 175-178 ° C
Launi Yellow
Syawan zafin rana -20 ° C
Water solubility > 50 g / L
Aikace-aikace Coenzyme a cikin aerobic da anaerobic oxidations

Menene β-Nicotinamide adenine dinucleotide phosphate gishiri disodium (NADP disodium salt)?

Nicotinamide adenine dinucleotide phosphate (NADP +) wani cofactor ne wanda aka yi amfani dashi a cikin halayen anabolic. salt-Nicotinamide adenine dinucleotide phosphate disodium gishiri ne mai disodium na NADP +, coenzyme wajibi ne don gubar glucose da narkewar oxidative na wasu abubuwa. Kuma yana faruwa sosai a cikin ƙwayoyin rai, musamman hanta.

Nicotinamide adenine dinucleotide phosphate (NADP) da NADPH sun samar da nau'i biyu na redox. Matsakaicin NADPH / NADP yana daidaita yiwuwar farfadowa na intracellular, musamman ma amsawar anaerobic, ta yadda yake shafar martani na jiki. Misalai sun hada da sinadarin lipid da nucleic acid. NADP kuma shine coenzyme biyu a cikin tsarin cytochrome P450 daban-daban da tsarin tsarin oxidase / reductase kamar tsarin thioredoxin reductase / thioredoxin.

NADPH yana samar da rage daidaituwa don halayen biosynthetic kuma yana ba da tasirin redox don hana haɗarin nau'in ƙwayar oxygen mai motsa jiki (ROS), ta haka ya sake haifar da glutathione (GSH). Hakanan ana amfani dashi a cikin hanyoyin anabolic kamar su cholesterol synthesis da kitse mai haɓaka Chain.

Bugu da ƙari, tsarin NADPH shi ma yana da alhakin haifar da tsattsauran ra'ayi a cikin ƙwayoyin rigakafi ta hanyar NADPH oxidase. Ana amfani da waɗannan 'yan tsattsauran ra'ayi kyauta don lalata ƙwayoyin cuta a cikin wani tsari da ake kira fashewar numfashi. Yana da raguwa daidai da tushen aromatics cytochrome P450 hydroxylated aromatics, steroids, giya, da kwayoyi.

Aikace-aikace na Nic-Nicotinamide adenine dinucleotide phosphate disodium gishiri

Nicotinamide adenine dinucleotide phosphate (NADP) da NADPH sun samar da nau'i biyu na redox. NADP / NADPH shine coenzyme wanda ke goyan bayan halayen redox ta hanyar jigilar wutan lantarki a cikin aikace-aikace masu yawa, musamman halayen anaerobic kamar su lipid da nucleic acid synthesis. NADP / NADPH ma'aurata ne na coenzyme a cikin nau'ikan tsarin P450 na cytochrome da tsarin tsarin oxidase / reductase, kamar tsarin thioredoxin reductase / thioredoxin.

Sauran enzymes waɗanda ke amfani da NADP azaman coenzyme sune: Althol dehydrogenase: NADP dogara; Aromatic ADH: NADP dogara; Ferredoxin-NADP reductase; L-Fucose dehydrogenase; Gabase; Galactose-1-phosphate uridyl watsa shi; Glucose dehydrogenase; L-Glutamic dehydrogenase; Glycerol dehydrogenase: takamaiman NADP; Isocitric dehydrogenase; Enzymes na Malic; 5,10-Methylenetetrahydrofolate dehydrogenase; 6-Phosphogluconate dehydrogenase da Succinic semialdehyde dehydrogenase.

reference:

  • Hashida SN, Kawai-Yamada M. Inter-Organelle NAD Metabolism Yana nuna Haskakawa NADP mai tsauri a cikin Tsire-tsire. Front Shuka Sci. 2019 Jul 26; 10: 960. doi: 10.3389 / fpls.2019.00960. eCollection 2019. PMID: 31404160. PMCID: PMC6676473.
  • Tak U, Vlach J, Garza-Garcia A, William D, Danilchanka O, de Carvalho LPS, Saad JS, Niederweis M. Maganin cutar tarin fuka shine NAD + da NADP + glycohydrolase tare da keɓaɓɓen enzymatic Properties.J Biol Chem. 2019 Mar 1; 294 (9): 3024-3036. doi: 10.1074 / jbc.RA118.005832. Epub 2018 Dec 28. PMID: 30593509. PMCID: PMC6398120.
  • Liang J, Huang H, Wang S. Rarraba, Juyin Halitta, Hanyar Katolika, da Ayyukan Jiki na Flavin-based Electron-Bifurcating NADH-Matsakaicin Rage Ferredoxin: NADP + Oxidoreductase. Microbiol na gaba. 2019 Mar 1; 10: 373. doi: 10.3389 / fmicb.2019.00373. eCollection 2019. PMID: 30881354. PMCID: PMC6405883.
  • Kawai S, Murata K. "Tsarin aiki da aikin NAD kinase da phosphatase NADP: maɓallin enzymes waɗanda ke daidaita daidaituwar ƙwaƙwalwar ƙwayoyin ciki na NAD (H) da NADP (H)". Halittu, Ilimin Lantarki, da kuma Biochemistry. 72 (4): 919-30. doi: 10.1271 / bbb.70738. PMID 18391451.
  • Hanukoglu I. "Tsarewar Maɓuɓɓugan Ilimin Enzyme-Coenzyme a FAD da NADP na haɓaka Adrenodoxin Rage-Abun Enzyme mai biari". Jaridar Juyin Halitta. 85 (5-6): 205-218. Bibcode: 2017JMolE..85..205H. doi: 10.1007 / s00239-017-9821-9.PMID 29177972.

BATSA DA TATTAUNAWA:

Ana Samun Wannan Abubuwan ne Don Amfani da Bincike Kawai. Sharuɗɗan Siyarwa suna Aiwatarwa. Ba don Amfani da Dan Adam bane, ko Likita, dabbobi, ko Amfani na Gida.


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