NADP gishiri mai narkewa (24292-60-2) bidiyo
Nic-Nicotinamide adenine dinocleotide phosphate disodium salt (NADP gishirin gishiri) Sfasali
| Product Name | Nic-Nicotinamide adenine dinucleotide phosphate gishiri disodium (NADP gishirin gishiri) |
| Chemical Name | NADP disodium; nadide phosphate disodium; NADP;β-NADP; Triphosphopyridine nucleotide disodium gishiri; |
| CAS Number | 24292-60-2 |
| InChIKey | UNRRSQIQTVFDLS-WUEGHLCSSA-L |
| Smile | C1=CC(=C[N+](=C1)C2C(C(C(O2)COP(=O)([O-])OP(=O)(O)OCC3C(C(C(O3)N4C=NC5=C(N=CN=C54)N)OP(=O)([O-])[O-])O)O)O)C(=O)N.[Na+].[Na+] |
| kwayoyin Formula | C21H26N7Na2O17P3 |
| kwayoyin Weight | 787.37 |
| Monoisotopic Mass | 787.039342 g / mol |
| Ƙaddamarwa Point | 175-178 ° C |
| Launi | Yellow |
| Syawan zafin rana | -20 ° C |
| Water solubility | > 50 g / L |
| Aikace-aikace | Coenzyme a cikin aerobic da anaerobic oxidations |
Menene β-Nicotinamide adenine dinucleotide phosphate gishiri disodium (NADP disodium salt)?
Nicotinamide adenin dinucleotide phosphate (NADP +) cofactor ne da ake amfani dashi a cikin halayen anabolic. β-Nicotinamide adenine dinucleotide phosphate disodium gishiri shine disodium gishiri na NADP +, shine coenzyme da ake buƙata don haɓakar barasa na glucose da oxidative dehydrogenation na wasu abubuwa. Kuma yana faruwa sosai a cikin nama mai rai, musamman a cikin hanta.
Nicotinamide adenine dinucleotide phosphate (NADP) da NADPH sun samar da nau'i biyu na redox. Matsakaicin NADPH / NADP yana daidaita yiwuwar farfadowa na intracellular, musamman ma amsawar anaerobic, ta yadda yake shafar martani na jiki. Misalai sun hada da sinadarin lipid da nucleic acid. NADP kuma shine coenzyme biyu a cikin tsarin cytochrome P450 daban-daban da tsarin tsarin oxidase / reductase kamar tsarin thioredoxin reductase / thioredoxin.
NADPH yana ba da raguwa daidai da halayen biosynthetic kuma yana ba da tasirin redox don hana gubar nau'in oxygen mai aiki (ROS), ta haka yana sake haɓaka glutathione (GSH). Hakanan ana amfani dashi a cikin hanyoyin anabolic kamar haɓakar cholesterol da fatty acid Tsawaita sarkar.
Bugu da ƙari, tsarin NADPH shi ma yana da alhakin haifar da tsattsauran ra'ayi a cikin ƙwayoyin rigakafi ta hanyar NADPH oxidase. Ana amfani da waɗannan 'yan tsattsauran ra'ayi kyauta don lalata ƙwayoyin cuta a cikin wani tsari da ake kira fashewar numfashi. Yana da raguwa daidai da tushen aromatics cytochrome P450 hydroxylated aromatics, steroids, giya, da kwayoyi.
Aikace-aikace na Nic-Nicotinamide adenine dinucleotide phosphate disodium gishiri
Nicotinamide adenine dinucleotide phosphate (NADP) da NADPH sun samar da nau'i biyu na redox. NADP / NADPH shine coenzyme wanda ke goyan bayan halayen redox ta hanyar jigilar wutan lantarki a cikin aikace-aikace masu yawa, musamman halayen anaerobic kamar su lipid da nucleic acid synthesis. NADP / NADPH ma'aurata ne na coenzyme a cikin nau'ikan tsarin P450 na cytochrome da tsarin tsarin oxidase / reductase, kamar tsarin thioredoxin reductase / thioredoxin.
Sauran enzymes waɗanda ke amfani da NADP azaman coenzyme sune: Althol dehydrogenase: NADP dogara; Aromatic ADH: NADP dogara; Ferredoxin-NADP reductase; L-Fucose dehydrogenase; Gabase; Galactose-1-phosphate uridyl watsa shi; Glucose dehydrogenase; L-Glutamic dehydrogenase; Glycerol dehydrogenase: takamaiman NADP; Isocitric dehydrogenase; Enzymes na Malic; 5,10-Methylenetetrahydrofolate dehydrogenase; 6-Phosphogluconate dehydrogenase da Succinic semialdehyde dehydrogenase.
reference:
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- Tak U, Vlach J, Garza-Garcia A, William D, Danilchanka O, de Carvalho LPS, Saad JS, Niederweis M. Maganin cutar tarin fuka shine NAD + da NADP + glycohydrolase tare da keɓaɓɓen enzymatic Properties.J Biol Chem. 2019 Mar 1; 294 (9): 3024-3036. doi: 10.1074 / jbc.RA118.005832. Epub 2018 Dec 28. PMID: 30593509. PMCID: PMC6398120.
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- Hanukoglu I. "Adana hanyoyin Enzyme-Coenzyme a cikin FAD da NADP Binding Adrenodoxin Reductase-A Ubiquitous Enzyme". Jaridar Juyin Halitta. 85 (5-6): 205–218. Bibcode: 2017JMolE..85..205H. Doi: 10.1007 / s00239-017-9821-9.PMID 29177972.
