Oleoylethanolamide (OEA) (111-58-0)

Maris 11, 2020

Oleoylethanolamide (OEA) sigar haɓaka peroxisome ne mai saurin haɓaka mai haɓaka alpha (PPAR-alpha) agonist. Yana da wani …… ..

 


Status: A Mass Production
Naúra: 25kg / Drum

 

Bidiyon Oleoylethanolamide (OEA) (111-58-0)

Bayanin Bayani na Oleoylethanolamide (OEA) (111-58-0)

 

Product Name Oleoylethanolamide (OEA) foda
Chemical Name n-oleoylethanolamine; N- (2-Hydroxyethyl) oleamide; Oleylethanolamide;

N-oleoyl ethanolamine; Oleamide MEA; Oleoyl monoethanolamide;

Oleoyl Ethanolamide;

CAS Number 111-58-0
InChIKey BOWVQLFMWHZBEF-KTKRTIGZSA-N
Smile CCCCCCCCC = CCCCCCCCC (= O) NCCO
kwayoyin Formula C20H39NO2
kwayoyin Weight 325.5 g / mol
Monoisotopic Mass 325.537 g · mol-1
Ƙaddamarwa Point 59 – 60 ° C (138 – 140 ° F; 332 – 333 K)
tafasar Point 496.4 ± 38.0 ° C (Tsinkaya)
yawa 0.915 ± 0.06 g / cm3 (Tsinkaya)
Launi Farin foda
Syawan zafin rana -20 ° C
Solution a cikin ethanol da DMSO Soluble
Aikace-aikace Filin wasan motsa jiki; kari;

 

Overview

Oleoylethanolamide (OEA) ko N-Oleoylethanolamide (OEA) wani kwayar halitta ce da aka samar a jiki, yawanci ana samun ta a cikin hanji. Evidencearin tabbaci yana ba da shawarar cewa OEA na iya aiki azaman abin da ke haifar da ƙwaƙwalwar ƙwaƙwalwar ƙwaƙwalwar ƙwayar cuta kuma ya shiga cikin ikon halayen da ke da alaƙa da sakamako. Hakanan, an bayyana shi azaman wakili mai rikitarwa wanda ke rage yawan cin abinci da yawan nauyin jiki.

 

Menene Oleoylethanolamide (OEA)?

Oleoylethanolamide (OEA) sigar haɓaka peroxisome ne mai saurin haɓaka mai haɓaka alpha (PPAR-alpha) agonist. Abun glycolamide ne na dabi'a wanda yake da nau'ikan kayan kwalliyar gida kamar su sarrafa abinci, aikin anti-kumburi, kara kuzari na lipolysis da kuma kitsewar mai. Oleoylethanolamide ana iya ɗaukarsa azaman hormone na kwakwalwar hanjin hanji. Oatmeal, nuts, da koko foda sune manyan kayan abinci na Oleoylethanolamide a cikin abinci. Koyaya, adadin Oleoylethanolamide da aka samo a cikin waɗannan abincin yayi ƙaranci (ƙasa da 2 µg / g).

A matsayin matsakaici mai tsayi na halitta, ana samar da oleylethanolamide (OEA) a cikin hanji da sauran kyallen takarda, kuma yana shiga cikin daidaita ma'aunin makamashi na mammalian, yana daidaita tsarin abinci da abinci mai gina jiki, kamar zai iya tsara abincin Vertebrate da nauyin jiki. Oleoylethanolamide shine mai acid ethanolamide (FAE), analogidted analog na endocannabinoid arachidonic acid ethanolamide (anandamide), da kuma aikin antagonist na anandamide. Yana da mahimmanci a lura cewa Oleoylethanolamide ya bambanta da anandamide, yana da 'yanci daga mai karɓar cannabinoid, kuma yana ɗaukar aikin aikinsa ta hanyar wasu hanyoyi, yana tsara ayyukan PPAR-α don tayar da lipolysis. Oleoylethanolamide shine mai yuwuwar kuma amintaccen magani mai kiba mai maye wanda ke maye gurbin maganin antagonism na CB1.

Karatuttukan bincike na farko sun nuna cewa Oleoylethanolamide shima ingantaccen maganin rigakafin jiki ne da kwayar halittar jiki wanda yake haifar da tasirin sakamako a cikin maye. Gudanarwa na Oleoylethanolamide zai iya hana maganin TLR4 mai rikice-rikice na rikice-rikice na kashin kansa, ta haka rage ƙaddamar da cytokines na proinflammatory da chemokines, oxidative da nitrosative stress, kuma a ƙarshe yana hana lalacewar jijiya a cikin kwalliya na jijiyoyin ƙwayoyin cuta.

 

Tushen Oleoylethanolamide (OEA)

Akwai hanyoyi guda biyu na samun Oleoylethanolamide (OEA), ɗayan ya fito ne daga tsire-tsire na halitta, ɗayan kuma ta hanyar haɗin kawai yake cikin Lab.

Achyranthes Aspera, asalinsa asalin Indiya ne, China da kuma wasu ƙasashe na Asiya, ana cewa yana ɗauke da Oleoylethanolamide OEA. Matsalar Oleoylethanolamide na dabi'un halitta shine cewa ana samun fitowar rabo kawai, 15: 1 sanannen shahararren bayani ne, kuma bashi da ƙarfi kamar yadda kwastomomi ko manufacturersan masana'antun ke tsammani. Tabbas, zai iya zama mafi girma, amma farashin zai kasance mai girma sosai, saboda haka ba shi da amfani don ƙirƙirar Oleoylethanolamide na OEA a cikin girma.

Babban tushen Oleoylethanolamide an haɗa shi ne daga oleic acid, ana aiki dashi azaman N-oleoyl-phosphatidylethanolamine, wanda N-acyl-phosphatidylethanolamine-zaɓe na fosholipase D (PLD) don sakin OleoylethanoA.

Oleoylethanolamide wani sinadari ne na otal acid. Sabili da haka, abinci yana wadatar da tushen acidic shine asalin kai tsaye na OEA.

 

Yaya Oleoylethanolamide (OEA) yake aiki?

A cikin mutane masu kiba, OEA na iya tsara ƙarfin homeostasis da ci gaba musamman ta kunnawa masu karɓar daban-daban da suka haɗa da karɓar karɓa-karɓa mai karɓa-P (PPAR-α), mai karɓar G-protein-mai haɗuwa 119 (GPR119) da mai karɓa mai jigilar yiwuwar tashar cation tashar subfamily V (TRPV1). Tabbas, OEA tana kunna waɗannan masu karɓar kuma tana jinkirta farawar abinci, rage girman abincin, rage takura tsakanin abinci kuma a ƙarshe yana daidaita nauyin jiki.

Bugu da ƙari, wasu nazarin gwaji sun nuna cewa OEA kuma yana hana maganganun IL-6, interleukin-8 (IL-8), kwayoyin adhesion molecule-1 (ICAM-1) da kwayar adhesion cell na jijiyoyin-1 (VCAM-1) a cikin TNF -α haifar da kumburi a cikin jijiyoyin jikin dan adam endothelial ta hanyar kunna masu karban kumburi. OEA kuma ya hana hanyar nukiliya hanyar kappa-B (NF-kB) cikin jiki. A cikin binciken YT et al, OEA (50 µmol / L) ya hana bayanin TNF-α ya haifar da VCAM-1 a cikin HUVEC.

 

Fa'idodin Oleoylethanolamide (OEA)

Oleoylethanolamide (OEA) foda yana da kyau don rasa nauyi azaman mai sarrafa abinci kuma yana tallafawa matakan lafiya na manya a cikin manya.

 

Oleoylethanolamide (OEA) azaman mai neman afuwa

Rage yawan ci kuma don haka rage cin abinci hanya ce mai kyau don magance daidaituwar kuzari da nauyin jikin mutum. Tunda damuwar ci abinci babban maki ne na sarrafa abinci (abinci), sarrafa abinci yana da mahimmanci wajen sarrafa nauyin jikin mutum lafiya, musamman idan aka hada shi da zabin yanayin rayuwar da ya shafi kiwon lafiya wanda ya hada da hankalin mutane game da yadda ya kamata, abinci, da kuma motsa jiki.

Oleoylethanolamide kari yana taimakawa wajen daidaita karfin lipid, yana taimakawa wajen sarrafa yunwar ta hanyar tura sakonni masu son ci gaba ga kwakwalwa kuma an nuna cewa zai taimaka rage yawan triglyceride da matakan cholesterol na jini.

 

Oleoylethanolamide don sarrafa mai mai

OEA shine ingantacciyar hanyar da ake sarrafa abubuwan ci da kashe kuzari.

Sakamakon OEA an fara nazarin shi saboda yana tarayya da kamanceceniya da wani sinadarai, cannabinoid da aka sani da anandamide. Cannabinoids suna da alaƙa da shuka Cannabis, kuma anandamides waɗanda ke cikin shuka (da marijuana) na iya haɓaka sha'awar mutum game da abun ciye-ciye ta hanyar haifar da amsa abinci. Dangane da Wikipedia, Oleoylethanolamide shine analogamide na endocannabinoid. Kodayake OEA yana da tsarin sunadarai wanda yayi kama da anandamide, tasirinsa akan abinci da sarrafa nauyi sun sha bamban. Ba kamar anandamide ba, OEA tana aiki da kansa ba tare da hanyar cannabinoid ba, yana daidaita ayyukan PPAR-α don haɓakar lipolysis.

 

Oleoylethanolamide mai gina jiki

Kowa yana neman lafiya ta hanyar gina jiki a cikin dakin motsa jiki. OEA yana ƙara zama sananne ga masu motsa jiki. A cikin filayen abinci na gina jiki, TTA (tetradecylthioacetic acid) ana amfani dashi sau da yawa tare da oleoylethanolamide (OEA), dukansu kuma suna taimakawa ƙone mai da rage yunwar. Hakanan TTA na iya kasancewa mai ban sha'awa sosai a tsakanin abinci mai ƙoshin mai, saboda ya bayyana yana ƙona kitse mai zaman kansa daga motsa jiki; Sakamakon farko ya nuna jikin yana nuna “cire” kitse daga kanta a maimakon buƙatar ƙone shi da aikin jiki.

Oleoylethanolamide (OEA) yana rage triglycerides da cholesterol, kuma, haɗe tare da antagonist na cannabinoid, yana toshe nauyin jikin mutum da inganta dyslipidaemia a cikin ƙirar dabbobi masu kiba.

Bugu da kari, an samo tsarin gudanarwar tinoylethanolamide don canza glucose homeostasis, haka kuma duka sakin insulin da siginar insulin a duka hepatocytes da adipocytes.

Wasu sake sakewa sun nuna cewa kari na oleoylethanolamide yana da sakamako mai kyau akan damuwa, kuma ana bukatar karin hanyoyi da shaidu don tallafawa.

 

Yadda ake amfani da Oleoylethanolamide OEA

 

Osakamako masu illa na yau da kullun

Oleoylethanolamide OEA ya kasance sabon sabo ne ga kasuwar ƙari, kuma ba a sami mummunan sakamako masu illa ba. Hukumar Abinci da Magunguna ta Amurka (FDA) ba ta da wata damuwa game da amincin OEA. A cikin rayuwar yau da kullun, oleoylethanolamide shine madadin madadin nauyi mai nauyi, wanda ake amfani dashi don tantance girman catabolism a cikin gastro-intestinal, yana taimakawa rage kitse ba tare da cutarwa ba da mummunar illa.

 

Osyeda_abubakar sashi

Babu wani shawarar da aka bayar da shawarar jama'a a fili don oleoylethanolamide tunda abubuwan da ake amfani da shi na omeoylethanolamide har yanzu basu shahara kuma a farkon matakin. RiduZone shine farkon OEA foda wanda aka kirkira a cikin 2015.

Samun shawarar oleoylethanolamide shine mai kwalliya guda 200mg lokacin da aka dauki shi ba tare da haɗuwa ba

Bincike ya nuna cewa Hakanan zaka iya rage ko kara yawan abincin rana gwargwadon girmanka.

100mg ga mutum 150lb

145mg ga mutum 200lb

180mg ga mutum 250lb

 

Aikace-aikacen Oleoylethanolamide (OEA)

Oleoylethanolamide foda yayi amfani da shi a cikin kari na Kiwan lafiya, wanda aka yi cikin kwalliyar kwalliya ko kwamfutar hannu don asarar nauyi.

 

reference:

  • Gaetani S, Oveisi F, Piomelli D (2003). "Canjin yanayin cin abinci a cikin bera ta mai sashin matsakaici mai matsakaicin matsakaici mai sarkakiya oleoylethanolamine". Neuropsychopharmacology. 28 (7): 1311-6. Doi: 10.1038 / sj.npp.1300166. PMID 12700681.

 

  • Lo Verme J, Gaetani S, Fu J, Oveisi F, Burton K, Piomelli D (2005). "Dokar cin abinci ta oleoylethanolamine". Kwayar halitta Mol. Life Sci. 62 (6): 708-16. Doi: 10.1007 / s00018-004-4494-0. PMID 15770421.

 

  • Giuseppe Astarita; Bryan C. Rourke; Johnnie B. Andersen; Jin Fu; Janet H. Kim; Albert F. Bennett; James W. Hicks & Daniele Piomelli (2005-12-22). "Para yawan aiki na oleoylethanolamine a cikin karamin hanji na tseren Burmese (Python molurus)". Am J Physiol Regul Haɗakar Comp Physiol. 290 (5): R1407 – R1412. Doi: 10.1152 / ajpregu.00664.2005. PMID 16373434.

 

  • Gaetani S, Kaye WH, Cuomo V, Piomelli D (Satumba 2008). "Matsayi na endocannabinoids da analogs ɗin su cikin kiba da rikicewar abinci". Ci Rashin nauyi. 13 (3): e42-8. PMID 19011363.

 

  • Serrano A, et al. Oleoylethanolamide: tasirin mai ɗaukar ƙwayar hypothalamic da kuma gut peptides suna sarrafa abinci. Neuropharmacology. (2011)