Ganglioside GT1b (59247-13-1)

Maris 15, 2020

Sunan Ganglioside wanda masanin kimiyyar nan na Jamus Ernst Klenk ya fara amfani da shi a shekarar 1942 zuwa wani sabon ruwan da aka ware daga kwayoyin ganglion kwakwalwa… ..

 


Status: A Mass Production
Naúra: 25kg / Drum

 

Bidiyo na Ganglioside GT1b (59247-13-1)

Ganglioside GT1b Sfasali

Product Name Ganglioside GT1b
Chemical Name GANGLIOSIDE GT1B TRISODIUM GASKIYA; GT1B 3NA; GT1B-GANGLIOSIDE; GT1B (NH4 + SALT); ƙungiya, gt1; (ganglioside gt1B) daga kwakwalwar bovine; trisialoganglioside-gt1b daga kwakwalwar bovine; GANGLIOSIDEGT1BTRISODIUMSALT, BOVINEBRAIN; Trisialoganglioside GT1b (NH4 + gishiri)
CAS Number 59247-13-1
InChIKey SDFCIPGOAFIMPG-VLTFPFDUSA-N
kwayoyin Formula C95H162N5Na3O47
kwayoyin Weight 2158.4 g / mol
Monoisotopic Mass 2157.119189 g / mol
Ƙaddamarwa Point N / A
Syawan zafin rana -20 ° C
solubility DMSO: mai narkewa
Aikace-aikace Magunguna; ilimin halittar jini;

 

Mene ne Ganglioside GT1b?

Sunan Ganglioside ya kasance masanin kimiyyar Jamusanci Ernst Klenk ya fara amfani da shi a cikin 1942 zuwa sabon ruwan da aka ware daga kwayoyin ganglion na kwakwalwa. Kwayar halitta ce wacce ta kunshi glycosphingolipids (ceramides da oligosaccharides) da daya ko fiye sialic acid da ke da nasaba da sarkar sukari. Yana da haɗin membrane na cytoplasmic wanda ke daidaita abubuwan canza siginar salula. Fiye da nau'ikan 60 na gangliosides sanannu ne, kuma babban banbanci tsakanin su shine matsayi da lambar ragowar NANA.

Ganglioside GT1b yana ɗayan ƙungiyoyi masu yawa kuma yana da ƙananan ƙungiyoyi tare da ragowar sialic acid guda biyu waɗanda ke da alaƙa da rukunin galactose na ciki. Yana da tasiri mai hanawa game da amsawar rigakafi ta jiki. A 0.1-10 μM, zai iya dakatar da samar da IgG, IgM da IgA ba tare da ɓata lokaci ba ta jikin kwayoyin halitta na mononuclear. An kuma samar da Ganglioside GT1b a matsayin mai karɓar ƙwayoyin ƙwayoyin cuta don ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar kaakakim a cikin kwayar cutar ta Merkel ah.

Ganglioside GT1b shima yana tasiri a cikin cututtukan da yawa a cikin kansa kuma ana ɗaukarsa a matsayin ƙungiya mai haɗari da ke haɗuwa da ƙwayoyin kwakwalwa. Nazarin sun gano cewa GM1, GD1a, da GT1b suna da tasirin sakamako akan siginar mai karɓar ƙwayar epidermal da kuma ƙaura da ƙaura keratinocytes, kuma kasancewar su na iya zama mai mahimmancin kayan tarihi don kimanta yiwuwar ƙwaƙwalwar kwakwalwa.

Ganglioside GT1b kuma yana shafar tsarin garkuwar jiki. Ganglioside GT1b yana da tasirin hanawa a jikin mutum game da ba da amsar rigakafinsa kuma yana hana immunoglobulins da ƙwayoyin halittar jikin mutum ke samarwa. Akwai shaidar cewa GD1b, GT1b, da GQ1b na iya haɓaka samar da cytokines na Th1 ta hanyar hana aikin adenylate cyclase, yayin hana samar da Th2.

A matsayin mai karɓar mai karɓar abubuwa daban-daban na tsarin oligosaccharide, ganglioside GT1b shine mai karɓa ta hanyar Clostridium botulinum kwayoyin botulinum neurotoxin shiga cikin ƙwayoyin jijiya. Nazarin ya nuna cewa tetanus toxin ya shiga cikin ƙwayoyin jijiya ta hanyar haɗuwa da GT1b da sauran ƙwayoyin gangliosides, yana hana sakin neurotransmitters a cikin tsarin juyayi na tsakiya, kuma yana haifar da cututtukan ƙwayar cuta. Nau'in botulinum C neurotoxin da ke shiga cikin jijiya ya bincika yiwuwar tasirin apoptotic na sel waɗanda ƙwayoyin ganglioside GT1b suka haifar akan neuroblastoma.

Bugu da ƙari, ganglioside GT1b ya ba da mummunar daidaita motsi na sel, watsawa, da manne wa fibronectin (FN) ta hanyar hulɗar kwayoyin kai tsaye tare da the5 subunit na α5β1 integrin, binciken da za a iya amfani da shi don haɓaka hanyoyin kwantar da hankali. Haɗin GT1b da MAG a saman farji na neurons na iya daidaita tsarin hulɗar da GT1b a cikin ƙwayoyin plasma na neurons, wanda ke haifar da hana ci gaban ƙwayoyin neurite.

 

Fa'idodin Ganglioside GT1b

Ganglioside GT1b shine glycosphingolipid na acidic wanda ke samar da tasoshin lipid a cikin ƙwayoyin jijiyoyi na tsakiya kuma yana shiga yaduwar sel, rarrabuwa, mamayewa, yaduwar sigina, hulɗar sel zuwa sel, tumorigenesis, da metastasis.

Amsoshi na autoimmune ga gangliosides na iya haifar da cutar Guillain-Barre. Ganglioside GT1b yana haifar da lalacewar ƙwayoyin cuta, wanda zai iya taimakawa wajen farawa ko ci gaban cutar ta Parkinson.

Ganglioside GT1b shine mai tunkarar radadin radadin OH, wanda ke kare kwakwalwa daga lalacewar mtDNA, tashin-hankali da kuma tsinkayar lipid wanda ya haifar da matattarar oxygen.

Cutar kumburin Ehrlich tana bayyana ganglioside GT1b, kuma anti-GT1b yana da babbar damar warkewar wannan cutar. Wannan ganglioside shima yana da alaƙa da cutar Miller Fisher.

 

Hanyoyi na ciki Ganglioside GT1b

Gangliosides na iya ɗaure wa lectins, aiki azaman rigakafi da masu karɓa na cell, shiga cikin siginar tantanin halitta, ƙwayar carcinogenesis da bambancin tantanin halitta, shafar haɓakar ƙwayar cuta da haɓaka jijiya, shiga cikin myelin kwanciyar hankali da farfadowa na jijiya, kuma suna aiki azaman ƙwayoyin cuta da kuma shiga mai guba na gubobi cikin sel .

Tarin tarin ƙwayoyin ganglioside GT1b an alakanta shi da wasu cututtuka da suka haɗa da cutar Thai-Sachs da cutar Sandhof.

Ganglioside GT1b yana hana antigen ko amsar yaduwar kwayar T wanda aka samu a cikin kwayar kuma an gano shi a matsayin mai karɓar maganin toxin botulinum, toxin da ba kasafai ake samu ba tare da sakamako mai tsanani na ilimin lissafi.

Ganglioside GT1b ya kasance kusan kusan a cikin ƙwayoyin jijiyoyi kuma an bayyana shi akan haɗuwa. GT1b yana haɓaka bambancin neuronal da ƙirƙirar dendritic, wanda ke haifar da halayyar ɗabi'a da haɓaka haɓakar haɓaka da allodynia.

Ganglioside GT1b na iya shafar tsarin garkuwar jiki. Yana da tasiri mai tasiri akan tasirin rashin lafiyar jikin mutum kuma yana hana rigakafin immunoglobulin wanda ƙwayoyin mononuclear jini na jikin mutum ke samarwa.

A cikin ƙari, Ganglioside GT1b yana da dangantaka da cututtuka masu zuwa: mura, guillain-garré syndrome, kwalara, tetanus, botulism, kuturta da kiba.

 

reference:

  • Erickson, KD, Garcea, RL, da Tsai, B. Ganglioside GT1b mai karɓar rakiyar garkuwa ce ta ƙwayar cuta ta Merkel cell polyomavirus. Journal of Virology 83 (19), 10275-10279 (2009).
  • Kanda, N., da Tamaki, K. Ganglioside GT1b suna hana samarwar immunoglobulin ta hanyar kwayoyin mononuclear na mutum. Immunology 96 (4), 628-633 (1999).
  • Schengrund, C.-L., DasGupta, BR, da Ringler, NJ Bindingin botulinum da neurotoxins na tetanus zuwa ga ganglioside GT1b da kuma abubuwan da suka samo asali. J. Neurochem. 57 (3), 1024-1032 (1991).
  • Gangliosides, tsari, abin da ya faru, ilmin halitta da bincike ”. Laburaren Lipid Americanungiyar 'Yan Chemists ta Amurka. An adana daga asali a kan 2009-12-17.
  • Nicole Gaude, Journal of Kwayoyin halitta, Vol. 279: 33 p. 34624-34630, 2004.
  • Elizabeth R Sturgill, Kazuhiro Aoki, Pablo HH Lopez, da dai sauransu. Biosynthesis na manyan kwakwalwar gangliosides GD1a da GT1b. Glycobiology, Volume 22, Fitowa ta 10, Oktoba 2012, Shafuka 1289–