Tsarin gishiri sodium Tianeptine (30123-17-2)

Oktoba

Tianeptine sodium salt powder wani fili ne mai tricyclic, shine mai gudanar da zabe na 5-HT (serotonin; sc-201146) a cikin vitro….


Status: A Mass Production
Naúra: 25kg / Drum
Capacity: 1290kg / watan

Tsarin gishiri sodium Tianeptine (30123-17-2)

 

Tsarin gishiri sodium Tianeptine (30123-17-2) Bayani

Product Name Rane Tianeptine sodium gishiri
Chemical Name Tianeptine sodium; Tianeptine gishiri sodium; 30123-17-2; Stablon; Coaxil;
Brand Name N / A
Drug Class N / A
CAS Number 30123-17-2
InChIKey HNTRDGDHBBFLPG-UHFFFAOYSA-M
kwayoyin FƘararraki C21H24ClN2NaO4S
kwayoyin Wtakwas 458.93
Monoisotopic Mass 458.104 g / mol
Gyarawa Point  1800C
Tafasayin Point 609.2 ° C a 760 mmHg
Half Half-Life N / A
Launi White zuwa kashe-farin foda
Solubility  DMSO: ≥20mg / mL
Storage Taikin zafi  Saduwa a RT
Aaikace-aikace Tianeptine sodium gishiri mai yalwa ne gishiri na Tianeptine.

Tianeptine ne antidepressant.

 

Tsarin gishiri sodium Tianeptine (30123-17-2)

Tumin sodium Tianeptine shine gishiri na Tianeptine. Tianeptine, mai tricyclic fili, mai gudanarwa na 5-HT (serotonin, sc-201146) ya ci gaba a cikin vitro da in vivo. Bugu da ƙari, an kwatanta Tianeptine a matsayin mai hana mai yin zabi na dopamine kuma yana kama da amineptine. Tianeptine ba shi da tasiri mai mahimmanci a kan hanyar binamine. A cikin wani binciken da ake amfani da synaptosomes mai tsabta daga kwakwalwar kwakwalwa, an ruwaito Tianeptine don bunkasa ci gaban serotonin a cikin yankuna masu kwakwalwa. An samo synaptosomes mai tsabta daga ratsi kuma an hada su tare da 5-HT da Tianeptine na tritium-labeled in vitro. An kuma gwada synaptosomes don ganowa da saki 5-HT ta hanyar rubutun scintillation na ruwa.

Tsarin gishiri sodium tarin Tianeptine shine mai maganin antidepressant tare da ayyuka daban-daban, mafi mahimmanci akan tsarin glutamatergic.Ya kawo karshen suturar glutamate da gyaran aikin mai karɓa na AMPA.Tianeptine ma yana aiki a matsayin agonist na mai karɓar μ-opioid (EC50s = 194 da 641 nM don masu karɓar ragamar ɗan adam da linzamin kwamfuta, bi da bi). Yana da tasiri sosai kamar yadda ake amfani da kwayar cutar ta fluoxetine a cikin kulawar rashin lafiya na matsanancin damuwa.

Gishirin sodium na Tianeptine yana da ƙwarewar nootropic dangane da mutanen da rikice-rikicen yanayi ke shafar tasirinsu na rashin tasiri kuma yana da ikon haɓaka haɓaka da mai da hankali ga mutanen da ke da ƙarancin kulawa.

Tianeptine sodium salt powder (30123-17-2) Hanyar Action

Binciken da aka yi kwanan nan ya nuna cewa ayyuka masu tsauraran ra'ayi a matsayin cikakkun agonist ne a mai karfin radiyo na opioid (MOR). Tianeptine ya kalubalanci batun maganganun da ake ciki na mutum guda daya, da kuma hanyoyin da aka kwantar da su wanda ya taimaka wajen aiwatar da ayyukan da aka fi sani da magunguna. Musamman, anyi amfani da wannan miyagun ƙwayoyi don cigaba da sauya karɓar mai karɓa na karuwa na hippocampal CA3 haɗin gwiwa. Binciken na yau da kullum yana nuna cewa tsine-tsine yana samar da sakamakon maganin antidepressant ta hanyar gyaran ayyukan haɓaka na glutamate (alal misali, masu karɓa na AMPA da masu karɓa na NMDA) kuma suna shafar sakin ƙwaƙwalwar ƙwayar neurotrophic (BDNF), wadda ke tasiri ga filayen ƙananan ruba. Binciken na baya-bayan nan ta hanyar goyon baya da nauyin tsinkaye a cikin yanayin da ake amfani da shi a cikin amygdala, yankin da ke cikin kwakwalwa yana hade da tunanin.

Tianeptine rage karfin hypothalamic-pituitary-adrenal zuwa damuwa, kuma ta haka yana hana matsalolin halayyar halayya. A cikin rodents, damuwa na rikitarwa mai zurfi yana ƙaruwa matakai na glutamate a cikin amygdala basolateral da tasiri wanda aka hana shi ta kareneptine. Abin sha'awa shine, cutar ta SSRI fluoxetine ta kara yawan matakan da ake yi a cikin amygdala ba tare da yanayin damuwa ba. Wadannan bayanan sun nuna cewa tsarin aiwatar da aikin tsararrakin ya bambanta daga SSRI kuma ya goyi bayan tsammanin cewa tsarin aikin dabbar na tsaneptine ke danganta da canje-canje na aikin gine-gine a amygdala da hippocampus.

Bugu da ƙari da abubuwan da ke sama, dianeptine na da magungunan magunguna da magungunan jin dadi wanda ke ƙarfafa maganin serotonin (5-hydroxytryptamine; 5-HT), da 5-hydroxyindoleacetic acid (5-HIAA) a cikin kwakwalwa.

Kodayake ana iya tabbatar da cewa kwayoyin siginar nero (5-HT) na kwayoyin halitta, noradrenaline (NA) da dopamine (DA) sun kasance sun danganta da abin da ke faruwa na cututtuka na nakasa, yanzu an gane cewa rashin daidaito guda ɗaya bai isa ba don bayyana tsarin aikin antidepressant magunguna.

amfanin of Furotin sodium na Tianeptine (30123-17-2)

  • Tsarin sodium Tianeptine zai iya magance matsalar rashin tausayi.
  • Gishirin sodium na Tianeptine yana da anti-tashin hankali da antidepressant da kuma halayen nootropic.
  • Tsarin sodium Tianeptine yana inganta yanayin da inganta halin mutum.
  • Tsarin sodium Tianeptine zai iya hana rikici daga abin da ke faruwa.
  • Tsarin sodium Tianeptine ya jiyar da ciwon da ke da alaka da fibromyalgia.
  • Gishirin sodium na Tianeptine wanda aka yi amfani dashi don maganin rashin damuwa a cikin maza tare da dysfunction.
  • Tsunin sodium Tianeptine yana da tasiri sosai ga ADHD.
  • Tsarin sodium Tianeptine yana inganta neuroplasticity.

Nagari Tianeptine sodium salt powder (30123-17-2) Dosage

Tsaneptine Sodium yana da ɗan gajeren rabi a kusan 2.5 hours14, kuma yana buƙatar biyu a cikin kwanakin rana. Sashin sodium na tsaneptine ita ce 12.5 MG dauki sau uku a kowace rana, domin yawancin 37.5mg kowace rana.

Kada ku wuce 50mg na Tsaneptine Sodium a rana ɗaya. Yin haka zai iya bude ƙofar don karin ci gaba da cin zarafi.

Side effects na Tianeptine sodium salt powder (30123-17-2)

Tianeptine sodium salt salt yana hulɗa da yawancin ɓangarorin kwakwalwa gami da masu karɓar opiod, wanda zai iya haifar da tasirin euphoria. Sauran cututtukan illa tare da sauye-sauye iri-iri sun haɗa da masu zuwa:

 Ciwon kai (har zuwa 18%)

 Dizziness (har zuwa 10%)

 Duka tsoro / dare (har zuwa 20%)

 Rawanci (har zuwa 10%)

 Dry baki (har zuwa 20%)

Sauran illolin sun hada da abubuwa kamar maƙarƙashiya, jiri, tashin hankali ko Ciwan hanta. Severearin damuwa mafi tsanani sun haɗa da janyewa bayan cin zarafi kuma kimanin 0.1 - 0.3% na masu amfani zasu sami wannan matsalar. Ta yaya koyaushe, kamar yadda kuke gani, illolin gishirin sodium na Tianeptine zasu dogara ne akan mutum da kuma ilimin kimiyyar ɗan adam.

Ya kamata mu lura cewa:

Mazan tsofaffi ya kamata su dauki ƙaramin kwayar cutar saline na Tumneptine, kamar yadda ya kamata marasa lafiya tare da raunin gaji. Yankewa bazai buƙatar gyarawa a marasa lafiya da cututtukan shan barasa ko rashin lafiya ba, ko marasa lafiya a kan dialysis .A yayin da Antidepressants, kamar dianeptine, ya kara yawan hadarin hanta.