Kayan kwakwalwan ƙwayoyin cuta na Sodium (GM1) (37758-47-7)

Bari 28, 2019

GM1 foda an yadu amfani dashi don magance raunin hypoxic-ischemic kwakwalwa rauni, cutar Parkinson… ..

 


Status: A Mass Production
Synthesized da Musamman Akwai
Capacity: 1277kg / watan

 

Ƙwallon ƙarancin ƙwayoyin Sodium (GM1) (37758-47-7) bidiyo

 

Sugar kwakwalwa na Sodium (GM1) kwakwalwa (37758-47-7)

Monosialotetrahexosylganglioside Sodium (GM1) kwakwalwar kwakwalwa (37758-47-7), gajeren sunan na iya zama GM1, wanda aka ciro daga kwakwalwar alade kuma memba ne na jerin ganglio na gangliosides wanda ke dauke da ragowar sialic acid guda daya.

GMl zai iya inganta farfadowa na aikin neuro bayan da raunin da ke tattare da magungunan yanayin da ke tattare da abubuwa masu yawa, yana inganta neuroplasticity. Gwaje-gwaje na nuna ciwo na GMl na kwakwalwa, kwakwalwa na kwakwalwa don mayar da kwayoyin tausayi a cikin rauni na kashin baya yana da tasiri mai karewa da inganta tasirin tantanin halitta.

Mataki na farko na gwaji na gwaji ya nuna, zai iya rage neurotoxicity na oxaliplatin (OIN). Amma ba a samo asali ta samfurin III ba. Ana buƙatar gwaji na zamani na uku don bincika tasirin da lafiyar lafiyar monosialotetrahexosylganglioside Ciwon maganin Sodium don rigakafin YIN a ciwon daji.

Sugar kwakwalwa na Sodium (GM1) (37758-47-7) Specifications

Product Name Alamar kwakwalwa ta ƙwayoyin Sodium (GM1)
Chemical Name Monosialotetrahexosylganglioside Sodium (Kwakwalwar kwakwalwa)

Ko GM1

jerin /
Brand Name Shenjie
Drug Class Sphingolipids
CAS Number 37758-47-7
InChIKey GTTLZSUWCRJZRC-CRQBLQEMSA-N
kwayoyin FƘararraki C73H134N4O31
kwayoyin Wtakwas 1563.85
Monoisotopic Mass 1563.85
Gyarawa Point  N / A
Half Half-Life /
Launi Kusar lyophilized mai tsabta
solubility  chloroform / methanol (9: 1): 10 mg / mL, bayyane, marar launi
Storage Taikin zafi  -20 ° C
Aaikace-aikace Masu karɓa na musamman don ƙwayar kwalara da ke tara a cikin kwakwalwa a cikin marigayi lipidosis babba.
Abubuwan gwaji A Tsarin Gida na gida
Character White ko farin foda; kadan smelly, m; rigar. Wannan samfurin yana mai narkewa a cikin ruwa, wanda aka narkar da shi sosai a methanol, kusan insoluble a cikin ethanol anhydrous.
Identification
Launi canzawa 1 Yi nazarin gwajin gwaji 0.2ml a karkashin ƙaddarar ƙin, ƙara 2ml na ruwa, sa'an nan kuma ƙara Hydroquinone hydrochloric acid bayani (hydroquinone 0.2g, ƙara 10ml da ruwa ta rushe, ƙara XKUMXml acid, ƙara 90mol / L Copper sulfate bayani 0.1ml, Ajiyayyen firiji) 0.25ml, ruwa wanka wanka don 2 minti, zane mai launin shuɗi da mulu, tare da barasa 15ml Binciken bidiyo, bane mai sanyi shine blue.
Launi canzawa 2 Ɗauki wannan samfurin game da 20mg, ƙara ruwan zafi mai zafi dumama 1ml, ruwan zafi mai zafi dumama da aka narkar da shi, ƙara 1 ruwa mai zurfin digiri mai yaduwa, a cikin ruwan wanka mai zafi tare da shinge mai suturta ya ƙara sulfuric acid 1ml, don haka bayani a cikin layuka biyu , ya kamata a yi launin ruwan kasa da ruwa-ƙira
Saltium gishiri Sakamakon ganewa da gishiri a cikin samfurin (samfurin 2015 na kasar Sin 0301 na kasar Sin).
Liquid chromatography (LC) A cikin zane-zane da aka rubuta a ƙarƙashin tabbacin ƙaddamarwa, lokacin riƙewa na babban mahimmancin gwajin gwajin ya kamata daidai da lokacin riƙewa na babban mahimmancin maganin sarrafawa.
Infrared spectroscopy Taswirar infrared haske ta wannan samfurin ya zama daidai da taswirar samfurin sarrafawa (Shafin 2015 na kasar Sin 0402 na kasar Sin).
Duba
PH 5.0 ~ 6.5
Clarity da launi na bayani Ya kamata a tsabtace launi; idan girgije ne, ba zai zama mafi girma fiye da ruwan sanyi na turbidity ba. 1th; Idan siffanta launi ya kamata ba zurfi fiye da bayani mai launi na YellowNet 1th.
Babban ƙaddamarwa Bayanin da ya gama ya kamata ya zama cikakke kuma a fili bayan babban zafin jiki, babu haske mai madara, babu hazo
Sensitizing factor (Furotin daban-daban) ≤50000
Total Sialic acid Bisa ga samfurin samfurin samfurori, ruwan da yake dauke da acid ya zama 19.0 ~ 21.0%
shafi abubuwa Sialic acid ≤0.3%; GD3, GD1a, ba a sani ba ne ≤ 0.5%; impurities da ≤2.0%
Protein ≤1.0%
Ƙananan nauyin ƙwayoyin kwayoyin ≤0.5%
Abubuwan da suka rage Methanol ≤ 0.1%; acetone ≤ 0.3%; Trichloromethane ≤0.003%
Water ≤4.0%
Ƙona saura ≤5.0%
Karfe ƙarfe ≤20ppm
Abubuwa masu guba Daidaita dokoki
Abubuwan da suka shafi antihypertensive Ya kamata daidai da sharuɗɗan (yawancin gwamnati)
Pyrogen Ya kamata daidai da sharuɗɗan (yawancin gwamnati)
Ƙafafen ƙwayoyi Adadin kwayoyin cutar aerobic ya kamata ya zama <100cfu / g, kuma yawan adadin kayan kwalliya da yisti ya zama <50cfu / g
Specific ≥98.0%

 

raw MONOSIALOTETRAHEXOSYLGANGLIOSIDE SODIUM (GM1)  foda (37758-47-7) Bayani

Sugar Sodium (37758-47-7) mai suna Monosialotetrahexosylganglioside (1-XNUMX-XNUMX), sunan ɗan gajeren na iya zama GMXNUMX, wanda aka samo daga kwakwalwar alade kuma yana mamba ne na jerin gangliosides wanda ya ƙunshi sialic acid.

GM1 na iya inganta dawo da aikin jijiyoyin jiki bayan rauni na tsarin jijiyoyin tsakiya na abubuwa da dama, inganta neuroplasticity. Gwaje-gwaje na nuna GM1 raunin ƙwaƙwalwar ƙwaƙwalwar ƙwaƙwalwar ƙwaƙwalwar ƙwaƙwalwar ƙwaƙwalwar ƙwaƙwalwar ƙwaƙwalwar ƙwaƙwalwar ƙwaƙwalwar ƙwaƙwalwar ƙwaƙwalwar ƙwaƙwalwar ƙwaƙwalwar ƙwaƙwalwar ƙwaƙwalwar ƙwaƙwalwar ƙwaƙwalwar ƙwaƙwalwar ƙwaƙwalwar ƙwaƙwalwar ƙwaƙwalwar ƙwaƙwalwar ƙwaƙwalwar ƙwaƙwalwar ƙwaƙwalwar ƙwaƙwalwar ƙwaƙwalwar ƙwaƙwalwar ƙwaƙwalwar ƙwaƙwalwar ƙwaƙwalwar ƙwaƙwalwar ƙwaƙwalwar ƙwaƙwalwar ƙwaƙwalwar ƙwaƙwalwar ƙwaƙwalwar ƙwaƙwalwar ƙwaƙwalwar ƙwaƙwalwar ƙwaƙwalwar ƙwaƙwalwar ƙwaƙwalwar ƙwaƙwalwar ƙwaƙwalwar ƙwaƙwalwar ƙwaƙwalwar ƙwaƙwalwar ƙwaƙwalwar ƙwaƙwalwar ƙwaƙwalwar ƙwaƙwalwar ƙwaƙwalwar ƙwaƙwalwar ƙwaƙwalwar ƙwaƙwalwar ƙwaƙwalwar ƙwaƙwalwar ƙwaƙwalwar ƙwaƙwalwar ƙwaƙwalwar ƙwaƙwalwar ƙwaƙwalwar ƙwaƙwalwar ƙwaƙwalwar ƙwaƙwalwar ƙwaƙwalwar ƙwaƙwalwar ƙwaƙwalwar ƙwaƙwalwar ƙwaƙwalwar ƙwaƙwalwar ƙwaƙwalwar ƙwaƙwalwar ƙwaƙwalwar ƙwaƙwalwar ƙwaƙwalwar ƙwaƙwalwar ƙwaƙwalwar ƙwaƙwalwar ƙwaƙwalwar ƙwaƙwalwar ƙwaƙwalwar ƙwaƙwalwar ƙwaƙwalwar ƙwaƙwalwar ƙwaƙwalwar ƙwaƙwalwar ƙwaƙwalwar ƙwaƙwalwar ƙwaƙwalwar ƙwaƙwalwar ƙwaƙwalwar ƙwaƙwalwar ƙwaƙwalwar ƙwaƙwalwar ƙwaƙwalwar ƙwaƙwalwar ƙwaƙwalwar ƙwaƙwalwar ƙwaƙwalwar ƙwaƙwalwar ƙwaƙwalwar ƙwaƙwalwar ƙwaƙwalwar ƙwaƙwalwar ƙwaƙwalwar ƙwaƙwalwar ƙwaƙwalwar ƙwaƙwalwar ƙwaƙwalwar ƙwaƙwalwar ƙwaƙwalwar ƙwaƙwalwar ƙwaƙwalwar ƙwaƙwalwar ƙwaƙwalwar ƙwaƙwalwar ƙwaƙwalwar ƙwaƙwalwar ƙwaƙwalwar ƙwaƙwalwar ƙwaƙwalwar GMXNUMX, ƙwaƙwalwar ƙwaƙwalwar ƙwaƙwalwar don mayar da ƙwayoyin jijiyoyin cikin rauni na kashin baya yana da tasirin kariya da haɓaka rawar kwayar halitta.

Mataki na farko na gwaji na gwaji ya nuna, zai iya rage neurotoxicity na oxaliplatin (OIN). Amma ba a samo asali ta samfurin III ba. Ana buƙatar gwaji na zamani na uku don bincika tasirin da lafiyar lafiyar monosialotetrahexosylganglioside Ciwon maganin Sodium don rigakafin YIN a ciwon daji.

MONOSIALOTETRAHEXOSYLGANGLIOSIDE SODIUM (GM1) foda (37758-47-7) Kayan aiki na ayyuka?

GM1 (monosialotetrahexosylganglioside) “samfurin” ganglioside, memba ne na jerin ganglio na gangliosides wanda ya ƙunshi saura sialic acid saura. GM1 yana da mahimmancin kimiyyar ilimin lissafi kuma yana tasiri tasirin filastik neuronal da gyaran hanyoyin, da sakin ƙwayoyin cuta a cikin kwakwalwa. Bayan aikinsa a cikin ilimin kimiyyar lissafi na kwakwalwa, GM1 ya kasance a matsayin shafin yanar gizon ɗaure duka cutar kwalara da E. coli mai saurin zafi-labile enterotoxin (gudawar matafiya)

amfanin of MONOSIALOTETRAHEXOSYLGANGLIOSIDE SODIUM (GM1)  foda (37758-47-7)

Ganglioside GM1 yana cikin membobin iyalin ganglioside wadda aka yi amfani da shi a kasashe da yawa kuma an yi la'akari da shi azaman magani mai mahimmanci don hana yawancin cututtuka na jiki, ciki har da cizon saurin ƙwayar cuta. Hanyoyin maganin cutar GM1 an tabbatar da su a cikin lalata da kuma tsofaffi masu biyo bayan lalacewar ƙwaƙwalwa.

Nagari MONOSIALOTETRAHEXOSYLGANGLIOSIDE SODIUM (GM1) foda (37758-47-7) Juyawa

An yi amfani da miyagun ƙwayoyi a kashi na 20-40 MG kowace rana ta hanyar intravenous ko sannu a hankali allurar intramuscular bisa ga shawarwarin likita. A cikin mummunan lokaci na canje-canje na cututtukan cututtuka: An yi amfani da kwayoyi a kashi na 100 MG kowace rana ta hanyar allurar hanji; Bayan makonni 2-3, yawanci kiyaye adadin 20-40 MG kowace rana har tsawon makonni shida, an fara amfani da kashi na farko na 500-1000 MG ta hanyar magudanar jini don cutar ta Parkinson; tun daga rana ta biyu, ana amfani da magani tare da kashi 200 na MG kowace rana ta hanyar subcutaneous, intramuscular allura ko intravenous drip na makonni 18 yawanci. lokacin da aka yi amfani da wannan maganin ta hanyar Subcutaneous ko intravenous allura, ya kamata a narkar da shi kuma a tsarma shi a cikin ruwa don allura har sai an samu 10 mg / ml a lokacin da; lokacin da aka zubar da kwayar, ba a son magani kuma aka tsarma shi cikin allurar sodium chloride ta 0.9% ko 5% allurar glucose.

Side effects of MONOSIALOTETRAHEXOSYLGANGLIOSIDE SODIUM (GM1) foda (37758-47-7)

Sakamakon sakamako na GM1 foda shi ne yafi raguwa bayan amfani.