7,8-dihydroxyflavone (38183-03-8) foda

7,8-DIHYDROXYFLAVONE (38183-03-8) Ƙididdiga

Product Name	7,8-dihydroxyflavone
Chemical Name	Tropoflavin; 7,8-dihydroxy-2-phenylchromen-4-daya;
nufin abu ɗaya ne	7,8-dihydroxy-2-phenyl-4H-chromen-4-daya; 7,8-dihydroxyflavone hydrate 7,8-DHF; 4H-1-Benzopyran-4-daya; 7,8-Dihydroxy-flavone; 7,8-Dihydroxy-2-phenyl-chromen-4-daya; 7,8-Dihydroxy-2-phenyl-4-benzopyrone;
CAS Number	38183-03-8
InChIKey	COCYGNDCWFKTMF-UHFFFAOYSA-N
Kwayoyin halitta FƘararraki	C15H10O4
Kwayoyin halitta Wtakwas	254.24
Monoisotopic Mass	254.05790880
Gyarawa ma'ana	243-246 ° C
tafasar batu	494.4 ± 45.0 ° C (Tsinkaya)
Launi	Yellow foda
Form	m
Solubility	DMSO: mai narkewa24mg/ml
Storage Taikin zafi	Yanayin rashin aiki, Zazzabin ɗaki
Aikace-aikace	7,8-dihydroxyflavone hydrate an yi amfani da shi azaman tropomyosin-receptor-kinase B (TrkB) agonist a cikin mice kuma don hana TrkB don saka idanu da tashin hankali na postsynaptic igiyoyi (eEPSCs).
Takardar Gwaji	Ya Rasu

 

7,8-Dihydroxyflavone foda - Menene 7,8-DHF? Ya da Tropoflavin?

Tropoflavin foda ko 7,8-dihydroxyflavone kwayar sinadari ce. Yana kwaikwayi ayyuka na Factor neurotrophic da aka samu Brain (BDNF). Ana samun BDNF ta halitta a cikin kwakwalwa da kashin baya. BDNF yana taka muhimmiyar rawa a cikin koyo, inganta ƙwaƙwalwar ajiya, neuroplasticity wanda shine ikon samar da sababbin hanyoyi da haɗin kai, da kuma manya neurogenesis wanda shine ikon girma sabon ƙwayoyin kwakwalwa a cikin manya tare da cikakkiyar kwakwalwa.

Tropoflavin foda an nuna yana taimakawa a cikin kwakwalwa gyare-gyare, ƙwaƙwalwar ajiyar lokaci mai tsawo, damuwa, da cututtuka na neurodegenerative a cikin bincike daban-daban na asibiti da gwaje-gwajen da aka gudanar akan berayen da mice. Duk da haka, ya zuwa yanzu, ba a gudanar da gwaji ko bincike a kan mutane ba. Yawancin shaidun da ke tabbatar da amfanin tropoflavin foda ya zo daga nazarin dabbobi. Shaida kamar: fa'idodi a cikin ƙwaƙwalwar ajiya, kariyar ƙwayoyin kwakwalwa da kiyaye aikin kwakwalwa wasu daga cikin sakamako mai kyau daga nazarin dabbobi daban-daban.

 

Ta yaya 7,8-Dihydroxyflavone Aiki? 

7,8-Dihydroxyflavone yana kwaikwayi ayyukan abubuwan neurotrophic da aka samu kwakwalwa. Yana yin haka musamman ta hanyar kunna hanyar mai karɓa wanda aka sani da hanyar Tropomyosin-related kinase B (TrkB) hanyar masu karɓa. Wannan ita ce hanya ɗaya da BDNF ke aiki. Bayan 7,8-DHF an ga yana aiki da kansa don samar da ayyukan antioxidant.

The m amfanin na BDNF an iyakance shi da gajeriyar rabin rayuwar sa wanda bai wuce mintuna 10 ba. BDNF kuma ba zai iya ketare shingen jini-kwakwalwa saboda girman girman kwayoyin halitta. A gefe guda, 7,8-dihydroxyflavone na iya shiga cikin sel a cikin kwakwalwa da kashin baya ta hanyar ketare wannan shinge. Tuni bincike ya nuna cewa 7,8-DHF yana samuwa a baki kuma yana iya shiga shingen jini na kwakwalwa. 7,8-dihydroxyflavone (7,8-dhf) na iya taimakawa ciki inganta aikin kwakwalwa da lafiya.

 

Menene 4'-Dimethylamino-7, 8-Dihydroxyflavone (Eutropoflavin)? 

4′-Dimethylamino-7,8-dihydroxyflavone (4'DMA-7, 8-DHF), wanda kuma ake kira eutropoflavin ko R13 a cikin s, sigar roba ce ta 7,8-dihydroxyflavone. Wani tsari ne na 7, 8-Dihydroxyflavone wanda aka gyara da kuma injiniyanci. Eutropoflavin yana da tsawon rayuwar rabin rayuwa kuma yana da ƙarfi fiye da 7, 8-Dihydroxyflavone.

Mahalli guda biyu suna da tsarin sinadarai iri ɗaya. 4'DMA-7, 8-DHF yana canzawa zuwa 7, 8-Dihydroxyflavone yayin wurare dabam dabam a cikin jiki.

Akwai ƙarancin bincike akan 4′-Dimethylamino-7,8-dihydroxyflavone. Duk taƙaitaccen binciken da ake samu an yi shi akan dabbobi. Shaidar da ke akwai ta nuna cewa 4'-Dimethylamino-7,8-dihydroxyflavone da 7,8-Dihydroxyflavone suna da hanyoyi iri ɗaya ko makamancin haka na aiki.

 

Menene 4′-DMA-7 8-dihydroxyflavone yake yi?  

4′-Dimethylamino-7,8-dihydroxyflavone ko Eutropoflavin wani flavone ne na roba. Yana da zaɓin ƙananan ƙwayoyin cuta wanda ke aiki akan masu karɓar TrkB, babban mai karɓa na abubuwan neurotrophic da aka samu kwakwalwa. An samo Eutropoflavin daga tsarin gyare-gyare da sinadarai na tropoflavin.

Idan aka kwatanta da tropoflavin, an nuna eutropoflavin yana da mafi kyawun aiki a mai karɓar TrkB. An gano Eutropoflavin yana da ƙarfi fiye da tropoflavin kuma ya nuna tsawon lokaci na aiki a cikin nazarin dabbobi. 4'-Dimethylamino-7,8-dihydroxyflavone an gano cewa yana da neuroprotective, neurogenic, da antidepressant-kamar kaddarorin a cikin dabbobi.

 

7,8-Dihydroxyflavone vs 4'-dma-7 8-dihydroxyflavone

Dukansu 7,8-Dihydroxyflavone da 4'-DMA-7 8-dihydroxyflavone an nuna su don samar da irin wannan sakamako a cikin binciken dabba. Har yanzu ba a yi nazarin tasirin hakan ba a cikin gwajin ɗan adam.

Ko da yake duka biyun suna da kamanceceniya, an sami babban bambanci tsakanin ayyukan biyun. Gwaje-gwaje na asibiti da bincike sun nuna cewa eutropoflavin ya fi ƙarfin gaske fiye da tropoflavin har ma ya nuna tsawon lokacin aiki.

Kamar yadda irin wannan, ko da yake 7,8-dhf da 4'-DMA-7 8-dihydroxyflavone suna da kama da sinadarai kuma har ma suna da irin wannan tasiri, 4'-DMA-7 8-dihydroxyflavonne an gano yana da tasiri mai ƙarfi kuma yayi aiki tsawon lokaci, a cikin bincike da aka yi a cikin dabbobin dabba.

 

Me yasa shan Tropoflavin foda yana samun Popularity? 

Tropoflavin foda ko 7,8-Dihydroxyflavone foda yana samun shahara. Tare da sababbin bincike da gwaje-gwaje na asibiti da ke fitowa tare da sakamako mai kyau, 7,8-Dihydroxyflavone foda yana fitowa a matsayin batu mai zafi har ma a cikin da'irar kimiyya.

Babu wani gwaji na asibiti ko bincike da aka yi akan mutane har yanzu. Duk da haka, waɗanda suka yi amfani da 7,8-Dihydroxyflavone foda sun yi iƙirarin cewa foda yana da gagarumin ci gaba a cikin su:

•   Memory
•   Energy
•   Learning
•   Mood
•   Ƙwaƙwalwar Ƙwaƙwalwar Ƙwaƙwalwar Ƙwaƙwalwar Ƙwaƙwalwar Ƙwaƙwalwa

Tropflavin foda kuma an tabbatar da cewa yana da tasiri don cimma daidaitattun yanayi, samun samar da makamashi mai kyau, da ciwon kwakwalwa-kariyar kaddarorin, da ciwon anti-oxidant Properties da kuma goyon bayan gut kwayoyin.

 

7,8-Dihydroxyflavone amfanin da tasiri - Menene 7,8-Dihydroxyflavone ke yi? 

7,8-Dihydroxyflavone foda (7,8-dhf) an nuna yana da fa'idodi daban-daban. Duk da haka, har zuwa yau, an yi ƙayyadaddun gwaje-gwaje na asibiti da bincike akan mutane. 7,8-Dihydroxyflavone foda an gani don zama mai tasiri a cikin bincike da gwaji da aka gudanar a cikin dabbobin dabba da bincike na tushen kwayar halitta. Ana buƙatar ƙarin nazarin kan tasiri a cikin mutane har yanzu. Wasu sakamako masu kyau daga bincike da gwaji akan 7,8-dhf foda daga nazarin dabba an jera su a ƙasa:

• Memory da Learning
• Gyaran Kwakwalwa
• neuroprotection
• Anti-mai kumburi
• Matsayi a cikin Cutar Neurodegenerative
• mawuyacin
• Addiction
• kiba
• jini
• Tsufawar fata
• Cancer

Memory da Learning

7,8-Dihydroxyflavone foda an gani yana da amfani wajen inganta ƙwaƙwalwar ajiya da ganewar abu, da rage damuwa a cikin berayen. An kuma ga yana da tasiri wajen inganta ƙwaƙwalwar ajiya a cikin berayen da suka tsufa.

 

Gyaran Kwakwalwa

7,8-Dihydroxyflavone foda (7,8-dhf) an gani yana da tasiri wajen inganta gyaran ƙwayoyin jijiyoyi masu lalacewa, ƙara samar da sababbin kwayoyin halitta a cikin kwakwalwar ƙwararrun ƙwararru bayan raunin kwakwalwa da kuma inganta haɓakar ƙwayar jijiyoyi a ciki. tsofaffin beraye

Hakazalika, 7,8-Dihydroxyflavone foda, an kuma gani yana da tasiri wajen inganta ayyukan kwakwalwa a cikin berayen da suka sami raunin kwakwalwa.

 

neuroprotection

7,8-Dihydroxyflavone foda an gani yana da tasiri don kare kariya daga lalacewar kwakwalwa da ke da alaka da bugun jini, musamman a cikin mice mata. Hakanan ya hana lalacewar ƙwayoyin jijiyoyi a cikin beraye bayan raunin da ya faru a cikin kwakwalwa.

 

Anti-Inflammatory

7,8-Dihydroxyflavone foda an gani don samun sakamako mai kumburi. An gani zai iya rage kumburi a cikin kwakwalwa da fararen jini.

 

Matsayi a cikin Cutar Neurodegenerative

7,8-dhf foda an gani don taka rawa daban-daban a cikin cututtuka daban-daban na neurodegenerative, wanda aka tattauna a kasa.

 

Cutar Alzheimer

Samfuran dabbobi sun nuna gaurayawan sakamako ga cutar Alzheimer. Wasu nazarin sun nuna cewa 7,8-Dihydroxyflavone foda yana da muhimmiyar rawa wajen hana shi, yayin da wasu ba su nuna wani amfani ba. Ana buƙatar ƙarin bincike a wannan yanki.

 

Cutar Parkinson

7,8-Dihydroxyflavone foda an gani don inganta ayyukan motsa jiki a cikin dabbobin dabba. An kuma ga yana da matakan kariya daga mutuwar ƙwayoyin cuta. Har ila yau, yana hana mutuwar ƙwayoyin ƙwayoyin cuta na dopamine a cikin nau'in biri na cutar Parkinson.

 

Cutar Huntington

7,8-Dihydroxyflavone foda an gani don tsawanta tsawon rayuwar dabbobin dabba tare da Cutar Huntington.

 

Amyotrophic Lateral Sclerosis (ALS)

7,8-Dihydroxyflavone foda ya inganta ƙarancin mota da haɓaka rayuwa a cikin binciken da aka yi a cikin ƙirar linzamin kwamfuta tare da ALS.

 

mahara Sclerosis

7,8-Dihydroxyflavone foda ya rage girman cutar.

 

Schizophrenia

7,8-Dihydroxyflavone foda ya inganta ayyukan koyo a cikin ƙirar bera.

 

Down Ciwo

Farkon shiga tsakani tare da 7,8-Dihydroxyflavone foda (7,8-dhf) an gani don ƙara yawan samar da sababbin ƙwayoyin cuta tare da ingantaccen ilmantarwa da ƙwaƙwalwa.

 

Rarraba X Syndrome

Fragile X ciwo yanayin halitta ne. Yana haifar da matsaloli iri-iri na ci gaba da suka haɗa da rashin fahimta da nakasar ilmantarwa.

A cikin samfurin linzamin kwamfuta na ciwo na X mai rauni, an ga 7,8-Dihydroxyflavone foda don inganta aikin fahimi da kuma rage rashin daidaituwa na kashin baya a cikin nau'in linzamin kwamfuta na Fragile X Syndrome.

 

Dama Ciwo

7,8-Dihydroxyflavone foda da aka gani don inganta bayyanar cututtuka a cikin wani linzamin kwamfuta model na Rett ciwo-kamar jinkirin girma girma, da wuya daidaituwa kula, da kuma al'amurran da suka shafi harshe.

 

mawuyacin

7,8-Dihydroxyflavone foda an gani don rage halin rashin tausayi a cikin rodents.

 

Addiction

7,8-Dihydroxyflavone foda an nuna cewa yana da tasiri wajen rage jin dadi da sakamako na cocaine a cikin mice.

 

kiba

7,8-Dihydroxyflavone foda an ga yadda za a iya rage yawan samar da mai da kuma gina jiki a cikin nazarin dabba.

 

jini

7,8-Dihydroxyflavone foda an gani don nuna raguwa a cikin karfin jini lokacin da aka yi masa allura. Magunguna na baka sun iya rage karfin jini, amma ba haka ba ne idan aka kwatanta da lokacin da aka ba da foda na 7,8-Dihydroxyflavone a cikin nau'i na allura.

 

Tsufawar fata

7,8-Dihydroxyflavone foda an gani don rage kumburi, ƙara yawan samar da collagen, da kuma ƙara yawan matakan enzyme antioxidant a cikin tsofaffin ƙwayoyin fata na mutum.

 

Cancer

7,8-Dihydroxyflavone foda an gani don zama mai tasiri a kashe kwayoyin cutar ciwon daji na baki da kuma ciwon daji na fata da aka sani da Melanoma a cikin karatun tasa. Duk da haka, ana buƙatar ƙarin bincike da yawa don cimma kowane matsaya, musamman a cikin mutane.

 

Yadda ake ɗaukar 7,8-Dihydroxyflavone kari?| Nawa tropoflavin foda zan sha?

7,8-Dihydroxyflavone Dosage

Babu wani bincike na asibiti da gwaji da aka gudanar akan mutane har yanzu. Sabili da haka, ƙimar lafiya na 7,8-Dihydroxyflavone foda har yanzu ba a san shi ba a cikin mutane.

Mafi yawan sashi a cikin abubuwan da ake samu na kasuwanci 10-30 MG kowace rana. Koyaya, yakamata ku duba tare da likitan ku kafin ku fara shan kari.

 

7,8-Dihydroxyflavone illa  

Kamar yadda ba a yi gwajin gwaji tare da mutane ba, abubuwan haɗari da illa na 7, 8-Dihydroxyflavone ba a sani ba. Kowa bayani kan aminci ko illa daga binciken da aka yi akan nau'ikan dabbobi. Koyaya, a cikin masu amfani waɗanda suka ɗauki 7, 8-Dihydroxyflavone, an lura da tasirin masu zuwa:

• wuce gona da iri
• Ƙaruwa
• Dizziness
• Tashin zuciya
• Madaba
•   Rashin barci

Har ila yau, ya kamata a lura da cewa 7,8-Dihydroxyflavone foda na iya hulɗa tare da wasu magungunan ƙwayoyi. 7, 8-Dihydroxyflavone yana da tasiri sosai tare da sauran kwayoyin halitta da mahadi. An ga shaidar da ke nuna rawar 7,8-Dihydroxyflavone a cikin canza aikin CYP450 enzymes hanta. Wannan na iya canza yadda sauran kwayoyi ke aiki. Yana da, sabili da haka, ko da yaushe lafiya don tuntubar likita, musamman ma idan kun kasance a kan magunguna.

 

7,8-Dihydroxyflavone tushen abinci - Yadda ake kari 7,8-Dihydroxyflavone ta halitta?

7,8-Dihydroxyflavone ya faɗi ƙarƙashin dangin flavonoid, wanda rukuni ne na abubuwan sinadarai da ke faruwa ta halitta tare da sifofin phenolic masu canzawa. Abubuwan abinci masu wadata a cikin 7, 8-Dihydroxyflavone sun haɗa da koren shayi, vinegar, soya, turmeric, qwai, kofi, blueberries, inabi da cakulan duhu. Duk da haka, don samun sakamako mafi kyau daga 7,8-dihydroxyflavone, sha daga waɗannan abincin ba zai zama hanya mai kyau ba, hanyar da ta fi dacewa ita ce ɗaukar 7,8-dihydroxyflavone kari. Nemo mafi kyawun 7,8-dihydroxyflavone foda mai kaya, zaku iya zama anan. Kuma saya 7,8-dihydroxyflavone foda wholesale zai sami mafi kyawun farashi.

 

Reviews na 7,8-Dihydroxyflavone

Babu wani binciken asibiti a cikin mutane game da 7,8-dhf. Duk da haka, nazarin dabbobi ya tabbatar da cewa yana da tasiri da inganci. Gwaje-gwaje na asibiti a cikin samfuran dabbobi sun nuna cewa 7,8-Dihydroxyflavone foda yana da fa'idodi iri-iri a inganta ƙwaƙwalwar ajiya, kare ƙwayoyin kwakwalwa da kuma kiyaye aikin kwakwalwa.

Mutanen da ke cin ta sun yi rahoton ƙasa kaɗan illa kamar wuce gona da iri, rashin natsuwa, tashin hankali, tashin zuciya, bacin rai da matsalar barci.

Ana buƙatar ƙarin bincike da yawa don kammala ainihin amfani da kasada na 7,8-Dihydroxyflavone foda a cikin mutane.

 

Best 7,8-Dihydroxyflavone foda manufacturer / Inda zan saya 7,8-Dihydroxyflavone foda girma?

Akwai 7 8-dihydroxyflavone da yawa don siyarwa akan layi. 7,8-Dihydroxyflavone foda za a iya saya a kan layi ta hanyoyi daban-daban da kuma tashar jiragen ruwa. Kuna iya siyan sa a cikin adadi wanda ya dace da ku. Siyan 7,8-Dihydroxyflavone foda a cikin adadi mai yawa zai iya taimaka muku tare da gabaɗayan kuɗi.

Lokacin neman zuwa saya kari na 7,8-Dihydroxyflavone foda, Yana da mahimmanci a duba sosai ta hanyar 7,8-Dihydroxyflavone foda masana'antun da kuma takardun shaidarka. Ziyarar wurin don ganin tsarin masana'anta na iya tabbatar da cewa ana bin ƙa'idodin aminci da ƙa'idodin masana'anta yayin samarwa.

Saboda haka, ingancin samfurin dole ne a tabbatar da kafin ku ƙare sayen 7,8-Dihydroxyflavone foda.

 

Tambayoyin da ake yawan yi (FAQs) Game da 7, 8-Dihydroxyflavone (7, 8-DHF), ko Tropoflavin

Shin Tropoflavin ne Nootropic? 

Nootropics kuma an san su azaman magunguna masu wayo. Magungunan nootropic / haɗin gwiwa yana haɓaka aikin fahimi ko aikin ƙwaƙwalwa. Gwaje-gwaje na asibiti a cikin dabbobi sun nuna cewa Tropoflavin na iya zama wakili na nootropic. Duk da haka, babu cikakkiyar shaida kuma ana buƙatar ƙarin bincike.

A cikin mutane, babu wani gwaji na asibiti da aka yi har zuwa yau tare da 7,8-Dihydroxyflavone foda. Saboda haka ba shi yiwuwa a ce ko 7,8-Dihydroxyflavone foda yana da wani nootropic aiki a cikin mutane.

 

Me yasa saya 7,8-Dihydroxyflavone foda don ingantacciyar lafiyar kwakwalwa?

7,8-Dihydroxyflavone foda ya nuna yana da fa'idodi iri-iri. Tare da bincike mai zurfi da gwaje-gwaje na asibiti da aka gudanar a cikin dabbobi, an gano 7,8-Dihydroxyflavone foda don samun tasiri mai kyau akan ƙwaƙwalwar ajiya da ilmantarwa, gyaran kwakwalwa, neuroprotection, anti-inflammatory, damuwa, jaraba, kiba, hawan jini da tsufa na fata.

7,8-Dihydroxyflavone foda kuma ya fi karfi fiye da BDNF da ke faruwa a cikin jikinmu. Akwai don,

 

Menene Bambanci Tsakanin 7, 8-Dihydroxyflavone da BDNF?   

Ana samar da BDNF ta halitta a cikin jikin ku yayin da 7,8-Dihydroxyflavone foda yana samuwa a cikin wasu nau'in tsire-tsire. 7,8-Dihydroxyflavone foda don haka an samar da shi ta hanyar synthetically kuma ana cinye shi don tasirinsa masu kyau iri-iri akan kwakwalwa.

7,8-Dihydroxyflavone foda an gani don samun tsawon rabin rayuwa da ƙarfin da aka kwatanta da BDNF. 7,8-Dihydroxyflavone foda kuma zai iya shiga cikin kwakwalwa saboda girman girmansa.

 

Yadda ake ɗaukar ƙarin 7, 8-Dihydroxyflavone don samun sakamako mafi kyau? 

A halin yanzu babu wani binciken ɗan adam akan 7,8-Dihydroxyflavone foda don yin la'akari da maganin miyagun ƙwayoyi. Yawancin ƙididdiga ta lissafi an ƙididdige su daga bincike a cikin beraye. Yawancin binciken dabba da aka yi ya nuna sakamako mai kyau a cikin siffofin allura. Tare da maganin baka tare da 7,8-Dihydroxyflavone foda, an ga sakamakon da aka samu, duk da haka, ba su da mahimmanci.

Tun da ba a yi gwajin ɗan adam ba, yana da wuya a yi tsokaci game da adadin a cikin ɗan adam. Yin shawarwari tare da likita zai iya taimakawa wajen bayyana wannan.

 

Shin Tropoflavin yana tallafawa Rage nauyi?  

Gwaje-gwaje na asibiti da bincike sun iya nuna cewa 7,8-Dihydroxyflavone foda ya haifar nauyi asara, musamman a cikin mice na mata. Ba a ga waɗannan binciken a cikin mutane ba saboda babu wani bincike da aka yi a yau.

Akwai kuma evi

dence wanda ke nuna 7,8-Dihydroxyflavone foda zai iya haifar da asarar nauyi ta hanyar inganta ci gaba da goyon baya ga kwayoyin cuta.

 

Shin Tropoflavin yana haifar da asarar gashi (ko tallafawa ci gaban gashi)? 

Har zuwa yau, babu wata shaida da ta nuna cewa 7,8-Dihydroxyflavone foda yana haifar da asarar gashi a kowane nau'i. Wasu nazarin dabba sun nuna cewa BDNF da sauran mahadi na iya yin tasiri wajen sarrafa girman gashi. Ana buƙatar bincike mai zurfi da gwaje-gwaje na asibiti a cikin mutane don yin sharhi game da lamarin.

 

Yadda ake adana Dihydroxyflavone (Tropoflavin)?  

Kamar kowane magani, yana da lafiya koyaushe don kiyaye foda 7,8-Dihydroxyflavone daga isar yara. Yana da kyau a nisantar da shi daga hasken rana kai tsaye kuma dole ne a adana shi a wuri mai sanyi, bushe.

 

Shin 7-8 Dihydroxyflavone yana ƙaruwa da damuwa?

7,8-Dihydroxyflavone foda da aka gani don zama tasiri a rage depressive hali a cikin mice. Babu bayanan asibiti da ke samuwa a yanzu don rawar 7,8-Dihydroxyflavone foda a cikin ciki a cikin mutane.

 

References

[1] 7,8-dihydroxyflavone, ƙaramin TrkB agonist na kwayoyin halitta, yana da amfani don magance cututtuka daban-daban na BDNF. Chaoyang Liu, Chi Bun Chan, Keqiang Ye Transl Neurodegener. 2016; 5: 2. An buga online 2016 Jan 6. doi: 10.1186/s40035-015-0048-7PMCID: PMC4702337

[2]Flavonoids: taƙaitaccen bayani. AN Panche, AD Diwan, SR Chandra J Nutr Sci. 2016; 5:e47. An buga akan layi 2016 Dec 29. doi: 10.1017/jns.2016.41 PMCID: PMC5465813

[3] Factor Neurotrophic-Brain-Derived Neurotrophic Factor: Maɓalli na Kwakwalwa don Ƙwaƙwalwar Ƙwaƙwalwar Lafiya da Ƙwaƙwalwar Kwakwalwa. Labarin Labari. Miranda M. Front Cell Neurosci. 2019 PMID: 31440144PMCID: PMC6692714

[4] Ƙwaƙwalwar neurotrophic da ta samo asali da kuma abubuwan da ke faruwa a asibiti. Bathina S. Arch Med Sci. 2015 PMID: 26788077PMCID: PMC4697050

[5] Ayyukan Ƙwaƙwalwar Ƙwararrun Ƙwararrun Ƙwararrun Ƙwararrun Ƙwararrun Ƙwararrun Ƙwararrun Ƙwararrun Ƙwararrun Ƙwararrun Ƙwararrun Ƙwararrun Ƙwararrun Ƙwararrun Ƙwararrun Ƙwararrun Ƙwararrun Ƙwararrun Ƙwararrun Ƙwararrun Ƙwararru. Numakawa T. Int J Mol Sci. 2017 PMID: 29099059PMCID: PMC5713281

[6] Factor Neurotrophic-Brain-Derived Neurotrophic Factor: Maɓalli Mai Mahimmanci don Ƙwaƙwalwar Ƙwaƙwalwar Lafiya da Ƙwaƙwalwar Kwakwalwa. Magdalena Miranda, Juan Facundo Morici, María Belén Zanoni da Pedro Bekinschtein. Gaba. Cell. Neurosci., 07 Agusta 2019 | https://doi.org/10.3389/fncel.2019.00363

[7]Prodrug na 7,8-dihydroxyflavone haɓakawa da ingantaccen magani don magance cutar Alzheimer. Chen C. Proc Natl Acad Sci US A. 2018 PMID: 29295929PMCID: PMC5777001

[8] Zaɓaɓɓen agonist na TrkB tare da ayyuka masu ƙarfi na neurotrophic ta 7,8-dihydroxyflavone

Sung-Wuk Jang 1, Xia Liu, Manuel Yepes, Kennie R Shepherd, Gary W Miller, Yang Liu, W David Wilson, Ge Xiao, Bruno Blanchi, Yi E Sun, Keqiang Ye

PMID: 20133810 PMCID: PMC2823863 DOI: 10.1073/pnas.0913572107

[9] Ƙananan ƙwayoyin BDNF mimetics suna kunna siginar TrkB kuma suna hana lalata neuronal a cikin rodents. Stephen M Massa, Tao Yang, Youmei Xie, Jian Shi, Mehmet Bilgen, Jeffrey N Joyce, Dean Nehama, Jayakumar Rajadas, Frank M Longo.

PMID: 20407211 PMCID: PMC2860903 DOI: 10.1172/JCI41356

[10] Ayyukan Antioxidant na 7,8-dihydroxyflavone yana kare kwayoyin PC12 daga 6-hydroxydopamine-induced cytotoxicity. Xiaohua Han, Shaolei Zhu, Bingxiang Wang, Lei Chen, Ran Li, Weicheng Yao, Zhiqiang Qu. 2014 Jan; 64: 18-23. doi: 10.1016/j.neuint.2013.10.018. Epub 2013 Nuwamba 9.

PMID: 24220540 DOI: 10.1016/j.neuint.2013.10.018

[11] 7,8-dihydroxyflavone, agonist mai karɓa na TrkB, yana toshe lalacewar ƙwaƙwalwar ajiyar sararin samaniya na dogon lokaci wanda ya haifar da damuwa na rashin motsi a cikin berayen. Raül Andero, Núria Daviu, Rosa Maria Escorihuela, Roser Nadal, Antonio Armario

PMID: 21136519 DOI: 10.1002/hipo.20906

[12]Ƙananan ƙwayoyin trkB agonists suna haɓaka farfadowar axon a cikin yanke jijiyoyi na gefe. Arthur W English , Kevin Liu, Jennifer M Nicolini, Amanda M Mulligan, Keqiang Ye.

2013 Oktoba 1; 110 (40): 16217-22. doi: 10.1073/pnas.1303646110. Epub 2013 Satumba 16.

PMID: 24043773 PMCID: PMC3791704 DOI: 10.1073/pnas.1303646110

[13] Matsayin 7,8-Dihydroxyflavone a cikin Hana Dendrite Degeneration a Cortex Bayan Ƙwararren Ƙwararren Ƙwararren Ƙwaƙwalwa. Shu Zhao, Xiang Gao, Weiren Dong, Jinhui Chen. Mol Neurobiol. 2016 Afrilu; 53 (3): 1884-1895. doi: 10.1007/s12035-015-9128-z. Laraba 2015 Maris 24.

PMID: 25801526 PMCID: PMC5441052

[14] 7,8-Dihydroxyflavone yana ƙaddamar da sakin masu shiga tsakani na pro-inflammatory da cytokines a cikin lipopolysaccharide-stimulated BV2 microglial Kwayoyin ta hanyar hana NF-κB da MAPK hanyoyin sigina. Hye Young Park, Cheol Park, Hye Jin Hwan, Byung Woo Kim, Gi-Young Kim, Cheol Min Kim, Nam Deuk Kim, Yung Hyun Choi.

Int J Mol Med. 2014 Afrilu; 33 (4): 1027-34. doi: 10.3892/ijmm.2014.1652. Epub 2014 Fabrairu 10.

PMID: 24535427 DOI: 10.3892/ijmm.2014.1652

[15]7,8-dihydroxyflavone yana hana asarar synaptic da ƙarancin ƙwaƙwalwar ajiya a cikin ƙirar linzamin kwamfuta na cutar Alzheimer. Zhentao Zhang, Xia Liu, Jason P Schroeder, Chi-Bun Chan, Mingke Song, Shan Ping Yu, David Weinshenker, Keqiang Ye.

Neuropsychopharmacology. 2014 Fabrairu; 39 (3): 638-50. doi: 10.1038/npp.2013.243. Epub 2013 Satumba 11.

PMID: 24022672 PMCID: PMC3895241

[16] 7,8-dihydroxyflavone Ameliorates Rarraba Motoci Ta Hannun Maganar α-synuclein da Damuwar Oxidative a cikin Model Mouse Mouse na MPTP na Cutar Parkinson. Xiao-Huan Li, Chun-Fang Dai, Long Chen, Wei-Tao Zhou, Hui-Li Han, Zhi-Fang Dong.

CNS Neurosci Ther. 2016 Yuli; 22 (7): 617-24. doi: 10.1111/cns.12555. Epub 2016 Afrilu 15.

PMID: 27079181 PMCID: PMC6492848

[17]7,8-Dihydroxyflavone yana inganta aikin motsa jiki kuma yana haɓaka ƙarancin rayuwa na neuronal a cikin ƙirar linzamin kwamfuta na amyotrophic lateral sclerosis.

Orhan Tansel Korkmaz, Nurgul Aytan, Isabel Carreras, Ji-Kyung Choi, Neil W Kowall, Bruce G Jenkins, Alpaslan Dedeoglu,

Neurosci Lett. 2014 Afrilu 30; 566: 286-91. doi: 10.1016/j.neulet.2014.02.058. Epub 2014 Maris 15.

PMID: 24637017 PMCID: PMC5906793

[18] Ƙananan-kwayoyin TrkB masu karɓar agonists suna haɓaka aikin motsa jiki da haɓaka rayuwa a cikin ƙirar linzamin kwamfuta na cutar Huntington.

Mali Jiang, Qi Peng, Xia Liu, Jing Jin, Zhipeng Hou, Jiangyang Zhang, Susumu Mori, Christopher A Ross, Keqiang Ye, Wenzhen Duan

Hum Mol Genet. 2013 Juni 15;22 (12):2462-70. doi: 10.1093/hmg/ddt098. Epub 2013 Fabrairu 27.

PMID: 23446639 PMCID: PMC3658168

[19] TrkB agonist, 7,8-dihydroxyflavone, yana rage girman asibiti da cututtukan cututtuka na samfurin murine na sclerosis da yawa. Tapas K Makar, Vamshi KC Nimmagadda, Ishwar S Singh, Kristal Lam, Fahad Mubariz, Susan IV Judge, David Trisler, Christopher T Bever Jr.

J Neuroimmunol. 2016 Maris 15; 292: 9-20. doi: 10.1016/j.jneuroim.2016.01.002. Epub 2016 Jan 6.

PMID: 26943953

[20]Ƙananan kwayoyin TrkB agonist 7,8-dihydroxyflavone yana juyar da fahimi da ƙarancin filastik synaptic a cikin ƙirar bera na schizophrenia.

Yuan-Jian Yang, Yan-Kun Li, Wei Wang, Jian-Guo Wan, Bin Yu, Mei-Zhen Wang, Bin Hu.

Pharmacol Biochem Behav. 2014 Yuli; 122: 30-6. doi: 10.1016/j.pbb.2014.03.013. Laraba 2014 Maris 21.

PMID: 24662915

[21] A flavonoid agonist na mai karɓar TrkB don BDNF yana haɓaka neurogenesis na hippocampal da ƙwaƙwalwar ajiyar hippocampus a cikin ƙirar linzamin kwamfuta na Ts65Dn na DS.

Fiorenza Stagni, Andrea Giacomini, Sandra Guidi, Marco Emili, Beatrice Uguagliati, Maria Elisa Salvala, Valeria Bortolotto, Mariagrazia Grilli, Roberto Rimondini, Renata Bartesaghi

Exp Neurol. 2017 Dec; 298 (Pt A): 79-96. doi: 10.1016/j.expneurol.2017.08.018. Epub 2017 Satumba 4.

PMID: 28882412

[22] 7, 8-Dihydroxyflavone yana haifar da maganganun synapse na AMPA GluA1 kuma yana inganta haɓakar fahimta da kashin baya a cikin ƙirar linzamin kwamfuta na ciwo na X mai rauni.

Mi Tian, ​​Yan Zeng, Yilan Hu, Xiuxue Yuan, Shumin Liu, Jie Li, Pan Lu, Yao Sun, Lei Gao, Daan Fu, Yi Li, Shasha Wang, Shawn M McClintock.

Neuropharmacology. 2015 Fabrairu; 89: 43-53. doi: 10.1016/j.neuropharm.2014.09.006. Epub 2014 Satumba 16.

PMID: 25229717

[23]7,8-dihydroxyflavone yana nuna ingancin warkewa a cikin ƙirar linzamin kwamfuta na ciwon Rett. Rebecca A Johnson, Maxine Lam, Antonio M Punzo, Hongda Li, Benjamin R Lin, Keqiang Ye, Gordon S Mitchell, Qiang Chang.

J App Physiol (1985). 2012 Maris; 112 (5): 704-10. doi: 10.1152/japplphysiol.01361.2011. Epub 2011 Dec 22.

PMID: 22194327 PMCID: PMC3643819

[24] 7,8-Dihydroxyflavone, agonist TrkB, yana rage rashin daidaituwa na dabi'a da neurotoxicity a cikin mice bayan gudanar da methamphetamine.

Qian Ren, Ji-Chun Zhang, Min Ma, Yuko Fujita, Jin Wu, Kenji Hashimoto.

Psychopharmacology (Berl). 2014 Jan; 231 (1): 159-66. doi: 10.1007/s00213-013-3221-7. Epub 2013 Agusta 10.

PMID: 23934209

[25]https://www.sciencedirect.com/topics/medicine-and-dentistry/7-8-dihydroxyflavone