Bayanan sunadarai na 5a-hydroxy laxogenin foda
| Product Name | 5a-hydroxy laxogenin foda |
| nufin abu ɗaya ne | 5 alpha-hydroxy laxogenin; 5-alpha-Hydroxy-laxogenin; 5 alpha hydroxy laxogenin; 5-alpha hydroxy laxogenin; 5-alpha-hydroxy laxogenin; 5a hydroxy laxogenin; 5a-hydroxy Laxogenin |
| Sinadarin Tsarkakewa | >> 99% |
| CAS Number | 56786-63-1 |
| Drug Class | Analogue spirostanic na brassinosteroid |
| InChI key | HCGPOQBVFMZFY-PPCFKNSFSA-N |
| Smile | CC1CCC2(C(C3C(O2)CC4C3(CCC5C4CC(=O)C6(C5(CCC(C6)O)C)O)C)C)OC1 |
| kwayoyin Formula | C27H42O5 |
| kwayoyin Weight | 446.6 |
| Monoisotopic Mass | 446.30322444 |
| Ƙaddamarwa Point | 247-250 ° C |
| tafasar Point | 578.4 ± 50.0 ° C (Tsinkaya) |
| Eiyakance rabin-rai | 6-8 sa'o'i |
| Launi | White foda |
| solubility | DMF: 15mg/ml; DMSO: 10mg/ml |
| Syawan zafin rana | Rufewa a bushe, Zazzabin ɗaki |
| Aikace-aikace | Kari; gina jiki; samun tsoka |
Bodybuilders and athletes are frequently on the lookout for methods to increase lean muscle mass without increasing the fat content in the body. One of the simplest ways to achieve this is to use anabolic steroids, but the long-term use of these steroids has certain illa that may be off-putting to many.
Recent studies have found a plant derivative that is believed by scientists to have the same effects as anabolic steroids, however, without any adverse illa of the steroids.
An san fili da 5a hydroxy laxogenin yawanci ko kuma da sunan kimiyya, 5-alpha-hydroxy laxogenin. 5a hydroxy laxogenin foda ana sayar da shi ta mafi yawan 5a hydroxy laxogenin foda masu samar da kayan aiki a matsayin kayan aikin jiki saboda yawancin amfanin samfurin.
Menene 5a-hydroxy laxogenin?
5a-hydroxy laxogenin, wani sinadari ne na laxogenin, wani sinadari da ake samu a yanayi, a cikin tsirrai. Laxogenin ko 3beta-hydroxy-25D, 5alpha-spirostan-6-one, wani tsire-tsire ne na anabolic steroid wanda ya zama sananne a tsakanin 'yan wasa da masu gina jiki don haɓaka ƙwayar tsoka.
Dalilin da ke bayan karuwar shaharar Laxogenins shine rawar da suke takawa a cikin tsire-tsire. Su hormones na tsire-tsire, wanda kuma aka sani da brassinosteroids waɗanda suke da tsari da aiki, kama da dabba da hormones na steroid na mutum. Saboda wannan, suna maye gurbin anabolic steroids.
Za a iya samun Laxogenins daga albasar Sinawa ko kuma tushen ƙasa na tsiron Asiya, Smilax sieboldii. Laxogenins, a cikin mafi yawan abubuwan da ake samarwa da kuma sayar da su ta hanyar 5a-hydroxy laxogenin foda masana'anta, an samo su ne daga wani diosgenin steroid. Haka kuma ana amfani da wannan shukar steorid wajen haxa wasu nau’o’in sinadarai masu yawa irin su progesterone, wanda ake amfani da shi sosai a cikin magungunan hana haihuwa.
Yawancin nau'ikan da ke da 5a hydroxy laxogenin foda don siyarwa, a matsayin kari, sun ƙunshi wannan haɓakar laxogenin, wanda aka samo daga diosgenin, maimakon samun laxogenin na halitta. Koyaya, wannan ba wani babban damuwa bane kamar yadda fa'idodin 5-alpha-hydroxy-laxogenin yayi daidai da na laxogenin.
Shin 5-alpha-hydroxy laxogenin prohormone ne?
Yawancin masana'antun 5a hydroxy laxogenin da 5a hydroxy laxogenin foda masu kaya suna lakafta fili a matsayin prohormone. Prohormone wani sashi ne wanda sau ɗaya a cikin jiki, zai sami canje-canje don zama takamaiman hormone.
Misalin da ya dace zai zama androgens, wanda ke aiki a matsayin prohormones kuma da zarar an sha shi kuma ya daidaita, ya canza zuwa hormone, testosterone. 5a hydroxy laxogenin foda ba shine pre-hormone kamar yadda ba ya canzawa zuwa hormone, amma yana da irin wannan amfani kamar hormone steroid.
Shin 5-alpha-hydroxy laxogenin steroid ne?
5a hydroxy laxogenin is a plant steroid that shares quite a few similarities with animal steroid hormones. It is the most similar to sex hormones in the jikin mutum that are derived from cholesterol. It is important to point out that 5a hydroxy laxogenin powder has a growth-enhancing function in plants but the effects of it on the human body are far more complicated than that.
Maimakon wucewa ta cikin membrane kuma haifar da canji a kan kansa, wannan fili yana ɗaure ga mai karɓa kuma yana kunna siginar sigina, wanda ya ƙare tare da karuwa mai yawa a cikin ikon gina tsoka na jiki.
Ƙayyadaddun furotin da aka kunna ta 5a hydroxy laxogenin foda shine furotin kinase B ko AKT 1. Wannan furotin yana da sananne don ikonsa ba kawai ƙara yawan samar da tsokoki a cikin jikin mutum ba har ma don rigakafin ƙwayar tsoka.
Sunadaran ƙwayoyin tsoka suna raguwa a lokacin motsa jiki masu yawa amma ana tsammanin cewa fa'idodin 5-alpha-hydroxy laxogenin iri-iri sun haɗa da rigakafin lalata furotin da rushewa yayin motsa jiki.
Another mechanism through which 5a hydroxy laxogenin powder produces the benefits that appeal to bodybuilders and athletes is by blocking the breakdown of an important enzyme, namely, cAMP.
Ƙara yawan adadin wannan enzyme a cikin jiki ta hanyar hana rushewar sa don haka yana haifar da karuwar raguwar mai a cikin jiki. A lokaci guda kuma, haɓaka wannan enzyme shima yana haifar da ingantaccen martanin faɗa ko tashi.
Gabaɗaya, 5a hydroxy laxogenin foda masu samar da samfuran suna siyar da samfurin da ke haɓaka ƙwayar tsoka, rage raguwar furotin, kuma yana ƙara raguwar mai, duk lokaci guda. An yi imanin cewa waɗannan tasirin suna faruwa kamar yadda waɗannan su ne tasirin da ake gani sau da yawa a cikin nau'o'in nau'in 5a hydroxy foda binciken da aka yi ko dai a kan nau'in dabba ko in vitro, a cikin dakin gwaje-gwaje. Duk da haka, waɗannan tasirin bazai iya gani a cikin jikin mutum ba lokacin da aka sayar da abubuwan da aka sayar da su ta daban-daban 5a hydroxy laxogenin foda masana'antun.
Shin 5a-hydroxy laxogenin iri ɗaya ne da Laxogenin: 5a hydroxy laxogenin vs laxogenin
5a-hydroxy laxogenin an samo shi daga hormone na shuka, laxogenin. Suna da fa'idodi iri ɗaya, bisa ga nau'ikan bincike daban-daban da aka yi akan nau'ikan dabbobi. Duk da haka, ba abu ɗaya ba ne.
Menene 5-alpha-hydroxy laxogenin ke yi?
5-alpha hydroxy laxogenin shine mafi kama da hormones na jima'i waɗanda aka haɗa su daga cholesterol a cikin jikin ɗan adam. Wadannan hormones na jima'i da aka samo su ta halitta a cikin jikin mutum suna aiki a kan masu karɓar nukiliya, yayin da 5a hydroxy laxogenin ya rataye zuwa mai karɓar salula, a saman tantanin halitta.
Yawancin kamfanoni waɗanda ke da 5a hydroxy laxogenin foda don siyarwa sukan sayar da wannan ƙarin tare da tallan cewa yana da ƙarfin 200 bisa dari kuma yana iya inganta sautin tsoka a tsakanin 'yan wasa sosai. Waɗannan ikirari da masana'antun daban-daban suka yi sune sakamakon binciken da yawa waɗanda aka yi tare da manufar tantance ƙimar haɓakar ƙwayar tsoka na laxogenins.
A recent Russian research on animal models found that thermogenic compounds derived from the same group of plant hormones as laxogenin, with the same effects as laxogenin. According to this study, these brassinosteroid derivatives were able to increase the protein content of liver, heart, kidney, and leg muscles. Moreover, researchers found that these derivatives did not produce these benefits by replicating or mimicking the effect of sex hormones in the human body.
Wani binciken bincike wanda kuma aka yi a kan nau'ikan dabbobi da kuma amfani da hormones na nau'in nau'in hormones na shuka kamar yadda laxogenin ya sami damar yin kwafin sakamako iri ɗaya kamar binciken na Rasha. An gudanar da wasu bincike da yawa don tabbatar da sahihancin waɗannan sakamakon kuma an gano cewa sakamakon ana iya maimaita su cikin sauƙi, don haka ya ba da tabbacin ƙarfinsu da ingancinsu.
Yana da mahimmanci a nuna cewa yayin da yawancin masu amfani da 5a hydroxy laxogenin foda suna da'awar ganin sakamakon da masu sayarwa suka yi tallace-tallace, gano ainihin shaidar kimiyya don tallafawa amfani da su ya kasance da wahala. Yawancin binciken ana yin su ne akan nau'ikan dabbobi kuma suna amfani da mahadi waɗanda ko dai na cikin nau'in brassinosteroid na hormones ko makamancin ƙwayar shuka, phytoecdysteroids. Laxogenins suna kama da waɗannan hormones kuma 5a hydroxy laxogenin wani abu ne na laxogenins, amma wannan baya bada garantin fa'idodin da aka gani tare da sauran hormones.
Ɗaya daga cikin binciken da aka yi ta amfani da laxogenin na halitta da na roba a cikin dakin gwaje-gwaje ya gano cewa wannan foda zai iya rage yawan damuwa a cikin jiki sosai. Rage damuwa na iskar oxygen ta laxogenins an yi shi ta hanyar rage radicals kyauta, nau'in abu mai cutarwa a cikin jiki wanda zai iya shiga cikin halayen sinadarai daban-daban kuma yana cutar da jiki sosai. Wannan raguwa a cikin radicals kyauta da damuwa na oxidative zai iya bayyana yadda 5a hydroxy laxogenin foda zai iya inganta farfadowa na tsoka, bayan motsa jiki. Duk da haka, dole ne a yi wannan binciken a kan nau'ikan dabbobi da kuma batutuwan ɗan adam kafin a yarda da sakamakon binciken.
Dukkanin binciken da aka ambata a sama an yi su tare da manufar gano ko laxogenins zasu iya ƙara yawan ƙwayar tsoka da sautin. Duk da haka, kawai amfani da 5 alpha-hydroxy laxogenin ba gina jiki ba kuma shine abin da wasu daga cikin sauran binciken ke fatan tabbatarwa.
A cikin nazarin daban-daban guda biyu, yin amfani da 5-alpha-hydroxy laxogenin foda a cikin marasa lafiya na ciwon daji ya rage girman ciwon daji sosai. Hakazalika, an gano ci gaban ciwon huhu da aka rage tare da yin amfani da 5a hydroxy laxogenin foda a cikin nau'in dabba. Duk da yake waɗannan karatun ba su iya ba da tabbataccen shaidar da ake buƙata don kowane kari ko magani don haɗawa cikin ka'idar jiyya, mataki ne kan madaidaiciyar hanya.
Lokacin shan 5-alpha-hydroxy laxogenin?
5-alpha-hydroxy laxogenin foda sashi yana farawa daga 25 MG, kuma shine nawa ya kamata mutum ya ɗauka a kowane takamaiman lokaci. Koyaya, har zuwa 6, kuma mafi ƙarancin 3, ana iya ɗaukar allurai a ko'ina cikin yini, yin adadin ƙarin, 150 MG kowace rana. Hakanan ana ba da shawarar shan ƙarin foda tare da abinci don ƙara sha cikin ciki.
5a hydroxy laxogenin foda za a iya ɗauka har zuwa watanni 3 zuwa watanni 4 a lokaci guda saboda wannan shine lokacin da sakamakon zai bayyana. Ana iya ci gaba da ɗauka fiye da haka idan an buƙata ko ana so. Kamar yadda fili na halitta ba shi da wani tasiri a kan matakan hormone na jiki, ba ya buƙatar ƙuntatawa zuwa wani ɗan gajeren lokaci.
5-alpha-hydroxy laxogenin side effects are not well known because most of the studies that are performed to assess the efficiency of the supplement are not performed on human subjects. They are performed on animal models and it is not possible to determine both the benefits and the side effects from these studies. However, the users of the supplements have not reported any toxicities or adverse effects, which has led to the belief that the supplement has no side effects.
Wanene ya kamata yayi la'akari da amfani da shi?
Masu gina jiki, 'yan wasa, da duk wani wanda ke son ƙara yawan ƙwayar tsoka da taro yayin rage yawan kitsen jiki ya kamata yayi la'akari da yin amfani da 5a hydroxy laxogenin foda.
Shin 5-alpha-hydroxy laxogenin halal ne?
Ana ɗaukar 5a hydroxy laxogenin a matsayin haramtacciyar sinadari wanda Ƙungiyar Abinci da Magunguna ko FDA a Amurka ta ba da gargaɗi da yawa game da. USADA tana kula da abun cikin na dogon lokaci saboda sun gano yana cikin samfura ko kari wanda kuma ya ƙunshi wasu abubuwan haɓaka aiki. Wani dalili na damuwa tare da 5a hydroxy laxogenin foda shine cewa ana tallata shi azaman halitta, steroid na tushen anabolic. Dukansu FDA da USADA sun tada tambayoyi game da ainihin tushen 5a hydroxy laxogenin kamar yadda tushen shuka na halitta ya ba da hormone laxogenin kawai. Ba a yi bayanin yadda ake samun hydroxy laxogenin daga laxogenin ba.
USADA ta yi cikakken bincike game da nau'ikan foda na 5a hydroxy laxogenin don siyarwa kuma ta sami rabin waɗancan abubuwan da za'a sanya su tare da abubuwan ƙara kuzari. A yunƙurin ceton ƴan wasa da masu gina jiki daga yin amfani da kwayoyi masu haɗari na haɗari ta hanyar amfani da wannan 'steroid steroid' na halitta, USADA ta buƙaci su kasance a lura da duk wani kari da ke dauke da laxogenin wanda za'a iya ambata a cikin jerin abubuwan kamar:
- Saukewa: UNII-HT7W184YG4
- Saukewa: HT7W184YG4
- SCHEMBL4027062
- ZINC70691911
- (25r) -3beta-hydroxy-5alpha-spirostan-6-daya
- Q272800835
- alpha-hydroxy-laxogenin
- 5a-hydroxy-laxogenin
- 5-laxogenin
- (25R) -3beta,5alpha-dihydroxyspirostan-6-daya
- 25-R-spirostan-5a-diol-6-daya-3-daya
- 25R spirostan-5a-diol-6-daya-3-daya decanoate
- 25R spirostan-5a-diol-6-daya-3-daya undecanoate
USADA kuma tana zargin cewa kalmar laxogenin akan jerin abubuwan sinadarai na iya zama alamar ɓoye ga waɗanda ke neman abubuwan ƙara kuzari, ma'ana cewa babu ainihin laxogenin ko 5a hydroxy laxogenin a cikin kari.
FDA, kamar USADA, ya bambanta na laxogenins a cikin abubuwan abinci na abinci saboda babu isasshen bayani game da amfani, aminci, da ƙarfinsa. Tare da ƙarin bincike, akwai yuwuwar karɓar sinadari a matsayin ƙarin ƙarin haɓakar tsoka.
Wannan yuwuwar ta wanzu saboda, duk da USADA ta ayyana laxogenins da abubuwan da suka samo asali a matsayin haramtacciyar sinadari, Hukumomin Yaƙin Karɓar Magunguna na Duniya ba su hana amfani da su a tsakanin 'yan wasa ba. 5a hydroxy laxogenin bai cika ka'idojin da za a lasafta shi azaman abin ƙara kuzari ba.
Bugu da ƙari, gwajin magani na 5a hydroxy laxogenin ba zai zo da kyau ba yayin bincika abubuwan doping muddin ba a lalata foda ko spiked da wasu abubuwan da aka haramta ba.
5-alpha-hydroxy laxogenin Reviews
Yawancin masu amfani da 5-alpha-hydroxy laxogenin foda suna rantsuwa da shi kuma suna da'awar ganin duk sakamakon da aka yi tallar akan kansu. Kusan duk masu amfani sun yaba da ƙarin aiki da sauri a cikin ƙara yawan ƙwayar tsoka da sautin.
Akwai sake dubawa da yawa akan layi suna iƙirarin ganin ingantaccen ƙwayar tsoka da haɓakar ƙwayar tsoka, tare da raguwa mai mahimmanci tare da kawai watanni uku zuwa hudu na yin amfani da 5a hydroxy laxogenin foda.
Mafi kyawun 5a-hydroxy laxogenin foda saya?
Ana iya siyan ƙarin foda ta hanyar 5a hydroxy laxogenin masu siyar da kaya idan an buƙata ko ana iya siyan shi a cikin ƙananan kuɗi. Mafi kyawun foda don siye shine wanda aka ƙera, magani, kuma an haɗa shi tare da ƙayyadaddun ƙa'idodin aminci kamar yadda wannan ke ba da garantin 5a hydroxy laxogenin foda mara-kamuwa da abubuwan da aka haramta.
References:
- Sinadarin da ba bisa ka'ida ba, 5-Alpha-Hydroxy-Laxogenin, Yana bayyana a Ƙarin Ƙari. Ilimi, Ruhun Wasanni / Disamba 4, 2019
- Bioorg Med Chem. 2012 Afrilu 15;20 (8): 2690-700. doi: 10.1016/j.bmc.2012.02.026. Epub 2012 Feb 15. Sabbin fahimta game da tsarin-cytotoxicity dangantaka na spirostan saponins da glycosides masu dangantaka. Karell Pérez-Labrada, Ignacio Brouard, Sara Estévez, María Teresa Marrero, Francisco Estévez, Jaime Bermejo, Daniel G Rivera. Saukewa: 22405922
- YW Zhang, I Morita, L Zhang, G Shao, XS Yao, S Murota. Nuna magungunan anti-hypoxia/reoxygenation ta hanyar in vitro. Sashe na 2: Hana kunnawar tyrosine kinase ya hana hypoxia/sake haifar da rauni a cikin ratar endothelial junctional sadarwar salula. Planta Med. 2000 Maris; 66 (2): 119-23. doi: 10.1055/s-2000-11126. Saukewa: 10763583
- Diana M. Cheng, Louis W. Kutzler, Dustin D. Boler, Jenny Drnevich, John Killefer, da Mary Ann Lilaa. Ci gaba da Jiko na 20-Hydroxyecdysone Ƙarfafa Mass na Triceps Brachii a C57BL/6 Mice. Buga kan layi 2012 Afrilu 12. doi: 10.1002/ptr.4679. Saukewa: PMC3410052
- Debora Esposito, Slavko Komarnytsky, Sue Shapses, da Ilya Raskin.Anabolic sakamako na shuka brassinosteroid. FASEB J. 2011 Oct; 25 (10): 3708- doi: 10.1096/fj.11-181271. Saukewa: PMC3177571
