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Anandamide (AEA) (94421-68-8)

Anandamide, wanda kuma aka sani da N-arachidonoylethanolamine (AEA), mai kyama mai narkewa ne wanda yake samu daga …… ..


Status: A Mass Production
Naúra: 25kg / Drum

description

Anandamide (AEA) (94421-68-8) Sfasali

Product Name Anandamide (AEA)
Chemical Name Arachidonylethanolamide; N-Arachidonoylethanolamine; Anandamide (20.4, n-6);

N-Arachidonoyl-2-hydroxyethylamide; Arachidonoyl ethanolamide; AEA;

CAS Number 94421-68-8
InChIKey LGEQQWMQCRIYKG-DOFZRALJSA-N
Smile CCCCCC = CCC = CCC = CCC = CCCCC (= O) NCCO
kwayoyin Formula C22H37NO2
kwayoyin Weight 347.53
Monoisotopic Mass 347.282429 g / mol
Ƙaddamarwa Point N / A
tafasar Point 522.3 ± 50.0 ° C (Tsinkaya)
yawa 0.92 g / mL a 25 ° C (lit.)
Launi Rawaya mai haske
Syawan zafin rana -20 ° C
solubility ethanol: mai narkewa
Aikace-aikace Ana amfani dashi don ƙwaƙwalwa, motsawa, hanyoyin fahimta, sarrafa motsi, kula da jin zafi, motsawar ci da haihuwa.

Menene Anandamide (AEA)?

Anandamide, wanda kuma aka sani da N-arachidonoylethanolamine (AEA), mai ne mai narkewa mai narkewa mai narkewa daga sinadarin eicosatetraenoic acid (arachidonic acid. ya lalata da farko ta hanyar enzyme na faty acid amide hydrolase (FAAH), wanda ya canza anandamide zuwa ethanolamine da arachidonic acid, A ƙarshe, Anandamide yana haɓaka cikin neuron ta hanyar ɗaukar ciki yana faruwa tsakanin arachidonic acid da ethanolamine a ƙarƙashin ƙididdigar calcium ion da monophoidhat cyclic adoposidase. Abu ne mai haɓaka ƙungiyar abubuwa masu aiki da ƙwaƙwalwa (Prostamides) waɗanda ke taka rawa a cikin ayyukan jiki da yawa, ciki har da ci, ƙwaƙwalwa, jin zafi, rashin jin daɗi, da yawan haihuwa .. Bugu da ƙari, Anandamide shima yana hana mutane haɓaka ƙwayoyin ƙwayar nono.

Anandamide yana cikin halittu da yawa, kamar su urchin roe, kwakwalwar aladu da kuma rayuwar mice, da dai sauransu, amma adadin sa kaɗan. Hakanan, masu binciken sun gano Anandamide da abubuwa guda biyu (N-oleoylethanolamine da N-Linoleylethanolamine) cikin cakulan duhu. Anandamide har ila yau yana cikin wasu hatsi da aka sarrafa, (fararen burodi), Alcohol (musamman, amfani na yau da kullun ko shaye-shaye), sukari mai sakewa, Abincin abinci mai narkewa, Abincin da aka soya a cikin kayan lambu da abinci na rashin kwayoyin da ke ɗauke da magungunan kashe ƙwari da dai sauransu.

A matsayin wani ɓangare na tsarin endocannabinoid (ECS), Anandamide an tsara shi azaman mai kula da homeostasis tare da wani aji na cannabis-kamar sunadarai 2-AG da masu karɓar cannabinoid na jiki baki ɗaya. Wannan tsarin ya kasance A cikin dukkanin hanyoyin katsewa. Anandamide yana taka rawa wajen daidaita halayen ciyarwa da motsawar jijiyoyi da nishadi, kiyaye jikinmu da hankalinmu a daidaito. Nazarin sun gano cewa motsin zuciyarmu, farin ciki, tsoro, damuwa, da ikon da za mu iya magance tashin hankali duk ana tsara su ta tsarin endocannabinoid, kuma cututtuka daban-daban daga schizophrenia zuwa ɓacin rai suna haɗuwa tare da matakan naƙasasshe na anandamide.

Anandamide, mai kama da THC, shine mai sassaucin ra'ayi na CB1R. Yana iya haifar da haɓakar haɓaka ta “cikakke” aikin kwakwalwa. Yana da mahimmanci a lura cewa duk waɗannan tasirin Anandamide kamar ana inganta su ta hanyar magunguna ta hana lalacewar aikinta. Abubuwan da aka gano na Anandamide na iya haifar da haɓaka sabuwar iyali na magungunan warkewa.

Anandamide (AEA) fa'idodi

Anandamide, wanda aka fi sani da "bliss molecule", shine mai haɓaka yanayi, neurotransmitter da endocannabinoid, waɗanda ke da fa'idodi da yawa da lafiyar kwakwalwa.

Anandamide yana rage saurin samar da ƙwayoyin kansa. A cikin 1998, wani rukuni na masana kimiyya na Italiya sun gano cewa anandamide na iya inganta neurogenesis kuma ya samar da sabbin ƙwayoyin jijiya, ta yadda yakamata a rage samuwar / ƙara darajar ƙwayoyin ciwon daji na nono.

Anarfin Anandamide na inganta neurogenesis (samuwar sabbin ƙwayoyin jijiya) yana taka rawa wajen sarrafa halayyar ciyarwa da haifar da motsa sha'awa da jin daɗin jiji. Wannan yana taimakawa rage bayyanar cututtuka na damuwa da damuwa. Nazarin a cikin 2015 na mutane da beraye sun gano cewa manyan matakan anandamide na iya inganta haɓaka yanayi da rage tsoro.

Bugu da ƙari, ikon anandamide don ɗaure wa CB1 da masu karɓar CB2 zai kuma tasiri tasiri akan hanyoyin fasahar da yawa, yana nuna kyakkyawar fa'ida ta fuskar ƙwaƙwalwa, motsawa, hanyoyin fahimtar juna, sarrafa motsi, kula da jin zafi, motsawar ci da haihuwa.

Yadda ake kara yawan anandamide(AEA) matakan a jikin mutum?

Saboda anandamide yana da matsayi a matsayin mai kula da neurotransmitter, wakili na vasodilator da mai amfani da jini na jini na mutum, da kuma lafiyar lafiyar da amfanin kwakwalwa da aka nuna, zaku iya so ku ƙara matakin anandamide a jikin ku. Anan akwai wasu hanyoyi don ƙara matakan anandamide na ɗan lokaci a cikin jikin mutum:

- Motsa jikiyin

Binciken ya gano cewa bayan mintuna 30 kawai na gudu, abubuwan da ke cikin anandamide (AEA) na mutane da karnuka sun haɓaka. Don haka idan kuna son samun fa'idodi mafi yawa, yi ɗan motsa jiki sau da yawa.

- Cin duhu cakulan

Cakulan duhu yana da babban adadin theobromine a cikin cakulan lafiya, kuma theobromine yana taimakawa wajen haɓaka samarwar anandamide a cikin kwakwalwa kuma yana rage jinkirinsa na ɗan lokaci.

- Cin black truffle

Black truffle (black naman gwari) ta halitta ya ƙunshi anandamide. Kodayake naman gwari ba zai iya amfani da anandamide a zahiri ba, masu binciken sun yi imanin cewa ana amfani da shi ne don jan hankalin dabbobi don su ci shi kuma su haifeshi.

- Samun maida hankali

Bincike ya nuna cewa lokacin da mutum yake cikin yanayin (da ake kira 'guduwa' ko 'a wani yanki,') na yawan maida hankali, aiwatarwa, da maida hankali, ba wai kawai zaka zamo mai amfani ne ko kirkirar ayyukan kirki a kwakwalwarka ba har ila yau yana fitar da adadi mai yawa, kamar su serotonin, dopamine, endorphin da anandamide.

Bugu da ƙari, shayi, coriander da seleri kuma zasu iya taimakawa wajen haɓakar haɓakar anandamide.

reference:

  • Berger, Alvin; Crozier, Gayle; Bisogno, Tiziana; Cavaliere, Paolo; Innis, Sheila; Di Marzo, Vincenzo (15 ga Mayu 2001). "Anandamide da rage cin abinci: Hada hancin arachidonate da docosahexaenoate yana haifar da karuwar matakan kwakwalwa na N-acylethanolamines masu daidaituwa a cikin alade". Ayyukan Kwalejin Kimiyya ta Kasa. 98 (11): 6402– Bibcode: 2001PNAS… 98.6402B. doi: 10.1073 / pnas.101119098. PMC 33480. PMID 11353819.
  • El-Talatini MR, Taylor AH, Konje JC (Afrilu 2010). "Dangantaka tsakanin matakan plasma na endocannabinoid, anandamide, steroids na jima'i, da gonadotrophins yayin haila." Fertil. Bakararre. 93 (6): 1989– doi: 10.1016 / j.fertnstert.2008.12.033. PMID 19200965.
  • Habib, Abdella M .; Okorokov, Andrei L .; Dutsen, Matta N .; Bras, Jose T .; Lee, Man-Cheung; Li, Shengnan; Gossage, Samuel J .; van Drimmelen, Marie; Morena, Mariya (Maris 2019). "Microdeletion a cikin wani ɓataccen bayani wanda aka gano a cikin mai haƙuri tare da babban maganin anandamide da rashin ƙarfi". Jaridar Burtaniya na maganin sa barci. 123: e249– doi: 10.1016 / j.bja.2019.02.019. PMID 30929760.
  • Mahler SV, Smith KS, Berridge KC (Nuwamba 2007). "Endocannabinoid hedonic hotspot don jin daɗin jin daɗi: anandamide a cikin ƙwaƙwalwar ƙwayar ƙwayar ƙwayar cuta yana haɓaka 'lik' na lada mai daɗi". Neuropsychopharmacology. 32 (11): 2267– doi: 10.1038 / sj.npp.1301376. PMID 17406653.
  • Mechoulam R, Fride E (1995). "Hanyar da ba a rufe ba zuwa kwakwalwar cannabinoid ligands, anandamides". A cikin Pertwee RG (ed.). Masu karɓa na cannabinoid. Boston: Labaran Ilimi. shafi na 233– ISBN 978-0-12-551460-6.
  • Mallet PE, Beninger RJ (1996). "Babban halittar cannabinoid mai karɓar agonist anandamide yana lalata ƙwaƙwalwar ajiya a cikin berayen". Dabarar Magunguna. 7 (3): 276– doi: 10.1097 / 00008877-199605000-00008.

BATSA DA TATTAUNAWA:

Ana Samun Wannan Abubuwan ne Don Amfani da Bincike Kawai. Sharuɗɗan Siyarwa suna Aiwatarwa. Ba don Amfani da Dan Adam bane, ko Likita, dabbobi, ko Amfani na Gida.


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