Adinin dinucleotide na Nicotinamide (53-84-9)

Maris 15, 2020

Nicotinamide adenine dinucleotide (NAD) shine mai haɗin gwiwa wanda ke taimakawa metabolism wanda aka samu a cikin dukkan ƙwayoyin rai. Ya wanzu a siffofi biyu …….

 


Status: A Mass Production
Naúra: 25kg / Drum

 

Nicotinamide adenine dinucleotide (53-84-9) bidiyo

Nicotinamide adenine dinucleotide (53-84-9) S.fasali

Product Name Nicotinamide adenine dinucleotide (NAD +)
Chemical Name Nadide; coenzyme I; beta-NAD; beta-NAD +; beta-Diphosphopyridine nucleotide; diphosphopyridine nucleotide; Enzopride;
CAS Number 53-84-9
InChIKey BAWFJGJZGIEFAR-NNYOXOHSSA-N
Smile C1=CC(=C[N+](=C1)C2C(C(C(O2)COP(=O)([O-])OP(=O)(O)OCC3C(C(C(O3)N4C=NC5=C(N=CN=C54)N)O)O)O)O)C(=O)N
kwayoyin Formula C21H27N7O14P2
kwayoyin Weight 663.4 g / mol
Monoisotopic Mass 663.109123 g / mol
Ƙaddamarwa Point 160 ° C (320 ° F; 433 K)
Launi White
Syawan zafin rana 2-8 ° C
solubility H2O: 50 mg / mL
Aikace-aikace Abinci na lafiya, na kwaskwarima, ƙari na abinci

 

Mene ne Nicotinamide adenin dinucleotide(NAD +)?

Nicotinamide adenine dinucleotide (NAD) wani cofactor ne wanda ke taimakawa metabolism da aka samu a cikin dukkanin sel. Ya wanzu a cikin nau'i biyu, oxidized (NAD +) da rage (NADH).

Coenzyme NAD +, nau'in ma'adinin oxidized na NAD, shine ya fara gano shi a cikin 1906 daga masanan kimiyyar ilimin halittar dan adam Arthur Harden da William John Young. NAD + yana haɓaka ta hanyoyi biyu na rayuwa, wanda za'a iya samar da shi daga hanyar de novo amino acid, ko kuma ana iya samar dashi ta hanyar sake fasalin abubuwanda aka riga aka kirkira (kamar nicotinamide) a kan hanyar ceto ta NAD +. Yana da mahimmancin pyridine nucleotide kuma yana aiki ne mai mahimmanci mai haɓakawa da ɗaukar hoto don yawancin hanyoyin salon salula waɗanda suka haɗa da sinadarin oxidative phosphorylation da kuma samar da ATP, gyaran DNA, ƙa'idar epigenetic na magana game da kwayoyin, siginar ƙwayar allurar ciki da aiki na Immunologi.

NAD + shine babban sinadarin yarda da wutan lantarki a cikin hadawar abu na abu. Yana karɓar electrons daga wasu kwayoyin kuma an rage shi. Hakanan yana aiki azaman coenzyme na watsawar hydride da wani abu wanda yake cinye NAD (+) polymerase, kuma yana samar da coenzyme redox tare da rage β-nicotinamide adenine dinucleotide (NADH). NAD (R) shine ADP-ribose mai ba da gudummawa ribosylation a cikin ADP-A. Hakan kuma shine farkon mai zuwa cyclic ADP-ribose (ADP-ribosyl cyclase).

A matsayin mai gurɓataccen abu a cikin kwayar halitta, NAD (R) shima yana da rawa a cikin adenosine diphosphate (ADP) -ribose canja wurin halayen da ya shafi diadenylate (ADP-ribose) polymerase da wasu matakai masu yawa na enzymatic. Zai iya ba NAD kariya don hana ko rage ciwon sukari, kansar da sauran cututtukan da suka shafi shekaru. Hakanan, masu haɓaka NAD + na iya aiki tare tare da kari kamar resveratrol don taimakawa sake sabunta mitochondria da yaƙi da cututtukan tsufa.

 

Nicotinamide adenin dinucleotide(NAD +) fa'idodi

A matsayin mai amfani da ƙwayar oxidant, Nicotinamide adenine dinucleotide yana nuna cewa wasu fa'idodi masu kyau a cikin ayyukan ɗan adam.

Inganta ayyukan salula,

Yourara ƙarfin ku a hankali;

♦ Inganta aikin kwakwalwa, mayar da hankali da ƙwaƙwalwar ajiya;

St Boost your metabolism;

Inganta bacci;

Bunkasa ayyukan sirtuin duniya;

♦ Inganta tasirin antioxidant;

Rage kumburi;

♦ Inganta daidaito, yanayi, hangen nesa da ji;

Nicotinamide adenine dinucleotid shima makasudin kai tsaye ne na maganin isoniazid, wanda ake amfani da shi wajen maganin tarin fuka, kamuwa da cutar tarin fuka na Mycobacterium. A cikin gwaji daya, berayen da aka ba NAD na mako guda sun inganta sadarwa ta hanyar nukiliya-mitochrondrial.

Bugu da kari, Nicotinamide adenine dinucleotide (NAD +) shima yana da rigakafi da lura da toshewar zuciya, aikin sinus da kuma abubuwan da suka shafi gwaji na gaggawa, nicotinamide na iya inganta yawan zuciya da kuma karfin guiwar atopve ta hanyar verapamil.

 

Nicotinamide adenin dinucleotide(NAD +) Application:

  1. Binciken reagents albarkatun ƙasa, ƙwarewar binciken kimiyya.
  2. Abinci na lafiya, na kwaskwarima, ƙari na abinci
  3. Samar da API

 

Kara Nicotinamide adenin dinucleotide(NAD +) bincike

Enzymes da ke yin amfani da NAD + da NADH suna da mahimmanci a cikin ilimin kimiyyar magani da kuma bincike kan maganin cutar nan gaba. Ba a amfani da coenzyme NAD + a halin yanzu azaman magani don kowane cuta. Koyaya, ana nazarin shi don amfanin sa a cikin maganin cututtukan neurodegenerative kamar su Alzheimer daParkinson.

 

reference:

  • Belenky P, Bogan KL, Brenner C (2007). "NAD + metabolism cikin lafiya da cuta" (PDF). Yanayin Biochem. Sci. 32 (1): 12– doi: 10.1016 / j.tibs.2006.11.006. PMID 17161604. An adana daga asali (PDF) a ranar 4 ga Yulin 2009. An dawo da 23 Disamba 2007.
  • Todisco S, Agrimi G, Castegna A, Palmieri F (2006). "Bayyanar jigilar mitochondrial NAD + a cikin Saccharomyces cerevisiae". J. Biol. Chem. 281 (3): 1524– doi: 10.1074 / jbc.M510425200. PMID 16291748.
  • Lin SJ, Guarente L (Afrilu 2003). "Nicotinamide adenine dinucleotide, mai kula da yanayin kwafi, tsawon rai da cuta". Curr. Bayyanawa Kwayar Biol. 15 (2): 241– doi: 10.1016 / S0955-0674 (03) 00006-1. PMID 12648681.
  • Williamson DH, Lund P, Krebs HA (1967). "Yanayin redox na kyautar nicotinamide-adenine dinucleotide a cikin cytoplasm da mitochondria na hanta bera". Biochem. J. 103 (2): 514– doi: 10.1042 / bj1030514. PMC 1270436. PMID 4291787.
  • Tallafa JW, Moat AG (1 Maris 1980). "Nicotinamide adenine dinucleotide biosynthesis da pyridine nucleotide sake zagayowar metabolism a cikin tsarin kwayoyin". Microbiol. Rev. 44 (1): 83– PMC 373235. PMID 6997723.
  • Faransanci SW. Binging na giya na yau da kullun yana cutar da hanta da sauran gabobin ta hanyar rage matakan NAD⁺ da ake buƙata don aikin deacetylase na sirtuin. Exp Mol Pathol. 2016 Apr; 100 (2): 303-6. Doi: 10.1016 / j.yexmp.2016.02.004. Epub 2016 Feb 16. PMID: 26896648.
  • Kane AE, Sinclair DA. Sirtuins da NAD + a cikin Haɓakawa da Kula da Cututtukan ƙwayoyin cuta da cututtukan zuciya. Circ Res. 2018 Sep 14; 123 (7): 868-885. doi: 10.1161 / CIRCRESAHA.118.312498. PMID: 30355082. PMCID: PMC6206880.