Nicotinamide adenine dinucleotide (53-84-9) bidiyo
Nicotinamide adenine dinucleotide (53-84-9) S.fasali
| Product Name | Nicotinamide adenine dinucleotide (NAD +) |
| Chemical Name | Nadide; coenzyme I; beta-NAD; beta-NAD +; beta-Diphosphopyridine nucleotide; diphosphopyridine nucleotide; Enzopride; |
| CAS Number | 53-84-9 |
| InChIKey | BAWFJGJZGIEFAR-NNYOXOHSSA-N |
| Smile | C1=CC(=C[N+](=C1)C2C(C(C(O2)COP(=O)([O-])OP(=O)(O)OCC3C(C(C(O3)N4C=NC5=C(N=CN=C54)N)O)O)O)O)C(=O)N |
| kwayoyin Formula | C21H27N7O14P2 |
| kwayoyin Weight | 663.4 g / mol |
| Monoisotopic Mass | 663.109123 g / mol |
| Ƙaddamarwa Point | 160 ° C (320 ° F; 433 K) |
| Launi | White |
| Syawan zafin rana | 2-8 ° C |
| solubility | H2O: 50 mg / mL |
| Aikace-aikace | Abinci na lafiya, na kwaskwarima, ƙari na abinci |
Mene ne Nicotinamide adenin dinucleotide(NAD +)?
Nicotinamide adenine dinucleotide (NAD) wani cofactor ne wanda ke taimakawa metabolism da aka samu a cikin dukkanin sel. Ya wanzu a cikin nau'i biyu, oxidized (NAD +) da rage (NADH).
Coenzyme NAD +, nau'in oxidized na NAD, an fara gano shi a cikin 1906 ta masana kimiyyar halittu na Burtaniya Arthur Harden da William John Young. An haɗa NAD + ta hanyoyi guda biyu na rayuwa, waɗanda za'a iya samarwa daga hanyar de novo amino acid, ko kuma ana iya samarwa ta hanyar sake yin amfani da abubuwan da aka riga aka tsara (kamar nicotinamide) zuwa hanyar ceto ta NAD +. Yana da mahimmancin pyridine nucleotide kuma yana aiki a matsayin mai mahimmanci mai mahimmanci kuma mai mahimmanci ga yawancin matakai na salon salula wanda ya shafi oxidative phosphorylation da kuma samar da ATP, gyaran DNA, tsarin epigenetic na maganganun kwayoyin halitta, siginar calcium na ciki da kuma aikin Immunological.
NAD + shine babban sinadarin yarda da wutan lantarki a cikin hadawar abu na abu. Yana karɓar electrons daga wasu kwayoyin kuma an rage shi. Hakanan yana aiki azaman coenzyme na watsawar hydride da wani abu wanda yake cinye NAD (+) polymerase, kuma yana samar da coenzyme redox tare da rage β-nicotinamide adenine dinucleotide (NADH). NAD (R) shine ADP-ribose mai ba da gudummawa ribosylation a cikin ADP-A. Hakan kuma shine farkon mai zuwa cyclic ADP-ribose (ADP-ribosyl cyclase).
A matsayin oxidant a cikin metabolism cell, NAD (R) kuma yana taka rawa a cikin adenosine diphosphate (ADP) - halayen canja wuri na ribose da ke tattare da diadenylate (ADP-ribose) polymerase da sauran matakan enzymatic da yawa. Yana iya ba da kariya ta NAD don hana ko rage ciwon sukari, ciwon daji da sauran cututtukan da suka shafi shekaru. Hakanan, masu haɓaka NAD + na iya aiki tare tare da kari kamar su sake sarrafawa don taimakawa sake farfado da mitochondria da yaki da cututtukan tsufa.
Nicotinamide adenin dinucleotide(NAD +) fa'idodi
A matsayin mai amfani da ƙwayar oxidant, Nicotinamide adenine dinucleotide yana nuna cewa wasu fa'idodi masu kyau a cikin ayyukan ɗan adam.
Inganta ayyukan salula,
Yourara ƙarfin ku a hankali;
♦ Inganta aikin kwakwalwa, mayar da hankali da ƙwaƙwalwar ajiya;
St Boost your metabolism;
Inganta bacci;
Bunkasa ayyukan sirtuin duniya;
♦ Inganta tasirin antioxidant;
Rage kumburi;
♦ Inganta daidaito, yanayi, hangen nesa da ji;
Nicotinamide adenine dinucleotid shima shine manufa kai tsaye maganin isoniazid, wanda ake amfani da shi wajen maganin tarin fuka, kamuwa da cutar ta Mycobacterium tarin fuka. A cikin gwaji ɗaya, berayen da aka ba NAD na mako ɗaya sun inganta sadarwar nukiliya-mitarondrial.
Bugu da kari, Nicotinamide adenine dinucleotide (NAD +) shima yana da rigakafi da lura da toshewar zuciya, aikin sinus da kuma abubuwan da suka shafi gwaji na gaggawa, nicotinamide na iya inganta yawan zuciya da kuma karfin guiwar atopve ta hanyar verapamil.
Nicotinamide adenin dinucleotide(NAD +) Aikace-aikace:
- Abubuwan bincike albarkatun kasa, gwaje-gwajen bincike na kimiyya.
- Abinci na lafiya, na kwaskwarima, ƙari na abinci
- Samar da API
Kara Nicotinamide adenin dinucleotide(NAD +) bincike
Enzymes da ke yin amfani da NAD + da NADH suna da mahimmanci a cikin ilimin kimiyyar magani da kuma bincike kan maganin cutar nan gaba. Ba a amfani da coenzyme NAD + a halin yanzu azaman magani don kowane cuta. Koyaya, ana nazarin shi don amfanin sa a cikin maganin cututtukan neurodegenerative kamar su Alzheimer daParkinson.
reference:
- Belenky P, Bogan KL, Brenner C (2007). "NAD + metabolism cikin lafiya da cuta" (PDF). Yanayin Biochem. Sci. 32 (1): 12– doi: 10.1016 / j.tibs.2006.11.006. PMID 17161604. An adana daga asali (PDF) a ranar 4 ga Yulin 2009. An dawo da 23 Disamba 2007.
- Todisco S, Agrimi G, Castegna A, Palmieri F (2006). "Bayyanar jigilar mitochondrial NAD + a cikin Saccharomyces cerevisiae". J. Biol. Chem. 281 (3): 1524– doi: 10.1074 / jbc.M510425200. PMID 16291748.
- Lin SJ, Guarente L (Afrilu 2003). "Nicotinamide adenine dinucleotide, mai kula da yanayin kwafi, tsawon rai da cuta". Curr. Bayyanawa Kwayar Biol. 15 (2): 241– doi: 10.1016 / S0955-0674 (03) 00006-1. PMID 12648681.
- Williamson DH, Lund P, Krebs HA (1967). "Yanayin redox na kyautar nicotinamide-adenine dinucleotide a cikin cytoplasm da mitochondria na hanta bera". Biochem. J. 103 (2): 514– doi: 10.1042 / bj1030514. PMC 1270436. PMID 4291787.
- Tallafa JW, Moat AG (1 Maris 1980). "Nicotinamide adenine dinucleotide biosynthesis da pyridine nucleotide sake zagayowar metabolism a cikin tsarin kwayoyin". Microbiol. Rev. 44 (1): 83– PMC 373235. PMID 6997723.
- Faransanci SW. Binging na giya na yau da kullun yana cutar da hanta da sauran gabobin ta hanyar rage matakan NAD⁺ da ake buƙata don aikin deacetylase na sirtuin. Exp Mol Pathol. 2016 Apr; 100 (2): 303-6. Doi: 10.1016 / j.yexmp.2016.02.004. Epub 2016 Feb 16. PMID: 26896648.
- Kane AE, Sinclair DA. Sirtuins da NAD + a cikin Haɓakawa da Kula da Cututtukan ƙwayoyin cuta da cututtukan zuciya. Circ Res. 2018 Sep 14; 123 (7): 868-885. doi: 10.1161 / CIRCRESAHA.118.312498. PMID: 30355082. PMCID: PMC6206880.
