NMN foda (1094-61-7)

Oktoba

Ma'aikatarmu tana da ikon samar da hoda sama da 1370kg Nicotinamide Mononucleotide (nmn) a kowane wata a karkashin yanayin GMP.


Status: A Mass Production
Naúra: 25kg / Drum
Capacity: 1370kg / watan

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bayani dalla-dalla

Product Name Raw Nicotinamide Mononucleotide (NMN) foda
Suna Ma'ana NAMN, β-NMN, β-Nicotinamide Mononucleotide ko Beta Nicotinamide Mononucleotide; NMN;

beta-NMN

Drug Class Adadin abinci na abinci
CAS Number 1094-61-7
InChIKey DAYLJWODMCOQEW-TURQNECASA-N
Tsarin kwayoyin halitta C11H15N2O8P
Nauyin kwayoyin halitta 334.22 g / mol
Monoisotopic Mass 334.056602 g / mol
Wurin narkewa  166 ° C (yankewa)
Daskarewa Point N / A
Half Half-Life N / A
Launi Fari zuwa farin-foda
solubility  Beta-NMN an kawota azaman ingantaccen ƙarfe. Beta-NMN yana narkewa cikin sauƙi a cikin ƙwayoyin ƙwayoyi kamar ethanol, DMSO, da dimethyl formamide. Don gwaje-gwajen nazarin halittu, muna ba da shawarar cewa hanyoyin samar da ruwa mai ƙarancin ruwa na Beta-NMN su kasance cikin shiri ta hanyar narkar da daskararren ƙarfe kai tsaye a cikin marufi na ruwa. Maganin Beta-NMN a cikin PBS, pH 7.2, kusan 10 mg / ml ne. Ba mu ba da shawarar adana maganin mai ruwa na sama da rana ɗaya ba.
Zazzabi na Ma'aji  Tsarin yanayi;

Adana a -20 ° C har zuwa shekaru 2.

Aikace-aikace Anti-tsufa abin da ake ci kari

 

Tarihin NMN

Nicotinamide mononucleotide (tsarin kwayoyin: C11H15N2O8P, lambar CAS: 1094-61-7, wanda aka fi sani da NMN, beta-Nicotinamide mononucleotide ko β-NMN) bitamin B3 ne wanda aka samu [1], wanda aka samo shi cikin jikin mutum, kuma a gama gari abinci kamar su broccoli da kabeji a ƙananan ƙananan abubuwa [2].

NMN ta fara samun riba a matsayin mai yuwuwar samar da abinci mai gina jiki a cikin 2013, bayan wani ci gaban binciken da masana kimiyyar Harvard suka gudanar kan beraye [3,4].

An fara samar da NMN a matsayin kari ga mutane a shekara ta 2015 [5], amma ya kasance mai tsada sosai wajen kerawa, har sai da aka kirkiro hanyoyin rage farashin samarwa da kara tsafta a cikin shekarar 2018 [6], a wannan lokacin ne aka fara binciken dakunan gwaje-gwaje don samar da kayan masarufi zuwa zo kan layi.

 

Menene NMN foda?

Nicotinamide mononucleotide (tsarin kwayoyin: C11H15N2O8P, lambar CAS: 1094-61-7, wanda aka fi sani da NMN, beta-Nicotinamide mononucleotide ko β-NMN) bitamin B3 ne wanda aka samu [1], wanda aka samo shi cikin jikin mutum, kuma a gama gari abinci kamar su broccoli da kabeji a ƙananan ƙananan abubuwa [2].

Nicotinamide Mononucleotide (NMN) haɗuwa ce da ke faruwa a cikin ɗabi'a wanda yake ƙananan a jikin mutum da kuma wasu abinci. NMN ana iya samun wadatar magana, kuma idan aka ɗauka da baki zai iya tallafawa matakan NAD + a cikin hanta da tsoka.

Binciken da aka yi kwanan nan ya nuna cewa NMN na iya tallafawa lafiyar zuciya, samar da makamashi, lafiyar hankali, da kuma lafiyar ido da ta kashi. Aya daga cikin abubuwan ban sha'awa mai ban sha'awa na binciken NMN shine cewa yana iya inganta gyaran DNA da tallafawa goyan bayan ƙwayoyin SIRTUIN waɗanda ake tsammanin zasu taka rawa cikin tsufa mai lafiya.

 

Yaya aiki?

NMN shine mai ƙaddara ga kwayoyin NAD +; jikin mutum yana buƙatar NMN don ƙirƙirar NAD + nasa.

NAD + shine nau'in NAD mai gurɓatsewa (Nicotinamide adenine dinucleotide), kwayar halitta da aka fara ganowa a shekarar 1906, kuma aka sameta a cikin dukkanin ƙwayoyin rai [7].

Arin tare da NAD + kanta ba zaɓi bane don haɓaka matakan NAD +, saboda yana da girma don sauƙaƙe membran ƙwayoyin salula don shiga ƙwayoyin cuta, sabili da haka ba zai iya tasiri mai tasiri ga tasirin metabolism [8] ba.

 

Fa'idodin NMN.

Aya daga cikin hanyoyin da zamu ci gaba da inganta lafiyar NAD + shine ta hanyar haɓaka jikin mu da abinda ke gabanta, nicotinamide mononucleotide (NMN).

Binciken yanzu yana nuna cewa wannan canji tsakanin NR da NMN dole ne ya faru don shigarwa zuwa wasu ƙwayoyin salula. Wannan yana haifar da masu bincike suyi imani cewa NMN, a zahiri, ɗayan hanyoyi mafi sauri don haɓaka aikin NAD. Koyaya, Nicotinamide mononucleotide foda suma suna tabbatar da suna da nasu amfanin tsufa fiye da na NAD kawai.

Baya ga hanyar NAD na rayuwa, ana iya ƙara ƙwayar NMN kai tsaye zuwa sel ba tare da juyawa zuwa NAD ba. Wannan lamarin zai yiwu ne ta hanyar sabbin sunadaran safarar da aka gano wadanda suke karuwa a lamba bayan matakan NAD sun sauka. A wannan hanyar, NMN na ba da gudummawa ga kuzarin salula kuma yana ba da damar kowane ɗayan abubuwan da aka ambata na tsufa wanda ya inganta ta hanyar ƙwayoyin cuta tare da isasshen ƙarfin girma da haɓaka.

Zaɓi don kari tare da NMN foda tare da NAD yana samar da wata hanya madaidaiciya kai tsaye don inganta haɓakar ƙwayoyin ƙwayoyin cuta kuma don haka hanya ce mafi sauri don yin hakan. Bugu da ƙari, an gano Nicotinamide mononucleotide foda don inganta aikin insulin da samarwa, wanda ke haifar da ƙarin fa'idodi na rayuwa tare da haƙuri glucose. Musamman, kariyar NMN na iya taimakawa aiki don sauƙaƙe yanayin rayuwa kamar ciwon sukari, ciwon hanta mai kiba, da kiba. [11]

 

Sauran Fa'idodi masu Amfani na NMN

  • Yana inganta lafiyar jijiyoyin jini da gudan jini. [11]
  • Inganta Endarfafa Muscle da ƙarfi
  • Yana Kare Daga Ciwon Zuciya
  • Yana rage Haɗarin Kiba. [10]
  • Yana inganta Kulawar Gyara DNA
  • Ara Aikin Mitochondrial. [9]

 

Yadda ake samun daidaito, tsarkakakke, mai aminci NMN?

Domin sanin yadda za a sami ci gaba, ingantacce, tsarkakakke kuma lafiyayyen samfuri, an gudanar da jerin gwaje-gwaje da bincike. Ana iya bayar da rahoton COA, HPLC da HNMR.

 

Inganta kwanciyar hankali

Ta hanyar nazarin tsarin monotoncleide na Nicotinamide da amfani da canjin caji da hanyar sa ido ta FTIR, an gano cewa NMN yana da tsarin gishiri guda ɗaya kuma maɓallin keɓaɓɓen gishirin ciki shine babban mahimmancin rashin zaman lafiya na NMN. Ruwa, a matsayin kwayar polar daya, zai haifar da tura wutar lantarki a cikin NMN wanda zai iya lalata kwararar gishirin ciki na NMN. Idan haka ne, NMN zai nuna wani tsarin canjin yanayi wanda yake kaskantar da kai cikin sauki, watau abinda ke cikin ruwa a cikin samfurin da kwayoyin ruwa masu kyauta a cikin iska kai tsaye zai lalata ma'anar isoelectric na gishirin ciki da kuma saukar da tsaftar NMN. Wannan babbar nasara ce a cikin bincike na kwanciyar hankali na NMN, wanda zai zama farkon farawa don ingantawa.

Don inganta zaman lafiyar NMN foda a ciki, masu bincike ƙirƙirar sabon NMN foda tare da tsari da ƙaramin tsarin microscopic.

 

Stabilityarfin ƙarfi, rayuwa mai tsayi.

Phcoker NMN foda ya fi tsari da tsari, yana toshe hanyar sadarwa tare da ruwa kyauta a cikin iska, yana ƙara zaman lafiyar NMN ƙwarai da gaske kuma yana faɗaɗa rayuwar samfurin. Akasin sabon tsarin NMN na karamin microscopic, tsarin sawtooth na ƙarni na farko ya nuna rikicewa da rashin aiki, saboda haka kowane kwayoyin zasu sami ƙarin iska zuwa iska kuma zasu sha ruwa sosai.

 

Matsayi mafi girma, ingantaccen sashi da sassauƙan tsari.

NMN foda tare da tsari mai ma'ana da ƙaramar microscopic yana da ƙimar girma mai yawa da ruwa, wanda ke nisantar tsaka-tsakin sashi saboda haɓaka ƙura yayin aiwatar da shiri. Abin da ya fi haka, zai iya shafar daidaitaccen sashi na capsules. A halin yanzu, tunda yana da mafi kyawun ruwa, Namu NMN ɗinmu na iya taimakawa rage lokacin samarwa da farashin masana'anta yayin samarwa.

 

Tabbaci mai inganci kuma mai tsarki

Ya kamata rahotonnin gwaji na ɓangare na uku ya zama dole don tabbatar da ainihi da tsabtar NNM. Kowane ɗayan kayan albarkatu dole ne ya wuce tsananin duba kansa da gwajin ɓangare na uku. Rahoton gwaji na HNMR da HPLC na iya ƙara tabbatar da inganci, inganci da tsarkin NMN.

 

Phcoker shine Nicotinamide mononucleotide (NMN) mai ƙera foda

Tare da masana'antar keɓaɓɓu, haɓakar NMN ɗinmu na wata-wata ya isa sama da tan 2.

 

Aikace-aikace

Cosmetic albarkatun kasa:

NMN abu ne a cikin jikin sel, kuma NMN kwayoyin halitta ne , yana da tasirin tsufa a bayyane yake, saboda haka ana iya amfani da shi a cikin kayan ɗanɗano na kwalliya.

 

Kayayyakin kiwon lafiya:

NMN foda za a iya shirya ta yisti ferment, hada sinadarai ko in vitro enzymatic catalysis.

NMN foda da ake amfani dashi a cikin masana'antar kiwon lafiya.

 

reference:

[1] Nicotinamide mononucleotide. Daga Wikipedia, encyclopedia kyauta. 2019.

[2] Gudanar da Tsawon Lokaci na Nicotinamide Mononucleotide Mitigates -arfafa Physarfin Jikin Jiki a cikin Mice. Mills KF, Yoshida S, Stein LR, Grozio A, Kubota S, Sasaki Y, Redpath P, Migaud ME, Apte RS, Uchida K, Yoshino J, Imai SI. Cell Metab. 2016 Disamba 13.

[3] Ragewar NAD + yana haifar da Statearya ta searya ta Disarfafa Sadarwar Nuclear-Mitochondrial a lokacin tsufa. Gomes AP, Farashin NL, Ling AJ, Moslehi JJ, Montgomery MK, Rajman L, White JP, Teodoro JS, Wrann CD, Hubbard BP, Mercken EM, Palmeira CM, de Cabo R, Rolo AP, Turner N, Bell EL, Sinclair DA. Kwayar halitta 2013 Disamba 19; 155 (7): 1624-38. Doi: 10.1016 / j.cell.2013.11.037.

[4] Sabon-Kuma Mai Sauya - Dalilin tsufa. David Cameron. Makarantar Kiwon Lafiya ta Harvard, Labarai & Bincike, Disamba 19, 2013

[5] Aljihun da aka adana NAD + wanda ke daidaita hulɗar furotin-furotin yayin tsufa. Li J, Bonkowski MS, Moniot S, Zhang D, Hubbard BP, Ling AJ, Rajman LA, Qin B, Lou Z, Gorbunova V, Aravind L, Steegborn C, Sinclair DA. Kimiyya. 2017 Mar 24; 355 (6331): 1312-1317. Doi: 10.1126 / kimiyya.aad8242.

[6] Hanyar keɓaɓɓiyar Hanyar Chromatography don Tsarkake Nicotinamide Mononucleotide (NMN) daga Kwayoyin Bacterial. George Cătălin Marinescu, Roua-Gabriela Popescu & Anca Dinischiotu. Rahoton Kimiyya Juzu'i na 8, Lambar Mataki: 4433 (2018).

[7] Nicotinamide adenin dinucleotide. Daga Wikipedia, kyauta kyauta. 2019.

[8] Tabbatar da jigilar NAD + mitochondrial a Saccharomyces cerevisiae., Todisco S, Agrimi G, Castegna A, Palmieri F. J Biol Chem. 2006 Janairu 20; 281 (3): 1524-31. Epub 2005 Nuwamba 16.

[9] Katalin Sas, Elza Szabó, László Vécsei. Mitochondria, Oxwarewar Oxidative da Tsarin Kynurenine, tare da Maida hankali kan Tsufa da Neuroprotection. Kwayoyin halitta, 2018; DOI: 10.3390 / kwayoyin23010191.

[10] Otarin Nicotinamide mononucleotide (NMN) yana inganta tasirin kiba na uwa a jikin beraye: kwatantawa da motsa jiki. Uddin GM, Youngson NA, Doyle BM, Sinclair DA, Morris MJ.

[11] Jun Yoshino, Kathryn F. Mills, Myeong Jin Yoon, Shin-ichiro Imai. Nicotinamide Mononucleotide, Key NAD + Matsakaici, Yana Kula da Pathophysiology na Abinci- da Ciwon Cutar Ciwon Suga a Mice. Cell Metab, 2011; DOI: 10.1016 / j.cmet.2011.08.014.

[12] Sabbin Magungunan Anti-tsufa: Nicotinamide Mononucleotide (NMN)