Raw Tadalafil foda (171596-29-5)

Oktoba

Raw Tadalafil foda a ƙarƙashin sunan Cialis ana amfani dashi don magance rashin ƙarfi (rashin ƙarfi) da alamun rashin lafiya mai saurin ciwo ………


Status: A Mass Production
Naúra: 25kg / Drum
Capacity: 1190kg / watan

Tadalafil foda video

 

Bayanan Basan

Product Name Tadalafil foda
Chemical Name (6R,12aR)-6-(1,3-benzodioxol-5-yl)-2,3,6,7,12,12a-hexahydro-2-methylpyrazino[1′,2′:1,6]pyrido[3,4-b]indole-1,4-dione
Brand Name Cialis, Adcirca
Drug Class PAH, PDE-5 Masu hanawa; Magunguna masu ƙwayar cuta ta 5 Enzyme
CAS Number 171596-29-5
InChIKey WOXKDUGGOYFFRN-IIBYNOLFSA-N
kwayoyin FƘararraki C22H19N3O4
kwayoyin Wtakwas 389.4
Monoisotopic Mass 389.138 g / mol
Gyarawa Point  298-300 ° C
Freezing Point 2 ℃
Half Half-Life 17.5 hours
Launi White zuwa Off-White Cyrstalline Solid
Solubility  Narkewa cikin DMSO (78 mg / ml a 25 ° C), methanol, ruwa (<1 mg / ml a 25 ° C), dichloromethane, da ethanol (<1 mg / ml a 25 ° C)
Storage Taikin zafi  Adana a zazzabin ɗaki tsakanin 59 ° F da 86 ° F (15 ° C da 30 ° C). Kada a adana wannan magani a wuraren danshi ko damshi.
Tadalafil Aaikace-aikace Raw Tadalafil foda allon, Jima'i alewa, Jima'i kofi, da dai sauransu.

 

description

Tadalafil, (6R-trans) -6- (1,3-benzodioxol-5-yl) -2,3,6,7,12,12a-hexahydro-2-methyl-pyrazino [1 ', 2': 1,6, 3,4] pyrido [1,4-b] indole-5-dione (Cialis), wani nau'in mai hana PDE5 ne kuma ana ba da magani da baki. Abun kirkirar b-carboline ne kuma ya sha bamban da vardenafil (Levitraw) da sildenafil (Viagraw), dukkansu biyun masu hana PDE171596 ne bisa tushen tsarin haɗin pyrimidine. Tadalafil foda (CAS 29-5-2003) yana ƙaruwa da jini a cikin corpus cavernosum ta hanyar sassauta jijiyoyin jijiyoyin jini, kuma wannan yana bawa mutum damar cimma mizani. Tadalafil foda ta amince da Amurka (US) Abinci da Magunguna (FDA) a XNUMX don maganin rashin aiki (ED), kuma an tallata ta a duniya a ƙarƙashin sunan Cialis. Hakanan ana amfani dashi don magance hauhawar jini na huhu da rashin karfin jini, wani yanayi wanda glandon prostate yake kara girma, yana haifar da matsala tare da yin fitsari.

Tsarin Tadalafil mai rarrabe kantin magani shine mafi rabin rayuwarsa (awanni 17.5) idan aka kwatanta da Viagra da Levitra (awa 4-5). Wannan tsawon rabin rayuwa yana haifar da tsawon lokacin aiki kuma a wani ɓangare, yana da alhakin laƙabin Cialis na "kwayar karshen mako." Wannan rabin rabin kuma shine asalin binciken da akeyi yanzu don amfani da tadalafil a cikin hauhawar jini na huhu a matsayin maganin yau da kullun.

Kayan aikin

Hanya ta Penile yayin tashin hankali ta hanyar jima'i yana samuwa ta wurin shakatawa na suturar na penile da kuma cacos cavernosal tsokoki mai tsayi, wanda zai haifar da kara yawan jini zuwa gawar. Wannan shakatawa yana ba da damar ƙãra jini ta hanyar jinji na penile, yayin da wannan jini ya cika dakuna biyu a cikin azzakari da ake kira corvern cavernosa. Yayinda ɗakunan da ke cika da jini, azzakari ya kara karfi. Sakamako yana ƙare lokacin da tsokoki na tsoka da jini mai yalwa zai iya kwarara daga cikin veins penile.

Wannan amsa tana shiga tsakani ne ta hanyar sakin nitric oxide (NO) daga tashoshin jijiyoyi da ƙwayoyin endothelial, wanda ke haifar da kira na cGMP a cikin ƙwayoyin tsoka mai santsi sannan kuma ke sarrafa yaduwa da raguwar jijiyoyin jini da ke ɗaukar jini zuwa da daga azzakari. GMP na Cyclic yana haifar da hutar da tsoka mai sassauci da haɓaka jini a cikin corpus cavernosum, kuma an wulakanta shi ta hanyar cGMP takamaiman nau'in phosphodiesterase nau'in 5 (PDE5) a cikin caprosus caprosos dake kusa da azzakari. Tadalafil yana hana PDE5 kuma don haka haɓakawa ta hanyar haɓaka adadin cGMP da ake samu. Tadalafil ya dakatar da PDE5 daga lalata cGMP sannan kuma ya haɓaka samfuran cGMP don cimma aiki kuma yana haifar da tsagewar ta daɗe.

Koyaya, yayin da rabin rayuwar Tadalafil yayi gajarta, sakamakonsa zai ƙare a cikin kwanaki 2 wanda zai sa PDE5 ya dawo kuma lafiyar jima'i - ta ƙara ta'azzara. Kila iya buƙatar ɗaukar tsawon lokaci don cimma tasirin da kuke so, kamar ƙananan Cialis mai ƙarfi 4-5 kwanakin 4-5 kwanakin.

Aikace-aikace

  • Dysfunction Erectile (ED)
  • Karfin jini na jini na yau da kullum
  • Nisan hyperplasia prostatic benign
  • Analgesic
  • Norepinephrine ta dauki caca
  • Mu-opiod receptor agonist

Shawara Tadalafil foda Dosage

Cialis yazo cikin ruwan hoda, mai ruɓin fim da allon almara a cikin allurai 5, 10 da 20. Sashin farawa na shawarar Cialis foda don amfani kamar yadda ake buƙata a mafi yawan marasa lafiya shine 10 MG, ɗauka kafin aikin jima'i da ake tsammani.

Sakamakon farko shine Xigin 10 (MG) akalla 30 mintuna kafin yin jima'i. Hakan zai iya karuwa zuwa 20 MG ko rage zuwa 5 MG, ​​bisa ga mutum nagarta da juriya. Amma, iyakar ita ce 20 MG kamar kashi guda. Matsakaicin shawarar dosing mita sau ɗaya kowace rana a mafi yawan marasa lafiya. Bai kamata ya dauki fiye da ɗaya kashi a cikin 24 hours ba. Marasa lafiya waɗanda suke tsammanin yin aiki da jima'i a kalla sau biyu a mako suna iya ɗaukar nauyin 5 na yau da kullum, kuma wannan zai iya ragewa zuwa 2.5 MG sau daya kowace rana, dangane da mutum.

Cialis foda don amfani dashi kamar yadda ake buƙata an nuna shi don inganta aiki idan aka kwatanta da placebo har zuwa awanni 36 bayan allurar. Sabili da haka, lokacin da kake ba da shawara ga marasa lafiya game da ingantaccen amfani da Cialis foda, wannan ya kamata a la'akari.

Yana da kyau a sani cewa tsawan bazai faruwa ba ta hanyar shan kwaya. Kuma kada ku ɗauki Cialis don lalata idan kuna shan Adcirca don hauhawar jini na huhun jini. Baicin, Tadalafil don lalata shine kawai don amfani da tsofaffi masu shekaru 18 shekaru da sama.

amfanin

Ada Tadalafil foda na iya taimakawa shakatawa tsoka a cikin prostate da mafitsara. Wannan na iya taimakawa inganta alamomin ku na BPH.

♦ Don inganta bayyanar cututtukan ED, tadalafil foda na taimakawa ƙara yawan jini zuwa azzakari. Wannan na iya taimaka maka samun ci gaba. Don tadalafil foda don taimaka muku samun tsage, kuna buƙatar sha'awar jima'i.

Ga PAH, tadalafil foda tana aiki don haɓaka ƙwarewar ku ta motsa jiki ta hanyar shakatawa jijiyoyin jini a cikin huhu. Wannan yana kara yawan jini.

Side effects

Tare da abubuwan da ake bukata, magani zai iya haifar da wasu cututtukan da ba'a so. Kodayake ba duka waɗannan cututtuka na iya faruwa ba, idan sun faru zasu iya buƙatar kula da lafiya. Da fatan a duba abubuwan da ke faruwa na tadalafil foda:

Abubuwan sakamako na al'ada

Ciwon kai

▪ cike ciki

▪ ciwon baya

▪ tsofaffin ƙwayoyi

▪ flushing (fata fata)

Cizon ko hanci

▪ zawo

Ra'ayoyin haɗari amma masu tsanani 

Tsarin tsayi mai tsawo wanda zai iya haifar da lalacewa ga azzakari, matsalolin hangen nesa, da hasara.

Idan waɗannan tasirin sun kasance m, zasu iya tafi cikin cikin 'yan kwanaki ko mako biyu. Idan sun kasance mafi tsanani ko kuma ba su tafi ba, magana da likitan ko likita.

Mutane da yanayin da ke biyowa ba za su dauki Cialis foda ba sai dai likita ya yarda:

Matsalar zuciya, angina, ko kowane cututtukan zuciya

High ko saukar karfin jini

Zuciyar zuciya ta zuciya ko bugun jini a cikin watanni 6 na ƙarshe, ko kuma infarction na sirri a cikin watanni 3 na ƙarshe

Ciwon sikila, mahaifa myeloma, hemophilia, cutar sankarar bargo, ko wani jini

Harkar ko cutar koda

Cutar ciwo

Retinitis pigmentosa

Lalacewar tsarin azzakari, kamar cutar Peyronie

Duk wani yanayin kiwon lafiya wanda aka shawarce su kada su yi jima'i

Tadalafil hulda

Lokacin da kake amfani da tadalafil, akwai wasu miyagun ƙwayoyi waɗanda zasu iya rinjayar maganin miyagun ƙwayoyi, wanda zai haifar da sakamako mai lalacewa. Harkokin hulɗa na kwayar cutar zai iya canza yadda magunguna ke aiki ko ƙara yawan haɗarinka ga masu tasiri.

Tadalafil yana da tasiri mai tasiri a kan rage rage yawan ƙwayoyin nitrate a cikin karfin jini. Tadalafil zai iya haifar da mummunan digirin jinin jini lokacin da ake amfani da nitrates, wanda zai haifar da matsananciyarsa, rashin ƙarfi, da kuma rashin ciwon zuciya ko bugun jini. Kada ku yi amfani da tadalafil tare da wasu daga cikin wadannan: wasu kwayoyi da ake amfani da su don maganin ciwon kwakwalwa / angina (nitrates irin su nitroglycerin, isosorbide), kayan wasan motsa jiki da ake kira "poppers" dauke da amyl ko butyl nitrite.

Idan kuma kuna shan magani na alpha (irin su doxazosin, tamsulosin) don bi da karuwar prostate / BPH ko cutar hawan jini, karfin jini zai iya zama ƙasa mai yawa wanda zai iya haifar da matsananciyar rashin tsoro ko kuma ya ɓace. Kwararka na iya fara jiyya tare da ƙaramin kashi na tadalafil ko gyara maganin maganin kafar alpha don rage girman hawan jini.

A cikin karatun asibiti, an ba da rahoton mahimmancin martani har zuwa 36 h bayan shigar magunguna. Tadalafil shine mafi yawan metabolized a cikin hanta ta CYP3A4 ga abubuwan da ba su da ƙarfi a kan PDE5 kuma an keɓe su musamman a matsayin metabolites a cikin feces da fitsari. Magungunan magunguna na tadalafil ba su da illa ga abubuwan da suka haɗa da yawan abinci da barasa, shekaru, kasancewar ciwon sukari, da kuma rashin isasshen rashin lafiyar hepatic. Abubuwan da suka fi dacewa da haɗarin haɗari da ke tattare da magunguna sune ciwon kai, ciwon baya, dyspepsia, da myalgia. A allurai na 10 da 20 allurai, Tadalafil bashi da tasiri a cikin karfin jini da raunin zuciya kuma baya haifar da karuwar yanayin rashin karfin myocardial. Rahotanni masu zafi na tsawaita tsawan da suka fi 4 h da kaduwa an lura da amfani da tadalafil. Idan ba a kula da shi sosai ba, zai iya haifar da lalacewar nama. An shawarci marasa lafiya waɗanda ke da tashin hankali wanda ya fi ƙarfin 4 h don neman likita na gaggawa. A cikin marasa lafiyar masu ciwon sukari, haɓaka aiki ta hanyar tadalafil ba tare da la'akari da irin ciwon sukari da kuma nau'in maganin ciwon sukari ba.

Wasu magunguna na iya shafar kawar da tadalafil daga jikinka, wanda zai iya tasiri yadda tadalafil ke aiki. Misalan sun hada da maganin rigakafin azole (irin su itraconazole, ketoconazole), maganin rigakafin macrolide (irin su clarithromycin, erythromycin), masu hana masu kare lafiyar HIV (irin su fosamprenavir, ritonavir), masu ciwon gizon C protease protease (kamar boceprevir, telaprevir), rifampin, da sauransu .

Kada ku ɗauki wannan magani tare da kowane samfurin da ya ƙunshi tadalafil ko wasu magunguna masu kama da aka yi amfani dasu don magance dysfunction-ED ko hauhawar huhu (kamar sildenafil, vardenafil).

Game da tadalafil hulɗa da sauran kwayoyi har yanzu yana da yawa, idan kana so ka yi amfani da miyagun ƙwayoyi tare da tadalafil foda (CAS 171596-29-5), ka tuna da farko don tuntuɓi likitanka kuma zai ba ka shawara na kwarai da abin dogara.

Bugu da ari bayanai

Tadalafil foda, sildenafil foda, da vardenafil foda duk suna aiki ta hana PDE5 enzyme, amma waɗannan kwayoyi kuma suna hana PDE enzymes 6, 1, da 11 a cikin digiri daban-daban. Misali, Sildenafil da vardenafil sun hana PDE6, wani enzyme da aka samu a cikin ido, fiye da tadalafil. Wasu masu amfani da sildenafil suna ganin launin shuɗi kuma suna da ƙarfin haskakawa zuwa haske saboda hana PDE6. Bayan haka, Sildenafil da vardenafil suma sun hana PDE1 fiye da tadalafil. Ana samun PDE1 a cikin kwakwalwa, zuciya, da kuma tsoka mai santsi. Ana tunanin cewa hana PDE1 ta sildenafil da vardenafil yana haifar da vasodilation, flushing, da tachycardia.

Idan aka kwatanta da aikin PDE6 da PDE1, tadalafil ya yi karin haske akan PDE11. PDE11 an bayyana shi a tsoka mai tsoka, da prostate, hanta, koda, glandan gwaninta, da gwajin. Duk da haka, ba a san abubuwan da ke kan jiki na hana PDE11 ba.