Urolithin A

Afrilu 8, 2021

Urolithin A an nuna shi don haɓaka mitophagy da haɓaka lafiyar tsoka a cikin tsofaffin dabbobi kuma a cikin ƙirar ƙirar tsufa. A halin yanzu, shi ma an nuna shi ya haye shingen ƙwaƙwalwar jini, kuma yana iya samun tasirin neuroprotective akan cutar Alzheimer.

Urolithin A (1143-70-0) bidiyo

Urolithin A (1143-70-0)bayani dalla-dalla

Product Name Urolithin A foda
Chemical Name 3,8-dihydroxy-6H-benzo [c] chromen-6-daya;

3,8-Dihydroxy-6H-dibenzo (b, d) pyran-6-daya;

3,8-Dihydroxyurolithin;

3,8-dihydroxybenzo [c] chromen-6-daya;

6H-Dibenzo [b, d] pyran-6-daya, 3,8-dihydroxy-;

3,8-Hydroxydibenzo-alpha-pyrone;

CAS Number 1143-70-0
InChIKey RIUPLDUFZCXCHM-UHFFFAOYSA-N
SMILES C1=CC2=C(C=C1O)C(=O)OC3=C2C=CC(=C3)O
kwayoyin FƘararraki C13H8O4
kwayoyin Wtakwas 228.2 g / mol
Monoisotopic Mass 228.042259 g / mol
narkewa batu 340-345 ° C
tafasar batu  527.9 ± 43.0 ° C (Tsinkaya)
Flash Point 214.2ºC
Half Half-Life Urolithin A yana nan cikin fitsari har zuwa awanni 48 bayan shan ruwan 'ya'yan rumman.
Launi Fari ga beige
Solubility  DMSO: 20 MG / ML, bayyana
Storage Taikin zafi  2-8 ° C
Aaikace-aikace An yi amfani dashi azaman ƙarin abinci da kayan tsufa, ana iya amfani dashi don rage kumburi da yaƙi da kansa;

 

reference:

[1] Garcia-Muñoz, Cristina; Vaillant, Fabrice (2014-12-02). "Tsarin rayuwa na Ellagitannins: Abubuwan da ke faruwa ga Kiwon Lafiya, da Ra'ayoyin Bincike don Ingantaccen Abincin Aiki". Mahimman bayanai game da Kimiyyar Abinci da Gina Jiki. 54 (12): 1584–1598. Doi: 10.1080 / 10408398.2011.644643. ISSN 1040-8398. PMID 24580560. S2CID 5387712.

[2] Ryu, D. et al. Urolithin A yana haifar da mitophagy kuma yana tsawanta rayuwa a cikin C. elegans kuma yana haɓaka aiki na tsoka a cikin beraye. Nat. Likita 22, 879–888 (2016).

[3] "FDA GRAS sanarwa GRN No. 791: urolithin A". Hukumar Abinci da Magunguna ta Amurka. 20 Disamba 2018. An dawo da 25 Agusta 2020.

[4] Singh, A.; Andreux, P.; Blanco-Bose, W.; Ryu, D.; Aebischer, P.; Auwerx, J.; Rinsch, C. (2017-07-01). "Urolithin A da aka gudanar ta baka yana da lafiya kuma yana daidaita tsoka da mitochondrial biomarkers a cikin tsofaffi". Bidi'a a cikin tsufa. 1 (suppl_1): 1223–

[5] Heilman, Jacqueline; Andreux, Pénélope; Tran, Nga; Rinsch, Chris; Blanco-Bose, William (2017). "Binciken lafiya na urolithin A, wani abu mai narkewa wanda hanjin dan adam ya samar akan abincin da ake samu na ellagitannins da ellagic acid" Abinci da Sinadarin Toxicology. 108 (Pt A): 289– doi: 10.1016 / j.fct.2017.07.050. PMID 28757461.