Ya taɓa jin labarin Nicotinamide Adenine Dinucleotide (NAD +) ko "Tushen Matasa"? " Tare da ingantaccen abinci mai gina jiki da kuma motsa jiki, jikinka an tsara shi da kullun don samun ingantaccen metabolism.

Abin takaici, tare da rashin lafiya, tsufa da / ko salon rayuwa mara kyau, jikinka ya fara jin ƙaranci daban-daban waɗanda suka ga ingancinsa yana raguwa da kyau. Narancin nicotinamide adenine dinucleotide (NAD +) na cikin waɗannan rashi, kuma a nan ne NAD + kari ya shigo cikin hanzari don rufewa a cikin rashi rashi, musamman wajen inganta tsarin tsufa lafiya.

Nicotinamide adenine dinucleotide (NAD) yana nufin babban abu wanda ke haɗuwa da adenine da nicotinamide. Duk wani kwayar halitta mai rai yana dauke da wannan sunadarai, wanda yake asalin Nicotinamide Riboside. Matakan NAD a jikin dan adam yana tasiri a cikin girman tsufansa.

Akwai nau'ikan NAD guda biyu, wato, nicotinamide adenine dinucleotide (NAD +) da nicotinamide adenine dinucleotide (NAD) + hydrogen (H) (NADH). Tsohon yana da ƙarin ƙarin electrons guda biyu, kuma shine abin da ya sanya shi ban da na ƙarshen.

NAD + 01

Menene NAD +?

Nicotinamide adenine dinucleotide (NAD +) wani kwayar halittar pyridine ne wanda yake a yanzu kuma yana da matukar mahimmanci a cikin kowane kwayar halitta. Wannan pyridine nucleotide yana taimakawa hanyoyin rayuwa dayawa inda yake amfani da matsayin babbar hanyar hada karfi da karfe. Wadannan hanyoyin sun hada da samar da makamashi, kiyayewar DNA da ingantacciyar kulawa, rigakafi da bayyana asalinsu. Wannan yana bayanin alamar tsufa na NAD + tsufa ikon sakewa.

NAD + kuma yana taka muhimmiyar rawa a siginar siginar sakandare da kuma ayyukan immunoregulatory.

A matsayin matasa, NAD + an gano shi azaman mahimmancin hanyar tsufa. Nazarin daban-daban sun goyi bayan matsayin cewa matakin NAD + a cikin jikin mutum yana da alaƙa ta kai tsaye tare da ƙuruciyarta. Mafi girman matakan NAD +, ƙarami jikin sel, nama da kuma gabaɗayan yanayin jikin mutum. Wannan shine tushen NAD + tsufa don koma bayan shahara.

A gefe guda, karancin NAD + na iya haifar da gajiya da cututtuka daban-daban. Don haka, isasshen matakan NAD + babu shakka suna da mahimmanci ga lafiyar mutum.

Yaya NAD + yake Aiki?

Lokacin da jikinka ya kasa samun ingantaccen enzyme da matakan samar da kwayoyin, ya fara bayyanar da batutuwan kiwon lafiya daban-daban kamar rage tashe tashen hankula, batutuwan ƙwaƙwalwar ajiya da rage yawan tunani. Wannan saboda rashin isasshen matakan NAD + da NADH don tallafawa haɓakawa na al'ada da aikin ƙwayoyin jikin mutum.

Musamman, maɓallin NAD + aiki shine don tallafawa martabar jiki na rayuwa, ta hanyar ba da damar canza kwayoyin daga kwaya zuwa wani, ta hanyar aiwatar da aka sani da redox dauki. Ta hanyar redox halayen, abinci mai gina jiki sami damar 'yantar da makamashi da aka adana a cikin rauni mai rauni oxygen biyu.

A yadda aka saba, ƙwayoyin jikinku suna buƙatar makamashi daga magudanar jini don iko da su don yin ayyuka na rayuwa daban-daban. Musamman, makamashin da suke buƙata ana adana shi azaman mai mai da kitse. Don haka, babban aikin NAD + enzyme a nan shine sauƙaƙe jigilar hanyoyin samar da makamashi daga jijiyoyin jini zuwa ƙwayoyin da suka dace.

Lokacin da kitsen acid da glucose ya saki makamashi, NAD + enzyme yana sauƙaƙe jigilar makamashi zuwa mitochondria don ƙarin musanyawa cikin ƙarfin salula. In ba haka ba, idan akwai rashin ƙarfi na NAD +, canja wurin makamashi a cikin tantanin halitta ya rikice, kuma wannan yana haifar da lalatawar mitochondrial, wanda ke haɓaka tsarin tsufa.

NAD + 02

Ga kowane NADH, NAD + yana iya samar da kwayoyin ATP guda uku. Sakamakon ƙarfin ƙwayoyin ƙwayoyin rai, kuna zama mai kuzari sosai, a kwakwalwa da kuma ta jiki, saboda NAD + ya ba da hanyoyin ayyukan ku na tsufa da haɓaka ta hanyar hada abubuwa da iskar shaka.

Musamman, babban aikin NAD + ya ƙunshi kunna enzymes da ke da alhakin gyara halayen a cikin jiki. Wadannan enzymes an hade su da suna 'oxidoreductases. Sun haɗa da enzymes na Sirtuin (SIRT), poly-ADP-ribose polymerases da cyclic ADP ribose hydrolase (CD38).

Yana mai da hankali kan kunna Sirtuin, yana da kyau a lura cewa babban aikin sinadaran sirtuin shine a kashe kwayoyin halittun da ke sauƙaƙa tsufa. Kwayoyin sun hada da wadanda ke yin amfani da kitse na kitse da adana abubuwa, kumburi da kuma tsarin sukari na jini. Don enzymes na sirtuin don cimma hakan, suna buƙatar enzymes na NAD kamar yadda waɗannan ƙwayoyin NAD ke taimaka musu su cire gungun acetyl daga sunadarai don canji.

Saboda haka, karuwa a cikin matakan NAD + yana fassara zuwa mafi yawan adadin Sirtuins masu aiki. Wannan yana haifar da karuwar numfashi mitochondrial har da haɓakar jijiyar insulin.

Sakamakon irin wannan haɓaka metabolism yana haifar da koma baya ga tasirin tsufa na kwakwalwa, godiya ga NAD + tsufa ikon sakewa. Hakanan, ingantaccen ƙwayar insulin yana taimakawa jikin ku don kula da matakan sukari mafi kyau na jini. Sakamakon haka, kwayoyin jikinka sun nuna karami kuma suna nuna hali irin na samari, suna baku kwatancen samari ma.

Ari, NAD + an gano shi azaman ƙwayar ƙwayar ƙwayar ƙwaƙwalwa wanda ke da alhaki don siginar siginar ƙwayar cuta, wanda ke samar da tushen sadarwar salula zuwa wayar salula. Hakanan, yana aiki azaman sabon labari mai narkewar ƙwayar cuta, yana yada bayanai daga jijiyoyi zuwa ƙwayoyin tsoka mai santsi.

Amfanin / Aikin NAD +

Akwai su da yawa NAD + fa'idodi da ayyuka wanda ya haɗa da:

1.Protection daga yanayin lalacewa na shekaru

Amfanin maganin tsufa na NAD + yana cikin manyan dalilan da yasa masu saurin lafiyar ke son ganin matakan NAD + su na lafiya a koyaushe. Yayinda mutane ke tsufa, lalata DNArsu yana ƙaruwa, kuma wannan yana haifar da raguwar matakan NAD +, raguwar ayyukan SIRT1 da rage aiki na mitochondrial. Wannan na faruwa ne sakamakon matsanancin sinadarin oxidative, wanda, a cikin harshen layman, yana nufin cewa magungunan antioxidants na jikin ba tare da daidaitawa ba.

Sakamakon haka, mutumin da ya tsufa ya fi kamuwa da cututtuka daban-daban kamar su atherosclerosis, cututtukan zuciya, arthritis, cataracts, ciwon sukari da hauhawar jini, da sauransu.

Abin farin ciki, bincike mai yawa ya nuna cewa NAD + yana ba da kariya ta damuwa da damuwa ga ƙwayoyin jikin mutum. Sabili da haka, shan NAD + abinci, kayan abinci ko ɗaukar wasu matakan inganta matakan NAD + na iya taimakawa tsofaffi, musamman waɗanda shekarunsu suka wuce 50, don samun ingantacciyar lafiya ko da zaman su a duniya yana ƙaruwa.

Narin NAD + yana inganta aiki da goyan baya ga ci gaban mitochondria. Yana taka muhimmiyar rawa wajen kiyaye isasshen matakan ATP a sel, wanda in ba haka ba zai iya tsufa da tsufa.

2.Fataran taimako

Kamar yadda aka ambata a baya, NAD + tana goyan bayan ƙarfin samarwa na mitochondria na jikin ku. Lokacin da mitochondria dinku ba ku samar da isasshen makamashi ba, abubuwa masu mahimmanci kamar zuciya, kwakwalwa, tsokoki da huhu ba sa iya yin aikin da ya fi dacewa kuma hakan yana haifar da gajiya da rage motsawa.

A gefe guda, lokacin da jikin ku yana da isasshen matakin NAD +, waɗannan gabobin suna da ikon aiwatarwa a matakan lafiya kuma a sakamakon haka, kuna jin kuzari, motsawa, rayuwa kuma tare da hankali. Kowane kwayar halitta mai rai yana buƙatar wannan coenzyme kamar yadda yake inganta samar da adenosine triphosphate.

Kwayoyin suna amfani da adenosine triphosphate don samar da makamashin da gabobin jikinku ke buƙata don aikin da ake so. Lokacin da jikinka yake kara kuzari, kwayoyinka suna iya yakar jijiyoyi gaba daya yadda yakamata.

NAD + 03

3.Inganta aikin kwakwalwa

Gajiya yana rage aiki da hankali. Yana sa ka ji kamar ranka yana da nauyi ko kuma gajimare. Koyaya, mun riga mun ga cewa NAD + yana ba da taimako gajiya. Don haka, coenzyme yana haɓaka aikin kwakwalwarka ta hanyar samar da isasshen samar da makamashi don ƙwaƙwalwar kwakwalwarka, yana ba su damar yin yaƙi da gajiya. Sakamakon haka, hankalinku zai zama mai faɗakarwa da kuma kuzari sosai don gudanar da ayyuka daban-daban waɗanda ke buƙatar ku yi tunani.

4.Jin matsin lambar kwayar halitta

A cikin binciken daya da nufin kafa tasirin NAD + akan damuwa na ƙwayoyin sel, masu bincike sun gano hakan NAD + magani sanya kwayoyin jikin dakin sunada matukar juriya. A gefe guda, ƙwayoyin da ba a kawo su tare da NAD + sun shawo kan matsalar damuwa na rashin ƙarfi. Saboda haka, yana nufin cewa wannan coenzyme yana ƙara tsawon rayuwar ƙwayoyin jikinku, yana taimakawa jikin ku don yaƙar ƙwayoyin cututtukan da ke haifar da cututtuka da kyau sosai.

5.DNA gyara na tsawon rayuwa

A rayuwar yau da kullunku, kun fallasa abubuwa daban-daban da yanayi waɗanda ke iya lalata DNA ɗin ku. DNA mai lalacewa ya rage tsawon rayuwar ku. Koyaya, tare da isasshen wadatar NAD + a cikin jikin ku, waɗannan coenzymes suna sauƙaƙe gyaran gyaran da ya lalace ta hanyar jigilar wutan zuwa wuraren da ke da DNA mai lalacewa. Wannan ya kasance ne bisa ga ɗimbin karatu da suka kawo game da ƙarshen cewa sake maye gurbin NAD + ya ninka tsawon rayuwar dabba ko na mutum.

6.Bayan bacci da tsarin aiki

Masu bincike da yawa sun gano cewa NAD + yana da tasiri mai mahimmanci akan tsarin baccin mutum da tsarin yunwar. Lokacin da kuka saba barci ko farkawa da kuma yawan aikin yau da kullunku ya dogara ne da irin rawar zuciyar ku. Hakanan, samar da kayan abinci na abinci a jikin ku yana tasiri sosai ta hanyar sunadarai.

Haɗin da ya dace tsakanin sirtuins da Sakamakon NAD + a cikin tashin zuciya hematse da ci. In ba haka ba, rushewar NAD + ko sirtuins yana haifar da rudani mai lalacewa, saboda haka rashin cin abinci da tsarin bacci. Sabili da haka, NAD + yana zuwa cikin sauri don ingantaccen barci da cin abinci na yau da kullun. Tare da waɗannan biyun a cikin rajista, zai zama maka sauƙi a gare ka ka cimma daidaitaccen nauyi.

Ta hanyar samar da duk ayyukan da ke sama, babu shakka cewa NAD + yana taka muhimmiyar rawa wajen taimaka wa mutane suyi rayuwa mai lafiya ko da kuwa a wani zamani na zamani.

Aikace-aikacen / Amfani da NAD +

1.Inawar koyon karatu da karfin ƙwaƙwalwa

Mutane da yawa suna sane da cewa wannan mahallin sunadarai yana ba da na halittaNAD + 04

sabuntawa da haɓaka hanyoyin hanyoyi na kwakwalwa a cikin kwakwalwa.

Bayan haka, yana kawar da gajiya da tunani gabaɗaya, don haka inganta tsabta ta hankali.

Sakamakon haka, mutum zai iya koyo da tunawa da ingantaccen aiki.

2.Thicker kusoshi da gashi

Ƙusoshin gashi da gashi ana ganinsu da yawa don ayyana ƙimar mutum, musamman mata. Saboda iyawarta don inganta gyaran DNA wanda ya lalace, NAD + yana da mahimmanci ga kusoshi masu kauri da gashi. Kamar wannan, yana da yawa-da ake nema wurin sunadarai ga mutanen da ke damuwa game da gashin bakinsu da / ko kusoshi.

3.Barin fata na fata

Samun shekaru tsakanin mutane yana zuwa da aibi na fata kamar wrinkles, layi mai kyau da kamala mara kyau. Koyaya, waɗanda suke so su ƙetare alamomin tsufa suna ɗaukar NAD + kari, waɗanda suke aiki da kyau don manufa. The NAD + anti tsufa fa'ida ya shahara sosai.

4.Yaukaka aikin

Yayinda mutane suka tsufa, zasu zama yayi guntu da rauni saboda rashin ƙarfi wanda yake zuwa tare da tsufa. Koyaya, waɗanda suka gano ƙarfin tsufa na NAD + sun yi amfani da ita don inganta aikin tsoka.

5.Farin cututtukan da suka shafi shekaru

Bugu da ƙari, mutanen da ke ƙarancin wadatar NAD + a jikinsu saboda tsufa suna neman hanyoyin waje na cibiyar sunadarai don haɓaka rigakafin su. Supplyarin samar da enzyme yana taimaka wa jikinsu su iya yin tsayayya da ƙarfi ga cututtuka daban-daban da ke da alaƙa da tsufa.

NAD + Sashi

Kodayake NAD + shine asalin halitta, dole ne a ɗauka tare da daidaitawa. A cewar hukumar Kula da Abinci da Magunguna (FDA), mafi aminci ne NAD + sashi shine mafi yawan gram biyu a rana. Lokacin da aka ba da shawarar magani shine kwana 7 zuwa 16, gwargwadon tarihin likita na mai amfani.

Sakamakon faduwar Matakan NAD +

Abune mafi mahimmanci ga kowa da kowa don tabbatar da cewa suna da isasshen matakan NAD +. .Ara

Matakan NAD + wajibi ne ga mutanen da ke fuskantar rashi na NAD +. Wannan saboda ƙarancin NAD + yana da illoli da yawa da ba a so wadanda suka hada da:

1. Alamar tsufa

A cikin matashi, NAD + da NADH suna cikin manyan adadin idan aka kwatanta da matakan da aka samu a cikin tsofaffi. Rage matakan NAD + tare da shekaru yana haifar da rage yawan ayyukan SIRT1, don haka yana hanzarta aukuwar alamun tsufa. A irin wannan yanayin, hanya mafi inganci don juyawa ko hana waɗannan alamun ita ce ƙara matakin NAD + a cikin jiki. Tare da haɓakar coenzyme zai haifar da ƙarin aikin SIRT1, don haka ƙarin farfadowa da hangen nesa na jiki da ji.

NAD + 05

2. Hypoxia

Hypoxia wani yanayi ne wanda ake saninsa da karancin iskar oxygen a jikin mutum. Halin yana haifar da karuwar NADH da ƙarancin NAD + kuma ana nuna shi ta alamu kamar ƙuƙwalwar fata, rikicewa, raunin zuciya, wahalar numfashi, ɗumi da tsananin tari.

Mutanen da ke fama da hypoxia na iya samun kwanciyar hankali daga alamu ta hanyar ƙara yawan matakan NAD + su. Waɗanda ke cikin haɗarin cutar kuma zasu iya rage karfinsu ta hanyar inganta matakan NAD + su ma.

3. Kunar rana a jiki da lalata fata

Tsoron kunar rana a jiki ko lalacewar fata sakamakon bayyanar hasken rana? NAD + da NADH kun rufe ku. Dukansu suna ba da kariya ta fata daga rana har da cutar kansa ta fata ta hanyar ɗaukar kwalliyar UVB da UVA, bi da bi.

4. gajiya

Idan kun ɗanɗana gajiya mai ƙwanƙwasawa da rauni na jiki gaba ɗaya, kuna iya kasancewa da ƙananan matakan NAD +, saboda haka rage ayyukan SIRT1. A irin wannan yanayin, karin NADH ko NAD + na iya sauƙaƙe alamun gajiya ta hanyar haɓaka aikin mitochondria.

5. Ciwon maganin ƙwayar cuta

Ta hanyar kunnawar Sirtuins, NAD + yana haɓaka aikin ƙwayoyin metabolism-tasiri ƙwayoyin cuta kai tsaye. Kamar yadda, mutanen da ke da alaƙar sarrafa nauyi saboda ƙarancin metabolism na iya cimma matakan da suke so ta hanyar NAD +. Wannan na iya kasancewa mafita a gare ku idan kun kasance kuna tsoron karuwar nauyi mara nauyi ko kuma ƙwayar LDL mai ƙarfi a sakamakon yanayin metabolism-daidaitawa yanayin.

6. Cutar zuciya

Aikin NAD + a cikin jiki yana shafar ayyukan mitochondria, wanda yake da mahimmanci don aiki daidai na zuciya. Rashin ƙwayar sunadarai na iya hanzarin bugun zuciya, abun da ba wanda zai so ya dandana. Don haka, idan kuna da ƙananan matakan Nicotinamide Adenine Dinucleotide (NAD +), watakila sakamakon raunin ischemia-sake-farfadowa ko wani cututtukan zuciya, zaku ji daɗi kuma lafiyar zuciyarku zata inganta yayin haɓaka samar da abinci na coenzyme a jikin ku.

7. Multiple Sclerosis (MS)

Shan wahala daga cututtukan sclerosis da yawa? Idan eh, to ya kamata ayi la'akari da amfani da fa'idodin NAD + foda ta NAD + kari ci don cutar alamar cutar.

Cutar cututtukan fata da yawa ana haifar da ƙananan matakin NAD + a cikin tsarin rigakafi yayin da ƙwaƙwalwar jijiya ke fuskantar rashi iri ɗaya. Nara tallafin NAD + zai rage ƙarancin ƙwayar sinadarai a cikin ƙwayar jijiya, don haka inganta alamun MS.

8. Lafiyar kwakwalwa da yanayin neurodegenerative

Idan kun sami lafiyar kwakwalwa ko yanayin ƙwayar cuta kamar cutar Alzheimer, cutar Parkinson ko bugun jini, to ƙarin NAD + ya zo a hannu don dawo da lafiyar ku. Wannan saboda waɗannan yanayi suna haifar da hakan Rashin NAD +, yana haifar da raguwa a cikin ƙwaƙwalwar kwakwalwarku da dopamine. Tunda kuzarin kwakwalwa da dopamine sune abubuwanda suka dace da tsarin kwakwalwarku da juyayi, alamominku na iya yin muni idan baku sami wata hanyar da zata bunkasa matakan NAD + ku ba.

NAD + 06

Ta yaya za a Kara NAD + Matakan a zahiri?

1. Yin motsa jiki

Yayinda kake girma, motsa jiki yana da mahimmanci ga lafiyarka. Tare da motsa jiki na yau da kullun, ƙarfin jikin ku na samar da NAD + an ba shi haɓaka. Kuna buƙatar makamashi don aiwatar da motsa jiki. Saboda haka, yayin da kuke motsa jiki, da yadda jikinku yake samar da makamashi ta hanyar inganta samar da ƙwaƙwalwar ƙwayar mitochondria. Sabili da haka, matakin NAD + ku yana ƙaruwa ta halitta.

2. Azumi na yau da kullun

Kodayake ana yin azumin azumi azaman hanyar sadaukar da kai ga addini, har ila yau yana da fa'idodi daban-daban na kiwon lafiya don bayarwa, gami da haɓaka matakan NAD + da kunna SIRT1.

3.Bita bayyanar hasken rana da yawa

Rashin kyawun hasken rana daga rana yana kara tsufa fata. Ko da muni, bayyanar da wuce gona da iri ga hasken rana yana lalata shagunan da ke ba da gudummawarsu wajen gyara ƙwayoyin fata masu lalacewa. Wannan yana haifar da raguwa a matakin NAD +. Kamar wannan, don hana wannan daga faruwa kuma taimaka jikin ku cikin kula da ƙayyadaddun matakin NAD + ta hanyar nisantar da yawaitar fuskantar hasken rana a duk lokacin da zaku iya. Hakanan, kare kanka daga cutarwa na rana ta hanyar rufe fatar ka da hasken rana mai kyau lokacin da kake fita waje a rana mai rana.

4. Shan NAD + kari

Dukda cewa lafiyayyen tsarin abinci shine kashin bayan kyakkyawan NAD + a jikin mu, wani lokacin kuma wani abu daya kamata ayi. Musamman, mutanen da suka cika shekaru 50 suna buƙatar NAD + fiye da abin da daidaitaccen tsarin abinci zai iya bayarwa. A wannan yanayin, magungunan NAD-infused supplements suna zuwa cikin amfani. Wadannan kari suna zuwa ta hanyan capsules kuma suna da sauƙin samu. Sun ƙunshi bitamin B3 (nicotinamide riboside) wanda daga baya aka canza shi zuwa NAD + a cikin jiki.

5. Barci ya isa

Samun isasshen bacci a kowace rana wata hanyace ta dabi'a ta haɓaka matakan ƙwayoyin rigakafin tsufa. Kyakkyawan kwanciyar bacci yana inganta samar da injunan nazarin halittu a jikin ku.

6.Taukar abinci NAD +

Masu binciken sun gano hakan, nicotinamide riboside, wani nau'in bitamin B3, ya canza zuwa NAD + a cikin jiki. Ana amfani da coenzymes, kamar na NAD + wanda aka samar da shi a jiki, daga baya ana amfani dasu a wasu matakai na rayuwa wadanda suke haifar da rage gudu ko kuma sauya tsarin tsufa a jikin mutum. Kamar wannan, abincin da ke dauke da wannan bitamin (abinci na NAD) zai iya ba da babban ƙari na NAD +.

Abincin da ke ɗauke da sinadarin nicotinamide riboside, wanda zaku iya dogara dashi don inganta matakin NAD + ɗabi'a ya haɗa da:

  • Madara madara: Bincike ya nuna cewa kowane lita na madara saniya ya ƙunshi 9mol na NAD +.

Kifi: wasu nau'ikan kifi kamar tuna da kifi suna da wadataccen abinci a NAD +. Abun NAD + a cikin kofi guda na tunawa shine kusan 20.5mg da 10.1mg don kifi.

  • Naman kaza na Crimini: Idan kuka sha kopin Muriyar Murya, zaku iya samar da jikinku da 3.3mg na NAD +.
  • Kayan alade: ko dai stewed, gasa ko gasa, cokali ɗaya na naman kaji zai baka 9.1mg na NAD +.
  • Yisti abinci: Yisti abu ne mai wadatar NAD + idan aka kwatanta da madara mai madara. Sabili da haka, abinci mai yisti kamar kek da gurasa na iya ba da gudummawa ga sake daidaita matakin NAD + a jikin ku. Kodayake giya na iya zama tushen tushen coenzyme, ya kamata a ɗauka tare da matsakaici.
  • Green veggies: Wasu koren kayan lambu ma Abincin NAD + , musamman Peas da bishiyar asparagus, suna da wadatar a cikin samarda sinadaran NAD + na matasa. Kofin Peas ya ƙunshi, 3.2mg na NAD + yayin da kopin asparagus yana da 2mg na fili.
  • Samun abincin ketogenic: Kasancewa a cikin abincin abinci na keto yana nufin iyakance kanka ga abincin da ke cikin mai mai ƙura amma mara nauyi. Lokacin da kuka fara amfani da wannan abincin, jikin ku yana shiga cikin yanayin da aka sani da ketosis inda yake amfani da mai maimakon glucose don makamashi. Wannan ya sa adadin NAD + zuwa NADH ya karu.

NAD + 07

Wasu Abubuwanda ke Rage NAD +

Levelsarancin matakan NAD + na iya haifar da abubuwa daban-daban da suka haɗa da:

1. Ciwon mara

Ciwon ciki na yau da kullun yana hana enzyme NAMPT da kwayoyin da ke haifar da kari. A sakamakon haka, matakan NAD + sun ragu.

2. Rashin lafiya na kewaye da circadian

Samfurin NAD + yana buƙatar enzyme NAMPT, musamman a matakin karshe na aiwatar. Koyaya, lokacin da rushewar mutum kewaya, kwayoyin halittun da ke haifar da sinadarin enzyme sun lalace kuma sakamakon hakan, samar da NAD + a cikin jiki yana raguwa.

3. Babban adadin sukari na jini da matakan insulin

Lokacin da matakan sukari na jini da insulin suka ƙaru sosai, yawan NADH / NAD + yana ƙaruwa. Wannan yana nuna cewa adadin NADH yana da girma sosai idan aka kwatanta da matakin NAD +.

4. Abun alkama

Yawancin bincike sun nuna cewa ethanol danniya a sakamakon Yawan shan barasa yana haifar da raguwar 20% a cikin matakan NAD +. Wannan saboda shan barasa yana haifar da lalacewa ta hanyar lalacewa ta hanyar lalacewa wanda ya saɓa wa aikin samar da abinci na coenzyme.

5. Lalata DNA

Lokacin da kwayar cutar ta lalace a cikin ƙwayar cuta, ana buƙatar ƙarin ƙwayoyin PARPNAD + 08

Gyara da kuma mayar da aikin aikin DNA mai lalacewa. Tunda kwayoyin halitta suke

poto daga NAD +, saboda haka yana nufin cewa ƙara haɗuwarsu zai iya

ga rashi daga cikin sunadarai a cikin jikin wanda aka azabtar.

6. Siarancin sirtuin

La'akari da cewa sirtuin yana daidaita tasirin sautin, yana rage matakan sirtuin don haka zai iya rikitar da yanayin cirbaden da gudana. Saboda haka, matakin NAD + ya ragu.

Shin Akwai Wani Sakamakon Ganowa Game da NAD +?

A mafi yawan lokuta, ƙarin NAD + yana da aminci. Nazarin ɗan adam wanda aka yi don tabbatar da matakan aminci na ƙara coenzyme a cikin jiki ya nuna cewa kullun 1,000mg zuwa 2,000 MG NAD + na yau da kullun ba shi da wata illa mai cutarwa ga mutane.

Koyaya, akwai lokuta kaɗan inda aka ruwaito sakamako masu illa don faruwa saboda yawan NAD +. Wadannan illolin sun hada da tashin zuciya, damuwa, ciwon kai, matsanancin gajiya (gajiya) da gudawa

Informationarin Bayani game da NAD +

NAD + foda, wanda ake amfani dashi don sanya kayan abinci na NAD +, fari ne, hygroscopic da ruwa mai narkewa sosai. Tsarin sunadarai na NAD + foda is C21H27N7O14P2.

Idan kun kasance masana'antar da aka yarda kuma kuna sha'awar NAD + foda don NAD + kari masana'antu, tabbatar cewa kun samo shi daga asalin martaba don gujewa siyan siyayya. Ya kamata ka tabbatar cewa kana ma'amala da mai siyar da amana yayin siyan sikelin NAD. Lura cewa zaka iya yin umarni da NAD + foda ko kayan abinci na NAD + akan layi.

Kammalawa

NAD + coenzyme kwayar halitta ce da ke taka muhimmiyar rawa a lafiyar dan adam. Amfanin NAD +, wanda ya haɗa da ingantacciyar lafiyar kwakwalwa, juriya damuwa da gyara DNA, fiye da theananan sakamako masu illa da ke tattare da haɓakar coenzyme. Bayan haka, amfanin NAD + anti tsufa shine wani abu wanda waɗanda suke so su ƙin alamun tsufa ya kamata su mai da hankali ta hanyar ƙarin NAD +. Koyaya, yana da mahimmanci don tabbatar da cewa ka sami Nicotinamide Adenine Dinucleotide / NAD + foda ko NAD + ƙarin fakiti daga tushe mai amintacce.

References
  1. Anderson RM, Bitterman KJ, Wood JG, et al. Hanyar kawar da hanyar NAD + ta hanyar nukiliya ta jinkirta tsufa ba tare da canza matakan NAD +-daidaitaccen yanayi ba. J Biol Chem. 2002 Mayu 24; 277 (21): 18881-90.
  2. Gomes AP, Farashin NL, Ling AJ, et al. Rage NAD (+) yana haifar da yanayin pseudohypoxic wanda ke rushe sadarwa na nukiliya-mitochondrial yayin tsufa. 2013 Dec 19;155(7):1624-38.
  3. Imai SI, Guarente L. NAD da sirtuins a cikin tsufa da cuta. Biol na zamani.2014 Aug;24(8):464-71.
  4. Farashin NL, Gomes AP, Ling AJ, et al. Ana buƙatar SIRT1 don kunnawa na AMPK da kuma amfanin amfanin resveratrol akan aikin mitochondrial. Cell Metab. 2012 Mayu 2; 15 (5): 675-90.
  5. Satoh MS, Poirier GG, Lindahl T. NAD (+) - mai dogaro da gyara daga DNA mai lalacewa ta hanyar abubuwan da aka ɗora daga sel. J Biol Chem. 1993 Mar 15; 268 (8): 5480-7.
  6. Sauve AA. NAD + da bitamin B3: daga metabolism zuwa hanyoyin kwantar da hankali. J Pharmacol Exp Ther. 2008 Mar;324(3):883-93.

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