+ 86 (1360) 2568149 info@phcoker.com

Oleoylethanolamide (OEA) (111-58-0)

Oleoylethanolamide (OEA) shine mai kawo rikicewar rikicewar rikicewar halitta mai aiki mai rikicewa mai rikicewa (PPAR-alpha). Yana da wani …… ..


Status: A Mass Production
Naúra: 25kg / Drum

description

Bayanin Bayani na Oleoylethanolamide (OEA) (111-58-0)

Product Name Oleoylethanolamide (OEA)
Chemical Name n-oleoylethanolamine; N- (2-Hydroxyethyl) oleamide; Oleylethanolamide;

N-oleoyl ethanolamine; Oleamide MEA; Oleoyl monoethanolamide;

Oleoyl Ethanolamide;

CAS Number 111-58-0
InChIKey BOWVQLFMWHZBEF-KTKRTIGZSA-N
Smile CCCCCCCCC = CCCCCCCCC (= O) NCCO
kwayoyin Formula C20H39NO2
kwayoyin Weight 325.5 g / mol
Monoisotopic Mass 325.537 g · mol-1
Ƙaddamarwa Point 59 – 60 ° C (138 – 140 ° F; 332 – 333 K)
tafasar Point 496.4 ± 38.0 ° C (Tsinkaya)
yawa 0.915 ± 0.06 g / cm3 (Tsinkaya)
Launi White
Syawan zafin rana -20 ° C
Solution a cikin ethanol da DMSO Soluble
Aikace-aikace Filin wasan motsa jiki; kari;

Menene Oleoylethanolamide (OEA)?

Oleoylethanolamide (OEA) shine mai kawo rikicewar rikicewar rikicewar halitta mai aiki mai rikicewa mai rikicewa (PPAR-alpha). Abu ne na halitta wanda ke faruwa a jiki wanda ke da tasirin gaske a cikin kayan kwalliyar gida kamar su sarrafa abinci, maganin hana kumburi, karfafawar lipolysis da iskar shaye shaye. Oleoylethanolamide ana iya ɗaukarsa a matsayin hormone na ƙwalwar hanji. Oatmeal, kwayoyi, da koko koko sune manyan hanyoyin abinci na Oleoylethanolamide a cikin abinci. Koyaya, adadin Oleoylethanolamide da aka samo a cikin waɗannan abincin yana da ƙasa (ƙasa da 2 µg / g).

A matsayin matsakaici mai tsayi na halitta, ana samar da oleylethanolamide (OEA) a cikin hanji da sauran kyallen takarda, kuma yana shiga cikin daidaita ma'aunin makamashi na mammalian, yana daidaita tsarin abinci da abinci mai gina jiki, kamar zai iya tsara abincin Vertebrate da nauyin jiki. Oleoylethanolamide shine mai acid ethanolamide (FAE), analogidted analog na endocannabinoid arachidonic acid ethanolamide (anandamide), da kuma aikin antagonist na anandamide. Yana da mahimmanci a lura cewa Oleoylethanolamide ya bambanta da anandamide, yana da 'yanci daga mai karɓar cannabinoid, kuma yana ɗaukar aikin aikinsa ta hanyar wasu hanyoyi, yana tsara ayyukan PPAR-α don tayar da lipolysis. Oleoylethanolamide shine mai yuwuwar kuma amintaccen magani mai kiba mai maye wanda ke maye gurbin maganin antagonism na CB1.

Karatuttukan bincike na farko sun nuna cewa Oleoylethanolamide shima ingantaccen maganin rigakafin jiki ne da kwayar halittar jiki wanda yake haifar da tasirin sakamako a cikin maye. Gudanarwa na Oleoylethanolamide zai iya hana maganin TLR4 mai rikice-rikice na rikice-rikice na kashin kansa, ta haka rage ƙaddamar da cytokines na proinflammatory da chemokines, oxidative da nitrosative stress, kuma a ƙarshe yana hana lalacewar jijiya a cikin kwalliya na jijiyoyin ƙwayoyin cuta.

Menene Oleoylethanolamide (OEA) yayi aiki?

A cikin mutane masu kiba, OEA na iya tsara ƙarfin homeostasis da ci gaba musamman ta kunnawa masu karɓar daban-daban da suka haɗa da karɓar karɓa-karɓa mai karɓa-P (PPAR-α), mai karɓar G-protein-mai haɗuwa 119 (GPR119) da mai karɓa mai jigilar yiwuwar tashar cation tashar subfamily V (TRPV1). Tabbas, OEA tana kunna waɗannan masu karɓar kuma tana jinkirta farawar abinci, rage girman abincin, rage takura tsakanin abinci kuma a ƙarshe yana daidaita nauyin jiki.

Haka kuma, wasu bincike na gwaji sun nuna cewa OEA shima yana hana bayyanar IL-6, interleukin-8 (IL-8), kwayoyin adhesion-1 (ICAM-1) da kwayar halitta ta jijiyoyin jiki-1 (VCAM-1) a cikin TNF -sa jawo kumburi a jikin sel ta hanyar jijiyawar mahaifa ta hanyar kunnawar masu karba mai kumburi. Har ila yau, OEA yana hana hanyar nukiliya kappa-B (NF-kB) a cikin jiki. A cikin binciken YT et al, OEA (50 µmol / L) ya hana bayyanar TNF-α jawo VCAM-1 a cikin HUVEC.

Fa'idodin Oleoylethanolamide (OEA)

A matsayin mai hana inshora na ceramidase, mai rikitarwar jinsi na mai karɓar GPR119, Oleoylethanolamide yana da tasiri a kan cututtukan neurodegenerative, anti-atherosclerosis, apoptosis, taimako na jin zafi, haɓakar haɓakar lipid, da ƙwayoyin sel a cikin sel. Kariya da sauran cututtuka na rayuwa suna da kyakkyawan kariya. Bugu da kari, zai iya rage kitse jikin mutum ta hanyar sarrafa ci, sarrafa nauyi, da kuma samun asarar nauyi. Oleoylethanolamide shima yana da ikon rage kumburi da ƙananan matakan cholesterol.

Amfani da Oleoylethanolamide (OEA)

  • Filin filayen kayan abinci
  • Gaetani S, Oveisi F, Piomelli D (2003). “Matsakaicin tsarin abinci a cikin bera ta mai tsattsauran ra'ayi mai maganin cutar lipoy mai cutar opoylethanolamine”. Neuropsychopharmacology. 28 (7): 1311-6. doi: 10.1038 / sj.npp.1300166. PMID 12700681.
  • Lo Verme J, Gaetani S, Fu J, Oveisi F, Burton K, Piomelli D (2005). "Dokar ta abinci mai maganin ta oleoylethanolamine". Tantaba. Mol. Rayuwa Sci. 62 (6): 708–16. doi: 10.1007 / s00018-004-4494-0. PMID 15770421.
  • Giuseppe Astarita; Bryan C. Rourke; Johnnie B. Andersen; Jin Fu; Janet H. Kim; Albert F. Bennett; James W. Hicks & Daniele Piomelli (2005-12-22). "Increasearin bayan Postoraninal na oleoylethanolamine tattara a cikin karamin hanji na Burmese Python (Python molurus)". Am J Physiol Regul Integr Comp Physiol. 290 (5): R1407 – R1412. doi: 10.1152 / ajpregu.00664.2005. PMID 16373434.
  • Gaetani S, Kaye WH, Cuomo V, Piomelli D (Satumba 2008). "Matsayin endocannabinoids da kwatankwacinsu a cikin kiba da rikicewar abinci". Ku ci Rashin nauyi. 13 (3): e42-8. PMID 19011363.
  • Serrano A, et al. Oleoylethanolamide: tasirin mai ɗaukar ƙwayar hypothalamic da kuma gut peptides suna sarrafa abinci. Neuropharmacology. (2011)

BATSA DA TATTAUNAWA:

Ana Samun Wannan Abubuwan ne Don Amfani da Bincike Kawai. Sharuɗɗan Siyarwa suna Aiwatarwa. Ba don Amfani da Dan Adam bane, ko Likita, dabbobi, ko Amfani na Gida.


Video

Bidiyon Oleoylethanolamide (OEA) (111-58-0)

COA

Karin bayani & amsoshin samfurin