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Raw Tadalafil foda (171596-29-5)

Raw Tadalafil foda a karkashin sunan Cialis ana amfani dashi don magance dysfunction (rashin ƙarfi) da alamun cututtukan ƙwaƙwalwa na…


Status: A Mass Production
Naúra: 25kg / Drum
Capacity: 1190kg / watan

description

Tadalafil foda video

Bayanan Basan

Product Name Tadalafil foda
Chemical Name (6R,12aR)-6-(1,3-benzodioxol-5-yl)-2,3,6,7,12,12a-hexahydro-2-methylpyrazino[1′,2′:1,6]pyrido[3,4-b]indole-1,4-dione
Brand Name Cialis, Adcirca
Drug Class PAH, PDE-5 Masu hanawa; Magunguna masu ƙwayar cuta ta 5 Enzyme
CAS Number 171596-29-5
InChIKey WOXKDUGGOYFFRN-IIBYNOLFSA-N
kwayoyin FƘararraki C22H19N3O4
kwayoyin Wtakwas 389.4
Monoisotopic Mass 389.138 g / mol
Gyarawa Point 298-300 ° C
Freezing Point 2 ℃
Half Half-Life 17.5 hours
Launi White zuwa Off-White Cyrstalline Solid
Solubility Soluble a DMSO (78 mg / ml a 25 ° C), methanol, ruwa (<1 mg / ml a 25 ° C), dichloromethane, ethanol (<1 mg / ml a 25 ° C)
Storage Taikin zafi Ajiye a cikin yawan zafin jiki tsakanin 59 ° F da 86 ° F (15 ° C da 30 ° C). Kada ku adana wannan magani a wuri mai m ko damp.
Tadalafil Aaikace-aikace Raw Tadalafil foda allon, Jima'i alewa, Jima'i kofi, da dai sauransu.

description

Tadalafil, (6R-trans) -6- (1,3-benzodioxol-5-yl) -2,3,6,7,12,12a-hexahydro-2-methyl-pyrazino [1 ', 2': 1,6] pyrido [3,4-b] indole-1,4-dione Cialis), wani nau'i ne na PDE5 inhibitor da maganin da aka baka. Abun b-carboline ne kuma yana da bambancin tsari ne daga vardenafil (Levitraw) da sildenafil (Viagraw), duka biyun sune PDE5 inhibitors bisa tsarin furucin pyrimidine fused. Tadalafil foda (CAS 171596-29-5) yana ƙaruwa yaduwar jini zuwa cikin coverus cavernosum ta hanyar shakata tsokoki na jijiyoyin jini, kuma wannan yana bawa mutum damar cimma ruwa. Amfani da Abinci da Magunguna (FDA) a Amurka ya amince da Tadalafil foda a cikin 2003 don kula da lalata (ED), kuma ya sami kasuwa a duk duniya a ƙarƙashin sunan mai suna Cialis. Hakanan ana amfani dashi don kula da hauhawar jijiyoyin jini da kuma jijiyoyin zuciya, yanayin da yake ƙara ƙaruwa, na haifar da matsaloli tare da urination.

Tadalafil ya nuna fassarar magungunan magani na tsawon rayuwarsa (17.5 hours) idan aka kwatanta da Viagra da Levitra (4-5). Wannan ya fi tsayi a cikin rabin lokaci a cikin tsawon lokaci na aiki kuma yana, a wani ɓangare, da alhakin laƙabin Cialis na "kwayar karshen mako". Wannan ya fi tsawon rabin rai shine tushen binciken da ake ciki na amfani da tadalafil a cikin hauhawar jini na jini kamar yadda wani sau daya-rana far.

Kayan aikin

Hanya ta Penile yayin tashin hankali ta hanyar jima'i yana samuwa ta wurin shakatawa na suturar na penile da kuma cacos cavernosal tsokoki mai tsayi, wanda zai haifar da kara yawan jini zuwa gawar. Wannan shakatawa yana ba da damar ƙãra jini ta hanyar jinji na penile, yayin da wannan jini ya cika dakuna biyu a cikin azzakari da ake kira corvern cavernosa. Yayinda ɗakunan da ke cika da jini, azzakari ya kara karfi. Sakamako yana ƙare lokacin da tsokoki na tsoka da jini mai yalwa zai iya kwarara daga cikin veins penile.

Wannan sulhun yana shiga tsakani ne ta hanyar fitar da sinadarin nitric oxide (NO) daga cibiyoyin jijiyoyi da kwayoyin halittun endothelial, wanda ke karfafa aikin cGMP a cikin jijiyoyin jiki mai santsi sannan kuma ke sarrafa bugu da kuma rikicewar jijiyoyin jini wadanda ke dauke jini zuwa da kuma daga azzakari. GMP na cyclic yana haifar da kwanciyar hankali na tsoka da ƙaruwar jini a cikin cavernosum, kuma an lalata shi ta hanyar cGMP takaddun ƙwayar phosphodiesterase nau'in 5 (PDE5) a cikin cavernosum na corpus wanda ke kewaye da azzakarin. Tadalafil yana hana PDE5 kuma don haka yana haɓaka ta hanyar haɓaka adadin cGMP da ake samu. Tadalafil ya dakatar da PDE5 daga lalata cGMP sannan kuma ya kara yawan cGMP don cimma aiki kuma yana haifar da tsawan tsawan shekaru.

Duk da haka, kamar rabin rabi na Tadalafil ba shi da ɗan gajeren lokaci, sakamakon da yake faruwa a lokacin kwanakin 2 yana yin PDE5 dawo da lafiyar jima'i - ya fi muni. Kuna buƙatar ɗaukar tsawon lokaci don cimma burin da kake so, kamar ƙananan ƙarfin Cialis 4-5 kwanakin kwanaki na 4-5.

Aikace-aikace

  • Dysfunction Erectile (ED)
  • Karfin jini na jini na yau da kullum
  • Nisan hyperplasia prostatic benign
  • Analgesic
  • Norepinephrine ta dauki caca
  • Mu-opiod receptor agonist

Shawara Tadalafil foda Dosage

Cialis ya zo a cikin rawaya, kayan shafa fina-finai da almond a cikin nau'ikan 5, 10 da 20 milligram (MG). Farawa da aka fara amfani da shi na Cialis foda don amfani kamar yadda ake buƙata a mafi yawan marasa lafiya shine 10 MG, ​​wanda aka dauka kafin a yi tsammani aikin jima'i.

Sakamakon farko shine Xigin 10 (MG) akalla 30 mintuna kafin yin jima'i. Hakan zai iya karuwa zuwa 20 MG ko rage zuwa 5 MG, ​​bisa ga mutum nagarta da juriya. Amma, iyakar ita ce 20 MG kamar kashi guda. Matsakaicin shawarar dosing mita sau ɗaya kowace rana a mafi yawan marasa lafiya. Bai kamata ya dauki fiye da ɗaya kashi a cikin 24 hours ba. Marasa lafiya waɗanda suke tsammanin yin aiki da jima'i a kalla sau biyu a mako suna iya ɗaukar nauyin 5 na yau da kullum, kuma wannan zai iya ragewa zuwa 2.5 MG sau daya kowace rana, dangane da mutum.

Cialis foda don amfani dashi kamar yadda ake buƙata an nuna shi don inganta aiki idan aka kwatanta da placebo har zuwa awanni 36 bayan allurar. Sabili da haka, lokacin da kake ba da shawara ga marasa lafiya game da ingantaccen amfani da Cialis foda, wannan ya kamata a la'akari.

Yana da kyau a sani cewa tsawan bazai faruwa ba ta hanyar shan kwaya. Kuma kada ku ɗauki Cialis don lalata idan kuna shan Adcirca don hauhawar jini na huhun jini. Baicin, Tadalafil don lalata shine kawai don amfani da tsofaffi masu shekaru 18 shekaru da sama.

amfanin

♦ Tadalafil foda zai iya taimaka shayar tsoka a cikin prostate da mafitsara. Wannan zai taimaka wajen bunkasa alamun BPH naka.

♦ Don inganta sifofin ED, tadalafil foda yana taimaka wajen kara yawan jini zuwa azzakari. Wannan zai iya taimaka maka ka samu ci gaba. Don tadalafil foda don taimaka maka samun tsage, kana buƙatar yin jima'i.

♦ Ga PAH, tadalafil foda yayi aiki don inganta ikon yin motsa jiki ta hanyar jin dadin jinin jini a cikin huhu. Wannan yana kara yawan jini.

Side effects

Tare da abubuwan da ake bukata, magani zai iya haifar da wasu cututtukan da ba'a so. Kodayake ba duka waɗannan cututtuka na iya faruwa ba, idan sun faru zasu iya buƙatar kula da lafiya. Da fatan a duba abubuwan da ke faruwa na tadalafil foda:

Abubuwan sakamako na al'ada

Ciwon kai

▪ cike ciki

▪ ciwon baya

▪ tsofaffin ƙwayoyi

▪ flushing (fata fata)

Cizon ko hanci

▪ zawo

Ra'ayoyin haɗari amma masu tsanani

Tsarin tsayi mai tsawo wanda zai iya haifar da lalacewa ga azzakari, matsalolin hangen nesa, da hasara.

Idan waɗannan tasirin sun kasance m, zasu iya tafi cikin cikin 'yan kwanaki ko mako biyu. Idan sun kasance mafi tsanani ko kuma ba su tafi ba, magana da likitan ko likita.

Mutane da yanayin da ke biyowa ba za su dauki Cialis foda ba sai dai likita ya yarda:

Matsalar zuciya, angina, ko kowane cututtukan zuciya

High ko saukar karfin jini

Zuciyar zuciya ta zuciya ko bugun jini a cikin watanni 6 na ƙarshe, ko kuma infarction na sirri a cikin watanni 3 na ƙarshe

Ciwon sikila, mahaifa myeloma, hemophilia, cutar sankarar bargo, ko wani jini

Harkar ko cutar koda

Cutar ciwo

Retinitis pigmentosa

Dandalin gina jiki na azzakari, irin su cutar Peyronie

Duk wani yanayin kiwon lafiya wanda aka shawarce su kada su yi jima'i

Tadalafil hulda

Lokacin da kake amfani da tadalafil, akwai wasu miyagun ƙwayoyi waɗanda zasu iya rinjayar maganin miyagun ƙwayoyi, wanda zai haifar da sakamako mai lalacewa. Harkokin hulɗa na kwayar cutar zai iya canza yadda magunguna ke aiki ko ƙara yawan haɗarinka ga masu tasiri.

Tadalafil yana da tasiri mai tasiri a kan rage rage yawan ƙwayoyin nitrate a cikin karfin jini. Tadalafil zai iya haifar da mummunan digirin jinin jini lokacin da ake amfani da nitrates, wanda zai haifar da matsananciyarsa, rashin ƙarfi, da kuma rashin ciwon zuciya ko bugun jini. Kada ku yi amfani da tadalafil tare da wasu daga cikin wadannan: wasu kwayoyi da ake amfani da su don maganin ciwon kwakwalwa / angina (nitrates irin su nitroglycerin, isosorbide), kayan wasan motsa jiki da ake kira "poppers" dauke da amyl ko butyl nitrite.

Idan kuma kuna shan magani na alpha (irin su doxazosin, tamsulosin) don bi da karuwar prostate / BPH ko cutar hawan jini, karfin jini zai iya zama ƙasa mai yawa wanda zai iya haifar da matsananciyar rashin tsoro ko kuma ya ɓace. Kwararka na iya fara jiyya tare da ƙaramin kashi na tadalafil ko gyara maganin maganin kafar alpha don rage girman hawan jini.

A cikin karatun asibiti, an ba da rahoton mahimmancin martani har zuwa 36 h bayan shigar magunguna. Tadalafil shine mafi yawan metabolized a cikin hanta ta CYP3A4 ga abubuwan da ba su da ƙarfi a kan PDE5 kuma an keɓe su musamman a matsayin metabolites a cikin feces da fitsari. Magungunan magunguna na tadalafil ba su da illa ga abubuwan da suka haɗa da yawan abinci da barasa, shekaru, kasancewar ciwon sukari, da kuma rashin isasshen rashin lafiyar hepatic. Abubuwan da suka fi dacewa da haɗarin haɗari da ke tattare da magunguna sune ciwon kai, ciwon baya, dyspepsia, da myalgia. A allurai na 10 da 20 allurai, Tadalafil bashi da tasiri a cikin karfin jini da raunin zuciya kuma baya haifar da karuwar yanayin rashin karfin myocardial. Rahotanni masu zafi na tsawaita tsawan da suka fi 4 h da kaduwa an lura da amfani da tadalafil. Idan ba a kula da shi sosai ba, zai iya haifar da lalacewar nama. An shawarci marasa lafiya waɗanda ke da tashin hankali wanda ya fi ƙarfin 4 h don neman likita na gaggawa. A cikin marasa lafiyar masu ciwon sukari, haɓaka aiki ta hanyar tadalafil ba tare da la'akari da irin ciwon sukari da kuma nau'in maganin ciwon sukari ba.

Wasu magunguna na iya shafar kawar da tadalafil daga jikinka, wanda zai iya tasiri yadda tadalafil ke aiki. Misalan sun hada da maganin rigakafin azole (irin su itraconazole, ketoconazole), maganin rigakafin macrolide (irin su clarithromycin, erythromycin), masu hana masu kare lafiyar HIV (irin su fosamprenavir, ritonavir), masu ciwon gizon C protease protease (kamar boceprevir, telaprevir), rifampin, da sauransu .

Kada ku ɗauki wannan magani tare da kowane samfurin da ya ƙunshi tadalafil ko wasu magunguna masu kama da aka yi amfani dasu don magance dysfunction-ED ko hauhawar huhu (kamar sildenafil, vardenafil).

Game da tadalafil hulɗa da sauran kwayoyi har yanzu yana da yawa, idan kana so ka yi amfani da miyagun ƙwayoyi tare da tadalafil foda (CAS 171596-29-5), ka tuna da farko don tuntuɓi likitanka kuma zai ba ka shawara na kwarai da abin dogara.

Bugu da ari bayanai

Tadalafil foda, sildenafil foda, da kuma vardenafil foda duk aiki ta hanyar hana PDE5 enzyme, amma wadannan kwayoyi ma sun hana PDE enzymes 6, 1, da 11 a cikin digiri daban-daban. Alal misali, Sildenafil da vardenafil sun hana PDE6, wani enzyme da ke cikin ido, fiye da tadalafil. Wasu masu amfani da sildenafil suna ganin kyakyawan bluish kuma suna da hankali ga haske saboda nauyin PDE6. Bayan haka, Sildenafil da vardenafil sun hana PDE1 fiye da tadalafil. PDE1 yana samuwa a cikin kwakwalwa, zuciya, da kuma tsokafin ƙwayar jikin mutum. Ana tsammanin cewa hanawa PDE1 ta hanyar sildenafil da vardenafil yana haifar da yaduwa, flushing, da tachycardia.

Idan aka kwatanta da aikin PDE6 da PDE1, tadalafil ya yi karin haske akan PDE11. PDE11 an bayyana shi a tsoka mai tsoka, da prostate, hanta, koda, glandan gwaninta, da gwajin. Duk da haka, ba a san abubuwan da ke kan jiki na hana PDE11 ba.

BATSA DA TATTAUNAWA:

Ana Samun Wannan Abubuwan ne Don Amfani da Bincike Kawai. Sharuɗɗan Siyarwa suna Aiwatarwa. Ba don Amfani da Dan Adam bane, ko Likita, dabbobi, ko Amfani na Gida.


Karin bayani & amsoshin samfurin

References

  • 1.National Center For Biotechnology Information, US. Ƙididdigar Magunguna ta Duniya, Tadalafil, Pubchem Sections 1-10.
  • 2.Evelyn C. Cortez, CIALIS (Tadalafil): Amfani, Dosage, Bayanin Bayanin Yanayi da kuma inda za a Saya Cialis (Tadalafil), Viagra (Sildenafil), da sauran Drugs Mafi Kyawun Kasuwanci da Lafiya, An wallafa, 13 Dec 2017, shafin 5-3
  • 3.James Lee Anderson, Cialis, Tadalafil: Yankewa da gurguntaccen Erectile, Alamar cututtuka na ƙwayar cuta na Benign Prostatic, da Rawan jini na jini, CreateSpace Independent Publishing Platform, 26 Mar 2015, shafi na 5-47.