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Kayan kwakwalwan ƙwayoyin cuta na Sodium (GM1) (37758-47-7)

GM1 foda an yi amfani dashi don bi da maganin neonatal hypoxic-ischemic kwakwalwa rauni, cutar Parkinson ... ..


Status: A Mass Production
Synthesized da Musamman Akwai
Capacity: 1277kg / watan

description

Ƙwallon ƙarancin ƙwayoyin Sodium (GM1) (37758-47-7) bidiyo

Sugar kwakwalwa na Sodium (GM1) kwakwalwa (37758-47-7)

Duka mai kwakwalwa na Sodium (GM1) (37758-47-7), sunan takaice zai iya zama GM1, cire daga kwakwalwar alade kuma yana cikin memba na jerin gangliosides wanda ya ƙunshi sialic acid.

GMl zai iya inganta farfadowa na aikin neuro bayan da raunin da ke tattare da magungunan yanayin da ke tattare da abubuwa masu yawa, yana inganta neuroplasticity. Gwaje-gwaje na nuna ciwo na GMl na kwakwalwa, kwakwalwa na kwakwalwa don mayar da kwayoyin tausayi a cikin rauni na kashin baya yana da tasiri mai karewa da inganta tasirin tantanin halitta.

Mataki na farko na gwaji na gwaji ya nuna, zai iya rage neurotoxicity na oxaliplatin (OIN). Amma ba a samo asali ta samfurin III ba. Ana buƙatar gwaji na zamani na uku don bincika tasirin da lafiyar lafiyar monosialotetrahexosylganglioside Ciwon maganin Sodium don rigakafin YIN a ciwon daji.

Sugar kwakwalwa na Sodium (GM1) (37758-47-7) Specifications

Product Name Alamar kwakwalwa ta ƙwayoyin Sodium (GM1)
Chemical Name Sugar Sodium (ƙwayar Porcine)

Ko GM1

jerin /
Brand Name Shenjie
Drug Class Sphingolipids
CAS Number 37758-47-7
InChIKey GTTLZSUWCRJZRC-CRQBLQEMSA-N
kwayoyin FƘararraki C73H134N4O31
kwayoyin Wtakwas 1563.85
Monoisotopic Mass 1563.85
Gyarawa Point N / A
Half Half-Life /
Launi Kusar lyophilized mai tsabta
solubility chloroform / methanol (9: 1): 10 mg / mL, bayyane, marar launi
Storage Taikin zafi -20 ° C
Aaikace-aikace Masu karɓa na musamman don ƙwayar kwalara da ke tara a cikin kwakwalwa a cikin marigayi lipidosis babba.
Abubuwan gwaji A Tsarin Gida na gida
Character White ko farin foda; kadan smelly, m; rigar. Wannan samfurin yana mai narkewa a cikin ruwa, wanda aka narkar da shi sosai a methanol, kusan insoluble a cikin ethanol anhydrous.
Identification
Launi canzawa 1 Yi nazarin gwajin gwaji 0.2ml a karkashin ƙaddarar ƙin, ƙara 2ml na ruwa, sa'an nan kuma ƙara Hydroquinone hydrochloric acid bayani (hydroquinone 0.2g, ƙara 10ml da ruwa ta rushe, ƙara XKUMXml acid, ƙara 90mol / L Copper sulfate bayani 0.1ml, Ajiyayyen firiji) 0.25ml, ruwa wanka wanka don 2 minti, zane mai launin shuɗi da mulu, tare da barasa 15ml Binciken bidiyo, bane mai sanyi shine blue.
Launi canzawa 2 Ɗauki wannan samfurin game da 20mg, ƙara ruwan zafi mai zafi dumama 1ml, ruwan zafi mai zafi dumama da aka narkar da shi, ƙara 1 ruwa mai zurfin digiri mai yaduwa, a cikin ruwan wanka mai zafi tare da shinge mai suturta ya ƙara sulfuric acid 1ml, don haka bayani a cikin layuka biyu , ya kamata a yi launin ruwan kasa da ruwa-ƙira
Saltium gishiri Sakamakon ganewa da gishiri a cikin samfurin (samfurin 2015 na kasar Sin 0301 na kasar Sin).
Liquid chromatography (LC) A cikin zane-zane da aka rubuta a ƙarƙashin tabbacin ƙaddamarwa, lokacin riƙewa na babban mahimmancin gwajin gwajin ya kamata daidai da lokacin riƙewa na babban mahimmancin maganin sarrafawa.
Infrared spectroscopy Taswirar infrared haske ta wannan samfurin ya zama daidai da taswirar samfurin sarrafawa (Shafin 2015 na kasar Sin 0402 na kasar Sin).
Duba
PH 5.0 ~ 6.5
Clarity da launi na bayani Ya kamata a tsabtace launi; idan girgije ne, ba zai zama mafi girma fiye da ruwan sanyi na turbidity ba. 1th; Idan siffanta launi ya kamata ba zurfi fiye da bayani mai launi na YellowNet 1th.
Babban ƙaddamarwa Bayanin da ya gama ya kamata ya zama cikakke kuma a fili bayan babban zafin jiki, babu haske mai madara, babu hazo
Sensitizing factor (Furotin daban-daban) ≤50000
Total Sialic acid Bisa ga samfurin samfurin samfurori, ruwan da yake dauke da acid ya zama 19.0 ~ 21.0%
shafi abubuwa Sialic acid ≤0.3%; GD3, GD1a, ba a sani ba ne ≤ 0.5%; impurities da ≤2.0%
Protein ≤1.0%
Ƙananan nauyin ƙwayoyin kwayoyin ≤0.5%
Abubuwan da suka rage Methanol ≤ 0.1%; acetone ≤ 0.3%; Trichloromethane ≤0.003%
Water ≤4.0%
Ƙona saura ≤5.0%
Karfe ƙarfe ≤20ppm
Abubuwa masu guba Daidaita dokoki
Abubuwan da suka shafi antihypertensive Ya kamata daidai da sharuɗɗan (yawancin gwamnati)
Pyrogen Ya kamata daidai da sharuɗɗan (yawancin gwamnati)
Ƙafafen ƙwayoyi Yawan yawan kwayoyin aerobic ya kamata <100cfu / g, kuma yawan adadin miki da zaren ya zama <50cfu / g
Specific ≥98.0%

raw MONOSIALOTETRAHEXOSYLGANGLIOSIDE SODIUM (GM1) foda (37758-47-7) Bayani

Sugar Sodium (37758-47-7) mai suna Monosialotetrahexosylganglioside (1-XNUMX-XNUMX), sunan ɗan gajeren na iya zama GMXNUMX, wanda aka samo daga kwakwalwar alade kuma yana mamba ne na jerin gangliosides wanda ya ƙunshi sialic acid.

GM1 na iya inganta farfadowa na aikin neuro bayan da ya ji rauni na tsarin da ke dauke da ƙwayoyin cuta da dama, yana inganta neuroplasticity. Gwaje-gwajen nuna GM1 ciwon jijiyoyin kwakwalwa kwakwalwa, cututtukan kwakwalwa don mayar da kwayoyin jikinsu a cikin rauni na kashin baya ya sami sakamako na karewa da kuma inganta tasirin tantanin halitta.

Mataki na farko na gwaji na gwaji ya nuna, zai iya rage neurotoxicity na oxaliplatin (OIN). Amma ba a samo asali ta samfurin III ba. Ana buƙatar gwaji na zamani na uku don bincika tasirin da lafiyar lafiyar monosialotetrahexosylganglioside Ciwon maganin Sodium don rigakafin YIN a ciwon daji.

MONOSIALOTETRAHEXOSYLGANGLIOSIDE SODIUM (GM1) foda (37758-47-7) Kayan aiki na ayyuka?

GM1 (monosialotetrahexosylganglioside) da "samfurin" ganglioside, yana cikin membobin ganglio jerin gangliosides wanda ya ƙunshi sialic acid sauran. GM1 yana da muhimmancin abubuwa masu ilimin lissafin jiki kuma yana tasiri nauyin gyare-gyare neuronal da gyare-gyare, da kuma sakin neurotrophins a kwakwalwa. Baya ga aikinsa a cikin ilimin lissafi na kwakwalwa, GM1 yana aiki ne a matsayin kundin shari'ar kwalara da kuma E. coli zafi-labile enterotoxin.

amfanin of MONOSIALOTETRAHEXOSYLGANGLIOSIDE SODIUM (GM1) foda (37758-47-7)

Ganglioside GM1 yana cikin membobin iyalin ganglioside wadda aka yi amfani da shi a kasashe da yawa kuma an yi la'akari da shi azaman magani mai mahimmanci don hana yawancin cututtuka na jiki, ciki har da cizon saurin ƙwayar cuta. Hanyoyin maganin cutar GM1 an tabbatar da su a cikin lalata da kuma tsofaffi masu biyo bayan lalacewar ƙwaƙwalwa.

Nagari MONOSIALOTETRAHEXOSYLGANGLIOSIDE SODIUM (GM1) foda (37758-47-7) Juyawa

An yi amfani da kwayar cutar Drug a cikin kwayar 20-40 ta kowace rana ta hanyar intravenous ko yin amfani da intramuscular sannu a hankali bisa ga ƙwararren likita. A cikin wani lokaci mai mahimmanci na sauye-sauye masu banbanci: An yi amfani da kwayoyi a kwayar 100 ta kowace rana ta hanyar allurar rigakafi; Bayan makonni 2-3, kullum kula da adadin 20-40 MG a kowace rana na makonni shida, an dauki nauyin farko na 500-1000 MG ta ciwo mai ciwo don cutar ta Parkinson; tun daga rana ta biyu, an yi amfani da miyagun ƙwayoyi tare da kashi na 200 MG yau da kullum ta hanyar subcutaneous, injection intramuscular ko ramuwa mai ciki don 18 makonni yawanci. lokacin da aka yi amfani da wannan magani ta hanyar Subcutaneous ko inji mai rauni, ya kamata a narkar da shi a cikin ruwa don allura har zuwa ƙaddamar da 10 MG / ml a lokacin; lokacin da yake da mummunan rauni, likita ya ƙaunace shi kuma an gurbata shi a 0.9% sodium chloride injection ko 5% glucose allura.

Side effects of MONOSIALOTETRAHEXOSYLGANGLIOSIDE SODIUM (GM1) foda (37758-47-7)

Sakamakon sakamako na GM1 foda shi ne yafi raguwa bayan amfani.

BATSA DA TATTAUNAWA:

Ana Samun Wannan Abubuwan ne Don Amfani da Bincike Kawai. Sharuɗɗan Siyarwa suna Aiwatarwa. Ba don Amfani da Dan Adam bane, ko Likita, dabbobi, ko Amfani na Gida.


Karin bayani & amsoshin samfurin