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Nicotinamide adenine dinucleotide (53-84-9)

Nicotinamide adenine dinucleotide (NAD) wani cofactor ne wanda ke taimakawa metabolism da aka samu a cikin dukkanin sel. Ya wanzu ta fuskoki biyu …….


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description

Nicotinamide adenine dinucleotide (53-84-9) Sfasali

Product Name Nicotinamide adenine dinucleotide (NAD +)
Chemical Name Nadide; coenzyme I; beta-NAD; beta-NAD +; beta-Diphosphopyridine nucleotide; diphosphopyridine nucleotide; Enzopride;
CAS Number 53-84-9
InChIKey BAWFJGJZGIEFAR-NNYOXOHSSA-N
Smile C1=CC(=C[N+](=C1)C2C(C(C(O2)COP(=O)([O-])OP(=O)(O)OCC3C(C(C(O3)N4C=NC5=C(N=CN=C54)N)O)O)O)O)C(=O)N
kwayoyin Formula C21H27N7O14P2
kwayoyin Weight 663.4 g / mol
Monoisotopic Mass 663.109123 g / mol
Ƙaddamarwa Point 160 ° C (320 ° F; 433 K)
Launi White
Syawan zafin rana 2-8 ° C
solubility H2O: 50 mg / mL
Aikace-aikace Abinci na lafiya, na kwaskwarima, ƙari na abinci

Mene ne Nicotinamide adenine dinucleotide(NAD +)?

Nicotinamide adenine dinucleotide (NAD) wani cofactor ne wanda ke taimakawa metabolism da aka samu a cikin dukkanin sel. Ya wanzu a cikin nau'i biyu, oxidized (NAD +) da rage (NADH).

Coenzyme NAD +, nau'in ma'adinin oxidized na NAD, shine ya fara gano shi a cikin 1906 daga masanan kimiyyar ilimin halittar dan adam Arthur Harden da William John Young. NAD + yana haɓaka ta hanyoyi biyu na rayuwa, wanda za'a iya samar da shi daga hanyar de novo amino acid, ko kuma ana iya samar dashi ta hanyar sake fasalin abubuwanda aka riga aka kirkira (kamar nicotinamide) a kan hanyar ceto ta NAD +. Yana da mahimmancin pyridine nucleotide kuma yana aiki ne mai mahimmanci mai haɓakawa da ɗaukar hoto don yawancin hanyoyin salon salula waɗanda suka haɗa da sinadarin oxidative phosphorylation da kuma samar da ATP, gyaran DNA, ƙa'idar epigenetic na magana game da kwayoyin, siginar ƙwayar allurar ciki da aiki na Immunologi.

NAD + shine babban sinadarin yarda da wutan lantarki a cikin hadawar abu na abu. Yana karɓar electrons daga wasu kwayoyin kuma an rage shi. Hakanan yana aiki azaman coenzyme na watsawar hydride da wani abu wanda yake cinye NAD (+) polymerase, kuma yana samar da coenzyme redox tare da rage β-nicotinamide adenine dinucleotide (NADH). NAD (R) shine ADP-ribose mai ba da gudummawa ribosylation a cikin ADP-A. Hakan kuma shine farkon mai zuwa cyclic ADP-ribose (ADP-ribosyl cyclase).

A matsayin mai shayarwa a cikin kwayoyin metabolism, NAD (R) shima yana taka rawa a cikin adenosine diphosphate (ADP) -ribose canjawar halayen polymerase diadenylate (ADP-ribose) da wasu hanyoyin enzymatic da yawa. Zai iya ba da kariya ta hanayar NAD don hana ko rage yawan ciwon sukari, cutar kansa da sauran cututtukan da suka shafi shekaru. Hakanan, masu haɓaka NAD + na iya yin aiki tare tare da kayan abinci kamar su resveratrol don taimakawa sake farfado da mitochondria da kuma yaƙi cututtukan tsufa.

Nicotinamide adenine dinucleotide(NAD +) fa'idodi

A matsayin mai amfani da ƙwayar oxidant, Nicotinamide adenine dinucleotide yana nuna cewa wasu fa'idodi masu kyau a cikin ayyukan ɗan adam.

Inganta ayyukan salula,

Yourara ƙarfin ku a zahiri;

♦ Inganta aikin kwakwalwa, mai da hankali da ƙwaƙwalwa;

Stara ƙarfin metabolism;

♦ Inganta bacci;

♦ stara ayyukan sirtuin na duniya;

Inganta ingancin antioxidant;

♦ Rage kumburi;

Balance Inganta daidaituwa, yanayi, hangen nesa da ji;

Nicotinamide adenine dinucleotid shima manufa ce ta kai tsaye na maganin isoniazid, wanda ake amfani dashi wajen maganin cutar tarin fuka, kamuwa da cuta wanda ya kamu da tarin fuka na Mycobacterium. A cikin gwaji daya, mice da aka ba NAD har sati guda sun inganta ingantaccen sadarwa ta nukiliya-mitochrondrial.

Bugu da kari, Nicotinamide adenine dinucleotide (NAD +) shima yana da rigakafi da lura da toshewar zuciya, aikin sinus da kuma abubuwan da suka shafi gwaji na gaggawa, nicotinamide na iya inganta yawan zuciya da kuma karfin guiwar atopve ta hanyar verapamil.

Nicotinamide adenine dinucleotide(NAD +) Application:

  1. Binciken reagents albarkatun ƙasa, ƙwarewar binciken kimiyya.
  2. Abinci na lafiya, na kwaskwarima, ƙari na abinci
  3. Samar da API

Kara Nicotinamide adenine dinucleotide(NAD +) bincike

Ingantattun enzymes da ke yin amfani da NAD + da NADH suna da mahimmanci a cikin magunguna biyu da kuma bincike kan hanyoyin magance cututtukan nan gaba. Ba a amfani da coenzyme NAD + a halin yanzu azaman magani don kowane cuta. Koyaya, ana yin nazarinsa don amfanin sa a cikin maganin cututtukan cututtukan neurodegenerative kamar cutarAlzheimer daParkinson.

reference:

  • Belenky P, Bogan KL, Brenner C (2007). "NAD + metabolism a kiwon lafiya da cuta" (PDF). Hanyoyin Ciki Sci. 32 (1): 12– doi: 10.1016 / j.tibs.2006.11.006. PMID 17161604. Sanyawa daga asalin (PDF) a ranar 4 ga Yuli 2009. Aka dawo da 23 Disamba 2007.
  • Todisco S, Agrimi G, Castegna A, Palmieri F (2006). “Sanarwar da daskararren masin din NAD + mai siyarwa a Saccharomyces cerevisiae”. J. Biol. Chem. 281 (3): 1524– doi: 10.1074 / jbc.M510425200. PMID 16291748.
  • Lin SJ, Guarente L (Afrilu 2003). "Nicotinamide adenine dinucleotide, mai tsara abinci na rayuwa wanda ya dade yana aiki da cuta". Curr. Fita. Biol Cell. 15 (2): 241– doi: 10.1016 / S0955-0674 (03) 00006-1. PMID 12648681.
  • Williamson DH, Lund P, Krebs HA (1967). "Sake fasalin yanayin sake sarrafa nicotinamide-adenine dinucleotide a cikin cytoplasm da mitochondria na hanta bera". Dabino. J. 103 (2): 514– doi: 10.1042 / bj1030514. PMC 1270436. PMID 4291787.
  • Foster JW, Moat AG (1 Maris 1980). "Nicotinamide adenine dinucleotide biosynthesis da kuma kwayoyin sake zagayowar nucleotide na tsarin kwayoyin halittar mutum". Microbiol. Rev. 44 (1): 83– PMC 373235. PMID 6997723.
  • Faransa SW. Bing na barasa mai rauni yana lalata hanta da sauran gabobin ta hanyar rage matakan NAD⁺ da ake buƙata don lalata ayyukan sirtuin. Exp Mol Pathol. 2016 Apr; 100 (2): 303-6. doi: 10.1016 / j.yexmp.2016.02.004. Epub 2016 Feb 16. PMID: 26896648.
  • Kane AE, Sinclair DA. Sirtuins da NAD + a cikin Haɓakawa da Kula da Cututtukan ƙwayoyin cuta da cututtukan zuciya. Circ Res. 2018 Sep 14; 123 (7): 868-885. doi: 10.1161 / CIRCRESAHA.118.312498. PMID: 30355082. PMCID: PMC6206880.

BATSA DA TATTAUNAWA:

Ana Samun Wannan Abubuwan ne Don Amfani da Bincike Kawai. Sharuɗɗan Siyarwa suna Aiwatarwa. Ba don Amfani da Dan Adam bane, ko Likita, dabbobi, ko Amfani na Gida.


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