Menene nau'in quinone na pyrroloquinoline (pqq)?

Pyrroloquinoline quinone (PQQ) wanda kuma akafi sani da methoxatin wani kwayar zarra ce mai kama da sinadari (cofactor) wanda ake gabatar dashi a yawancin abinci na shuka. PQQ kuma yana faruwa ta dabi'a a cikin madarar nono na mutum da kuma a cikin ƙwayoyin dabbobi masu shayarwa.

Koyaya, ana samun shi a cikin adadin kaɗan a cikin abincin don haka pqq foda mai girma samarwa ya zama dole don samun wadataccen abu a jiki.

PQQ an fara gano shi azaman coenzyme a cikin ƙwayoyin cuta wanda aikinsa yayi kama da na B-Vitamin a cikin mutane, kuma yana taka rawa wajen haɓaka haɓakar waɗannan kwayoyin.

A cikin mutane, yana aiki kamar abubuwan da ba su da ƙwayoyin bitamin tare da fa'idodi masu yawa na kiwon lafiya.

Kayan aikin

Pyrroloquinoline quinone (pqq) yana nuna fa'idodi na kiwon lafiya da yawa ta hanyoyi daban-daban kamar tsara hanyoyin siginar wayar salula, kawar da abubuwa masu tsattsauran ra'ayi da aikin sake fasalin aiki.

Hanyoyin aikin pqq na aikin sun hada da:

• Yana shafar yadda kwayoyin halitta suke aiki

Quinone na Pyrroloquinoline na iya shafar yadda ake bayyana nau'ikan halittu daban-daban kuma musamman kwayoyin halittar da ke cikin ayyukan mitochondria. An ce ayyukanta na antioxidant sau 100 ne na bitamin C.

An nuna ƙarin PQQ don kunna ayyukan CREB da PGC-1a masu saurin hanyoyi waɗanda ke shiga kai tsaye cikin biogenesis mitochondria.

Ayyuka a matsayin maganin antioxidant

Ayyukan aikin phyroloquinoline quinone (pqq) anti-oxidative shine mafi yawanci saboda iyawarta don ragewa zuwa PQQH2 ta hanyar dauki tare da rage wakilai kamar cysteine, alkama ko nicotinamide adenine dinucleotide phosphate (NADPH).

• Yana hana enzymes

Pyrroloquinoline quinone shima yana hana enzyme Amintaccen bayan ragewa 1 (TrxR1), wanda a cikin sa yake haifar da ayyukan Nuclear factor erythroid 2 mai alaƙa da abubuwan 2 (Nrf2) waɗanda ke haɓaka samar da magungunan ƙwayoyin cuta.

Hakanan an san PQQ don hana ci gaban quinoproteins (lalacewa sunadarai) wanda ke haifar da rikicewar Parkinson.

Babban mahimmancin (PQQ) quinone pyrroloquinoline quinone

Akwai fa'idodin quinone pyrroloquinoline da suka hada da:

ni. PQQ yana haɓaka aikin mitochondrial

Mitochondria sune kwayoyin da ke samar da makamashi a cikin sel a cikin hanyar ATP ta hanyar numfashi na salula. Ana kiran su galibi zuwa gidajen wuta ko keɓaɓɓun masana'antu.

Maganin samar da makamashi shine mabuɗin don samar da lafiya.

Rashin daidaituwa na Mitochondrial yana da alaƙa da rikice-rikice da yawa kamar rage girma, rauni na tsoka, raunin neurodegenerative kamar cutar zuciya, rashin jin daɗi da ciwon sukari tsakanin sauran yanayin kiwon lafiya.

Pyrroloquinoline quinone yana haɓaka aikin mitochondrial ta hanyar haɓaka samar da sababbin ƙwayoyin mitochondria (biogenesis na mitochondrial). Wannan na faruwa ne ta hanyar kunna CAMP mai ɗaukar martani mai ɗaukar nauyin furotin 1 (CREB) da Peroxisome proliferator-kunna mai karɓar-gamma coactivator (PGC) -1alpha, hanyoyin da ke haɓaka biogenesis na mitochondrial.

Pyrroloquinoline quinone shima yana ƙara abubuwa masu rikitarwa waɗanda ke aiki azaman maganin antioxidants a cikin ƙwayar mitochondria don haka yana kare mu daga damuwa na damuwa.

Pqq yana kara haifar da enzymes a cikin mitochondria wanda ke haɓaka samar da makamashi.

A cikin samfurin bera, an ruwaito ƙarancin PQQ a cikin abincin don lalata aikin mitochondrial.

pungroloquinoline quinone amfanin

ii. Yana rage kumburi

Ciwon mara na yau da kullun shine tushen yawancin rikice-rikice kamar cutar zuciya da ciwon sukari. Quinone na Pyrroloquinoline yana da kaddarorin antioxidant waɗanda ke taimaka masa kawar da tsattsauran ra'ayi don haka hana kumburi da lalacewar salula.

Wasu bincike sun nuna hakan Kari na PQQ yana haifar da raguwa mai ban mamaki a cikin alamomi masu yawa na kumburi kamar nitric oxide a cikin kwana uku kawai.

A cikin nazarin mice da ke fama da cututtukan cututtukan cututtukan fata, an bayar da rahoton PQQ don bayar da kariya daga lalacewar kumburi bayan kwanaki 45.

iii. Inganta lafiyar kwakwalwa da aiki

Quinone na Pyrroloquinoline yana da ikon haɓaka kwakwalwa kuma (neurogenesis) ta hanyar samar da abubuwan ci gaban jijiyoyi da yawa.

Studyaya daga cikin binciken ya kammala cewa kari na pqq yana haɓaka aikin haɓakar jijiya (NGF) da ƙwayoyin neuron.

Pyrroloquinoline quinone yana da alaƙa da ingantaccen ƙwaƙwalwar ajiya da koyo saboda iyawarsa na sake fasalin ƙwaƙwalwar kwakwalwa.

A cikin binciken wanda ya ƙunshi 41 masu lafiya amma tsofaffi tsofaffi, PQQ wanda aka gudanar a 20 MG / rana don makonni 12 ya sami damar hana rage aikin kwakwalwa, ƙari don haka cikin kulawa da ƙwaƙwalwar ƙwaƙwalwa.

Hakanan pyarroloquinoline quinone na iya taimakawa a hana rauni kwakwalwa.

A cikin 2012, binciken berayen da aka ba pqq na tsawon kwanaki 3 kafin raunin kwakwalwa ya gano cewa ƙarin yana iya kare sel kwakwalwa daga wannan raunin.

iv. PQQ yana haɓaka bacci

Pyrroloquinoline quinone (PQQ) yana taimaka wajan haɓaka ingancin baccinku ta hanyar rage lokacin da za'a iya barci, yana ƙaruwa tsawon lokacin bacci da haɓaka darajar bacci gaba ɗaya.

Pyrroloquinoline quinone shima yana iya rage adadin lokacin damuwa (cortisol) a cikin mutane daban don haka inganta baccin su.

A cikin nazarin tsofaffi 17, PQQ da aka bayar a 20 MG / rana don makonni 8 don inganta ingancin bacci dangane da karuwar lokacin bacci da ƙarancin bacci.

PQQ yana haɓaka bacci

v. Inganta lafiyar zuciya

Ofarfin pyrroloquinoline quinone don sarrafa matakan cholesterol ya sa ya rage haɗarin cututtukan zuciya kamar bugun jini.

A cikin nazarin tsofaffi 29, karin pqq ya rage mummunan matakan LDL cholesterol.

Pyrroloquinoline quinone shima yana rage matakan triglycerides wanda ke haifar da haɓaka aikin mitochondrial. A cikin binciken tare da berayen, ppq da aka bayar an samu raguwar matakan triglyceride.

Arin Pqq na iya taimakawa hana ko juyawar atherosclerosis (bugun jini). Wasu nazarin sun nuna cewa ppq na iya rage furotin na C-reactive da trimethylamine-N-oxide waɗanda sune alamun alamun wannan cuta.

vi. Mai yuwuwar tsawon rai

Ana daukar kwayar cutar Pyrroloquinoline a matsayin mara girman ci gaban bitamin kuma saboda haka yana iya taimakawa wajen haɓaka haɓaka da haɓaka.

Aikin quinone na Pyrroloquinoline a cikin fada da kumburi, hana damuwa da iskar shaka da tallafawa aikin mitochondrial yana tabbatar da ikonsa na fadada rayuwar mutum.

An kuma tabbatar da PQQ don kunna hanyar siginar siginar wacce ta juya tsufa salon salula.

Abubuwan da ke haifar da daidaituwa waɗanda aka samo daga waɗannan hanyoyin suna taimakawa PQQ don kare ku daga tsufawar salula kuma yana haɓaka tsawon rai.

A cikin samfurin dabba, an samo kari tare da pqq don rage damuwa da iskar shaka da kuma tsawaita tsawon lokacin zagayawa.

vii. Kariya daga damuwa na damuwa

PQQ yana ɗaure su don furotin don haka yana hana hada hada hada abu abu da iskar shaka a cikin ƙwayoyin. Hakanan yana da ikon samun kawar da abubuwa masu illa a jiki.

A cikin nazarin dabba, an samo kari don pqq don hana mutuwa mutuwar ƙwayoyin sel.

Wani binciken ya gudana a vitro ya ba da rahoton cewa PQQ ya kare sel mitochondria na hanta mai lalacewa daga lalacewa bayan damuwa da iskar shaka da kuma kawar da sifofin superoxide.

An ci gaba da yin nazari tare da mitar cututtukan cututtukan mahaifa (STZ), PQQ da aka bayar a 20 MG / kg nauyin jiki na tsawon kwanaki 15 don rage yawan matakan glucose da samfuran peroxidation, kuma har ila yau yana bunkasa ayyukan antioxidants a cikin kwakwalwar masu cutar sukari. .

Sauran amfani da quinone pyrroloquinoline sun haɗa da:

Hana kiba

Yana inganta tsarin garkuwar jiki

Inganta haihuwa

Yana inganta aiki da fahimta da kwakwalwa

Taimaka fama da gajiya

A halin da ake ciki yanzu a duniya, labarai marasa kyau saboda COVID 19 suna zuwa a kowane lokaci. Za'a iya amfani da pyrroloquinoline quinone coronavirus yaƙi. Wannan ƙarin ƙarin abubuwan ingantawa zai haɓaka rigakafi tare kuma yana ba da taimako na barci don yaye muku damuwa.

pyarroloquinoline quinone yana amfani

Menene tasirin sakamako na pyrroloquinoline quinone (pqq)?

Lokacin da ake samun PQQ daga tushen abinci ba za'a iya samun sakamako mai illa ba sai dai idan mutum yana rashin lafiyan abincin.

A cikin nazarin dabbobi tare da beraye, raunin ƙwayar cuta yana da alaƙa da ƙari na PQQ. A cikin binciken daya ƙunshi berayen, PQQ allura a 11-12 mg / kg nauyin jiki ya ruwaito cewa yana haifar da kumburin koda.

A cikin wani binciken berayen, PQQ a 20 MG / kg nauyin jiki wanda aka samu yana haifar da guba ga kyallen na koda da hepatic.

An kuma bayar da rahoton mace-mace na ƙarancin ƙwayar cuta tare da ƙarin allurai na kimanin 500 MG.

A cikin mutane, ba a ba da rahoton mummunan sakamako pyrroloquinoline quinone sakamako tare da allurai har zuwa 20 mg / rana.

Koyaya, a cikin abubuwan da ba a sani ba, wasu yiwuwar sakamakon pindroloquinoline quinone side na iya faruwa saboda shan abubuwan maye. Wadannan illolin da suka shafi sun hada da ciwon kai, gajiya, amai, bacci da rashin bacci.

Sashi na PQQ

Tun da pyrroloquinoline quinone (pqq) bai riga ya amince da Dokar Kula da Magunguna ta Tarayya don amfani da magunguna ba, babu daidaitattun magungunan quinone pyrroloquinoline daga 2 MG / rana suna da amfani. Koyaya, yawancin PQQ suna cikin allurai na 20 zuwa 40 MG.

Pyrroloquinoline quinone sashi na iya bambanta dangane da manufar da aka nufa. Wasu nazarin sun nuna cewa sashi na 0.075 zuwa 0.3 mg / kg kowace rana yana da inganci wajen haɓaka aikin mitochondria, yayin da kashi mafi girma na kimanin 20 MG kowace rana na iya zama dole don yaƙi da kumburi.

Lokacin da aka haɗu tare da COQ10, ana ba da shawarar allurai 20 mg PQQ da 200 mg COQ10, kodayake wasu nazarin da suke amfani da 20 mg na PQQ da 300 mg COQ10 basu bayar da rahoton wani sakamako masu illa ba.

Dole ne a karɓi ƙarin PQQ a baki kuma zai fi dacewa kafin abinci-a kan komai a ciki.

Ana baka shawarar sosai don fara daga ƙananan allurai da ƙaruwa kamar yadda ya cancanta.

Kuma abin lura shine cewa karatun da yawa basa bada shawarar shan kashi fiye da 80 MG kowace rana.

Wadanne nau'ikan abinci ne ke dauke da kwayar kwayar pyrroloquinoline (pqq)?

Pyrroloquinoline quinone (pqq) ana samun shi a yawancin abincin tsire-tsire, kodayake yawanci yana da ƙarancin yawa. Tsire-tsire suna samun PQQ kai tsaye daga ƙwayoyin ƙasa da ƙwayoyin ƙasa kamar su methylotrophic, rhizobium, da kwayoyin acetobacter.

Pqq a cikin kyallen dan adam ya zo ne daga abinci kuma wani bangare daga samarwar kwayoyin cuta.

Matsayin quinine na pyrroloquinoline a cikin waɗannan hanyoyin abinci ya bambanta daga 0.19 zuwa 61ng / g. Koyaya, pqq ya fi mai da hankali ga waɗannan abubuwan abinci masu zuwa:

Pqq-Abinci

Sauran hanyoyin abinci na PQQ sun hada da tsiron broccoli, mustard filin, wake fava, apples, qwai, gurasa, giya da madara.

Sakamakon karancin pqq a cikin yawancin abinci, zai zama da wahala a sami wadataccen abu don tsallake fa'idodin da ke tattare da pqq sai dai idan mun ɗauki yawa na wani abinci. Don haka ya zama dole mutum ya sayi kari na pqq don dacewa da abinci mai kyau.

PQQ da COQ10

Coenzyme Q10 (COQ10) sau da yawa ana ɗauka azaman mai haɓaka mitochondria yana faruwa a cikin jikin mutum kuma a cikin yawancin abinci. Hakan yayi kama da PQQ; duk da haka, pyrroloquinoline quinine da CQ10 suna aiki ta hanyoyi dabam dabam ko kuma suna amfani da hanyoyi daban-daban don inganta ayyukan mitochondrial.

Coenzyme Q10 shine ainihin cofactor wanda ke aiki a cikin mitochondria kuma yana taka muhimmiyar rawa a cikin numfashi na salula da kuma amfani da iskar oxygen don samar da makamashi. PQQ a gefe guda yana ƙara yawan ƙwayoyin mitochondria kuma yana inganta ingantaccen mitochondria.

Lokacin da aka haɗu tare, pyrroloquinoline quinine da CQ10, suna ba da tasirin alamu don haɓaka aikin mitochondrial, kare mu daga damuwa na damuwa da kuma daidaita hanyoyin siginar salula.

Sayi Karin PQQ

Akwai fa'idodi da yawa da babu makawa game da kari na pqq foda kuma ya kamata kuyi la'akari da yaba irin abincin ku da shi. PQQ foda na siyarwa yana samuwa a kan layi. Koyaya, don mafi kyawun sakamako shine kasancewa cikin shiri sosai lokacin da ka sayi ƙarin pqq don tabbatar da cewa ka sami mafi kyawun inganci.

Idan kayi la'akari da sayen pqq girma foda tabbatar da samun shi daga masu samarwa.

References

  1. Chowanadisai W., Bauerly KA, Tchaparian E., Wong A., Cortopassi GA, Rucker RB (2010). Pyrroloquinoline quinone yana motsa biogenesis na mitochondrial ta hanyar cAMP mayar da martani kashi-ɗaurin furotin phosphorylation da haɓaka furcin PGC-1α. Biol. Chem. 285: 142–152.
  2. Harris CB1, Chowanadisai W, Mishchuk DO, Satre MA, Slupsky CM, Rucker RB. (2013). Abincin pyrroloquinoline quinone (PQQ) yana canza alamun da ke haifar da kumburi da ƙwaƙwalwar haɗin jini na mitochondrial a cikin abubuwan mutum. J Nutr Biochem.Dec; 24 (12): 2076-84. Doi: 10.1016 / j.jnutbio.2013.07.008.
  3. Kumazawa T., Sato K., Seno H., Ishii A., da Suzuki O. (1995). Matakan pyrroloquinoline quinone a cikin abinci iri-iri. J.307: 331-333.
  4. Nunome K., Miyazaki S., Nakano M., Iguchi-Ariga S., Ariga H. (2008). Quinone na Pyrroloquinoline yana hana mutuwar damuwa yanayin damuwa na rashin isashshen abu wanda ya faru ta hanyar yiwuwar canje-canje a cikin yanayin oxidative na DJ-1. Pharm. Bull. 31: 1321- 1326.
  5. Paul Hwang & Darryn S. Willoughby (2018). Hanyoyin da ke Bayan hindarin Quinone na Pyrroloquinoline akan Skeletal Muscle Mitochondrial Biogenesis: Sakamako mai yiwuwa Sakamako tare da motsa jiki, Journal of the American College of Nutrition, 37: 8, 738-748, DOI: 1080 / 07315724.2018.1461146.
  6. Tashoshi T, Hadari D, da Bauerly K, et al. (2006). Cikakken rubutu: Pyrroloquinoline quinone yana daidaita adadin mitochondrial da aiki a cikin mice. J Nutr. Feb; 136 (2): 390-6.
  7. Zhang L, Liu J, Cheng C, Yuan Y, Yu B, Shen A, Yan M. (2012). Tasirin neuroprotective na pyrroloquinoline quinone akan raunin kwakwalwa. J Neurotrauma. Maris 20; 29 (5): 851-64.

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